MX2014007277A - Aparato de aerosolizacion para administracion de farmaco independiente del perfil de inhalacion. - Google Patents

Aparato de aerosolizacion para administracion de farmaco independiente del perfil de inhalacion.

Info

Publication number
MX2014007277A
MX2014007277A MX2014007277A MX2014007277A MX2014007277A MX 2014007277 A MX2014007277 A MX 2014007277A MX 2014007277 A MX2014007277 A MX 2014007277A MX 2014007277 A MX2014007277 A MX 2014007277A MX 2014007277 A MX2014007277 A MX 2014007277A
Authority
MX
Mexico
Prior art keywords
openings
receptacle
powder
pharmaceutical formulation
flow
Prior art date
Application number
MX2014007277A
Other languages
English (en)
Inventor
Leo Chan
Try Keith Ung
Jeffry Weers
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014007277A publication Critical patent/MX2014007277A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Un aparato de aerosolización de polvo que comprende un alojamiento (110) que comprende una salida adaptada para ser insertada en la boca de un usuario y una o más aberturas de aire de derivación. Un soporte del receptáculo (135) dentro del alojamiento soporta un receptáculo (130) que contiene una formulación farmacéutica en polvo. Un mecanismo de perforación dentro del alojamiento crea en el receptáculo una o más aberturas de entrada y una o más aberturas de salida de polvo (150), en donde las aberturas de salida de polvo tienen un área total de 0.2 mm2 a 4.0 mm2. Tras la inhalación de un usuario a través de la salida, el aire fluye a través de la una o más aberturas de aire de derivación y a través del receptáculo para aerosolizar la formulación farmacéutica en polvo en el receptáculo. En una versión, se seleccionan los parámetros de flujo relativos entre el flujo a través de la una o más aberturas de derivación y la una o más aberturas de salida de polvo, de tal manera que el flujo de la formulación farmacéutica en forma de aerosol no se produce hasta que se logra una tasa de flujo de inhalación predeterminada.
MX2014007277A 2011-12-16 2012-12-14 Aparato de aerosolizacion para administracion de farmaco independiente del perfil de inhalacion. MX2014007277A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576768P 2011-12-16 2011-12-16
US201161576735P 2011-12-16 2011-12-16
PCT/US2012/069938 WO2013090841A2 (en) 2011-12-16 2012-12-14 Aerosolization apparatus for inhalation profile-independent drug delivery

Publications (1)

Publication Number Publication Date
MX2014007277A true MX2014007277A (es) 2014-07-28

Family

ID=47501481

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007277A MX2014007277A (es) 2011-12-16 2012-12-14 Aparato de aerosolizacion para administracion de farmaco independiente del perfil de inhalacion.

Country Status (13)

Country Link
US (1) US9744318B2 (es)
EP (1) EP2790761B1 (es)
JP (1) JP2015500712A (es)
KR (1) KR20140103939A (es)
CN (1) CN103998087B (es)
AU (1) AU2012351947B2 (es)
BR (1) BR112014014399A2 (es)
CA (1) CA2858247A1 (es)
ES (1) ES2924032T3 (es)
IL (1) IL232762A0 (es)
MX (1) MX2014007277A (es)
RU (1) RU2615076C2 (es)
WO (1) WO2013090841A2 (es)

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EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
HUE058896T2 (hu) 2010-10-01 2022-09-28 Modernatx Inc N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
AU2013243951A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
AR095222A1 (es) * 2013-04-03 2015-09-30 Sanofi Sa Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición
EP3024523B1 (en) 2013-07-22 2018-08-29 Inhalation Sciences Sweden AB Apparatus and method for generating an aerosol
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
JP2017047130A (ja) * 2015-09-04 2017-03-09 原田車両設計株式会社 薬剤吸入装置
EP3346987A1 (en) * 2015-09-09 2018-07-18 Novartis AG Targeted delivery of spray-dried formulations to the lungs
CN205916436U (zh) * 2016-07-13 2017-02-01 深圳市合川医疗科技有限公司 一种泡罩穿刺元件
ES2936415T3 (es) * 2017-04-17 2023-03-16 Respira Therapeutics Inc Inhalador de dosis unitaria de polvo seco
JP2020535880A (ja) * 2017-10-02 2020-12-10 ノバルティス アーゲー 医薬品を調製するための方法
US11864587B2 (en) * 2018-06-15 2024-01-09 Valley Product Concepts, LLC Capsules for use in personal vaporizers
CN110286064B (zh) * 2019-08-05 2021-07-27 贵州大学 一种矿物颗粒润湿性测量装置及其测量方法
CN115089825A (zh) * 2022-07-06 2022-09-23 苏州易合医药有限公司 肺部给药装置

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Also Published As

Publication number Publication date
CA2858247A1 (en) 2013-06-20
KR20140103939A (ko) 2014-08-27
RU2615076C2 (ru) 2017-04-03
WO2013090841A2 (en) 2013-06-20
WO2013090841A3 (en) 2013-08-08
US9744318B2 (en) 2017-08-29
IL232762A0 (en) 2014-07-31
US20140318539A1 (en) 2014-10-30
EP2790761B1 (en) 2022-05-11
ES2924032T3 (es) 2022-10-04
RU2014128828A (ru) 2016-02-10
CN103998087A (zh) 2014-08-20
BR112014014399A2 (pt) 2017-06-13
JP2015500712A (ja) 2015-01-08
EP2790761A2 (en) 2014-10-22
AU2012351947B2 (en) 2017-08-17
CN103998087B (zh) 2017-04-05
AU2012351947A1 (en) 2014-06-26

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