MX2011012696A - Una coleccion y metodos para su uso. - Google Patents

Una coleccion y metodos para su uso.

Info

Publication number
MX2011012696A
MX2011012696A MX2011012696A MX2011012696A MX2011012696A MX 2011012696 A MX2011012696 A MX 2011012696A MX 2011012696 A MX2011012696 A MX 2011012696A MX 2011012696 A MX2011012696 A MX 2011012696A MX 2011012696 A MX2011012696 A MX 2011012696A
Authority
MX
Mexico
Prior art keywords
class
prevalent
present disclosure
methods
collection
Prior art date
Application number
MX2011012696A
Other languages
English (en)
Inventor
Stefanie Urlinger
Thomas Tiller
Markus Enzelberger
Josef Prassler
Tanja Herrmann
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of MX2011012696A publication Critical patent/MX2011012696A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

La presente descripción permite métodos para identificar los pares clase VH y VL en el repertorio inmune humano, determinando los pares clase VH y VL que son más prevalentes y los que tienen propiedades biofísicas favorables. Más Específicamente, las colecciones de la presente descripción comprenden los pares clase VH y VL más prevalentes y/o preferidos con CDRs altamente diversificados.
MX2011012696A 2009-05-29 2010-05-29 Una coleccion y metodos para su uso. MX2011012696A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18235009P 2009-05-29 2009-05-29
EP09162724 2009-06-15
US29940110P 2010-01-29 2010-01-29
PCT/EP2010/057507 WO2010136598A1 (en) 2009-05-29 2010-05-29 A collection and methods for its use

Publications (1)

Publication Number Publication Date
MX2011012696A true MX2011012696A (es) 2012-03-29

Family

ID=41210731

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012696A MX2011012696A (es) 2009-05-29 2010-05-29 Una coleccion y metodos para su uso.

Country Status (18)

Country Link
US (3) US8685896B2 (es)
EP (1) EP2435568B1 (es)
JP (1) JP5804521B2 (es)
KR (1) KR101805202B1 (es)
CN (1) CN102449149B (es)
AU (1) AU2010252939B2 (es)
CA (1) CA2758356C (es)
DK (1) DK2435568T3 (es)
ES (1) ES2511051T3 (es)
HK (1) HK1168635A1 (es)
IL (1) IL216536B (es)
MX (1) MX2011012696A (es)
NZ (1) NZ596603A (es)
PT (1) PT2435568E (es)
RU (1) RU2569187C2 (es)
SG (1) SG175407A1 (es)
WO (1) WO2010136598A1 (es)
ZA (1) ZA201107652B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CN102449149B (zh) 2009-05-29 2014-04-23 莫佛塞斯公司 集合及其使用方法
TR201906650T4 (tr) 2010-02-08 2019-05-21 Regeneron Pharma Ortak hafif zincirli fare.
US20120021409A1 (en) * 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
JP6253986B2 (ja) 2010-11-19 2017-12-27 モルフォシス・アーゲー コレクション及びその使用方法
EP2698431B1 (en) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
PT2702146T (pt) * 2011-04-28 2019-04-22 Univ Leland Stanford Junior Identificação de polinucleótidos associados a uma amostra
MX358099B (es) 2011-05-17 2018-08-06 Univ Rockefeller Anticuerpos que neutralizan el virus de inmunodeficiencia humano y metodos de uso de ellos.
ES2872081T3 (es) 2011-08-05 2021-11-02 Regeneron Pharma Ratones con cadena ligera universal humanizada
EP2744931B1 (en) * 2011-08-18 2018-05-02 Affinity Biosciences Pty Ltd Soluble polypeptides
CA2791109C (en) * 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
KR102366029B1 (ko) 2011-09-30 2022-02-23 추가이 세이야쿠 가부시키가이샤 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
CA3186007A1 (en) 2011-09-30 2013-04-04 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
US9717803B2 (en) 2011-12-23 2017-08-01 Innate Pharma Enzymatic conjugation of polypeptides
LT2825036T (lt) 2012-03-16 2018-07-10 Regeneron Pharmaceuticals, Inc. Histidino pakeitimus lengvoje grandinėje turintys antikūnai ir genetiškai modifikuoti graužikai, išvesti ju gamybai
RS59076B1 (sr) 2012-03-16 2019-09-30 Regeneron Pharma Glodari koji eksprimiraju imunoglobulinske sekvence senzitivne na ph
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
US10036010B2 (en) 2012-11-09 2018-07-31 Innate Pharma Recognition tags for TGase-mediated conjugation
EP2959041A4 (en) * 2013-02-20 2016-08-24 Affinity Biosciences Pty Ltd CYTOPLASMATIC EXPRESSION OF FAB PROTEINS
WO2014140300A1 (en) 2013-03-15 2014-09-18 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
US10071169B2 (en) 2013-06-20 2018-09-11 Innate Pharma Enzymatic conjugation of polypeptides
AU2014283185B2 (en) 2013-06-21 2019-05-02 Innate Pharma Enzymatic conjugation of polypeptides
EP3995145A1 (en) * 2013-06-24 2022-05-11 NexImmune, Inc. Compositions and methods for immunotherapy
US20150011405A1 (en) 2013-07-03 2015-01-08 Atreca, Inc. Use of Nanoexpression to Interrogate Antigen Repertoires
KR20210088756A (ko) 2014-03-21 2021-07-14 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물
AU2016232715A1 (en) 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
US10221249B2 (en) * 2015-09-10 2019-03-05 Affigen, Llc Method of making patient specific anti-idiotype antibodies
SG11202000250PA (en) 2017-07-12 2020-02-27 Nouscom Ag A universal vaccine based on shared tumor neoantigens for prevention and treatment of micro satellite instable (msi) cancers
AU2020359070A1 (en) * 2019-10-03 2022-04-21 Janssen Biotech, Inc. Methods for producing biotherapeutics with increased stability by sequence optimization

