MX2009006553A - Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina. - Google Patents

Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.

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Publication number
MX2009006553A
MX2009006553A MX2009006553A MX2009006553A MX2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A MX 2009006553 A MX2009006553 A MX 2009006553A
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Mexico
Prior art keywords
sup
alkyl
imidazo
tetrahydro
alkoxy
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MX2009006553A
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English (en)
Inventor
Ralf Koberstein
Thierry Sifferlen
Hamed Aissaoui
Christoph Boss
Markus Gude
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Actelion Pharmaceuticals Ltd
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Publication of MX2009006553A publication Critical patent/MX2009006553A/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Abstract

La presente invención se refiere a derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina de fórmula (I), en donde X representa CH2 u O; R1 representa un grupo fenilo, en el cual el grupo es independientemente mono, di o tri sustituido, en donde los sustituyentes son seleccionados independientemente del grupo que consiste de alquilo (C1-4), alcoxi (C1-4), halógeno, ciano, trifluorometoxi y trifluorometilo; R2 representa alquilo (C1-4), alcoxi (C1-4), alquenilo (C2-4), halógeno, ciano, hidroximetilo, trifluorometilo, C(O)NR5R6 o ciclopropilo; R3 representa alquilo (C1-4), alcoxi-metilo (C1-4) o halógeno; R4 representa alquilo (C1-4); R5 representa hidrógeno o alquilo (C1-4); y R6 representa hidrógeno o alquilo (C1-4). La invención también se refiere a sales farmacéuticamente aceptables de tales compuestos; y al uso de tales compuestos como medicamentos; especialmente como antagonistas del receptor de orexina.
MX2009006553A 2006-12-22 2007-12-20 Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina. MX2009006553A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055019 2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en) 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

Publications (1)

Publication Number Publication Date
MX2009006553A true MX2009006553A (es) 2009-06-26

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MX2009006553A MX2009006553A (es) 2006-12-22 2007-12-20 Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina.

Country Status (15)

Country Link
US (1) US8188082B2 (es)
EP (1) EP2125823B1 (es)
JP (1) JP2010513466A (es)
KR (1) KR20090106538A (es)
CN (1) CN101568542B (es)
AT (1) ATE545647T1 (es)
AU (1) AU2007337659A1 (es)
BR (1) BRPI0720522A2 (es)
CA (1) CA2669561A1 (es)
ES (1) ES2380391T3 (es)
MA (1) MA31002B1 (es)
MX (1) MX2009006553A (es)
NO (1) NO20092715L (es)
RU (1) RU2009127842A (es)
WO (1) WO2008078291A1 (es)

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CN108101930B (zh) * 2017-12-22 2020-10-30 武汉大学 一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
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WO2022072647A1 (en) * 2020-10-02 2022-04-07 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
WO2022072648A1 (en) * 2020-10-02 2022-04-07 Board Of Regents, The University Of Texas System Imidazopiperazine inhibitors of transcription activating proteins
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ES2339822T3 (es) 2006-08-28 2010-05-25 Actelion Pharmaceuticals Ltd. Derivados de 1,4,5,6,7,8-hexahidro-1,2,5-triaza-azuleno como antagonistas del receptor de orexina.
EP2125823B1 (en) 2006-12-22 2012-02-15 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
PE20091010A1 (es) 2007-10-10 2009-08-08 Actelion Pharmaceuticals Ltd Derivados de tetrahidroquinolina
CA2726834A1 (en) 2008-06-25 2009-12-30 Actelion Pharmaceuticals Ltd 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds

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US8188082B2 (en) 2012-05-29
EP2125823A1 (en) 2009-12-02
CN101568542B (zh) 2013-03-27
ES2380391T3 (es) 2012-05-11
JP2010513466A (ja) 2010-04-30
KR20090106538A (ko) 2009-10-09
NO20092715L (no) 2009-07-20
US20100093740A1 (en) 2010-04-15
MA31002B1 (fr) 2009-12-01
RU2009127842A (ru) 2011-01-27
CN101568542A (zh) 2009-10-28
EP2125823B1 (en) 2012-02-15
ATE545647T1 (de) 2012-03-15
CA2669561A1 (en) 2008-07-03
AU2007337659A1 (en) 2008-07-03
BRPI0720522A2 (pt) 2014-01-07

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