MX2009013581A - Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio. - Google Patents
Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio.Info
- Publication number
- MX2009013581A MX2009013581A MX2009013581A MX2009013581A MX2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A MX 2009013581 A MX2009013581 A MX 2009013581A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- provides
- potassium channel
- channel modulators
- azacycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invención proporciona moduladores del canal de potasio que son compuestos de fórmula I (ver fórmula (I)) en donde al menos uno de W y Z es N; en donde la porción (ver fórmula (II)) es uno de los Grupos A o B siguientes (ver fórmula (A)) en donde Ar es un grupo anular aromático fusionado en las posiciones 1,2, de seis miembros, que porta los sustituyentes R1 y R2 como se define a continuación, y que contiene cero o un átomo de nitrógeno en el anillo; y en donde los otros sustituyentes son como se define en la presente; la invención también proporciona una composición que comprende un portador farmacéuticamente aceptable y al menos uno de lo siguiente: i) una cantidad farmacéuticamente efectiva de un compuesto de fórmula I y ii) una sal, éster o profármaco farmacéuticamente aceptable del mismo; la invención también proporciona un método para prevenir o tratar una enfermedad o trastorno, que es afectado por las actividades de los canales de potasio, que comprende administrar a un paciente en necesidad del mismo, una cantidad terapéuticamente efectiva de un compuesto de fórmula I o una sal, éster o profármaco del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93439607P | 2007-06-13 | 2007-06-13 | |
US12/138,251 US8367684B2 (en) | 2007-06-13 | 2008-06-12 | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
PCT/US2008/066984 WO2008157404A2 (en) | 2007-06-13 | 2008-06-13 | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009013581A true MX2009013581A (es) | 2010-01-26 |
Family
ID=40137141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009013581A MX2009013581A (es) | 2007-06-13 | 2008-06-13 | Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8367684B2 (es) |
EP (1) | EP2170861B1 (es) |
JP (1) | JP2010530002A (es) |
KR (1) | KR20100018618A (es) |
CN (1) | CN101868451A (es) |
AU (1) | AU2008266009B2 (es) |
BR (1) | BRPI0812564A2 (es) |
CA (1) | CA2689208A1 (es) |
DK (1) | DK2170861T3 (es) |
ES (1) | ES2392774T3 (es) |
HR (1) | HRP20120857T1 (es) |
MX (1) | MX2009013581A (es) |
PL (1) | PL2170861T3 (es) |
PT (1) | PT2170861E (es) |
RU (1) | RU2010100893A (es) |
SI (1) | SI2170861T1 (es) |
TW (1) | TW200914452A (es) |
WO (1) | WO2008157404A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
US20120115900A1 (en) | 2009-04-21 | 2012-05-10 | Neurosearch A/S | Substituted naphthyridine derivatives and their medical use |
MX2013000138A (es) * | 2010-07-08 | 2013-03-05 | Pfizer | Amidas de piperidinil pirimidina como abridores de canales de potasio de kv7. |
KR20150000900A (ko) | 2012-04-10 | 2015-01-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 1-치환된 인다졸 유도체 |
CN103694163A (zh) * | 2012-09-27 | 2014-04-02 | 上海先声药物研究有限公司 | 作为钾通道调节剂的化合物 |
EP3319479A4 (en) | 2015-07-07 | 2019-02-27 | Colgate-Palmolive Company | MOUTH CARE AND MONOFILAMENT BRISTLE FOR USE THEREOF |
CN110511220B (zh) * | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
WO2023125935A1 (zh) * | 2021-12-31 | 2023-07-06 | 上海翰森生物医药科技有限公司 | 苯并哌啶衍生物调节剂、其制备方法和应用 |
CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4181803A (en) * | 1973-12-14 | 1980-01-01 | Eisai Co., Ltd. | Propiophenone derivatives and preparation thereof |
DE3337593A1 (de) | 1982-10-27 | 1984-05-03 | Degussa Ag, 6000 Frankfurt | 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung |
ATE25078T1 (de) * | 1982-10-27 | 1987-02-15 | Degussa | 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung. |
ATE46265T1 (de) | 1985-01-23 | 1989-09-15 | Asta Pharma Ag | Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika. |
ATE43789T1 (de) * | 1985-02-23 | 1989-06-15 | Asta Pharma Ag | Kombination von flupirtin und anticholinergisch wirkenden spasmolytika. |
DE3604575A1 (de) | 1985-02-23 | 1986-08-28 | Degussa Ag, 6000 Frankfurt | Kombination von flupirtin und anticholinergisch wirkenden spasmolytika |
JP2583067B2 (ja) * | 1987-08-04 | 1997-02-19 | 住友化学工業株式会社 | モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法 |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
MC2029A1 (fr) | 1988-05-16 | 1990-04-25 | Asta Pharma Ag | (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments |
US5629307A (en) * | 1989-10-20 | 1997-05-13 | Olney; John W. | Use of ibogaine in reducing excitotoxic brain damage |
US6004945A (en) * | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
IN172468B (es) * | 1990-07-14 | 1993-08-14 | Asta Medica Ag | |
US5643921A (en) * | 1990-09-26 | 1997-07-01 | E.R. Squibb & Sons, Inc. | Cardiopulmonary bypass and organ transplant using a potassium channel activator |
US5234947A (en) * | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
DE4200259A1 (de) * | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
US5262419A (en) * | 1992-06-11 | 1993-11-16 | E. R. Squibb & Sons, Inc. | Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator |
CA2115792C (en) * | 1993-03-05 | 2005-11-01 | David J. Mayer | Method for the treatment of pain |
US5428039A (en) * | 1994-02-20 | 1995-06-27 | The Center For Innovative Technology | Method for electively achieving reversible hyperpolarized cardiac arrest |
WO1996004266A2 (de) * | 1994-08-03 | 1996-02-15 | Asta Medica Aktiengesellschaft | Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung |
USRE38115E1 (en) * | 1994-09-22 | 2003-05-06 | Center For Neurologic Study | Dextromethorphan and an oxidase inhibitor for treating intractable conditions |
US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
CA2206119C (en) * | 1994-12-12 | 2008-05-13 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
DE19539861A1 (de) * | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
DE19701694A1 (de) * | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
IN188411B (es) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
US5760007A (en) * | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
AU8561298A (en) * | 1997-08-08 | 1999-03-01 | Chugai Seiyaku Kabushiki Kaisha | Remedies for complications of diabetes |
US6593335B1 (en) * | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
US6265417B1 (en) * | 1997-12-18 | 2001-07-24 | Abbott Laboratories | Potassium channel openers |
US6211171B1 (en) * | 1998-05-19 | 2001-04-03 | Dalhousie University | Use of antidepressants for local analgesia |
JP3441970B2 (ja) | 1998-06-30 | 2003-09-02 | 株式会社サミー | 豆腐の製造方法及び製造装置 |
JP2000143510A (ja) | 1998-11-16 | 2000-05-23 | Taisho Pharmaceut Co Ltd | 外用組成物 |
WO2000035434A2 (en) * | 1998-12-14 | 2000-06-22 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
US6281211B1 (en) * | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
GB9903476D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Therapeutic agents |
WO2000053225A1 (en) * | 1999-03-10 | 2000-09-14 | Warner-Lambert Company | Analgesic compositions comprising anti-epileptic compounds and methods of using same |
WO2000055137A1 (en) | 1999-03-17 | 2000-09-21 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
AT409083B (de) | 1999-04-01 | 2002-05-27 | Sanochemia Pharmazeutika Ag | Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung |
US6610324B2 (en) | 1999-04-07 | 2003-08-26 | The Mclean Hospital Corporation | Flupirtine in the treatment of fibromyalgia and related conditions |
GB9915414D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
ES2278619T3 (es) | 1999-07-06 | 2007-08-16 | Eli Lilly And Company | Antagonistas selectivos del receptor iglur 5 para el tratamiento de la migraña. |
US6472165B1 (en) * | 1999-08-03 | 2002-10-29 | Arzneimittelwerk Dresden Gmbh | Modulatory binding site in potassium channels for screening and finding new active ingredients |
US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
NZ516743A (en) * | 1999-08-04 | 2004-02-27 | Icagen Inc | Methods for treating or preventing pain and anxiety |
DE60037321D1 (de) * | 1999-08-04 | 2008-01-17 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
US6117900A (en) * | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
US6383511B1 (en) * | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
US6538004B2 (en) * | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
US20020015730A1 (en) * | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
TWI287984B (en) * | 2000-10-17 | 2007-10-11 | Wyeth Corp | Pharmaceutical composition for modulating bladder function |
US6589986B2 (en) * | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
CN1250544C (zh) * | 2001-02-07 | 2006-04-12 | 奥索-麦克尼尔药品公司 | 吡啶并芳基苯基噁唑烷酮抗菌剂和相关组合物及方法 |
US6469042B1 (en) * | 2001-02-20 | 2002-10-22 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators if KCNQ potassium channels |
AU2002338333A1 (en) | 2001-04-04 | 2002-10-21 | Wyeth | Methods for treating hyperactive gastric motility |
GB0121214D0 (en) | 2001-08-31 | 2001-10-24 | Btg Int Ltd | Synthetic method |
US6831087B2 (en) * | 2001-11-09 | 2004-12-14 | Hoffmann-La Roche Inc. | Pyridine substituted isoquinoline derivatives |
AU2003244463A1 (en) * | 2002-02-05 | 2003-09-02 | Yamanouchi Pharmaceutical Co., Ltd. | 2,4,6-triamino-1,3,5-triazine derivative |
AU2003202115A1 (en) * | 2002-02-12 | 2003-09-04 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
AU2003241453A1 (en) | 2002-05-17 | 2003-12-02 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
WO2003106454A1 (en) | 2002-06-12 | 2003-12-24 | Orchid Chemicals & Pharmaceuticals Ltd | 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents |
AUPS312602A0 (en) * | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
US7419981B2 (en) * | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
US7045551B2 (en) * | 2002-11-22 | 2006-05-16 | Bristol-Myers Squibb Company | 1-aryl-2-hydroxyethyl amides as potassium channel openers |
CA2505195C (en) * | 2002-12-23 | 2012-07-10 | Icagen, Inc. | Quinazolinones as potassium channel modulators |
AU2003287922B2 (en) | 2002-12-27 | 2009-12-10 | H. Lundbeck A/S | 1,2,4-triaminobenzene derivatives useful for treating disorders of the central nervous system |
EP1606247A1 (en) | 2003-03-14 | 2005-12-21 | H. Lundbeck A/S | Substituted aniline derivatives |
CA2519582A1 (en) | 2003-03-21 | 2004-09-30 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
US20060264496A1 (en) | 2003-04-25 | 2006-11-23 | H. Lundbeck A/S | Substituted indoline and indole derivatives |
EP1644043A1 (en) | 2003-05-27 | 2006-04-12 | ALTANA Pharma AG | Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility |
EP1644370A4 (en) * | 2003-07-11 | 2008-06-04 | Bristol Myers Squibb Co | TETRAHYDROCHINOLINE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS |
EP1663239A4 (en) * | 2003-09-10 | 2008-07-23 | Cedars Sinai Medical Center | KALIUM CHANNEL-MEDIATED FEEDING OF MEDICINES BY THE BLOOD BRAIN BARRIER |
US7799832B2 (en) * | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
DE10359335A1 (de) | 2003-10-23 | 2005-05-25 | Viatris Gmbh & Co. Kg | Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen |
ES2235626B1 (es) | 2003-11-10 | 2006-11-01 | Almirall Prodesfarma, S.A. | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
AU2005233642A1 (en) | 2004-04-13 | 2005-10-27 | Astellas Pharma Inc. | Polycyclic pyridines as potassium ion channel modulators |
WO2005110405A1 (en) * | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
CA2571133C (en) * | 2004-07-15 | 2011-04-19 | Japan Tobacco Inc. | Fused benzamide compound and vanilloid receptor 1 (vr1) activity inhibitor |
UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
JP2008513508A (ja) * | 2004-09-21 | 2008-05-01 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫に関連する用途に用いる化合物 |
CA2589001A1 (en) | 2004-11-19 | 2006-05-26 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for neuropathic pain |
EP1688141A1 (en) * | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
EP2298766B1 (en) | 2005-03-03 | 2013-09-18 | H. Lundbeck A/S | Pharmaceutical formulations comrpising a substituted pyridine derivative |
US7683058B2 (en) * | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
JP5140597B2 (ja) * | 2005-10-21 | 2013-02-06 | メルク・シャープ・エンド・ドーム・コーポレイション | カリウムチャネル阻害剤 |
RU2009110172A (ru) | 2006-08-23 | 2010-09-27 | Валеант Фармасьютикалс Интернэшнл (Us) | Производные 4-(n-азациклоалкил)анилидов в качестве модуляторов калиевых каналов |
ES2375417T3 (es) | 2006-11-28 | 2012-02-29 | Valeant Pharmaceuticals International | Análogos 1,4-diamino bicíclicos de retigabina como moduladores de los canales de potasio. |
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
EP2445340B1 (en) * | 2009-06-22 | 2016-05-18 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
-
