MX2012005340A - Sistemas de expresion regulada. - Google Patents
Sistemas de expresion regulada.Info
- Publication number
- MX2012005340A MX2012005340A MX2012005340A MX2012005340A MX2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A
- Authority
- MX
- Mexico
- Prior art keywords
- hepato
- promoter
- inducer agent
- specific
- operator
- Prior art date
Links
- 230000001105 regulatory effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000000411 inducer Substances 0.000 abstract 4
- 102000040945 Transcription factor Human genes 0.000 abstract 2
- 108091023040 Transcription factor Proteins 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se relaciona con métodos y herramientas para la expresión inducible hepatoespecífica de un gen de interés mediante el uso de promotores bidireccionales hepatoespecíficos que se encuentran operativamente acoplados a dicho gen de interés y a un transactivador que es capaz de promover la transcripción en presencia de un determinado gen de interés. La invención se refiere también a construcciones génicas y viriones que permiten la expresión regulada hepatoespecifica así como al uso de los mismos para el tratamiento de enfermedades hepáticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200902122 | 2009-11-05 | ||
PCT/ES2010/070715 WO2011054994A1 (es) | 2009-11-05 | 2010-11-04 | Sistemas de expresión regulada |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012005340A true MX2012005340A (es) | 2012-12-05 |
Family
ID=43569271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012005340A MX2012005340A (es) | 2009-11-05 | 2010-11-04 | Sistemas de expresion regulada. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20120225933A1 (es) |
EP (1) | EP2497830A1 (es) |
JP (1) | JP2014503173A (es) |
CN (1) | CN102712933A (es) |
AU (1) | AU2010316996A1 (es) |
BR (1) | BR112012010755A2 (es) |
CA (1) | CA2780671A1 (es) |
MX (1) | MX2012005340A (es) |
RU (1) | RU2012123145A (es) |
WO (1) | WO2011054994A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130034599A1 (en) * | 2010-01-19 | 2013-02-07 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
JP6591956B2 (ja) * | 2013-03-15 | 2019-10-16 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Mps1を治療するための組成物および方法 |
CN105316352A (zh) * | 2014-07-29 | 2016-02-10 | 深圳先进技术研究院 | 一种调节性表达目的基因的载体及其制备方法和应用 |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
EP3184548A1 (en) * | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
US11208669B2 (en) | 2016-01-12 | 2021-12-28 | University Of Cincinnati | Lentivirus packaging system comprising a synthetic positive feedback loop |
SG11201912631PA (en) | 2017-07-06 | 2020-01-30 | Univ Pennsylvania | Aav9-mediated gene therapy for treating mucopolysaccharidosis type i |
CN107365785B (zh) * | 2017-09-11 | 2020-02-18 | 东南大学 | 一种调控细胞内NF-κB活性的基因表达载体及其调控方法和应用 |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
WO2023178067A1 (en) * | 2022-03-16 | 2023-09-21 | Rutgers, The State University Of New Jersey | Controlled muscle‐specific gene delivery |
CN114891829B (zh) * | 2022-05-24 | 2023-09-26 | 新乡医学院 | 一种肝特异性游离型表达载体和基因治疗载体及其应用 |
Family Cites Families (36)
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US4970154A (en) | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
WO1995013392A1 (en) | 1993-11-09 | 1995-05-18 | Medical College Of Ohio | Stable cell lines capable of expressing the adeno-associated virus replication gene |
US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
US5484720A (en) | 1994-09-08 | 1996-01-16 | Genentech, Inc. | Methods for calcium phosphate transfection |
US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
JPH10511264A (ja) | 1994-12-06 | 1998-11-04 | ターゲティッド ジェネティックス コーポレイション | 高力価組換えaavベクターの生成のためのパッケージング細胞株 |
US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
