MX2010003927A - Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b. - Google Patents

Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b.

Info

Publication number
MX2010003927A
MX2010003927A MX2010003927A MX2010003927A MX2010003927A MX 2010003927 A MX2010003927 A MX 2010003927A MX 2010003927 A MX2010003927 A MX 2010003927A MX 2010003927 A MX2010003927 A MX 2010003927A MX 2010003927 A MX2010003927 A MX 2010003927A
Authority
MX
Mexico
Prior art keywords
sup
protein kinase
pyrrolo
inhibitors
compounds
Prior art date
Application number
MX2010003927A
Other languages
English (en)
Inventor
Richard William Arthur Luke
Zbigniew Stanley Matusiak
Andrew Leach
Jeffrey James Morris
Paul David Johnson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251789&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010003927(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2010003927A publication Critical patent/MX2010003927A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Abstract

La invenci?n se refiere a un grupo nuevo de compuestos de F?rmula (I) o sales de lo mismo: en donde Y, Z1, Z2, R1, R4, R5 y n son como se describen en la especificaci?n, en el cual pueden utilizarse en el tratamiento o prevenci?n de una enfermedad o afecci?n m?dica mediada por la prote?na cinasa B (PKB) tal como c?ncer. La invenci?n tambi?n se refiere a composiciones farmac?uticas que comprenden tales compuestos, m?todos de tratamiento de enfermedades mediadas por PKB que usan tales compuestos y m?todos para preparar compuestos de F?rmula (I).
MX2010003927A 2007-10-11 2008-10-09 Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b. MX2010003927A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97919207P 2007-10-11 2007-10-11
US4786208P 2008-04-25 2008-04-25
PCT/GB2008/050925 WO2009047563A1 (en) 2007-10-11 2008-10-09 Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors

Publications (1)

Publication Number Publication Date
MX2010003927A true MX2010003927A (es) 2010-04-30

Family

ID=40251789

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003927A MX2010003927A (es) 2007-10-11 2008-10-09 Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b.

Country Status (38)

Country Link
US (8) US8101623B2 (es)
EP (1) EP2201012B1 (es)
JP (2) JP4705695B2 (es)
KR (1) KR101494734B1 (es)
CN (1) CN101861321B (es)
AR (1) AR068846A1 (es)
AU (1) AU2008309383B2 (es)
BR (1) BRPI0818533B8 (es)
CA (1) CA2701057C (es)
CL (1) CL2008003023A1 (es)
CO (1) CO6270328A2 (es)
CR (1) CR11359A (es)
CU (1) CU23886B1 (es)
CY (1) CY1116929T1 (es)
DK (1) DK2201012T3 (es)
DO (1) DOP2010000103A (es)
EA (1) EA018512B1 (es)
ES (1) ES2522365T3 (es)
GT (1) GT201000082A (es)
HK (1) HK1143154A1 (es)
HN (1) HN2010000653A (es)
HR (1) HRP20140807T1 (es)
IL (1) IL204721A (es)
ME (1) ME01999B (es)
MX (1) MX2010003927A (es)
MY (1) MY150059A (es)
NI (1) NI201000050A (es)
NZ (1) NZ585261A (es)
PE (2) PE20130152A1 (es)
PL (1) PL2201012T3 (es)
PT (1) PT2201012E (es)
RS (1) RS53552B1 (es)
SA (1) SA08290625B1 (es)
SI (1) SI2201012T1 (es)
TW (1) TWI453021B (es)
UY (1) UY31384A1 (es)
WO (1) WO2009047563A1 (es)
ZA (1) ZA201002318B (es)

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Also Published As

Publication number Publication date
US11236095B2 (en) 2022-02-01
US11760760B2 (en) 2023-09-19
CA2701057C (en) 2015-03-24
SA08290625B1 (ar) 2012-02-12
IL204721A0 (en) 2010-11-30
IL204721A (en) 2013-10-31
US20200239483A1 (en) 2020-07-30
GT201000082A (es) 2015-03-10
PT2201012E (pt) 2014-09-04
CR11359A (es) 2010-07-15
SI2201012T1 (sl) 2014-10-30
HRP20140807T1 (hr) 2014-11-21
JP2011157364A (ja) 2011-08-18
US20220220116A1 (en) 2022-07-14
HN2010000653A (es) 2013-03-18
BRPI0818533A2 (pt) 2017-06-06
AU2008309383B2 (en) 2012-04-19
CU23886B1 (es) 2013-04-19
WO2009047563A1 (en) 2009-04-16
NZ585261A (en) 2011-10-28
US8101623B2 (en) 2012-01-24
US9492453B2 (en) 2016-11-15
AR068846A1 (es) 2009-12-09
EA018512B1 (ru) 2013-08-30
MY150059A (en) 2013-11-29
TW200927128A (en) 2009-07-01
JP4705695B2 (ja) 2011-06-22
US20090163524A1 (en) 2009-06-25
KR20100101077A (ko) 2010-09-16
KR101494734B1 (ko) 2015-02-26
ME01999B (me) 2015-05-20
US10059714B2 (en) 2018-08-28
PE20130152A1 (es) 2013-03-17
CU20100062A7 (es) 2011-10-05
CY1116929T1 (el) 2017-04-05
CA2701057A1 (en) 2009-04-16
EP2201012B1 (en) 2014-06-25
RS53552B1 (en) 2015-02-27
BRPI0818533B8 (pt) 2021-05-25
ZA201002318B (en) 2012-09-26
JP5330430B2 (ja) 2013-10-30
EP2201012A1 (en) 2010-06-30
US20150182531A1 (en) 2015-07-02
DOP2010000103A (es) 2010-05-31
HK1143154A1 (en) 2010-12-24
PL2201012T3 (pl) 2014-11-28
CO6270328A2 (es) 2011-04-20
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US20180312516A1 (en) 2018-11-01
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AU2008309383A1 (en) 2009-04-16
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US20240109902A1 (en) 2024-04-04
ES2522365T3 (es) 2014-11-14
EA201000552A1 (ru) 2010-12-30
CN101861321B (zh) 2013-02-06
PE20090964A1 (es) 2009-08-15
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