MX168497B - Ultrafiltracion de flujo tangencial por afinidad - Google Patents

Ultrafiltracion de flujo tangencial por afinidad

Info

Publication number
MX168497B
MX168497B MX004907A MX490787A MX168497B MX 168497 B MX168497 B MX 168497B MX 004907 A MX004907 A MX 004907A MX 490787 A MX490787 A MX 490787A MX 168497 B MX168497 B MX 168497B
Authority
MX
Mexico
Prior art keywords
affinity
tangential flow
flow ultrafiltration
molecules
interest
Prior art date
Application number
MX004907A
Other languages
English (en)
Inventor
Jen Chang Hsia
Original Assignee
Hemosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemosol Inc filed Critical Hemosol Inc
Publication of MX168497B publication Critical patent/MX168497B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a un proceso para la separación de móleculas de interés biológico de una mezcla que contiene dichas moléculas de interés, el cual comprende someter dicha mezcla a ultrafiltración de flujo tangencial en presencia de al menos una sustancia macromolecular de afinidad que ligue específicamente las moléculas de interés e impida su filtración mientras otras moléculas de menor tamaño se remueven por su filtración.
MX004907A 1986-01-10 1987-01-09 Ultrafiltracion de flujo tangencial por afinidad MX168497B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868600582A GB8600582D0 (en) 1986-01-10 1986-01-10 Purifying biological materials

Publications (1)

Publication Number Publication Date
MX168497B true MX168497B (es) 1993-05-27

Family

ID=10591196

Family Applications (1)

Application Number Title Priority Date Filing Date
MX004907A MX168497B (es) 1986-01-10 1987-01-09 Ultrafiltracion de flujo tangencial por afinidad

Country Status (19)

Country Link
US (1) US4780210A (es)
EP (2) EP0253845B1 (es)
JP (1) JPS63502183A (es)
KR (1) KR880700683A (es)
CN (1) CN1015512B (es)
AR (1) AR240990A1 (es)
AT (1) ATE68502T1 (es)
AU (1) AU590046B2 (es)
CA (1) CA1297630C (es)
DE (1) DE3773778D1 (es)
DK (1) DK469987D0 (es)
ES (1) ES2027325T3 (es)
GB (1) GB8600582D0 (es)
GR (1) GR3003413T3 (es)
IL (2) IL81183A (es)
MX (1) MX168497B (es)
NZ (1) NZ218878A (es)
WO (1) WO1987004169A1 (es)
ZA (1) ZA87140B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
FR2611527A1 (fr) * 1987-02-26 1988-09-09 Sfec Membrane inorganique d'ultrafiltration ou de microfiltration modifiee par un polymere hydrophile, son procede de preparation et son utilisation pour la separation de proteines
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5456835A (en) * 1993-11-08 1995-10-10 Hemasure, Inc. Device and process for removing free hemoglobin from blood
CA2127605A1 (en) * 1993-12-23 1995-06-24 Peter J. Degen Affinity separation method
US6150507A (en) * 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
KR0154384B1 (ko) * 1995-07-03 1998-10-15 박원훈 중공사 막을 사용하는 수처리 장치
US7026468B2 (en) * 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US7807822B2 (en) 1996-08-01 2010-10-05 Robert Bridenbaugh Methods for purifying nucleic acids
US6011148A (en) * 1996-08-01 2000-01-04 Megabios Corporation Methods for purifying nucleic acids
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
US6315900B1 (en) * 1998-06-03 2001-11-13 Accurate Polymers Static separation method using non-porous cellulose beads
PT1200578E (pt) 1999-07-23 2004-08-31 Genentech Inc Metodo para purificacao de adn de plasmideo sem solventes organicos e sem arnase utilizando filtracao de fluxo tangencial
WO2003010512A2 (en) * 2001-07-23 2003-02-06 Accurate Polymers, Inc. High-speed, solid-liquid separation
US7314746B2 (en) 2002-09-13 2008-01-01 Valentis, Inc. Apparatus and method for preparative scale purification of nucleic acids
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
US7811572B2 (en) * 2005-08-24 2010-10-12 Immunogen, Inc. Process for preparing purified drug conjugates
US7988859B2 (en) * 2009-02-05 2011-08-02 Chromatan Inc. Countercurrent tangential chromatography methods, systems, and apparatus
MX349210B (es) 2009-06-03 2017-07-18 Immunogen Inc Métodos de conjugación.
US20120157905A1 (en) * 2010-12-15 2012-06-21 Biovec Transfusion, Llc Methods for treating carbon monoxide poisoning by tangential flow filtration of blood
CN102600378B (zh) * 2011-01-19 2014-01-22 邯郸摩罗丹药业股份有限公司 一种采用超滤工艺制备药物组合物的方法
AU2012236398B2 (en) 2011-03-29 2016-02-11 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
CN102649823B (zh) * 2012-04-28 2014-06-11 浙江工业大学 一种径向流耦合超滤分离制备铜藻多糖的方法
WO2014055877A1 (en) 2012-10-04 2014-04-10 Immunogen, Inc. Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
WO2015164511A1 (en) 2014-04-23 2015-10-29 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843444A (en) * 1972-04-18 1974-10-22 V Likhite Membrane separation process
CH566798A5 (es) * 1973-05-29 1975-09-30 Battelle Memorial Institute
SE434914B (sv) * 1975-07-07 1984-08-27 Jonsson U R S Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna
US4163714A (en) * 1975-11-07 1979-08-07 Gregor Harry P Separating substances with pressure-driven affinity sorption membranes
GB2024829B (en) * 1978-06-28 1982-08-04 Amicon Corp Method and product for separation of glycoproteins
SE8006102L (sv) * 1980-09-02 1982-03-03 Gambro Ab Sett att utvinna en peptidinnehallande forening samt medel for genomforande av settet
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
FR2520632B1 (fr) * 1982-02-01 1988-05-13 Diffusion Materiels Pour Fluid Procede de filtration et microfiltration tangentielle sur surface filtrante de revolution et filtre pour sa mise en oeuvre
SE451843B (sv) * 1983-05-09 1987-11-02 Gambro Lundia Ab Forfarande for utvinning av en forening

Also Published As

Publication number Publication date
WO1987004169A1 (en) 1987-07-16
IL81188A0 (en) 1987-08-31
NZ218878A (en) 1990-05-28
AU590046B2 (en) 1989-10-26
KR880700683A (ko) 1988-04-11
DK469987A (da) 1987-09-09
EP0253845B1 (en) 1991-10-16
DE3773778D1 (de) 1991-11-21
EP0253845A1 (en) 1988-01-27
GB8600582D0 (en) 1986-02-19
CN1015512B (zh) 1992-02-19
CN87100660A (zh) 1988-01-27
JPS63502183A (ja) 1988-08-25
EP0229696A1 (en) 1987-07-22
AR240990A2 (es) 1991-04-30
ZA87140B (en) 1988-02-24
US4780210A (en) 1988-10-25
GR3003413T3 (en) 1993-02-17
IL81188A (en) 1990-08-31
ES2027325T3 (es) 1992-06-01
IL81183A (en) 1990-08-31
DK469987D0 (da) 1987-09-09
ATE68502T1 (de) 1991-11-15
AR240990A1 (es) 1991-04-30
AU6848587A (en) 1987-07-28
CA1297630C (en) 1992-03-17

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