MX2012014497A - Un proceso mejorado para la preparación de amilsuprida. - Google Patents
Un proceso mejorado para la preparación de amilsuprida.Info
- Publication number
- MX2012014497A MX2012014497A MX2012014497A MX2012014497A MX2012014497A MX 2012014497 A MX2012014497 A MX 2012014497A MX 2012014497 A MX2012014497 A MX 2012014497A MX 2012014497 A MX2012014497 A MX 2012014497A MX 2012014497 A MX2012014497 A MX 2012014497A
- Authority
- MX
- Mexico
- Prior art keywords
- amino
- methoxy
- ethyl
- amisulpride
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso novedoso para la preparación de amisulprido (I) que está relacionado con: metilación de 4-amino-salcílico-acido (VI) con sulfato de dimetilo y base, opcionalmente en presencia de TBAB para obtener 4-amino-2-metoxi benzoato de metilo (VII) y (ii) oxidación de 4-amino-2-metoxi-5-etil ácido tiobenzoico (IX) o 4-amino-5-etil benzoato de tiometilo (X) con agente oxidante en presencia del tungstato de sodio o molibdato de amonio para dar 2-metoxi-4-amino-5-etilo-sulfonil ácido benzoico (IV) o 2-metoxi-4-amino-5-etilo-sulfonil benzoato de metilo (XI) respectivamente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN648KO2010 | 2010-06-17 | ||
IN1365KO2010 | 2010-12-01 | ||
PCT/IB2011/001301 WO2011158084A1 (en) | 2010-06-17 | 2011-06-09 | An improved process for preparation of amisulpride |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012014497A true MX2012014497A (es) | 2013-04-03 |
Family
ID=44314997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012014497A MX2012014497A (es) | 2010-06-17 | 2011-06-09 | Un proceso mejorado para la preparación de amilsuprida. |
Country Status (5)
Country | Link |
---|---|
US (1) | US20130096319A1 (es) |
EP (1) | EP2582665A1 (es) |
BR (1) | BR112012031959A2 (es) |
MX (1) | MX2012014497A (es) |
WO (1) | WO2011158084A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102807516A (zh) * | 2012-08-16 | 2012-12-05 | 四川省百草生物药业有限公司 | 氨磺必利的中间体及利用该中间体制备氨磺必利的方法 |
CN103819383A (zh) * | 2012-11-19 | 2014-05-28 | 上海美迪西生物医药有限公司 | 一种氨磺必利的合成方法 |
CN103319385B (zh) * | 2013-06-18 | 2015-07-08 | 苏州诚和医药化学有限公司 | 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法 |
CN103450058B (zh) * | 2013-09-18 | 2015-10-14 | 广安凯特医药化工有限公司 | 一种氨磺必利酸的制备方法 |
CN103553989B (zh) * | 2013-11-08 | 2015-03-11 | 苏州诚和医药化学有限公司 | 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸甲酯的合成方法 |
CN104725292B (zh) * | 2015-03-23 | 2017-07-25 | 湖北荆江源制药股份有限公司 | 一种(s)(‑)‑氨磺必利的制备方法 |
CN105237422A (zh) * | 2015-09-06 | 2016-01-13 | 南京理工大学 | 一种4-氨基-5-氯-2-甲氧基苯甲酸的合成方法 |
CN112236138B (zh) | 2017-12-05 | 2024-05-31 | 赛诺维信制药公司 | 晶体形式及其制备方法 |
CA3084953A1 (en) | 2017-12-05 | 2019-06-13 | Sunovion Pharmaceuticals Inc. | Nonracemic mixtures and uses thereof |
SG11202113266YA (en) | 2019-06-04 | 2021-12-30 | Sunovion Pharmaceuticals Inc | Modified release formulations and uses thereof |
CN113024432A (zh) * | 2019-12-24 | 2021-06-25 | 上海科胜药物研发有限公司 | 一种氨磺必利药典杂质的制备方法 |
CN113735755B (zh) * | 2021-07-28 | 2024-05-31 | 深圳市新浩瑞医药科技有限公司 | 一种氨磺必利的制备方法 |
CN114230497A (zh) * | 2021-10-21 | 2022-03-25 | 广东省科学院生物与医学工程研究所 | 一种4-氨基-5-乙基磺酰基-2-甲氧基苯甲酸的制备方法 |
CN114088845B (zh) * | 2021-12-06 | 2022-08-16 | 广东金城金素制药有限公司 | 一种测定氨磺必利口服溶液中糖精钠及苯甲酰胺类降解杂质含量的分析方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052445A (en) * | 1975-02-01 | 1977-10-04 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | Process for the production of alkyl sulfonic acids |
FR2415099A1 (fr) | 1978-01-20 | 1979-08-17 | Ile De France | Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes |
US20100105755A1 (en) * | 2008-09-12 | 2010-04-29 | Auspex Pharmaceuticals, Inc. | Substituted benzamide modulators of dopamine receptor |
-
2011
- 2011-06-09 EP EP11730425.3A patent/EP2582665A1/en not_active Withdrawn
- 2011-06-09 MX MX2012014497A patent/MX2012014497A/es active IP Right Grant
- 2011-06-09 WO PCT/IB2011/001301 patent/WO2011158084A1/en active Application Filing
- 2011-06-09 BR BR112012031959A patent/BR112012031959A2/pt not_active IP Right Cessation
- 2011-06-09 US US13/704,935 patent/US20130096319A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20130096319A1 (en) | 2013-04-18 |
BR112012031959A2 (pt) | 2015-09-22 |
EP2582665A1 (en) | 2013-04-24 |
WO2011158084A1 (en) | 2011-12-22 |
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