2008
- 2008-06-12 US US12/138,251 patent/US8367684B2/en active Active
- 2008-06-13 SI SI200830745T patent/SI2170861T1/sl unknown
- 2008-06-13 AU AU2008266009A patent/AU2008266009B2/en not_active Ceased
- 2008-06-13 CA CA002689208A patent/CA2689208A1/en not_active Abandoned
- 2008-06-13 PT PT08771077T patent/PT2170861E/pt unknown
- 2008-06-13 BR BRPI0812564-3A2A patent/BRPI0812564A2/pt not_active Application Discontinuation
- 2008-06-13 CN CN200880102338A patent/CN101868451A/zh active Pending
- 2008-06-13 KR KR1020107000706A patent/KR20100018618A/ko not_active Application Discontinuation
- 2008-06-13 ES ES08771077T patent/ES2392774T3/es active Active
- 2008-06-13 WO PCT/US2008/066984 patent/WO2008157404A2/en active Application Filing
- 2008-06-13 RU RU2010100893/04A patent/RU2010100893A/ru not_active Application Discontinuation
- 2008-06-13 DK DK08771077.8T patent/DK2170861T3/da active
- 2008-06-13 MX MX2009013581A patent/MX2009013581A/es active IP Right Grant
- 2008-06-13 TW TW097122339A patent/TW200914452A/zh unknown
- 2008-06-13 EP EP08771077A patent/EP2170861B1/en not_active Not-in-force
- 2008-06-13 JP JP2010512399A patent/JP2010530002A/ja active Pending
- 2008-06-13 PL PL08771077T patent/PL2170861T3/pl unknown
-
2012
- 2012-10-23 HR HRP20120857AT patent/HRP20120857T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP2170861A2 (en) | 2010-04-07 |
RU2010100893A (ru) | 2011-07-20 |
PL2170861T3 (pl) | 2013-01-31 |
EP2170861B1 (en) | 2012-08-29 |
WO2008157404A3 (en) | 2009-02-19 |
BRPI0812564A2 (pt) | 2015-02-10 |
SI2170861T1 (sl) | 2012-12-31 |
KR20100018618A (ko) | 2010-02-17 |
AU2008266009B2 (en) | 2013-06-06 |
DK2170861T3 (da) | 2012-11-26 |
TW200914452A (en) | 2009-04-01 |
AU2008266009A1 (en) | 2008-12-24 |
WO2008157404A2 (en) | 2008-12-24 |
JP2010530002A (ja) | 2010-09-02 |
PT2170861E (pt) | 2012-09-06 |
HRP20120857T1 (hr) | 2012-11-30 |
CN101868451A (zh) | 2010-10-20 |
CA2689208A1 (en) | 2008-12-24 |
US20080318979A1 (en) | 2008-12-25 |
US8367684B2 (en) | 2013-02-05 |
ES2392774T3 (es) | 2012-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009013581A (es) | Derivados de 4-(n-azacicloalquil)anilidas como moduladores del canal de potasio. | |
MX2010001189A (es) | Derivados de naftiridina como modulares del canal de potasio. | |
NO20091938L (no) | 7,8-dihydro-1,6-naftyridin-5(6H)-oner og relaterte bicykliske forbindelser som inhibitorer av dipeptidyl-peptidaser IV og metoder | |
TW200716528A (en) | Cyclopropanecarboxamide derivatives | |
DE602004008098D1 (de) | Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren | |
EA201001669A1 (ru) | Замещенные пиримидин-5-карбоксамиды 281 | |
EA200601896A1 (ru) | Производные пролина и их применение в качестве ингибиторов дипептидилпептидазы iv | |
EA023500B1 (ru) | Соединения, композиции и способы их применения для коррекции уровня мочевой кислоты | |
EA200601350A1 (ru) | Азотсодержащие гетероциклические производные и их фармацевтические применения | |
MY140638A (en) | New heterocyclic compounds, which are active as inhibitors of beta-lactamases | |
MX2011012627A (es) | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. | |
TW200639159A (en) | Treatment of pain | |
WO2008012635A3 (en) | Amine derivatives useful as anticancer agents | |
MA32135B1 (fr) | Inhibiteurs de pim kinase et leurs procedes d'utilisation | |
RS20050180A (en) | Novel benzoimidazole derivatives useful as antiproliferative agensts | |
TW200806299A (en) | Treatment of pain | |
NO20076196L (no) | Nye 2-azetidinonderivater som kolesterolabsorpsjonsinhibitorer for behandling av hyperlipidemiske tilstander | |
MX2010009922A (es) | Activadores de piridazinona glucocinasa. | |
HK1142898A1 (en) | 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine- beta-hydroxylase | |
EA200970705A1 (ru) | Новые фармацевтические композиции | |
GB0701366D0 (en) | Novel pharmaceutical compositions | |
TW200800951A (en) | Substituted imidazole compounds as KSP inhibitors | |
WO2009066041A3 (fr) | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
RS51661B (en) | NEW DIOSMETHINE DERIVATIVES, THE PROCEDURE FOR THEIR MAKING AND THE PHARMACEUTICAL MIXTURES CONTAINING THEM | |
GEP20125548B (en) | New dihidroindolone compounds, a process for its preparation and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FG | Grant or registration |