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3885459T2 (de) 1987-05-14 1994-03-24 Commw Scient Ind Res Org Molkeproteinfraktionen.
JPH02500329A (ja) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP3771253B2 (ja) 1988-09-02 2006-04-26 ダイアックス コープ． 新規な結合タンパク質の生成と選択
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
CA2057923A1 (en) 1989-05-16 1990-11-17 William D. Huse Co-expression of heteromeric receptors
US6291160B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
CA2016841C (en) 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ES2330052T3 (es) 1991-03-01 2009-12-03 Dyax Corporation Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
AU1457992A (en) 1991-03-01 1992-10-06 Stratagene Pcr generated dicistronic dna molecules for producing antibodies
JPH06509473A (ja) 1991-08-10 1994-10-27 メディカル・リサーチ・カウンシル 細胞個体群の処理
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
DK0605522T3 (da) 1991-09-23 2000-01-17 Medical Res Council Fremgangsmåde til fremstilling af humaniserede antistoffer
ES2227512T3 (es) 1991-12-02 2005-04-01 Medical Research Council Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago.
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5395750A (en) 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
JP3507073B2 (ja) 1992-03-24 2004-03-15 ケンブリッジ アンティボディー テクノロジー リミティド 特異的結合対の成員の製造方法
US5855885A (en) 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
CA2175579A1 (en) 1993-10-26 1995-05-04 Chang Yi Wang Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics
US20010049107A1 (en) 1994-01-31 2001-12-06 Boston University Polyclonal antibody libraries
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
AU6113396A (en) 1995-06-14 1997-01-15 Regents Of The University Of California, The Novel high affinity human antibodies to tumor antigens
US6706484B1 (en) 1995-08-18 2004-03-16 Morphosys Ag Protein/(poly)peptide libraries
WO1997008320A1 (en) 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Protein/(poly)peptide libraries
GB9603507D0 (en) 1996-02-20 1996-04-17 Isis Innovation Antibody variants
CA2297070A1 (en) 1997-08-01 1999-02-11 Morphosys Ag Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
IL144559A0 (en) 1999-03-01 2002-05-23 Genentech Inc Antibodies for cancer therapy and diagnosis
EP1990409A3 (en) 1999-07-20 2011-05-18 MorphoSys AG Bacteriophage
IL136459A0 (en) 2000-05-30 2001-06-14 Galim Galil Immunology Ltd Antibody library
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
ATE434040T1 (de) 2001-10-01 2009-07-15 Dyax Corp Mehrkettige eukaryontische display-vektoren und deren verwendungen
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
CA2471116A1 (en) 2001-12-21 2003-07-03 Serge Muyldermans Method for cloning of variable domain sequences
US7244592B2 (en) 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
WO2004013276A2 (en) 2002-07-30 2004-02-12 Morphosys Ip Gmbh Novel tricistronic vectors and uses therefor
US8557743B2 (en) 2002-09-05 2013-10-15 Dyax Corp. Display library process
GB0309126D0 (en) 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
US20120202710A1 (en) 2003-09-09 2012-08-09 Integrigen, Inc. Methods and compositions for generation of germline human antibody genes
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
EP1742969A2 (en) 2003-11-12 2007-01-17 OncoMab GmbH Methods of identifying neoplasm-specific antibodies and uses thereof
US20080003566A1 (en) 2004-01-26 2008-01-03 David Vaux Molecular Analysis
ATE505727T1 (de) 2004-05-26 2011-04-15 Fraunhofer Ges Forschung Isolation allergen-spezifischer immunoglobulin- gene aus humanen b-zellen von atopikern
MX2007000103A (es) * 2004-07-06 2007-05-11 Bioren Inc Bibliotecas de anticuerpos universales.
WO2006028987A2 (en) 2004-09-02 2006-03-16 Bioarray Solutions Ltd. Nucleic acid amplification with integrated multiplex detection
US20060078898A1 (en) 2004-10-12 2006-04-13 Curry Bo U Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II
JP4829609B2 (ja) 2004-12-22 2011-12-07 独立行政法人科学技術振興機構 ヒト抗体酵素およびその生産方法
US8551920B2 (en) 2005-02-01 2013-10-08 Morpho Sys AG Libraries and methods for isolating antibodies
WO2007056441A2 (en) 2005-11-07 2007-05-18 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
CA2634387C (en) 2005-12-20 2015-11-24 Morphosys Ag Novel collection of hcdr3 regions and uses therefor
EP2021795A4 (en) 2006-05-04 2009-05-13 Abmaxis Inc CROSS SPECIES AND MULTI-SPECIAL PRESENTATION SYSTEMS
JP2011504722A (ja) 2007-08-21 2011-02-17 モルフォシス・アー・ゲー ジスルフィド結合形成のための改良された方法
BRPI0816785A2 (pt) 2007-09-14 2017-05-02 Adimab Inc bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas
WO2009085462A1 (en) 2007-12-19 2009-07-09 Centocor, Inc. Design and generation of human de novo pix phage display libraries via fusion to pix or pvii, vectors, antibodies and methods
EP2088432A1 (en) 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
US8143007B2 (en) 2008-03-13 2012-03-27 National Institute Of Immunology Nested primer sets for amplifying mouse immunoglobulin variable gene segments
CA2736277C (en) 2008-09-10 2016-06-21 Philochem Ag Display library for antibody selection
JP2012508017A (ja) 2008-11-07 2012-04-05 ファブラス エルエルシー 抗ｄｌｌ４抗体及びその使用
WO2010130824A2 (en) 2009-05-15 2010-11-18 Morphosys Ag Collections and uses thereof
CN102449149B (zh) 2009-05-29 2014-04-23 莫佛塞斯公司 集合及其使用方法
EP2528944B1 (en) 2010-01-29 2015-08-12 MorphoSys AG Rodent combinatorial antibody libraries

