MX2009004702A - Derivados de azaindol como moduladores del regulador de conductancia de transmembrana de fibrosis quistica. - Google Patents

Derivados de azaindol como moduladores del regulador de conductancia de transmembrana de fibrosis quistica.

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Publication number
MX2009004702A
MX2009004702A MX2009004702A MX2009004702A MX2009004702A MX 2009004702 A MX2009004702 A MX 2009004702A MX 2009004702 A MX2009004702 A MX 2009004702A MX 2009004702 A MX2009004702 A MX 2009004702A MX 2009004702 A MX2009004702 A MX 2009004702A
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MX
Mexico
Prior art keywords
modulators
cftr modulators
azaindole derivatives
relates
present
Prior art date
Application number
MX2009004702A
Other languages
English (en)
Inventor
Brian Bear
Jinglan Zhou
Sara Hadida Ruah
Mark Miller
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009004702A publication Critical patent/MX2009004702A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

La presente invención se refiere a moduladores de los transportadores de casete de enlace a ATP ("ABC", por sus siglas en inglés) o fragmentos de los mismos, incluyendo el regulador de conductividad de la transmembrana de fibrosis quística ("CFTR", por sus siglas en inglés), composiciones de los mismos, y métodos en relación con esto. La presente invención también se refiere a los métodos para tratar las enfermedades mediadas por el transportador ABC usando tales moduladores.
MX2009004702A 2006-11-03 2007-11-02 Derivados de azaindol como moduladores del regulador de conductancia de transmembrana de fibrosis quistica. MX2009004702A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85658406P 2006-11-03 2006-11-03
PCT/US2007/083464 WO2008127399A2 (en) 2006-11-03 2007-11-02 Azaindole derivatives as cftr modulators

Publications (1)

Publication Number Publication Date
MX2009004702A true MX2009004702A (es) 2009-06-19

Family

ID=39864541

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004702A MX2009004702A (es) 2006-11-03 2007-11-02 Derivados de azaindol como moduladores del regulador de conductancia de transmembrana de fibrosis quistica.

Country Status (15)

Country Link
EP (2) EP2826778B1 (es)
JP (3) JP5284268B2 (es)
KR (1) KR20090082456A (es)
CN (2) CN101715450B (es)
AU (1) AU2007351454B2 (es)
CA (1) CA2668305C (es)
ES (2) ES2471890T3 (es)
HK (1) HK1140475A1 (es)
HU (1) HUE034579T2 (es)
IL (1) IL198509A0 (es)
MX (1) MX2009004702A (es)
NO (1) NO20091720L (es)
NZ (1) NZ576642A (es)
RU (1) RU2009120976A (es)
WO (1) WO2008127399A2 (es)

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AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
PT3068392T (pt) 2013-11-12 2021-05-14 Vertex Pharma Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por condutância transmembrana da fibrose quística (cftr)
PL3925607T3 (pl) 2014-04-15 2023-10-30 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
KR20170095814A (ko) * 2014-10-06 2017-08-23 플랫틀리 디스커버리 랩, 엘엘씨 트라이아졸로피리딘 화합물 및 낭성 섬유증의 치료 방법
CN112250627B (zh) 2014-10-06 2024-02-02 弗特克斯药品有限公司 囊性纤维化跨膜转导调节因子调节剂
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HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
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IL277491B (en) 2016-12-09 2022-08-01 Vertex Pharma Modulatory modulation of transmembrane conductance in cystic fibrosis, pharmaceutical preparations, treatment methods, and a process for creating the modulator
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US11498904B2 (en) 2017-11-14 2022-11-15 Merck Sharp & Dohme Llc Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
EP3710444B1 (en) 2017-11-14 2023-04-12 Merck Sharp & Dohme LLC Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
MX2020005753A (es) 2017-12-08 2020-08-20 Vertex Pharma Procesos para producir moduladores de regulador de conductancia transmembranal de fibrosis quistica.
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
MD3752510T2 (ro) 2018-02-15 2023-06-30 Vertex Pharma Macrociclii ca modulatori ai regulatorului conductanței transmembranare în fibroza chistică, compoziții farmaceutice ale acestora, utilizarea lor în tratamentul fibrozei chistice, și procedeu pentru fabricarea acestora
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
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CN103159760B (zh) 2016-06-08
WO2008127399A2 (en) 2008-10-23
EP2118103A2 (en) 2009-11-18
EP2826778A1 (en) 2015-01-21
EP2826778B1 (en) 2017-09-20
EP2118103B1 (en) 2014-04-23
CA2668305C (en) 2017-01-03
RU2009120976A (ru) 2010-12-10
JP2013144716A (ja) 2013-07-25
JP5937540B2 (ja) 2016-06-22
CN101715450A (zh) 2010-05-26
JP5284268B2 (ja) 2013-09-11
CN103159760A (zh) 2013-06-19
HUE034579T2 (en) 2018-02-28
AU2007351454A1 (en) 2008-10-23
JP2010540408A (ja) 2010-12-24
JP2014231529A (ja) 2014-12-11
NO20091720L (no) 2009-07-21
CN101715450B (zh) 2013-03-13
CA2668305A1 (en) 2008-10-23
AU2007351454B2 (en) 2013-07-18
HK1140475A1 (en) 2010-10-15
IL198509A0 (en) 2010-02-17
NZ576642A (en) 2011-11-25
ES2646175T3 (es) 2017-12-12
WO2008127399A3 (en) 2008-12-31
ES2471890T3 (es) 2014-06-27
KR20090082456A (ko) 2009-07-30

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