MX2007010841A - 8-pirrolidinobenzimidazoles biciclicos sustituidos, un metodo para su produccion y su uso como medicamentos. - Google Patents

8-pirrolidinobenzimidazoles biciclicos sustituidos, un metodo para su produccion y su uso como medicamentos.

Info

Publication number
MX2007010841A
MX2007010841A MX2007010841A MX2007010841A MX2007010841A MX 2007010841 A MX2007010841 A MX 2007010841A MX 2007010841 A MX2007010841 A MX 2007010841A MX 2007010841 A MX2007010841 A MX 2007010841A MX 2007010841 A MX2007010841 A MX 2007010841A
Authority
MX
Mexico
Prior art keywords
benzimidazoles
pyrrolidino
medicaments
bicyclic
substituted
Prior art date
Application number
MX2007010841A
Other languages
English (en)
Inventor
Elisabeth Defossa
Karl Schoenafinger
Ulrich Werner
Gerhard Jaehne
Georg Tschank
Christian Bunning
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2007010841A publication Critical patent/MX2007010841A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invencion se refiere a 8-pirrolidinobenzimidazoles biciclicos sustituidos, y a su sales fisiologicamente compatibles y derivados fisiologicamente funcionales; la invencion se refiere a compuestos de la formula (I) (ver formula I) en la que los grupos se definen como se cita en la parte descriptiva y a sales fisiologicamente compatibles de dichos compuestos; los compuestos son adecuados para uso, por ejemplo, como medicamentos para la prevencion y el tratamiento de diabetes de tipo 2.
MX2007010841A 2005-03-19 2006-03-07 8-pirrolidinobenzimidazoles biciclicos sustituidos, un metodo para su produccion y su uso como medicamentos. MX2007010841A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005012872A DE102005012872A1 (de) 2005-03-19 2005-03-19 Substituierte, bizyklische 8-Pyrrolidino-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP2006/002055 WO2006099940A1 (de) 2005-03-19 2006-03-07 Substituierte, bizyklische 8-pyrrolidino-benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
MX2007010841A true MX2007010841A (es) 2007-11-09

Family

ID=36579682

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010841A MX2007010841A (es) 2005-03-19 2006-03-07 8-pirrolidinobenzimidazoles biciclicos sustituidos, un metodo para su produccion y su uso como medicamentos.

Country Status (11)

Country Link
US (1) US7569700B2 (es)
EP (1) EP1863817B1 (es)
JP (1) JP2008533064A (es)
AT (1) ATE396997T1 (es)
AU (1) AU2006226637A1 (es)
BR (1) BRPI0608456A2 (es)
CA (1) CA2602229A1 (es)
DE (2) DE102005012872A1 (es)
IL (1) IL185805A0 (es)
MX (1) MX2007010841A (es)
WO (1) WO2006099940A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260265B (zh) * 2010-05-24 2015-09-02 上海阳帆医药科技有限公司 六氢吡咯[3,4-b]吡咯衍生物、其制备方法及其用途
TW202220968A (zh) * 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
EP3860998B1 (en) 2018-10-05 2023-12-27 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60023100T2 (de) * 2000-01-05 2006-07-06 Pfizer Inc. Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten
KR100545431B1 (ko) * 2000-12-06 2006-01-24 에프. 호프만-라 로슈 아게 축합된 이종방향족 글루코키나제 활성화제
US6855708B2 (en) * 2001-03-20 2005-02-15 Merck & Co., Inc. N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors
EP1553089B1 (en) * 2002-07-30 2009-09-30 Banyu Pharmaceutical Co., Ltd. Antagonist of melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient
US7531558B2 (en) * 2003-02-14 2009-05-12 Glaxo Group Limited Carboxamide derivatives
WO2005035526A1 (en) * 2003-10-09 2005-04-21 Argenta Discovery Ltd. Bicyclic compounds and their therapeutic use

Also Published As

Publication number Publication date
WO2006099940A8 (de) 2006-11-09
EP1863817B1 (de) 2008-05-28
IL185805A0 (en) 2008-01-06
US20080090890A1 (en) 2008-04-17
DE502006000850D1 (de) 2008-07-10
WO2006099940A1 (de) 2006-09-28
DE102005012872A1 (de) 2006-09-28
CA2602229A1 (en) 2006-09-28
ATE396997T1 (de) 2008-06-15
BRPI0608456A2 (pt) 2010-01-05
JP2008533064A (ja) 2008-08-21
EP1863817A1 (de) 2007-12-12
AU2006226637A1 (en) 2006-09-28
US7569700B2 (en) 2009-08-04

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal