MX2014007042A - Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu. - Google Patents

Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.

Info

Publication number
MX2014007042A
MX2014007042A MX2014007042A MX2014007042A MX2014007042A MX 2014007042 A MX2014007042 A MX 2014007042A MX 2014007042 A MX2014007042 A MX 2014007042A MX 2014007042 A MX2014007042 A MX 2014007042A MX 2014007042 A MX2014007042 A MX 2014007042A
Authority
MX
Mexico
Prior art keywords
buprenorphine
opioid receptor
compositions
receptor antagonists
composition
Prior art date
Application number
MX2014007042A
Other languages
English (en)
Inventor
Daniel Deaver
Elliot Ehrich
Original Assignee
Alkermes Pharma Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Pharma Ireland Ltd filed Critical Alkermes Pharma Ireland Ltd
Publication of MX2014007042A publication Critical patent/MX2014007042A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4748Quinolines; Isoquinolines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se relaciona a una composición que comprende buprenorfina y un antagonista del receptor opioide mu, en donde la composición se caracteriza por un índice de actividad de Antagonista-Agonista (AAnAI) de entre aproximadamente 0.7 y aproximadamente 2.2; en donde (ver Fórmula).
MX2014007042A 2011-12-15 2012-12-14 Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu. MX2014007042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161576233P 2011-12-15 2011-12-15
PCT/IB2012/002900 WO2013088243A1 (en) 2011-12-15 2012-12-14 Compositions of buprenorphine and mu-opioid receptor antagonists

Publications (1)

Publication Number Publication Date
MX2014007042A true MX2014007042A (es) 2015-01-22

Family

ID=47757653

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007042A MX2014007042A (es) 2011-12-15 2012-12-14 Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.

Country Status (24)

Country Link
US (8) US8822488B2 (es)
EP (3) EP3153171B1 (es)
JP (2) JP6038170B2 (es)
KR (1) KR101996108B1 (es)
CN (2) CN104159586A (es)
AU (1) AU2012351806C1 (es)
BR (1) BR112014012409B8 (es)
CA (1) CA2858812C (es)
CY (1) CY1121081T1 (es)
DK (1) DK3153171T3 (es)
EA (1) EA030609B8 (es)
ES (2) ES2791764T3 (es)
HR (1) HRP20181950T1 (es)
HU (1) HUE041883T2 (es)
IL (1) IL232785B (es)
LT (1) LT3153171T (es)
MX (1) MX2014007042A (es)
PL (1) PL3153171T3 (es)
PT (1) PT3153171T (es)
RS (1) RS58322B1 (es)
SI (1) SI3153171T1 (es)
TR (1) TR201815154T4 (es)
WO (1) WO2013088243A1 (es)
ZA (1) ZA201405029B (es)

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Publication number Priority date Publication date Assignee Title
EP2506712B8 (en) 2009-12-04 2019-06-19 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
FI3446565T3 (fi) 2010-08-23 2024-01-30 Alkermes Pharma Ireland Ltd Menetelmiä antipsykoottisten lääkkeiden aiheuttaman painonnousun hoitamiseksi
JP6038170B2 (ja) 2011-12-15 2016-12-07 アルカーメス ファーマ アイルランド リミテッド ブプレノルフィンおよびμ−オピオイド受容体アンタゴニストの組成物
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
NZ631018A (en) 2013-05-24 2017-12-22 Alkermes Pharma Ireland Ltd Morphan and morphinan analogues, and methods of use
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
TW201636329A (zh) 2015-02-02 2016-10-16 佛瑪治療公司 作為hdac抑制劑之雙環[4,6,0]異羥肟酸
EA201792673A1 (ru) 2015-02-02 2018-04-30 Форма Терапьютикс, Инк. 3-арил-4-амидобициклические [4,5,0] гидроксамовые кислоты в качестве ингибиторов hdac
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

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Also Published As

Publication number Publication date
JP2015505853A (ja) 2015-02-26
EP2790702B1 (en) 2020-04-01
KR20140107258A (ko) 2014-09-04
KR101996108B1 (ko) 2019-10-01
CA2858812A1 (en) 2013-06-20
CN104159586A (zh) 2014-11-19
PL3153171T3 (pl) 2019-02-28
US20150051240A1 (en) 2015-02-19
BR112014012409B8 (pt) 2022-09-13
US10806731B2 (en) 2020-10-20
BR112014012409A2 (pt) 2017-06-13
US20170056392A1 (en) 2017-03-02
AU2012351806B2 (en) 2016-03-10
EP3153171B1 (en) 2018-09-19
JP6403726B2 (ja) 2018-10-10
DK3153171T3 (en) 2018-11-19
TR201815154T4 (tr) 2018-11-21
CY1121081T1 (el) 2019-12-11
IL232785A0 (en) 2014-07-31
EA201491153A1 (ru) 2015-04-30
US10314838B2 (en) 2019-06-11
AU2012351806A1 (en) 2014-05-15
US10188643B2 (en) 2019-01-29
US20210196703A1 (en) 2021-07-01
ES2791764T3 (es) 2020-11-05
HUE041883T2 (hu) 2019-06-28
CN106727562A (zh) 2017-05-31
WO2013088243A1 (en) 2013-06-20
US8822488B2 (en) 2014-09-02
AU2012351806C1 (en) 2016-06-16
LT3153171T (lt) 2018-12-10
PT3153171T (pt) 2018-11-16
ZA201405029B (en) 2015-10-28
US9918978B2 (en) 2018-03-20
IL232785B (en) 2021-04-29
ES2692771T3 (es) 2018-12-05
US20130190342A1 (en) 2013-07-25
JP2016222706A (ja) 2016-12-28
US9913837B2 (en) 2018-03-13
RS58322B1 (sr) 2019-03-29
US20160256450A1 (en) 2016-09-08
US20180078543A1 (en) 2018-03-22
SI3153171T1 (sl) 2019-01-31
EP3415148A1 (en) 2018-12-19
CN106727562B (zh) 2019-07-05
CA2858812C (en) 2019-02-26
EA030609B1 (ru) 2018-08-31
EP2790702A1 (en) 2014-10-22
HRP20181950T1 (hr) 2019-03-22
JP6038170B2 (ja) 2016-12-07
EA030609B8 (ru) 2018-10-31
NZ624056A (en) 2016-07-29
BR112014012409B1 (pt) 2022-08-23
EP3153171A1 (en) 2017-04-12
US9498474B2 (en) 2016-11-22
US20180078542A1 (en) 2018-03-22
US20190247387A1 (en) 2019-08-15

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