MX2008003387A - Rod type iontophoresis device - Google Patents

Abstract

Rod type iontophoresis device (10) comprising retention part (20) and, disposed at a distal end thereof, small working-side electrode structure (12) and non-working-side electrode structure (14). Pin-point infiltration of drug solution can be accomplished by closely adhering first ion exchange membrane (44) and fourth ion exchange membrane (54) provided at the distal end thereof to, for example, the site of skin cancer and carrying out iontophoresis. The working-side electrodestructure (12) and non-working-side electrode structure (14) are mounted at a distal end of rodlike member (16), and the rodlike member (16) is freely attachable to or detachable from the distal end of the retention part (20), being replaceable integrally.

Description

VARILLA TYPE IONTOPHORESIS DEVICE Field of the Invention The present invention relates to a rod-type iontophoresis device for administering a drug ion to an organism.

Background of the Invention This iontophoresis device as described above is proposed to permeate a drug solution in a skin or mucous membrane, and has been used conventionally for a mucous or cutaneous membrane having a relatively large area of at least approximately 20 mm in diameter. On the other hand, in the case of, for example, therapy / treatment in an oral cavity such as stomatitis therapy, local anesthesia in an oral cavity, or local anesthesia in wave therapy, or an integument therapy as melanoma or skin cancer, the direct injection of a drug solution into an affected area as in a part (precise point) of an organism can increase a therapeutic effect. In this case, iontophoresis is preferred to the injection to permeate a solution of a drug because the iontophoresis is not invasive.

In photodynamic therapy (PDT), a photosensitized reactive material is administered and irradiated with light, and an anti-cancer action of the irradiation is expected. However, the patient should be prevented from irradiating with sunlight because the sensitizer circulates in his body. In addition, the sensitizer can circulate in a portion except an affected area to provide a side effect. Therefore, the PDT has demanded the administration of a sensitizer to only one affected area.

Description of the Invention An object of the invention is to provide an iontophoresis device suitably used to permeate a drug solution in a part of an organism that can be observed by a doctor from the outside in, for example, local anesthesia in a oral cavity or melanoma therapy. The above object can be achieved by the following several examples. (1) A rod-type iontophoresis device that includes: an electrode assembly of the working side and an electrode assembly of the non-working side each used to administer an ionic drug by iontophoresis; and a DC electric power source connected to the working electrode assembly and the non-working side electrode assembly with opposite polarities, characterized by including: a rod type member to support the working side electrode assembly and mounting electrode on the non-working side; and a rod-like retention portion for removably supporting the rod-like member, the working-side electrode assembly and the non-working side electrode assembly that are placed on the tip of the rod-type member, and a predetermined amount of spacing that is provided between the working electrode assembly and the non-working electrode assembly. (2) The rod-type iontophoresis device according to item (1) above, characterized in that the ionic drug is a photosensitized reactive material that is going to be activated upon absorbing light, the retention portion has an optical variation system to apply light from the vicinity of the tip of the working side electrode voltage. (3) The rod-type iontophoresis device according to item (2) above, characterized in that the retaining portion includes: a light source composed of a light emitting diode or a laser diode for emitting light having a length of wave sensitized by the photosensitized reactive material; and an optical fiber for irradiation to introduce light emitted from the light source to the rod-like member or a vicinity thereof. (4) The rod-type iontophoresis device according to any of points (1) to (3) above, characterized in that: the holding portion has a working electrode terminal on the side of the electric power source and a non-working electrode terminal on the side of the electric power source connected to the DC electric power source with opposite polarities through wiring from the DC power source, the wiring that is housed in the holding portion; the rod-like member has a proximal end of a removable side thereof of the holding portion, an electrode terminal of the working side and an electrode terminal of the non-working side which are connected to or are separated from the electrode terminal of the rod. work on the side of the electric power source and the non-working electrode terminal on the side of the electric power source when they are attached to or disassembled from the holding portion; and the working side electrode terminal and the non-working side electrode terminal are connected to a working side electrode and a non-working side electrode in the non-working side electrode assembly and the working side electrode and electrode assembly on the non-working side, respectively. (5) The rod-type iontophoresis device according to item (4) above, characterized in that a controller is provided in the retention portion, the controller that is placed in a power source circuit between the electrode terminal of work from the side of the electric power source and the non-working electrode terminal from the side of the electric power source and the DC electric power source to adjust, outside a current value during energization and an energizing time as the administration time, at least the current value. (6) The rod-type iontophoresis device according to any of points (1) to (5) above, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are placed such that the central axes of them are in parallel with each other. (7) The rod-type iontophoresis device according to any of points (1) and (5) above, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are placed such that the central axes thereof extend in the direction of the tip. (8) The rod-type iontophoresis device according to any of points (1) to (5) above, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are placed such that the central axes thereof cross each other in the direction of the tip. (9) The rod-type iontophoresis device according to any of points (1) to (8) above, characterized in that: the work-side electrode assembly includes: the work-side electrode connected to the source CD electric power having the same polarity as that of an ion charged with the ionic drug; a retention portion of the electrolyte solution which retains an electrolyte solution, the retention portion of the electrolyte solution which is placed on the front surface of the working side electrode; a second ion exchange membrane that selects an ion having an opposite polarity from the charged ion of the ionic drug, the second ion exchange membrane that is placed on the front surface of the electrolyte solution holding portion; a retention portion of drug solution that retains the ionic drug, the retention portion of drug solution that is placed on the front surface of the second ion exchange membrane; and a first ion exchange membrane which is the ion exchange membrane that selects an ion having the same polarity as that of the charged ion of the ionic drug, the first ion exchange membrane that is placed on the front surface of the retention portion of drug solution; and the electrode assembly of the non-working side includes: the non-working side electrode connected to the DC electric power source having a polarity opposite to that of the charged ion of the ionic drug; a retaining portion of the second electrolyte solution that retains a second electrolyte solution, the retention portion of the second electrolyte solution that is placed on the front surface of the non-working side electrode; a third ion exchange membrane that selects an ion having the same polarity as that of the charged ion of the ionic drug, the third ion exchange membrane that is placed on the front surface of the retention portion of the second electrolyte solution; a retaining portion of the third electrolyte solution retaining a third electrolyte solution, the retention portion of the third electrolyte solution which is placed on the front surface of the third ion exchange membrane; and a fourth ion exchange membrane which is the ion exchange membrane which selects an ion having a plurality opposite to that of the charged ion of the ionic drug, the fourth ion exchange membrane which is placed on the front surface of the holding portion of the third electrolyte solution.

BRIEF DESCRIPTION OF THE FIGURES Figure 1.- A plan view showing an iontophoresis device according to an embodiment of the present invention. Figure 2.- An enlarged sectional view taken along line II-II of Figure 1. Figure 3.- An enlarged sectional view showing a main portion of each of an electrode assembly of the working side and a Electrode assembly on the non-working side. Figure 4.- A plan view showing another example of placing the electrode assembly on the working side and the electrode assembly on the non-working side. Figure 5.- A plan view showing yet another example of placing the electrode assembly on the working side and the electrode assembly on the non-working side. Figure 6 .- An enlarged front view showing a main portion of a rod-type iontophoresis device according to Example 2 of the present invention. Figure 7.- A view of the left side of the rod-type iontophoresis device.

Best mode for carrying out the invention. Hereinafter, the best mode for carrying out the present invention will be described, in detail with reference to the Figures. As shown in Figures 1 and 2, a rod-type iontophoresis device 10 according to the best mode is constituted by an electrode assembly 12 of the working side and an electrode assembly 14 of the non-working side each used to administer an ionic drug, a rod-like member 16 to support them integrally, and a DC power source 18 connected to the work-side electrode assembly 12 and the non-working side electrode assembly 14 with opposite polarities. The work-side electrode assembly 12 and the non-working side electrode assembly 14 are attached to the tip of the rod-like member 16, and the rod-like member 16 is removably supported by the tip of a portion 20 of Bar type retention. As a result, the electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side is exchanged integrally with the rod-like member 16. A proximal terminal portion of the retaining portion 20 opposite the rod-like member 16 serves as a holding portion 21 having a diameter large enough to be held by a human hand. The holding portion 20 has an optical irradiation system 26 which includes: a radiation source 22 composed of a light emitting diode (LED) or a laser diode present within the system; and an optical fiber 24 for irradiating to introduce light emitted from the irradiating light source 22 into a vicinity of the rod-like member 16. As shown in Figure 2, the optical fiber 24 for irradiation is positioned such that a tip thereof is adjacent to the rod-like member 16, and is adapted to emit, from the tip, irradiation light with which a radiation is irradiated. affected or similar area of an organism in a position with which the electrode assembly 12 of the working side can contact. The electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side are connected to different polarities at the DC power source 18 through a power source circuit 28. The irradiation light source 22 is also connected to the DC power source 18 through a switch 23. A terminal portion of the rod-like member 16 on the side of the retaining portion 20 is provided with a terminal 32 of working side electrode to be connected to the working side electrode assembly 12 and an electrode terminal 34 of the non-working side to be connected to the electrode assembly 14 of the non-working side.

