MX2015007846A - Anticuerpos anti-b7-h4 humana y sus usos. - Google Patents

Anticuerpos anti-b7-h4 humana y sus usos.

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Publication number
MX2015007846A
MX2015007846A MX2015007846A MX2015007846A MX2015007846A MX 2015007846 A MX2015007846 A MX 2015007846A MX 2015007846 A MX2015007846 A MX 2015007846A MX 2015007846 A MX2015007846 A MX 2015007846A MX 2015007846 A MX2015007846 A MX 2015007846A
Authority
MX
Mexico
Prior art keywords
human
molecules
activity
tumor
antibodies
Prior art date
Application number
MX2015007846A
Other languages
English (en)
Inventor
Solomon Langermann
Linda Liu
Sheng Yao
Lieping Chen
Michael Glen Overstreet
Original Assignee
Amplimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amplimmune Inc filed Critical Amplimmune Inc
Publication of MX2015007846A publication Critical patent/MX2015007846A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Se divulga el anticuerpo "6H3" anti-B7-H4 humana, fragmentos de unión a antígeno, derivados y variantes humanizadas del mismo que sean capaces de unirse inmunoespecíficamente a B7-H4 y los usos de dichas moléculas en el diagnóstico y el tratamiento del cáncer y otras enfermedades. En realizaciones preferidas, las moléculas se utilizan para retrasar o prevenir el crecimiento de tumores, inhibir la supresión mediada por tumor, eliminar los tumores y/o agotar o bloquear la actividad de los macrófagos asociados con tumor ("TAM") de manera que altere su actividad y/o reduzca la supresión inmune mediada por TAM.
MX2015007846A 2012-12-19 2013-12-19 Anticuerpos anti-b7-h4 humana y sus usos. MX2015007846A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261739353P 2012-12-19 2012-12-19
US201261739272P 2012-12-19 2012-12-19
US201261739287P 2012-12-19 2012-12-19
PCT/US2013/076701 WO2014100483A1 (en) 2012-12-19 2013-12-19 Anti-human b7-h4 antibodies and their uses

Publications (1)

Publication Number Publication Date
MX2015007846A true MX2015007846A (es) 2016-04-28

Family

ID=49917300

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007846A MX2015007846A (es) 2012-12-19 2013-12-19 Anticuerpos anti-b7-h4 humana y sus usos.

Country Status (13)

Country Link
US (1) US9574000B2 (es)
EP (2) EP2934575A2 (es)
JP (2) JP2016509582A (es)
KR (1) KR20150100716A (es)
CN (1) CN104955475A (es)
AU (2) AU2013361275B2 (es)
BR (1) BR112015014063A2 (es)
CA (2) CA2894689A1 (es)
HK (1) HK1210027A1 (es)
MX (1) MX2015007846A (es)
RU (1) RU2015129551A (es)
SG (1) SG11201504764SA (es)
WO (2) WO2014100439A2 (es)

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US20150315275A1 (en) 2015-11-05
HK1210027A1 (en) 2016-04-15
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