MX2009002538A - Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina. - Google Patents

Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina.

Info

Publication number
MX2009002538A
MX2009002538A MX2009002538A MX2009002538A MX2009002538A MX 2009002538 A MX2009002538 A MX 2009002538A MX 2009002538 A MX2009002538 A MX 2009002538A MX 2009002538 A MX2009002538 A MX 2009002538A MX 2009002538 A MX2009002538 A MX 2009002538A
Authority
MX
Mexico
Prior art keywords
sup
benzo
tetrahydro
oxo
diazepine derivatives
Prior art date
Application number
MX2009002538A
Other languages
English (en)
Inventor
Roland Jakob-Roetne
Alexander Flohr
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009002538A publication Critical patent/MX2009002538A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a derivados de 4-oxo- 2,3,4,5-tetrahidro-benzo[b] [1,4jdiazepina de la fórmula (1) (ver fórmula I) en donde R', R2, R3 y R4 son como se define en la descripción y reivindicaciones, los cuales son inhibidores de y-secretasa y los cuales pueden ser útiles en el tratamiento de enfermedad de Alzheimer.
MX2009002538A 2006-09-20 2007-09-11 Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina. MX2009002538A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120956 2006-09-20
PCT/EP2007/059488 WO2008034735A2 (en) 2006-09-20 2007-09-11 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives

Publications (1)

Publication Number Publication Date
MX2009002538A true MX2009002538A (es) 2009-03-20

Family

ID=39099887

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002538A MX2009002538A (es) 2006-09-20 2007-09-11 Derivados de 4-oxo-2,3,4,5-tetrahidro-benzo[b][1,4]diazepina.

Country Status (11)

Country Link
US (1) US7414049B2 (es)
EP (1) EP2069317A2 (es)
JP (1) JP5001372B2 (es)
KR (1) KR101096476B1 (es)
CN (1) CN101516859B (es)
AU (1) AU2007299129A1 (es)
BR (1) BRPI0717587A2 (es)
CA (1) CA2663240A1 (es)
IL (1) IL197149A0 (es)
MX (1) MX2009002538A (es)
WO (1) WO2008034735A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008209861B2 (en) * 2007-02-02 2012-08-09 F. Hoffmann-La Roche Ag 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
US8309299B2 (en) * 2010-05-19 2012-11-13 Hoffmann-La Roche Inc. Combination therapy and method for assessing resistance to treatment
TWI530489B (zh) 2011-03-22 2016-04-21 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯二氮呯酮化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU721081B2 (en) * 1996-12-10 2000-06-22 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
NZ528315A (en) 2001-04-12 2005-04-29 F Dihydro-benzo [b] [1, 4] diazepin-2-one derivatives as MGLUR2 antagonists II
ES2311795T3 (es) 2003-02-04 2009-02-16 F. Hoffmann-La Roche Ag Derivados de malonamida como inhibidores de gamma-secretasa.
KR20070087233A (ko) 2003-09-09 2007-08-27 에프. 호프만-라 로슈 아게 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체
US7166587B2 (en) 2003-10-06 2007-01-23 Hoffmann-La Roche Inc. Carbamic acid alkyl ester derivatives
US7211573B2 (en) * 2004-12-08 2007-05-01 Hoffmann-La Roche Inc. Malonamide derivatives

Also Published As

Publication number Publication date
WO2008034735A3 (en) 2008-05-08
IL197149A0 (en) 2009-11-18
KR101096476B1 (ko) 2011-12-20
JP5001372B2 (ja) 2012-08-15
WO2008034735A2 (en) 2008-03-27
JP2010504297A (ja) 2010-02-12
EP2069317A2 (en) 2009-06-17
US7414049B2 (en) 2008-08-19
AU2007299129A1 (en) 2008-03-27
US20080103133A1 (en) 2008-05-01
KR20090052367A (ko) 2009-05-25
CA2663240A1 (en) 2008-03-27
BRPI0717587A2 (pt) 2013-10-29
CN101516859A (zh) 2009-08-26
CN101516859B (zh) 2012-07-04

Similar Documents

Publication Publication Date Title
WO2007120647A3 (en) Compositions useful as inhibitors of voltage-gated sodium channels
TW200726753A (en) 2,4-diamino-pyrimidines as aurora inhibitors
MX2007011023A (es) 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3.
TW200736233A (en) Cyclohexyl piperazinyl methanone derivatives
IN2012DN01233A (es)
EA201070422A1 (ru) Производные оксадиазола
WO2009049180A3 (en) Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
WO2008030412A3 (en) Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
MX2010001754A (es) Derivados de azepina como inhibidores de gamma secretasa.
MX2008011633A (es) Aminoquinolonas como inhibidores de gsk-3.
MX2009005048A (es) Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
EP2091328A4 (en) SPIROPIPERIDININHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER DISEASE
AU2005313582A8 (en) Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease
JO2682B1 (en) Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
IL191751A0 (en) Pyrrolo[2,3-c]pyridine derivatives
UA99787C2 (en) Lactams as beta secretase inhibitors
EP1951709A4 (en) IMIDAZOLIDINONE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS IN THE TREATMENT OF ALZHEIMER'S DISEASE
TW200637817A (en) 5-aminoindole derivatives
MX2012006805A (es) Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa.
IL205696A0 (en) Heterocyclic derivatives, compositions comprising the same and uses thereof
IL183636A0 (en) Quinoline derivative, use and production thereof, and drug containing the same
TW200716564A (en) Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
WO2007131907A3 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
WO2006081516A3 (en) USE OF BAFF TO TREAT Th2-MEDIATED CONDITIONS
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents

Legal Events

Date Code Title Description
FG Grant or registration