MX2009010828A - Antagonistas del receptor de la hormona liberadora de gonadotropina y metodos relacionados con los mismos. - Google Patents

Antagonistas del receptor de la hormona liberadora de gonadotropina y metodos relacionados con los mismos.

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Publication number
MX2009010828A
MX2009010828A MX2009010828A MX2009010828A MX2009010828A MX 2009010828 A MX2009010828 A MX 2009010828A MX 2009010828 A MX2009010828 A MX 2009010828A MX 2009010828 A MX2009010828 A MX 2009010828A MX 2009010828 A MX2009010828 A MX 2009010828A
Authority
MX
Mexico
Prior art keywords
receptor antagonists
gonadotropin
releasing hormone
methods relating
hormone receptor
Prior art date
Application number
MX2009010828A
Other languages
English (en)
Inventor
Graham Beaton
Mi Chen
Timothy Richard Coon
Todd Ewing
Wanlong Jiang
Richard Lowe
Willy Moree
Nicole Smith
Warren Wade
Liren Zhao
Yun-Fei Zhu
Martin Rowbottom
Neil Ashweek
Original Assignee
Neurocrine Biosciences Inc
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Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of MX2009010828A publication Critical patent/MX2009010828A/es

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract

Se describen antagonistas del receptor GnRH que tienen utilidad en el tratamiento de una diversidad de afecciones relacionadas con las hormonas sexuales tanto en hombres como en mujeres. Los compuestos de esta invención tienen la estructura, (ver fórmula) en la que R1a, R1b, R1c, R1d, R2, R2a y A son como se han definido en este documento, incluyendo estereoisómeros, ésteres, solvatos y sales farmacéuticamente aceptables de los mismos. También se describen composiciones que contienen un compuesto de esta invención en combinación con un vehículo farmacéuticamente aceptable, así como métodos para el uso de los mismos para antagonizar la hormona liberadora de gonadotropina en un sujeto que lo necesita.
MX2009010828A 2007-04-06 2008-04-04 Antagonistas del receptor de la hormona liberadora de gonadotropina y metodos relacionados con los mismos. MX2009010828A (es)

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