MX2013004776A - Hidrato de tartrato de 1-{ (2s)-2-amino-4-[2,4-bis(trifluorometil) -5,8-di-hidropirido [3,4-d] pirimidin-7 (6h)-il]-4-oxobutil}-5, 5-difluoro-piperidin-2-ona. - Google Patents

Hidrato de tartrato de 1-{ (2s)-2-amino-4-[2,4-bis(trifluorometil) -5,8-di-hidropirido [3,4-d] pirimidin-7 (6h)-il]-4-oxobutil}-5, 5-difluoro-piperidin-2-ona.

Info

Publication number
MX2013004776A
MX2013004776A MX2013004776A MX2013004776A MX2013004776A MX 2013004776 A MX2013004776 A MX 2013004776A MX 2013004776 A MX2013004776 A MX 2013004776A MX 2013004776 A MX2013004776 A MX 2013004776A MX 2013004776 A MX2013004776 A MX 2013004776A
Authority
MX
Mexico
Prior art keywords
oxobutyl
pyrimidin
tartrate
hydrate
trifluoromethyl
Prior art date
Application number
MX2013004776A
Other languages
English (en)
Other versions
MX341584B (es
Inventor
Ki Sook Park
Ji Hye Lee
Jung Min Yun
Bong Chan Kim
Kyu Young Kim
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45995015&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013004776(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of MX2013004776A publication Critical patent/MX2013004776A/es
Publication of MX341584B publication Critical patent/MX341584B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere al 1, 5 hidrato de tartrato de 1-{(2S)-2-amino-4-[2, 4-bis(trifluorometil)-5, 8-dihidropirido[3, 4-d]pirimidin-7(6H)-il]-4-oxobutil}-5, 5-difluoropiperidin-2-ona, un proceso para prepararlo, y una composición farmacéutica para inhibir la DPP-IV, que comprende dicho compuesto como componente activo.
MX2013004776A 2010-11-01 2011-10-31 Hidrato de tartrato de 1-{ (2s)-2-amino-4-[2,4-bis(trifluorometil) -5,8-di-hidropirido [3,4-d] pirimidin-7 (6h)-il]-4-oxobutil}-5, 5-difluoro-piperidin-2-ona. MX341584B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100107868 2010-11-01
PCT/KR2011/008186 WO2012060590A2 (en) 2010-11-01 2011-10-31 Hydrate of 1-{(2s)-2-amino-4-[2,4-bis(trifluoromethyl)-5,8-di- hydropyrido[3,4-d]pyrimidin-7(6h)-yl]-4-oxobutyl}-5,5-difluoro-piperidin-2-one tartrate

Publications (2)

Publication Number Publication Date
MX2013004776A true MX2013004776A (es) 2013-11-04
MX341584B MX341584B (es) 2016-08-25

Family

ID=45995015

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004776A MX341584B (es) 2010-11-01 2011-10-31 Hidrato de tartrato de 1-{ (2s)-2-amino-4-[2,4-bis(trifluorometil) -5,8-di-hidropirido [3,4-d] pirimidin-7 (6h)-il]-4-oxobutil}-5, 5-difluoro-piperidin-2-ona.

Country Status (28)

Country Link
US (1) US8859567B2 (es)
EP (1) EP2635580B1 (es)
JP (1) JP6193762B2 (es)
KR (1) KR101446789B1 (es)
CN (1) CN103189375B (es)
AP (1) AP3287A (es)
AR (1) AR083591A1 (es)
AU (1) AU2011324253B2 (es)
BR (1) BR112013010586A2 (es)
CA (1) CA2814357C (es)
CL (1) CL2013001137A1 (es)
CO (1) CO6710945A2 (es)
DO (1) DOP2013000090A (es)
EA (1) EA024679B1 (es)
EC (1) ECSP13012599A (es)
GE (1) GEP20156218B (es)
IL (1) IL225808A (es)
MA (1) MA34625B1 (es)
MX (1) MX341584B (es)
MY (1) MY156428A (es)
NZ (1) NZ609644A (es)
PE (3) PE20180464A1 (es)
SG (1) SG189931A1 (es)
TW (1) TWI519533B (es)
UA (1) UA106445C2 (es)
UY (1) UY33696A (es)
WO (1) WO2012060590A2 (es)
ZA (1) ZA201302646B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2007752E (pt) 2006-03-31 2010-10-18 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas e pirazinas como moduladores do receptor de histamina h4
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
MY180726A (en) 2013-03-06 2020-12-08 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE451369T1 (de) * 2002-07-15 2009-12-15 Merck & Co Inc Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes
US7388019B2 (en) 2003-01-31 2008-06-17 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
TWI357902B (en) 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth

Also Published As

Publication number Publication date
US20130203787A1 (en) 2013-08-08
ECSP13012599A (es) 2013-07-31
GEP20156218B (en) 2015-01-12
SG189931A1 (en) 2013-06-28
MA34625B1 (fr) 2013-10-02
AU2011324253A1 (en) 2013-05-02
PE20140392A1 (es) 2014-03-22
MY156428A (en) 2016-02-26
AU2011324253B2 (en) 2015-10-29
WO2012060590A3 (en) 2012-06-28
ZA201302646B (en) 2014-01-29
PE20240220A1 (es) 2024-02-16
MX341584B (es) 2016-08-25
EP2635580A2 (en) 2013-09-11
CN103189375A (zh) 2013-07-03
EP2635580B1 (en) 2015-08-12
UA106445C2 (ru) 2014-08-26
AP2013006866A0 (en) 2013-05-31
TWI519533B (zh) 2016-02-01
CO6710945A2 (es) 2013-07-15
EA024679B1 (ru) 2016-10-31
CL2013001137A1 (es) 2013-09-06
JP6193762B2 (ja) 2017-09-06
PE20180464A1 (es) 2018-03-06
KR20120046069A (ko) 2012-05-09
US8859567B2 (en) 2014-10-14
IL225808A (en) 2016-08-31
EP2635580A4 (en) 2014-04-02
AP3287A (en) 2015-05-31
EA201390644A1 (ru) 2014-11-28
UY33696A (es) 2012-04-30
CA2814357A1 (en) 2012-05-10
CN103189375B (zh) 2016-08-10
BR112013010586A2 (pt) 2016-08-09
KR101446789B1 (ko) 2014-10-01
NZ609644A (en) 2016-02-26
CA2814357C (en) 2015-07-07
AR083591A1 (es) 2013-03-06
JP2013540810A (ja) 2013-11-07
WO2012060590A2 (en) 2012-05-10
TW201245189A (en) 2012-11-16
DOP2013000090A (es) 2018-06-30
IL225808A0 (en) 2013-06-27

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