MX2012015279A - Derivado de tetrahidrocarbonila. - Google Patents
Derivado de tetrahidrocarbonila.Info
- Publication number
- MX2012015279A MX2012015279A MX2012015279A MX2012015279A MX2012015279A MX 2012015279 A MX2012015279 A MX 2012015279A MX 2012015279 A MX2012015279 A MX 2012015279A MX 2012015279 A MX2012015279 A MX 2012015279A MX 2012015279 A MX2012015279 A MX 2012015279A
- Authority
- MX
- Mexico
- Prior art keywords
- disclosed
- enpp2
- inhibitory activity
- urine evacuation
- evacuation disorders
- Prior art date
Links
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 abstract 2
- 101000897035 Homo sapiens Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 210000002700 urine Anatomy 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Como un producto farmacéutico útil para pacientes con trastornos de evacuación de orina para quienes los fármacos convencionales son inefectivos, se describe un fármaco que tiene actividad inhibitoria en ENPP2, que es un objetivo diferente al de los fármaco existentes. Se describen un compuesto representado por la fórmula (I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010154280 | 2010-07-06 | ||
JP2011060765 | 2011-03-18 | ||
PCT/JP2011/065312 WO2012005227A1 (ja) | 2010-07-06 | 2011-07-05 | テトラヒドロカルボリン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012015279A true MX2012015279A (es) | 2013-04-29 |
Family
ID=45441206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012015279A MX2012015279A (es) | 2010-07-06 | 2011-07-05 | Derivado de tetrahidrocarbonila. |
Country Status (21)
Country | Link |
---|---|
US (3) | US9006246B2 (es) |
EP (2) | EP3002285B1 (es) |
JP (2) | JP5821848B2 (es) |
KR (1) | KR101831005B1 (es) |
CN (1) | CN102971318B (es) |
AU (1) | AU2011274970C1 (es) |
BR (1) | BR112012031580A2 (es) |
CA (1) | CA2802216C (es) |
DK (1) | DK2592081T3 (es) |
ES (2) | ES2623286T3 (es) |
IL (1) | IL223028A0 (es) |
MX (1) | MX2012015279A (es) |
MY (1) | MY161001A (es) |
NZ (1) | NZ603575A (es) |
PL (1) | PL2592081T3 (es) |
PT (1) | PT2592081T (es) |
RU (1) | RU2572818C2 (es) |
SG (1) | SG186826A1 (es) |
TW (2) | TWI525092B (es) |
WO (1) | WO2012005227A1 (es) |
ZA (1) | ZA201300032B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101831005B1 (ko) | 2010-07-06 | 2018-02-21 | 오노 야꾸힝 고교 가부시키가이샤 | 테트라히드로카르볼린 유도체 |
TW201309698A (zh) * | 2011-03-18 | 2013-03-01 | Ono Pharmaceutical Co | 四氫咔啉衍生物 |
WO2015002755A2 (en) * | 2013-06-21 | 2015-01-08 | The Broad Institute, Inc. | Compounds for the treatment of malaria |
TW201623239A (zh) | 2014-04-24 | 2016-07-01 | 田邊三菱製藥股份有限公司 | 新穎2-胺基-吡啶及2-胺基-嘧啶衍生物及其醫藥用途 |
AR100767A1 (es) | 2014-06-06 | 2016-11-02 | Biogen Ma Inc | Agentes moduladores de la atx |
GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
WO2016197009A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
CN110483424A (zh) * | 2018-06-11 | 2019-11-22 | 上海睿升化工科技有限公司 | 一种1-h-1,2,3-三氮唑-4-羧酸叔丁酯的制备方法 |
HUE062356T2 (hu) | 2018-07-27 | 2023-10-28 | Mitsubishi Tanabe Pharma Corp | Új 3, 5-diszubsztituált piridin- és 3,5-diszubsztituált piridazin-származékok, és ezek gyógyászati alkalmazása |
US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
CN111272918A (zh) * | 2020-03-31 | 2020-06-12 | 广西-东盟食品检验检测中心 | 一种那非类医药中间体的高效液相色谱-质谱检测方法 |
CN111454260B (zh) * | 2020-05-25 | 2023-02-28 | 贵州大学 | 一类含异丙醇胺亚结构的1,2,3,4-四氢-β-咔啉类化合物及其制备方法和应用 |
WO2024053650A1 (ja) * | 2022-09-06 | 2024-03-14 | 小野薬品工業株式会社 | ジアシルグリセロールキナーゼαおよび/またはζ阻害活性を有する化合物およびその医薬用途 |