The working electrode terminal 32 and the non-working electrode terminal 34 are adapted to be connected to an electrode terminal 33 on the working side of the electrical power source and a non-working electrode terminal 35 on the power side. the source of electrical power on the side of the holding portion 20, respectively, when the rod type member 16 is attached to the retaining portion 20. The working electrode terminal 33 on the side of the electrical power source and the non-working electrode terminal 35 on the side of the electric power source are additionally connected to the DC electric power source 30 placed on the outside via of circuit 28 of electric power source. The rod-like member 16 is a cylindrical member having a diameter smaller than that of the tip of the retaining portion 20, and is adapted to be able to: be attached to the threaded being with a male threaded portion 16A in a portion 20A female thread at the tip of retaining portion 20; and of being disassembled when turned in the opposite direction. Figure 3 is an enlarged view showing that the electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side are positioned such that the central axes thereof are in parallel with each other.

In addition, the working side electrode assembly 12 is formed by laminating a working side electrode 36, an electrolyte solution holding portion 38, a second ion exchange membrane 40, a drug solution holding portion 42. , and a first ion exchange membrane 44 in this order from the side of the rod-like member 16, and formed in a disk shape of approximately 2 to 6 mm in diameter. The working side electrode 36 is desirably constituted by a conductive paint applied to a surface of a base sheet 13 and mixed with a non-metallic conductive filler such as a carbon paste. The working side electrode 36 may be constituted by a copper plate or a thin metal film, but a metal eluted from the plate or the thin film may be transferred to an organism in administration of a drug. Therefore, it is preferably non-metallic from the electrode 36 on the working side. The retaining portion 38 of electrolyte solution is constituted for example by an electrolytic paint applied to the working side electrode 36. Electrolytic paint is a paint that contains an electrolyte, and an electrolyte that oxidizes or reduces more easily than the electrolytic reaction of water (oxidation at a positive pole and reduction at a negative pole) is used particularly preferably. Examples of this electrolyte include: Medical agents such as ascorbic acid (vitamin C) and sodium ascorbate; and organic acids such as lactic acid, oxalic acid, malic acid, succinic acid and fumaric acid and / or salts thereof. The use of this electrolyte can suppress the generation of an oxygen gas or a hydrogen gas. In addition, mixing multiple classes of electrolytes that serve as a combination of buffer electrolyte solutions when dissolved in a solvent can suppress a change in pH during energization. The electrolytic paint is mixed with a hydrophilic polymer such as polyvinyl alcohol, polyacrylic acid, polyacrylamide, or polyethylene glycol in order to improve the property of application and the film-forming property of the paint, and is mixed with an appropriate amount of solvent such as as water, ethanol, or propanol to adjust the viscosity of the electrolytic paint. The paint can be mixed with an appropriate additional component such as a thickener, a thixotropic agent, a defoaming agent, a pigment, a flavor, a coloring agent. The second ion exchange membrane 40 is formed by applying a second ion exchange paint to the retention portion 38 of electrolyte solution. The second ion exchange paint is a paint containing an ion exchange resin in which an ion exchange group is introduced which uses, as a counter ion, an ion having a type of conductivity opposite to that of an ion. drug in the retention portion 42 of drug solution to be described below. In the case where a drug is used whose drug component dissociates to more drug ions in the retention portion 42 and drug solution, the paint is mixed with an anion exchange resin. On the other hand, in the case where a drug whose drug component is dissociated to less drug ions is used, the paint is mixed with a cation exchange resin. The drug solution retention portion 42 is comprised of a drug paint applied to the second ion exchange membrane 40. The paint is a paint that contains a drug (which includes a precursor for the drug) whose drug component dissociates to more or less ions (drug ions) as a result of, for example, dissolution in a solvent such as water. Examples of a drug whose drug component dissociates to more ions include lidocaine hydrochloride as a drug anesthetic and morphine hydrochloride as an anesthetic drug. Examples of a drug whose drug component dissociates at less ions include ascorbic acid as a vitamin agent. The first ion exchange membrane 44 is formed from a first ion exchange paint applied to the drug solution retention portion 42. The first ion exchange paint is a paint that contains an ion exchange resin in which an ion exchange group is introduced that uses, as a counter-ion, an ion having the same type of conductivity as that of the drug ion in the drug solution retention portion 42. In the case where a drug whose drug component is dissociated to plus / minus drug ions is used in the drug solution retention portion 42, the paint is mixed with an anion / cation exchange resin. An ion exchange resin obtained by introducing a cation exchange group (an exchange group using a common counter-ion cation) such as a sulfonic group, a carboxylic group, or a phosphoric group in a polymer having a network structure Three-dimensional such as a hydrocarbon-based resin (for example, a polystyrene resin or an acrylic resin) or a fluorine-based resin having a perfluorocarbon structure can be used as the cation exchange resin without any limitation. An ion exchange resin obtained by introducing an anion exchange group (an exchange group using a common ion counter ion) such as a primary amino group, a secondary amino group, a tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary pyridinium group, or a quaternary imidazolium group in a polymer having a three-dimensional network structure similar to that in the case of the cation exchange resin can be used as the anion exchange resin without no limitation. The electrode mount 14 of the non-working side is constituted by laminating an electrode 46 on the non-working side, a retaining portion 48 of the second electrolyte solution, a third ion exchange membrane 50, a retaining portion 52 of a third solution of electrolyte, and a fourth ion exchange membrane 54 in this order arranged on a surface side of the non-working base sheet 15, and formed in a disk shape as in the case of the electrode assembly 12 on the working side. The electrode 46 on the non-working side has the same constitution as that of the electrode 36 on the working side in the working electrode assembly 12, and the constitutions and components of the retaining portion 48 of the second electrolyte solution is the portion The retention of the third electrolyte solution is the same as that of the retention portion 38 of the electrolyte solution. Additionally, the third ion exchange membrane 50 is formed of an ion exchange paint applied to the retention portion 48 of the second electrolyte solution. The ion exchange paint is the same as the first ion exchange paint from which the first ion exchange membrane 44 is formed, and the third ion exchange membrane 50 functions as an ion exchange membrane similar to the first membrane 44 of ion exchange The fourth ion exchange membrane 54 is formed from the same second ion exchange paint as that described above applied to the retention portion 52 of the third electrolyte solution. The fourth ion exchange membrane 54 functions as an ion exchange membrane similar to the second ion exchange membrane 40. A working end electrode terminal plate 32A is arranged on the other surface of the base sheet 13, and conduction is established between the plate 32A of the working side electrode terminal and the electrode 36 of the working side of the mounting 12 of the working side electrode through a through hole formed in the base sheet 13, and the plate 32A of the working side electrode terminal is increased to the working side electrode terminal 32 through the pilot hole. He passed. Similarly, a plate 34A of the working side electrode terminal is arranged on the other surface of the base sheet 15 on the non-working side, and conduction is established between the plate 34A of the electrode terminal on the non-working side. work and the electrode 46 on the non-working side of the electrode assembly 14 on the non-working side through a through hole formed in the base sheet 15 on the non-working side, and the plate 34A of the non-working electrode terminal is connected to the electrode terminal 34 on the non-working side through the through hole. The first ion exchange membrane 44 and the fourth ion exchange membrane 54 at the tips of the working side electrode assembly 12 and the working side electrode assembly 14 are exposed to be able to make contact with the side of a organism, respectively. The CD electric power source 18 is composed, for example, of an AC / DC converter, and the electric power source circuit 28 between the CD electric power source 18 and the working electrode terminal 33 of the side. of the electric power source and between the DC electric power source 18 and the non-working electrode terminal 35 on the side of the electric power source is provided with a controller 56 for adjusting, outside of a current value during the energization and an energization time as administration time, at least the current value. As a result, each of the current value and the time of administration can be adjusted in a certain interval. A predetermined amount of spacing S is provided between the first ion exchange membrane 44 and the fourth ion exchange membrane 54 at each of the tips of the work side electrode assembly 12 and the electrode assembly 14 of the non-working side in order to prevent a current from flowing directly between the membranes in the energization. The spacing S has substantially the same size as that of the diameter of each of the first ion exchange membrane 44 and the fourth ion exchange membrane 54. In the embodiment, the electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side are joined such that the central axes thereof are in parallel with each other. However, the present invention is not limited to this. For example, as shown in Figure 4, the electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side can be positioned such that the central axes thereof cross each other in a direction of the tip with an angle of 60 degrees between the axes. Alternatively, as shown in Figure 5, the electrode assembly 12 of the working side and the electro assembly 14 of the non-working side can be positioned such that the central axes thereof extend in the direction of the tip. In this embodiment, the work side electrode assembly 12 and the non-working side electrode assembly 14 are placed on the tip of the bar-like retention portion 20 with the spacing S therebetween. Therefore, when a drug solution is permeated in an affected area in therapy or treatment outside of a body (such as melanoma or skin cancer) or in a mouth (such as local anesthesia in dentistry, stomatitis therapy, or local anesthesia in an oral cavity), a doctor fastened to the holding portion 21 to place the first ion exchange membrane 44 at the tip of the working side electrode assembly 12 at the tip of the holding portion 21 in contact close to the affected area, and at the same time, to put the fourth ion exchange membrane 54 at the tip of the electrode assembly 14 of the non-working side in close contact with a mucous membrane or the like near the affected area for energization. As a result, a target drug solution can be easily permeated into a target site in a precise point manner. When the affected area is placed in an oral cavity (i.e., in the dark), the affected area in the dark can be illuminated by turning on the switch 23 to irradiate the area with the light emitted from the tip of the optical fiber 24 to irradiation of the irradiation optical system 26. In addition, the electrode assembly 12 on the working side and the electrode assembly 14 on the non-working side can be disassembled together with the rod-like member 16 of the retaining portion 20, so that a drug solution can be easily exchanged. The rod-type iontophoresis device 10 can be used for example for therapy based on photodynamic therapy (PDT) as an anticancer remedy comprising: applying a photosensitized reactive material to a cancer cell; and irradiate the material with light to cause the material to absorb light. In this case, the following constitution is adopted.

That is, the drug solution retention portion 42 in the working side electrode assembly 12 retains the photosensitized reactive material, and an affected area can be irradiated with light having a wavelength that is to be absorbed with the reactive photosensitized material and emit from the irradiation light source 22 through the optical fiber 24 for irradiation. In the case of PDT, the electrode assembly 12 of the working side is displaced from the affected area after the photosensitized reactive material has permeated into the affected area by iontophoresis. Then, light that is to be absorbed by the photosensitized reactive material is applied, with the tip of the optical fiber 24 for irradiation as the position of the affected area. When the affected area has a complicated shape (a two-dimensional convex-concave figure), an image is plotted by means of a light-proof insulating paint so that the shape remains on the surface of the first ion exchange membrane 44. Iontophoresis is performed in this state with the iontophoresis device pressed against the skin, so that the photosensitized reactive material enters only the affected area, and at the same time, the light-proof insulating paint adheres to the periphery of the affected area . That is, the photosensitized reactive material does not enter a normal site and does not irradiate with light. In other words, double protection can be achieved.

Example 1 Next, a rod-type iontophoresis device 60 according to Example 2 shown in Figures 6 and 7 will be described. In the rod-type iontophoresis device 60, the tip of the retaining portion 20 is provided with a guide 62. of ring type light to be connected to the optical fiber 24 for irradiation, and the electrode assembly 12 of the working side and the electrode assembly 14 of the non-working side are adapted to be able to slide back and forth to a cancer along with the rod-like member 16. The sliding structure is identical to a blow structure in a ballpoint pen to change the position of the pen tip in two stages. A projected position and a retracted position. Therefore, a detailed description of the sliding structure is omitted. The ring-like light guide 62 is constituted in such a way that light can be emitted from the tip of the optical fiber 24 for irradiation connected to the light guide and is introduced in a ring-like manner and transferred from the inner peripheral surface of the light guide. The Guide. The tip of the light guide 62 in the projected position is adapted to substantially coincide with the tips of the working side electrode assembly 12 and the non-working side electrode assembly 14. Accordingly, the rod-like member 16 or the like is placed in the projected position in the administration of a drug solution, and the member or the like is placed in the retracted position after administration of the drug solution. As a result, an affected area to which the drug solution has been administered is separated from the work-side electrode assembly 12, and the spacing between the area and the assembly is irradiated with light from the inner peripheral surface of the guide 62. of light. In this example, the retention portion 20 is provided with the optical fiber 24 for irradiation. However, the optical irradiation system 26 including the optical fiber 24 for irradiation is not needed when the device is not used for PDT or when there is no need to illuminate an affected area.

Effect of the Invention In the present invention, the electrode assembly of the working side and the electrode assembly of the non-working side in the iontophoresis device are placed on the tip of the rod-like member, and the rod-type member is supported on removable form by the tip of the bar-type retention portion. For example, an anti-cancer agent is permeated by iontophoresis at a precise point such as the melanoma site, whereby efficient therapy can be performed with little side effect. In addition, the drug solution can be exchanged by disassembling the working side electrode assembly and the non-working side electrode assembly together with the rod member member of the support member.

Claims (9)

1. CLAIMS 1. Rod-type iontophoresis device, comprising: an electrode assembly of the working side and an electrode assembly of the non-working side each used to administer an ionic drug by iontophoresis; and a DC electric power source connected to the working side electrode assembly and the non-working side electrode assembly with opposite polarities, characterized in that it comprises: a rod member to support the working side electrode assembly and the electrode assembly of the non-working side; and a bar-like retention portion for removably supporting the rod-like member, the working-side electrode assembly and the working-side electrode assembly which are placed on a tip of the rod-like member, and a predetermined amount of spacing that is provided between the electrode assembly on the working side and the electrode assembly on the non-working side. The rod-type iontophoresis device according to claim 1, characterized in that the ionic drug comprises a photosensitized reactive material that is to be activated upon absorbing light, the retaining portion comprises an optical irradiation system for applying light from a vicinity of one end of the electrode assembly on the working side. 3. Rod-type iontophoresis device according to claim 2, characterized in that the retaining portion comprises: a light source comprising a light-emitting diode or a laser diode for emitting light having a wavelength perceived by the photosensitized reactive material, and an optical fiber for irradiation to introduce light emitted from the light source to the rod-like member or a vicinity thereof. 4. Rod-type iontophoresis device according to any of claims 1 to 3, characterized in that: the retaining portion comprises a working electrode terminal on the side of the electric power source and a non-working electrode terminal on the side of the source of electrical energy connected to the DC electric power source with opposite polarities through the wiring of the DC electric power source, the wiring that is housed in the retaining portion; the rod-like member comprises at a proximal end of a removable side of the retaining portion an electrode terminal on the working side and an electrode terminal on the working side which are connected or separated from the working electrode terminal on the side of the electric power source and the non-working electrode terminal on the side of the electric power source when joining or dismounting from the holding portion, and the working side electrode terminal and the electrode terminal of the Working side are connected to an electrode on the working side and an electrode on the non-working side in the electrode assembly on the working side and the electrode assembly on the non-working side, respectively. The rod-type iontophoresis device according to claim 4, characterized in that a controller is provided in the retention portion, the controller which is placed in a power source circuit in the working electrode terminal on the source side of electric power and the non-working electrode terminal on the side of the electric power source and the DC electric power source to adjust, outside of a current value during energization and an energization time as the time of administration, at minus the current value. 6. Rod-type iontophoresis device according to claim 1, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are placed such that the central axes thereof are in parallel each. 7. Rod-type iontophoresis device according to any of claims 1 to 5, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are positioned such that the central axes thereof extend in the direction of the tip. 8. Rod-type iontophoresis device according to any of claims 1 to 5, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are placed such that the central axes thereof cross each other. yes in the direction of the tip. 9. Patch-type iontophoresis device according to any of claims 8, characterized in that: the work-side electrode assembly comprises: the working-side electrode connected to the CD electric power source having the same polarity as that of a charged ion of the ionic drug; a retention portion of electrolyte solution that retains an electrolyte solution, the retention portion of electrolyte solution that is placed on a front surface of the working electrode; a second ion exchange membrane that selects an ion having a plurality opposite to that of the charged ion of the ionic drug, the second ion exchange membrane which is placed on a front surface of the electrolyte solution holding portion; a retention portion of drug solution that retains the ionic drug, the retention portion of drug solution that is placed on a front surface of the second ion exchange membrane; and a first ion exchange membrane that selects an ion having the same polarity as that of the charged ion of the ionic drug, the first ion exchange membrane that is placed on a front surface of the drug solution holding portion; and the non-working side electrode assembly comprises: the non-working side electrode connected to the DC electric power source having a polarity opposite to that of the charged ion of the ionic drug; a retaining portion of the second electrolyte solution that retains a second electrolyte solution, the retention portion of the second electrolyte solution that is placed on a front surface of the non-working electrode; a third ion exchange membrane that selects an ion having the same polarity as that of the charged ion of the ionic drug, the third ion exchange membrane that is placed on a front surface of the retention portion of the second electrolyte retention; a retaining portion of the third electrolyte solution that retains a third electrolyte solution, the retention portion of the third electrolyte solution that is placed on a front surface of the third ion exchange membrane; and a fourth ion exchange membrane which is the ion exchange membrane that selects an ion having a plurality opposite to that of the charged ion of the ionic drug, the fourth ion exchange membrane which is placed on a front surface of the retention portion of the ion. The third electrolyte solution.