MX2010004669A - Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios. - Google Patents

Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.

Info

Publication number
MX2010004669A
MX2010004669A MX2010004669A MX2010004669A MX2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A MX 2010004669 A MX2010004669 A MX 2010004669A
Authority
MX
Mexico
Prior art keywords
preparation
dihydropyrrol
intermediates
derivatives
formula
Prior art date
Application number
MX2010004669A
Other languages
English (en)
Inventor
Paul Spurr
Pius Waldmeier
Christophe Pfleger
Rene Trussardi
Shaoning Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010004669A publication Critical patent/MX2010004669A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a un nuevo proceso escalable para la preparación de compuestos de fórmula (I), que comprende un nuevo proceso para la preparación del intermediario clave, un derivado de dihidropirrol de fórmula (II) o una sal del mismo.
MX2010004669A 2007-11-29 2008-11-19 Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios. MX2010004669A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07121841 2007-11-29
PCT/EP2008/065820 WO2009068463A2 (en) 2007-11-29 2008-11-19 Process for the preparation of isoindole derivatives as well as a process for the preparation of their intermediates

Publications (1)

Publication Number Publication Date
MX2010004669A true MX2010004669A (es) 2010-05-27

Family

ID=40551563

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004669A MX2010004669A (es) 2007-11-29 2008-11-19 Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.

Country Status (13)

Country Link
US (3) US20090143589A1 (es)
EP (1) EP2225202B1 (es)
JP (1) JP5255647B2 (es)
KR (1) KR101196543B1 (es)
CN (1) CN101874019B (es)
AT (1) ATE539054T1 (es)
AU (1) AU2008328951B2 (es)
BR (1) BRPI0821102A2 (es)
CA (1) CA2705950A1 (es)
ES (1) ES2378185T3 (es)
IL (1) IL204936A (es)
MX (1) MX2010004669A (es)
WO (1) WO2009068463A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015210833B2 (en) 2014-02-03 2019-01-03 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
JP6564029B2 (ja) 2014-10-14 2019-08-21 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
MX2018006223A (es) 2015-11-20 2018-12-19 Vitae Pharmaceuticals Inc Moduladores de ror-gamma.
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
EP3658555A1 (en) 2017-07-24 2020-06-03 Vitae Pharmaceuticals, LLC Inhibitors of ror
EP3687992A1 (en) * 2017-09-27 2020-08-05 Meiji Seika Pharma Co., Ltd. Crystalline forms of diazabicyclooctane derivatives and production process thereof
CN111808102B (zh) * 2020-08-03 2021-12-31 南通大学 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
JP2832584B2 (ja) * 1995-03-27 1998-12-09 日本農薬株式会社 カルボン酸エステル類の製造方法
ES2186823T3 (es) * 1996-07-23 2003-05-16 Lonza Ag Procedimiento para la preparacion de esteres del acido piridin-2,3-dicarboxilico.
MX2007009342A (es) * 2005-02-07 2007-09-21 Hoffmann La Roche Fenil-metanonas sustituidas por heterociclo como inhibidor del transportador 1 de glicina.

Also Published As

Publication number Publication date
ATE539054T1 (de) 2012-01-15
AU2008328951B2 (en) 2012-12-13
AU2008328951A1 (en) 2009-06-04
IL204936A (en) 2013-12-31
EP2225202A2 (en) 2010-09-08
WO2009068463A3 (en) 2009-09-11
KR101196543B1 (ko) 2012-11-01
CA2705950A1 (en) 2009-06-04
WO2009068463A9 (en) 2009-11-12
JP2011504896A (ja) 2011-02-17
EP2225202B1 (en) 2011-12-28
CN101874019A (zh) 2010-10-27
ES2378185T3 (es) 2012-04-09
WO2009068463A2 (en) 2009-06-04
US20120041205A1 (en) 2012-02-16
CN101874019B (zh) 2013-06-12
KR20100075664A (ko) 2010-07-02
US20130060038A1 (en) 2013-03-07
JP5255647B2 (ja) 2013-08-07
IL204936A0 (en) 2010-11-30
BRPI0821102A2 (pt) 2015-06-16
US20090143589A1 (en) 2009-06-04

Similar Documents

Publication Publication Date Title
MX2010004669A (es) Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.
AU2008303600A8 (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
MX2007014172A (es) Procedimiento para la produccion de 4-bifenililacetidina-2-onas fenolicos.
IN2012DN02751A (es)
TN2012000248A1 (en) Novel spiropiperidine compounds
MY156954A (en) PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES
GEP20125512B (en) Process for synthesis of agomelatin
MX2009008660A (es) Metodo para la preparacion de derivados de trifenilbuteno terapeuticamente valiosos.
MX2011011776A (es) Nuevos profarmacos de triptolite.
MX2009012125A (es) Compuestos terapeuticos.
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
TW200728310A (en) Process for the preparation of ferri-succinylcasein
MX2009012376A (es) Derivados de pirimidona sustituidos con heteroarilamida para el tratamiento de enfermedades neurodegenerativas.
MX2010005809A (es) Proceso de dehidrohalogenacion para la preparacion de intermediarios utiles en el suministro de compuestos 6,6-dimetil-3-azabiciclo-[3,1,0]-hexano.
IN2012DN05081A (es)
MY152557A (en) 3-aminocyclopentanecarboxamides as chemokine receptor modulators
WO2009039362A3 (en) Chiral synthesis of diazepinoquinolines
MX2010009876A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexanocarboxilico por medio del derivado de ciclohexanocarboxamida correspondiente.
WO2008141097A9 (en) Stereoisomers propofol therapeutic compounds
MX2007013872A (es) Procedimiento para la produccion de 4-bifenililazetidina-2-onas.
NO20065157L (no) Biotransformasjon av colchicinoidforbindelser
IN2012DN02000A (es)
WO2007143014A3 (en) Methods for preparing glutamic acid derivatives and intermediates thereof
TW200801011A (en) New compounds II
GB0612027D0 (en) Novel process

Legal Events

Date Code Title Description
FG Grant or registration