EP0832269A1 (en) | 1995-06-07 | 1998-04-01 | Baylor College Of Medicine | Nucleic acid transporters for delivery of nucleic acids into a cell |
US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
US5679559A (en) | 1996-07-03 | 1997-10-21 | University Of Utah Research Foundation | Cationic polymer and lipoprotein-containing system for gene delivery |
AU4645697A (en) | 1996-09-11 | 1998-04-02 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Aav4 vector and uses thereof |
AU5603998A (en) | 1996-12-18 | 1998-07-15 | Targeted Genetics Corporation | Recombinase-activatable AAV packaging cassettes for use in the production of AV vectors |
US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
US6251677B1 (en) | 1997-08-25 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
EP1080218A1 (en) | 1998-05-27 | 2001-03-07 | University of Florida | Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient |
CA2745131C (en) | 1998-05-28 | 2016-08-09 | John A. Chiorini | Aav5 vector and uses thereof |
JP2002523032A (ja) * | 1998-08-18 | 2002-07-30 | リサーチ ディベロップメント ファンデーション | 遺伝子の発現の増強および制限方法 |
US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
AU768729B2 (en) | 1998-11-05 | 2004-01-08 | Trustees Of The University Of Pennsylvania, The | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
DE69929718T2 (de) * | 1998-11-09 | 2006-11-09 | Aventis Pharma S.A. | Neues regulationssystem zur kontrolle der expression eines transgens |
US6491907B1 (en) | 1998-11-10 | 2002-12-10 | The University Of North Carolina At Chapel Hill | Recombinant parvovirus vectors and method of making |
ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
US6387368B1 (en) | 1999-02-08 | 2002-05-14 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
WO2002022175A2 (en) * | 2000-09-11 | 2002-03-21 | Musc Foundation For Research Development | Method and composition for treating tumors by selective induction of apoptosis |
US6835568B2 (en) * | 2001-10-30 | 2004-12-28 | Virxsys Corporation | Regulated nucleic acid expression system |
US7271002B2 (en) | 2001-11-09 | 2007-09-18 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
WO2003093293A2 (en) | 2002-04-29 | 2003-11-13 | Saint Louis University | Peptide antagonists of tgf-beta family members and therapeutic uses thereof |
ES2862206T3 (es) | 2003-06-19 | 2021-10-07 | Genzyme Corp | Viriones de AAV con inmunorreactividad disminuida y sus usos |
ES2304069B1 (es) | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
US6852505B1 (en) * | 2003-10-15 | 2005-02-08 | Chau-Ting Yeh | Hepatitis |
US8242081B2 (en) | 2005-12-06 | 2012-08-14 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
CN101481704A (zh) * | 2009-01-21 | 2009-07-15 | 中国人民解放军第四军医大学 | 一种四环素严紧调控的真核表达载体 |
-
2010
- 2010-11-04 MX MX2012005340A patent/MX2012005340A/es not_active Application Discontinuation
- 2010-11-04 CA CA2780671A patent/CA2780671A1/en not_active Abandoned
- 2010-11-04 AU AU2010316996A patent/AU2010316996A1/en not_active Abandoned
- 2010-11-04 US US13/508,494 patent/US20120225933A1/en not_active Abandoned
- 2010-11-04 CN CN201080060595XA patent/CN102712933A/zh active Pending
- 2010-11-04 RU RU2012123145/10A patent/RU2012123145A/ru not_active Application Discontinuation
- 2010-11-04 BR BR112012010755A patent/BR112012010755A2/pt not_active IP Right Cessation
- 2010-11-04 EP EP10795406A patent/EP2497830A1/en not_active Withdrawn
- 2010-11-04 JP JP2012537425A patent/JP2014503173A/ja not_active Withdrawn
- 2010-11-04 WO PCT/ES2010/070715 patent/WO2011054994A1/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
BR112012010755A2 (pt) | 2015-09-22 |
CN102712933A (zh) | 2012-10-03 |
EP2497830A1 (en) | 2012-09-12 |
CA2780671A1 (en) | 2011-05-12 |
WO2011054994A1 (es) | 2011-05-12 |
US20120225933A1 (en) | 2012-09-06 |
AU2010316996A1 (en) | 2012-06-14 |
JP2014503173A (ja) | 2014-02-13 |
RU2012123145A (ru) | 2013-12-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |