MX2008016558A - Preparacion y aplicacion terapéutica de derivados de 2-benzoil-imidazopiridinas. - Google Patents
Preparacion y aplicacion terapéutica de derivados de 2-benzoil-imidazopiridinas.Info
- Publication number
- MX2008016558A MX2008016558A MX2008016558A MX2008016558A MX2008016558A MX 2008016558 A MX2008016558 A MX 2008016558A MX 2008016558 A MX2008016558 A MX 2008016558A MX 2008016558 A MX2008016558 A MX 2008016558A MX 2008016558 A MX2008016558 A MX 2008016558A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- optionally substituted
- cycloalkyl
- sub
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a derivados que tienen la fórmula general (I), en donde X representa un grupo fenilo opcionalmente sustituido; R1 representa un átomo de hidrógeno, un grupo alcoxi (de 1 a 6 átomos de carbono) opcionalmente sustituido, un grupo alquilo (de 1 a 6 átomos de carbono), un grupo cicloalquil(de 3 a 7 átomos de carbono)-alquilo(de 1 a 6 átomos de carbono), un grupo cicloalquil(de 3 a 7 átomos de carbono)-alcoxi(de 1 a 6 átomos de carbono), un hidroxi, un amino; R2 representa un átomo de hidrógeno, un grupo alquilo (de 1 a 6 átomos de carbono) opcionalmente sustituido, un grupo alcoxi (de 1 a 6 átomos de carbono) opcionalmente sustituido, un grupo cicloalquil(de 3 a 7 átomos de carbono)-alquilo(de 1 a 6 átomos de carbono), un grupo cicloalquil(de 3 a 7 átomos de carbono)-alcoxi(de 1 a 6 átomos de carbono), un grupo alquileno (de 2 a 6 átomos de carbono), un grupo alquinilo (de 2 a 6 átomos de carbono), un grupo -CO-R5-, un grupo -CO-NR6R7, -CO-O-R8-, un grupo -NR9-CO-R10, un grupo -NR11, R12, un átomo de halógeno, un grupo ciano o un grupo fenilo opcionalmente sustituido; R3 representa un átomo de hidrógeno, un grupo alquilo (de 1 a 6 átomos de carbono) o un átomo de halógeno; y R4 representa un átomo de hidrógeno o un átomo de halógeno, los derivados toman la forma de una base o una sal de adición de ácido. La invención también se refiere a su método de preparación y su uso en terapéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0606010A FR2903105A1 (fr) | 2006-07-03 | 2006-07-03 | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
PCT/FR2007/001123 WO2008003854A2 (fr) | 2006-07-03 | 2007-07-03 | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008016558A true MX2008016558A (es) | 2009-05-20 |
Family
ID=37661856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008016558A MX2008016558A (es) | 2006-07-03 | 2007-07-03 | Preparacion y aplicacion terapéutica de derivados de 2-benzoil-imidazopiridinas. |
Country Status (21)
Country | Link |
---|---|
US (1) | US7902219B2 (es) |
EP (1) | EP2040703B1 (es) |
JP (1) | JP2009541469A (es) |
KR (1) | KR20090024775A (es) |
CN (1) | CN101484163A (es) |
AT (1) | ATE446089T1 (es) |
AU (1) | AU2007271082A1 (es) |
BR (1) | BRPI0713260A2 (es) |
CA (1) | CA2656045A1 (es) |
CY (1) | CY1109743T1 (es) |
DE (1) | DE602007002915D1 (es) |
DK (1) | DK2040703T3 (es) |
ES (1) | ES2335323T3 (es) |
FR (1) | FR2903105A1 (es) |
IL (1) | IL195818A0 (es) |
MX (1) | MX2008016558A (es) |
PL (1) | PL2040703T3 (es) |
PT (1) | PT2040703E (es) |
RU (1) | RU2009103300A (es) |
SI (1) | SI2040703T1 (es) |
WO (1) | WO2008003854A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2925905B1 (fr) * | 2008-01-02 | 2010-11-05 | Sanofi Aventis | DERIVES DE 2-BENZOYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2928921B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique |
FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
FR2933609B1 (fr) | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
FR2955110A1 (fr) | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
CN103772381B (zh) * | 2013-09-16 | 2015-11-25 | 广东华南新药创制中心 | 一种四稠环喹啉类化合物及其制备方法 |
WO2021204626A1 (en) | 2020-04-06 | 2021-10-14 | Almirall, S.A. | Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
US6489337B1 (en) * | 2000-03-31 | 2002-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating histamine H3 receptor-mediated disorders with 2- or 3-aryl substituted imidazo[1,2-a] pyridines |
DE10117184A1 (de) | 2001-04-05 | 2002-10-17 | Gruenenthal Gmbh | Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen |
JP5082033B2 (ja) * | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Lxrのモジュレーター |
GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
WO2004089366A1 (en) * | 2003-04-10 | 2004-10-21 | Pfizer Japan, Inc. | Bicyclic compounds as nr2b receptor antagonists |
AR045944A1 (es) | 2003-09-24 | 2005-11-16 | Novartis Ag | Derivados de isoquinolina 1.4-disustituidas |
JP4842829B2 (ja) * | 2003-10-31 | 2011-12-21 | 武田薬品工業株式会社 | 含窒素縮合複素環化合物 |
WO2005048953A2 (en) | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Amide derivatives as kinase modulators |
WO2006024834A1 (en) | 2004-08-31 | 2006-03-09 | Astrazeneca Ab | Quinazolinone derivatives and their use as b-raf inhibitors |
AR053992A1 (es) | 2004-12-22 | 2007-05-30 | Astrazeneca Ab | Compuestos quimicos con actividad anticancerosa, un procedimiento para su preparacion, su uso en la preparacion de medicamentos y composicion farmaceutica. |
DE602005013819D1 (de) | 2004-12-22 | 2009-05-20 | Astrazeneca Ab | Pyridincarbonsäureamidderivate zur verwendung als antikrebsmittel |
-
2006
- 2006-07-03 FR FR0606010A patent/FR2903105A1/fr active Pending
-
2007
- 2007-07-03 WO PCT/FR2007/001123 patent/WO2008003854A2/fr active Application Filing
- 2007-07-03 ES ES07803831T patent/ES2335323T3/es active Active
- 2007-07-03 MX MX2008016558A patent/MX2008016558A/es unknown
- 2007-07-03 AT AT07803831T patent/ATE446089T1/de active
- 2007-07-03 AU AU2007271082A patent/AU2007271082A1/en not_active Abandoned
- 2007-07-03 EP EP07803831A patent/EP2040703B1/fr not_active Not-in-force
- 2007-07-03 CN CNA2007800252640A patent/CN101484163A/zh active Pending
- 2007-07-03 JP JP2009517330A patent/JP2009541469A/ja not_active Withdrawn
- 2007-07-03 SI SI200730133T patent/SI2040703T1/sl unknown
- 2007-07-03 KR KR1020097000049A patent/KR20090024775A/ko not_active Application Discontinuation
- 2007-07-03 BR BRPI0713260-3A patent/BRPI0713260A2/pt not_active IP Right Cessation
- 2007-07-03 DE DE602007002915T patent/DE602007002915D1/de active Active
- 2007-07-03 PT PT07803831T patent/PT2040703E/pt unknown
- 2007-07-03 DK DK07803831.2T patent/DK2040703T3/da active
- 2007-07-03 CA CA002656045A patent/CA2656045A1/fr not_active Abandoned
- 2007-07-03 RU RU2009103300/15A patent/RU2009103300A/ru not_active Application Discontinuation
- 2007-07-03 PL PL07803831T patent/PL2040703T3/pl unknown
-
2008
- 2008-12-09 IL IL195818A patent/IL195818A0/en unknown
- 2008-12-17 US US12/336,989 patent/US7902219B2/en not_active Expired - Fee Related
-
2010
- 2010-01-20 CY CY20101100057T patent/CY1109743T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20090143420A1 (en) | 2009-06-04 |
WO2008003854A3 (fr) | 2008-03-06 |
CY1109743T1 (el) | 2014-09-10 |
ES2335323T3 (es) | 2010-03-24 |
CN101484163A (zh) | 2009-07-15 |
DK2040703T3 (da) | 2010-03-08 |
IL195818A0 (en) | 2009-09-01 |
CA2656045A1 (fr) | 2008-01-10 |
PL2040703T3 (pl) | 2010-03-31 |
BRPI0713260A2 (pt) | 2012-04-03 |
SI2040703T1 (sl) | 2010-02-26 |
DE602007002915D1 (de) | 2009-12-03 |
EP2040703B1 (fr) | 2009-10-21 |
RU2009103300A (ru) | 2010-08-10 |
KR20090024775A (ko) | 2009-03-09 |
ATE446089T1 (de) | 2009-11-15 |
EP2040703A2 (fr) | 2009-04-01 |
FR2903105A1 (fr) | 2008-01-04 |
PT2040703E (pt) | 2010-01-19 |
WO2008003854A2 (fr) | 2008-01-10 |
JP2009541469A (ja) | 2009-11-26 |
AU2007271082A1 (en) | 2008-01-10 |
US7902219B2 (en) | 2011-03-08 |
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