CN115728428A (zh) * | 2022-11-15 | 2023-03-03 | 山东省医药工业设计院有限公司 | 一种他达拉非中间体顺式四氢咔啉盐酸盐有关物质的测定方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL130238A0 (en) * | 1999-06-01 | 2000-06-01 | Peptor Ltd | Conformationally constrained backbone cyclized interleukin-6 antagonists |
UA74826C2 (en) * | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
EP1313736B1 (en) | 2000-06-26 | 2005-07-27 | Lilly Icos LLC | Condensed pyrazindione derivatives as inhibitors of pde5 |
EP1360186B1 (en) * | 2001-02-12 | 2006-11-22 | Lilly Icos LLC | Carboline derivatives |
JP4596314B2 (ja) | 2002-05-28 | 2010-12-08 | 小野薬品工業株式会社 | β−アラニン誘導体およびその用途 |
JP4671123B2 (ja) | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
EP1706404A2 (en) * | 2004-01-23 | 2006-10-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
EA010546B1 (ru) | 2004-04-09 | 2008-10-30 | Миллениум Фармасьютикалз, Инк. | Бета-карболины, применяемые для лечения воспалительных заболеваний |
ES2459742T3 (es) * | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co., Ltd. | Compuesto tricíclico y uso del mismo |
JP2008297278A (ja) | 2007-06-01 | 2008-12-11 | Astellas Pharma Inc | Lpa受容体アゴニスト |
KR101831005B1 (ko) | 2010-07-06 | 2018-02-21 | 오노 야꾸힝 고교 가부시키가이샤 | 테트라히드로카르볼린 유도체 |
TW201309698A (zh) | 2011-03-18 | 2013-03-01 | Ono Pharmaceutical Co | 四氫咔啉衍生物 |
-
2011
- 2011-07-05 KR KR1020137000248A patent/KR101831005B1/ko active IP Right Grant
- 2011-07-05 PT PT118035617T patent/PT2592081T/pt unknown
- 2011-07-05 EP EP15190651.8A patent/EP3002285B1/en not_active Not-in-force
- 2011-07-05 SG SG2012095501A patent/SG186826A1/en unknown
- 2011-07-05 RU RU2013104866/04A patent/RU2572818C2/ru not_active IP Right Cessation
- 2011-07-05 ES ES11803561.7T patent/ES2623286T3/es active Active
- 2011-07-05 DK DK11803561.7T patent/DK2592081T3/en active
- 2011-07-05 CN CN201180033552.7A patent/CN102971318B/zh not_active Expired - Fee Related
- 2011-07-05 BR BR112012031580A patent/BR112012031580A2/pt not_active Application Discontinuation
- 2011-07-05 MX MX2012015279A patent/MX2012015279A/es active IP Right Grant
- 2011-07-05 TW TW100123652A patent/TWI525092B/zh not_active IP Right Cessation
- 2011-07-05 EP EP11803561.7A patent/EP2592081B1/en not_active Not-in-force
- 2011-07-05 PL PL11803561T patent/PL2592081T3/pl unknown
- 2011-07-05 NZ NZ603575A patent/NZ603575A/en not_active IP Right Cessation
- 2011-07-05 JP JP2012523864A patent/JP5821848B2/ja not_active Expired - Fee Related
- 2011-07-05 CA CA2802216A patent/CA2802216C/en not_active Expired - Fee Related
- 2011-07-05 WO PCT/JP2011/065312 patent/WO2012005227A1/ja active Application Filing
- 2011-07-05 TW TW104140762A patent/TWI586666B/zh not_active IP Right Cessation
- 2011-07-05 US US13/807,947 patent/US9006246B2/en not_active Expired - Fee Related
- 2011-07-05 AU AU2011274970A patent/AU2011274970C1/en not_active Ceased
- 2011-07-05 MY MYPI2012701218A patent/MY161001A/en unknown
- 2011-07-05 ES ES15190651.8T patent/ES2693247T3/es active Active
-
2012
- 2012-11-14 IL IL223028A patent/IL223028A0/en active IP Right Grant
-
2013
- 2013-01-02 ZA ZA2013/00032A patent/ZA201300032B/en unknown
-
2015
- 2015-02-25 US US14/630,708 patent/US9636330B2/en not_active Expired - Fee Related
- 2015-05-18 JP JP2015100802A patent/JP6065052B2/ja not_active Expired - Fee Related
-
2017
- 2017-03-21 US US15/464,408 patent/US9974777B2/en not_active Expired - Fee Related
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Legal Events
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---|---|---|---|
FG | Grant or registration |