MX2010004310A - Moduladores de gamma-secretasa con enlaces de carbono. - Google Patents

Moduladores de gamma-secretasa con enlaces de carbono.

Info

Publication number
MX2010004310A
MX2010004310A MX2010004310A MX2010004310A MX2010004310A MX 2010004310 A MX2010004310 A MX 2010004310A MX 2010004310 A MX2010004310 A MX 2010004310A MX 2010004310 A MX2010004310 A MX 2010004310A MX 2010004310 A MX2010004310 A MX 2010004310A
Authority
MX
Mexico
Prior art keywords
secretase
carbon linked
modulators
linked modulators
compounds
Prior art date
Application number
MX2010004310A
Other languages
English (en)
Inventor
Chih Yung Ho
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2010004310A publication Critical patent/MX2010004310A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se relaciona con los compuestos de la Fórmula (I) como se describe en la presente, en donde las definiciones de A, X, R1, R2, R3, R4, R5, R6, R7y R8 se proporcionan en la descripción. Los compuestos de la Fórmula (I) son útiles para el tratamiento de enfermedades asociadas con la actividad ?-secretasa, que incluye la enfermedad de Alzheimer. (Ver fórmula I).
MX2010004310A 2007-10-19 2008-10-17 Moduladores de gamma-secretasa con enlaces de carbono. MX2010004310A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98120907P 2007-10-19 2007-10-19
PCT/US2008/080241 WO2009052334A1 (en) 2007-10-19 2008-10-17 Carbon linked modulators of y-secretase

Publications (1)

Publication Number Publication Date
MX2010004310A true MX2010004310A (es) 2010-05-03

Family

ID=40338749

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004310A MX2010004310A (es) 2007-10-19 2008-10-17 Moduladores de gamma-secretasa con enlaces de carbono.

Country Status (17)

Country Link
US (1) US8692017B2 (es)
EP (1) EP2215043B1 (es)
JP (1) JP5417334B2 (es)
KR (1) KR101618068B1 (es)
CN (1) CN101896452B (es)
AU (1) AU2008312355B2 (es)
BR (1) BRPI0818773A2 (es)
CA (1) CA2702959C (es)
CO (1) CO6280527A2 (es)
CR (1) CR11448A (es)
EA (1) EA019710B1 (es)
ES (1) ES2401833T3 (es)
IL (1) IL205046A (es)
MX (1) MX2010004310A (es)
NI (1) NI201000065A (es)
WO (1) WO2009052334A1 (es)
ZA (1) ZA201003520B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2582593A1 (en) * 2004-10-07 2006-04-20 Merck & Co., Inc. Cgrp receptor antagonists
CN101903335A (zh) 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
EP2215043B1 (en) 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
CN105801350B (zh) * 2016-04-29 2018-07-27 宜春学院 二芳基甲醇类化合物的合成方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790287A (fr) 1971-10-28 1973-04-19 Delalande Sa Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
BE826017R (fr) 1974-03-19 1975-08-26 Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
US4252951A (en) * 1979-10-09 1981-02-24 Eli Lilly And Company Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid
US5391817A (en) * 1993-12-21 1995-02-21 Bristol-Myers Squibb Biaryl phospholipase A2 inhibitors
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
EP1284729A4 (en) * 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
MXPA05013848A (es) * 2003-06-16 2006-09-04 Anacor Pharmaceuticals Inc Agentes terapeuticos que contienen boro hidroliticamente resistentes y metodos de uso.
WO2006004555A1 (en) 2004-06-30 2006-01-12 Paysetter Pte Ltd System and method for facilitating transfer of physical money and/or credit
DE102004033876B4 (de) 2004-07-13 2009-01-15 Christoph Kaesbohrer Dreidimensionales Struktursystem
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
EP1650183A1 (en) 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
DK1847524T3 (da) 2006-04-21 2010-01-11 Cellzome Ltd Terphenylderivater til behandling af Alzheimers sygdom
ES2328616T3 (es) 2006-04-21 2009-11-16 Cellzome Limited Acidos bifenil carboxilicos sustituidos y sus derivados.
CN101490001A (zh) 2006-06-09 2009-07-22 Icos股份有限公司 用作dp-2拮抗剂的取代的苯乙酸
EP2044044A2 (en) * 2006-06-09 2009-04-08 Icos Corporation Substituted phenyl acetic acids as dp-2 antagonists
US7897643B2 (en) 2007-10-17 2011-03-01 Janssen Pharmaceutica N.V. Biphenyl carboxylic acids and derivatives thereof
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
EP2215043B1 (en) 2007-10-19 2013-03-06 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
US20090306392A1 (en) 2007-10-19 2009-12-10 Chih Yung Ho Gsm intermediates
CA2702835A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica N.V. Amide linked modulators of .gamma.-secretase
CN101903335A (zh) 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
US7968725B2 (en) 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase

Also Published As

Publication number Publication date
IL205046A0 (en) 2010-11-30
CN101896452B (zh) 2013-07-31
EP2215043B1 (en) 2013-03-06
CA2702959A1 (en) 2009-04-23
NI201000065A (es) 2010-09-13
AU2008312355B2 (en) 2013-07-04
AU2008312355A1 (en) 2009-04-23
EA019710B1 (ru) 2014-05-30
KR20100090688A (ko) 2010-08-16
KR101618068B1 (ko) 2016-05-04
JP5417334B2 (ja) 2014-02-12
US20090105288A1 (en) 2009-04-23
CO6280527A2 (es) 2011-05-20
ES2401833T3 (es) 2013-04-24
IL205046A (en) 2014-09-30
JP2011500719A (ja) 2011-01-06
CN101896452A (zh) 2010-11-24
CR11448A (es) 2011-01-14
ZA201003520B (en) 2012-07-25
CA2702959C (en) 2016-07-26
EP2215043A1 (en) 2010-08-11
BRPI0818773A2 (pt) 2015-04-14
US8692017B2 (en) 2014-04-08
WO2009052334A1 (en) 2009-04-23
EA201070496A1 (ru) 2010-10-29

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