MX2011006764A - Procedimiento y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc. - Google Patents
Procedimiento y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc.Info
- Publication number
- MX2011006764A MX2011006764A MX2011006764A MX2011006764A MX2011006764A MX 2011006764 A MX2011006764 A MX 2011006764A MX 2011006764 A MX2011006764 A MX 2011006764A MX 2011006764 A MX2011006764 A MX 2011006764A MX 2011006764 A MX2011006764 A MX 2011006764A
- Authority
- MX
- Mexico
- Prior art keywords
- intermediates
- preparing
- processes
- hcv
- protease inhibitor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
Abstract
La presente invención se refiere a la sal de cinconidina (ver fórmula (XXa)) útil en la preparación de compuestos intermedios para preparar un inhibidor del VHC macrocíclico, así como también se refiere a procedimientos que involucran esta sal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08172691 | 2008-12-23 | ||
PCT/EP2009/067715 WO2010072742A1 (en) | 2008-12-23 | 2009-12-22 | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011006764A true MX2011006764A (es) | 2011-08-03 |
Family
ID=40548041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011006764A MX2011006764A (es) | 2008-12-23 | 2009-12-22 | Procedimiento y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc. |
Country Status (23)
Country | Link |
---|---|
US (2) | US8927722B2 (es) |
EP (1) | EP2382198B1 (es) |
JP (1) | JP5687631B2 (es) |
KR (1) | KR101734507B1 (es) |
CN (1) | CN102264715B (es) |
AR (1) | AR074863A1 (es) |
AU (1) | AU2009331530B2 (es) |
BR (1) | BRPI0923393B1 (es) |
CA (1) | CA2745565C (es) |
CY (1) | CY1114488T1 (es) |
DK (1) | DK2382198T3 (es) |
ES (1) | ES2429013T3 (es) |
HK (1) | HK1164839A1 (es) |
HR (1) | HRP20130906T1 (es) |
IL (1) | IL213246A (es) |
MX (1) | MX2011006764A (es) |
PL (1) | PL2382198T3 (es) |
PT (1) | PT2382198E (es) |
RU (1) | RU2016120007A (es) |
SI (1) | SI2382198T1 (es) |
SM (1) | SMT201300116B (es) |
TW (1) | TWI461424B (es) |
WO (1) | WO2010072742A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101734507B1 (ko) | 2008-12-23 | 2017-05-11 | 얀센 파마슈티칼스 인코포레이티드 | Hcv의 마크로시클릭 프로테아제 억제제를 제조하기 위한 방법 및 중간체 |
AR087993A1 (es) * | 2011-09-22 | 2014-04-30 | Janssen Pharmaceuticals Inc | Procesos e intermediarios para la preparacion de un inhibidor macrociclico de la proteasa del hcv |
KR20140086967A (ko) * | 2011-10-28 | 2014-07-08 | 얀센 파마슈티칼즈, 인코포레이티드 | 거대고리 프로테아제 저해제 tmc435의 중간체를 제조하는 개선된 방법 |
CN103387509B (zh) * | 2012-05-11 | 2016-06-08 | 重庆博腾制药科技股份有限公司 | 一种hcv蛋白酶抑制剂中间体的制备方法 |
BR112014030649A2 (pt) | 2012-06-08 | 2017-06-27 | Gilead Sciences Inc | inibidores macrocíclicos da flaviviridae vírus |
AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
BR112014030630A2 (pt) * | 2012-06-08 | 2017-06-27 | Gilead Sciences Inc | inibidores macrocíclicos de vírus flaviviridae |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
JP6511432B2 (ja) | 2013-03-15 | 2019-05-15 | ギリアード サイエンシーズ, インコーポレイテッド | C型肝炎ウイルスの大環状二環式阻害剤 |
