MX2010004880A - Derivados heterociclicos de urea y tiourea, y metodos de uso de los mismos. - Google Patents

Derivados heterociclicos de urea y tiourea, y metodos de uso de los mismos.

Info

Publication number
MX2010004880A
MX2010004880A MX2010004880A MX2010004880A MX2010004880A MX 2010004880 A MX2010004880 A MX 2010004880A MX 2010004880 A MX2010004880 A MX 2010004880A MX 2010004880 A MX2010004880 A MX 2010004880A MX 2010004880 A MX2010004880 A MX 2010004880A
Authority
MX
Mexico
Prior art keywords
thiourea derivatives
heterocyclic urea
methods
disorder
urea
Prior art date
Application number
MX2010004880A
Other languages
English (en)
Inventor
Timothy J Guzi
Arshad M Siddiqui
Praveen K Tadikonda
David F Cauble Jr
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010004880A publication Critical patent/MX2010004880A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se refiere a derivados de urea heterocíclica y tiourea novedosos de la fórmula (I), las composiciones comprenden los derivados de urea heterocíclica y tiourea y los métodos para el uso de los derivados de urea heterocíclica y tiourea para tratar o prevenir un trastorno proliferativo, un trastorno anti-proliferativo, inflamación, artritis, un trastorno del sistema nervioso central, una enfermedad cardiovascular, alopecia, una enfermedad neuronal, una lesión isquémica, una infección viral, una infección fúngica, o un trastorno relacionado con la actividad de una proteína quinasa.
MX2010004880A 2007-10-29 2008-10-27 Derivados heterociclicos de urea y tiourea, y metodos de uso de los mismos. MX2010004880A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98324807P 2007-10-29 2007-10-29
PCT/US2008/081351 WO2009058739A1 (en) 2007-10-29 2008-10-27 Heterocyclic urea and thiourea derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2010004880A true MX2010004880A (es) 2010-07-28

Family

ID=40242663

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004880A MX2010004880A (es) 2007-10-29 2008-10-27 Derivados heterociclicos de urea y tiourea, y metodos de uso de los mismos.

Country Status (7)

Country Link
US (1) US20110129440A1 (es)
EP (1) EP2209779A1 (es)
JP (1) JP2011502160A (es)
CN (1) CN101910163A (es)
CA (1) CA2703981A1 (es)
MX (1) MX2010004880A (es)
WO (1) WO2009058739A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090075869A (ko) * 2006-10-31 2009-07-09 쉐링 코포레이션 단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드
WO2009058728A1 (en) * 2007-10-29 2009-05-07 Schering Corporation Thiazole derivatives as protein kinase inhibitors
EP2225235B1 (en) * 2007-10-29 2017-09-06 Merck Sharp & Dohme Corp. Thiazole carboxamide derivatives and their use to treat cancer
US8435976B2 (en) * 2009-09-08 2013-05-07 F. Hoffmann-La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
MA34234B1 (fr) * 2010-04-07 2013-05-02 Hoffmann La Roche Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation
JP5960688B2 (ja) 2010-05-17 2016-08-02 インコゼン セラピューティクス プライベート リミテッド プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
KR20120048250A (ko) * 2010-11-05 2012-05-15 숙명여자대학교산학협력단 티오우레아계 화합물 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 항염증 조성물
WO2013144737A2 (en) 2012-03-30 2013-10-03 Rhizen Pharmaceuticals Sa Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
WO2013161919A1 (ja) * 2012-04-26 2013-10-31 小野薬品工業株式会社 Ｔｒｋ阻害化合物
BR122017003181A2 (pt) 2013-02-19 2019-09-10 Ono Pharmaceutical Co composto inibidor de trk, composição farmacêutica e medicamento compreendendo dito composto e seu uso para profilaxia e/ou terapia de doença relacionada à trk e/ou para inibir trk

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889190A1 (fr) * 2005-08-01 2007-02-02 Merck Sante Soc Par Actions Si Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant
WO2007024754A1 (en) * 2005-08-22 2007-03-01 Amgen Inc. Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes
EP2009005A4 (en) * 2006-04-19 2010-06-02 Astellas Pharma Inc AZOLECARBOXAMIDE DERIVATIVE
US7838698B2 (en) * 2006-09-29 2010-11-23 Johnson & Johnson Vision Care, Inc. Hydrolysis-resistant silicone compounds
KR20090075869A (ko) * 2006-10-31 2009-07-09 쉐링 코포레이션 단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드
US7829063B2 (en) * 2007-04-05 2010-11-09 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
WO2009058728A1 (en) * 2007-10-29 2009-05-07 Schering Corporation Thiazole derivatives as protein kinase inhibitors

Also Published As

Publication number Publication date
US20110129440A1 (en) 2011-06-02
CA2703981A1 (en) 2009-05-07
JP2011502160A (ja) 2011-01-20
WO2009058739A1 (en) 2009-05-07
CN101910163A (zh) 2010-12-08
EP2209779A1 (en) 2010-07-28

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