Also Published As

Publication number Publication date
EP2435568A1 (en) 2012-04-04
WO2010136598A1 (en) 2010-12-02
US20120077713A1 (en) 2012-03-29
AU2010252939B2 (en) 2014-06-26
JP5804521B2 (ja) 2015-11-04
ES2511051T3 (es) 2014-10-22
JP2012527881A (ja) 2012-11-12
HK1168635A1 (en) 2013-01-04
CN102449149B (zh) 2014-04-23
US20170218048A1 (en) 2017-08-03
AU2010252939A1 (en) 2011-10-13
NZ596603A (en) 2013-07-26
RU2011147741A (ru) 2013-07-10
DK2435568T3 (da) 2014-09-08
EP2435568B1 (en) 2014-07-02
PT2435568E (pt) 2014-10-08
CN102449149A (zh) 2012-05-09
KR20120087809A (ko) 2012-08-07
ZA201107652B (en) 2012-06-27
CA2758356A1 (en) 2010-12-02
SG175407A1 (en) 2011-11-28
US9624293B2 (en) 2017-04-18
US10647757B2 (en) 2020-05-12
RU2569187C2 (ru) 2015-11-20
KR101805202B1 (ko) 2017-12-07
IL216536B (en) 2018-06-28
US20140163208A1 (en) 2014-06-12
CA2758356C (en) 2016-07-26
US8685896B2 (en) 2014-04-01
IL216536A0 (en) 2012-02-29

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