CN105308043B (zh) * | 2014-05-29 | 2018-01-30 | 杭州普晒医药科技有限公司 | 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途 |
MA41812A (fr) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8300536A (nl) | 1983-02-14 | 1984-09-03 | Oce Andeno Bv | Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan. |
JPS6124539A (ja) | 1984-07-11 | 1986-02-03 | Sagami Chem Res Center | 光学活性(r)−2,5,12−トリヒドロキシ−1,2,3,4−テトラヒドロナフタセン−6,11−ジオン−2−カルボン酸の取得方法 |
JP4218040B2 (ja) | 1997-12-26 | 2009-02-04 | 曽田香料株式会社 | 有機酸とアミンの複合塩の製造法 |
JP3844112B2 (ja) | 2000-08-23 | 2006-11-08 | 高砂香料工業株式会社 | 3,5,6−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法 |
US7608590B2 (en) | 2004-01-30 | 2009-10-27 | Medivir Ab | HCV NS-3 serine protease inhibitors |
CN101146794A (zh) | 2005-01-21 | 2008-03-19 | 阿斯泰克斯治疗有限公司 | 用于抑制cdk和gsk的吡唑衍生物 |
US8012939B2 (en) * | 2005-07-29 | 2011-09-06 | Tibotec Pharmaceuticals Ltd. Co | Macrocyclic inhibitors of hepatitis C virus |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
TWI455936B (zh) * | 2007-02-01 | 2014-10-11 | Tibotec Pharm Ltd | 用於製備hcv之大環蛋白酶抑制劑之方法及中間物 |
KR20090111326A (ko) * | 2007-02-08 | 2009-10-26 | 티보텍 파마슈티칼즈 리미티드 | Hcv 억제 마크로사이클릭 페닐카바메이트 |
KR101734507B1 (ko) | 2008-12-23 | 2017-05-11 | 얀센 파마슈티칼스 인코포레이티드 | Hcv의 마크로시클릭 프로테아제 억제제를 제조하기 위한 방법 및 중간체 |
-
2009
- 2009-12-22 KR KR1020117017333A patent/KR101734507B1/ko active IP Right Grant
- 2009-12-22 US US13/141,715 patent/US8927722B2/en not_active Expired - Fee Related
- 2009-12-22 JP JP2011541509A patent/JP5687631B2/ja not_active Expired - Fee Related
- 2009-12-22 DK DK09801447.5T patent/DK2382198T3/da active
- 2009-12-22 AR ARP090105059 patent/AR074863A1/es unknown
- 2009-12-22 PT PT09801447T patent/PT2382198E/pt unknown
- 2009-12-22 CA CA2745565A patent/CA2745565C/en not_active Expired - Fee Related
- 2009-12-22 TW TW98144049A patent/TWI461424B/zh not_active IP Right Cessation
- 2009-12-22 MX MX2011006764A patent/MX2011006764A/es active IP Right Grant
- 2009-12-22 EP EP09801447.5A patent/EP2382198B1/en active Active
- 2009-12-22 ES ES09801447T patent/ES2429013T3/es active Active
- 2009-12-22 CN CN200980152851.5A patent/CN102264715B/zh not_active Expired - Fee Related
- 2009-12-22 AU AU2009331530A patent/AU2009331530B2/en not_active Ceased
- 2009-12-22 BR BRPI0923393-8A patent/BRPI0923393B1/pt not_active IP Right Cessation
- 2009-12-22 WO PCT/EP2009/067715 patent/WO2010072742A1/en active Application Filing
- 2009-12-22 PL PL09801447T patent/PL2382198T3/pl unknown
- 2009-12-22 RU RU2016120007A patent/RU2016120007A/ru not_active Application Discontinuation
- 2009-12-22 SI SI200930731T patent/SI2382198T1/sl unknown
-
2011
- 2011-05-31 IL IL213246A patent/IL213246A/en not_active IP Right Cessation
-
2012
- 2012-05-29 HK HK12105238.7A patent/HK1164839A1/zh not_active IP Right Cessation
-
2013
- 2013-09-24 HR HRP20130906AT patent/HRP20130906T1/hr unknown
- 2013-10-10 CY CY20131100890T patent/CY1114488T1/el unknown
- 2013-10-10 SM SM201300116T patent/SMT201300116B/xx unknown
-
2014
- 2014-11-25 US US14/552,550 patent/US9115077B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |