IL213246A0 - Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv - Google Patents
Processes and intermediates for preparing a macrocyclic protease inhibitor of hcvInfo
- Publication number
- IL213246A0 IL213246A0 IL213246A IL21324611A IL213246A0 IL 213246 A0 IL213246 A0 IL 213246A0 IL 213246 A IL213246 A IL 213246A IL 21324611 A IL21324611 A IL 21324611A IL 213246 A0 IL213246 A0 IL 213246A0
- Authority
- IL
- Israel
- Prior art keywords
- hcv
- intermediates
- preparing
- processes
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08172691 | 2008-12-23 | ||
PCT/EP2009/067715 WO2010072742A1 (en) | 2008-12-23 | 2009-12-22 | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
Publications (2)
Publication Number | Publication Date |
---|---|
IL213246A0 true IL213246A0 (en) | 2011-07-31 |
IL213246A IL213246A (en) | 2017-10-31 |
Family
ID=40548041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL213246A IL213246A (en) | 2008-12-23 | 2011-05-31 | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
Country Status (23)
Country | Link |
---|---|
US (2) | US8927722B2 (en) |
EP (1) | EP2382198B1 (en) |
JP (1) | JP5687631B2 (en) |
KR (1) | KR101734507B1 (en) |
CN (1) | CN102264715B (en) |
AR (1) | AR074863A1 (en) |
AU (1) | AU2009331530B2 (en) |
BR (1) | BRPI0923393B1 (en) |
CA (1) | CA2745565C (en) |
CY (1) | CY1114488T1 (en) |
DK (1) | DK2382198T3 (en) |
ES (1) | ES2429013T3 (en) |
HK (1) | HK1164839A1 (en) |
HR (1) | HRP20130906T1 (en) |
IL (1) | IL213246A (en) |
MX (1) | MX2011006764A (en) |
PL (1) | PL2382198T3 (en) |
PT (1) | PT2382198E (en) |
RU (1) | RU2016120007A (en) |
SI (1) | SI2382198T1 (en) |
SM (1) | SMT201300116B (en) |
TW (1) | TWI461424B (en) |
WO (1) | WO2010072742A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2382198T1 (en) | 2008-12-23 | 2013-11-29 | Janssen Pharmaceuticals, Inc. | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
AU2012311461B2 (en) * | 2011-09-22 | 2017-07-06 | Janssen Pharmaceuticals, Inc. | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
BR112014009849A2 (en) | 2011-10-28 | 2016-07-05 | Janssen Pharmaceuticals Inc | improved process for preparation of tmc 435 macrocyclic protease inhibitor intermediate |
CN103387509B (en) * | 2012-05-11 | 2016-06-08 | 重庆博腾制药科技股份有限公司 | The preparation method of a kind of HCV protease inhibitor intermediate |
JP6209601B2 (en) | 2012-06-08 | 2017-10-04 | ギリアード サイエンシーズ, インコーポレイテッド | Macrocyclic inhibitors of flaviviridae viruses |
AR091279A1 (en) * | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | MACROCICLIC INHIBITORS OF VIRUS FLAVIVIRIDAE |
ES2656087T3 (en) * | 2012-06-08 | 2018-02-23 | Gilead Sciences, Inc. | Macrocyclic Flaviviridae virus inhibitors |
UA119315C2 (en) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Inhibitors of hepatitis c virus |
ES2735355T3 (en) | 2013-03-15 | 2019-12-18 | Gilead Sciences Inc | Hepatitis C virus macrocyclic and bicyclic inhibitors |
CN105308043B (en) * | 2014-05-29 | 2018-01-30 | 杭州普晒医药科技有限公司 | Crystal formation of hepatitis C medicine and preparation method thereof, its pharmaceutical composition and purposes |
MA41812A (en) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | METHODS AND INTERMEDIARIES FOR THE PREPARATION OF A HCV MACROCYCLIC PROTEASE INHIBITOR |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8300536A (en) | 1983-02-14 | 1984-09-03 | Oce Andeno Bv | OPTICALLY ACTIVE ALFA-AZIDO-P-HYDROXYPHENYLACACIC ACID AND ITS SALTS AND ITS PREPARATION. |
JPS6124539A (en) | 1984-07-11 | 1986-02-03 | Sagami Chem Res Center | Method for obtaining optically active (r)-2,5,12-trihydroxy-1,2,3,4-tetrahydronaphthacene-6,11-dione-2-carboxylic acid |
JP4218040B2 (en) | 1997-12-26 | 2009-02-04 | 曽田香料株式会社 | Process for producing complex salt of organic acid and amine |
JP3844112B2 (en) | 2000-08-23 | 2006-11-08 | 高砂香料工業株式会社 | 3,5,6-Trihydroxyhexanoic acid ammonium salt derivative and method for producing the same |
ES2336009T3 (en) * | 2004-01-30 | 2010-04-07 | Medivir Ab | INHIBITORS OF THE NS-3 SERINA PROTEASA HCV. |
CN101146795A (en) | 2005-01-21 | 2008-03-19 | 阿斯泰克斯治疗有限公司 | Pyrazole derivatives for the inhibition of CDK and GSK |
PE20070211A1 (en) | 2005-07-29 | 2007-05-12 | Medivir Ab | MACROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS |
PL1919904T3 (en) * | 2005-07-29 | 2014-06-30 | Janssen R&D Ireland | Macrocyclic inhibitors of hepatitis c virus |
AU2008209697B2 (en) * | 2007-02-01 | 2014-02-20 | Janssen Sciences Ireland Uc | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
JP5554570B2 (en) * | 2007-02-08 | 2014-07-23 | ヤンセン・アールアンドデイ・アイルランド | HCV-inhibited macrocyclic phenylcarbamate |
SI2382198T1 (en) | 2008-12-23 | 2013-11-29 | Janssen Pharmaceuticals, Inc. | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
-
2009
- 2009-12-22 SI SI200930731T patent/SI2382198T1/en unknown
- 2009-12-22 JP JP2011541509A patent/JP5687631B2/en not_active Expired - Fee Related
- 2009-12-22 CN CN200980152851.5A patent/CN102264715B/en not_active Expired - Fee Related
- 2009-12-22 US US13/141,715 patent/US8927722B2/en not_active Expired - Fee Related
- 2009-12-22 PT PT09801447T patent/PT2382198E/en unknown
- 2009-12-22 KR KR1020117017333A patent/KR101734507B1/en active IP Right Grant
- 2009-12-22 DK DK09801447.5T patent/DK2382198T3/en active
- 2009-12-22 AR ARP090105059 patent/AR074863A1/en unknown
- 2009-12-22 MX MX2011006764A patent/MX2011006764A/en active IP Right Grant
- 2009-12-22 AU AU2009331530A patent/AU2009331530B2/en not_active Ceased
- 2009-12-22 EP EP09801447.5A patent/EP2382198B1/en active Active
- 2009-12-22 TW TW98144049A patent/TWI461424B/en not_active IP Right Cessation
- 2009-12-22 PL PL09801447T patent/PL2382198T3/en unknown
- 2009-12-22 BR BRPI0923393-8A patent/BRPI0923393B1/en not_active IP Right Cessation
- 2009-12-22 ES ES09801447T patent/ES2429013T3/en active Active
- 2009-12-22 WO PCT/EP2009/067715 patent/WO2010072742A1/en active Application Filing
- 2009-12-22 CA CA2745565A patent/CA2745565C/en not_active Expired - Fee Related
- 2009-12-22 RU RU2016120007A patent/RU2016120007A/en not_active Application Discontinuation
-
2011
- 2011-05-31 IL IL213246A patent/IL213246A/en not_active IP Right Cessation
-
2012
- 2012-05-29 HK HK12105238.7A patent/HK1164839A1/en not_active IP Right Cessation
-
2013
- 2013-09-24 HR HRP20130906AT patent/HRP20130906T1/en unknown
- 2013-10-10 CY CY20131100890T patent/CY1114488T1/en unknown
- 2013-10-10 SM SM201300116T patent/SMT201300116B/en unknown
-
2014
- 2014-11-25 US US14/552,550 patent/US9115077B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |