ME03379B - Pozitivni alosterni modulatori muskarinskog m1 receptora - Google Patents

Pozitivni alosterni modulatori muskarinskog m1 receptora

Info

Publication number
ME03379B
ME03379B MEP-2019-99A MEP201999A ME03379B ME 03379 B ME03379 B ME 03379B ME P201999 A MEP201999 A ME P201999A ME 03379 B ME03379 B ME 03379B
Authority
ME
Montenegro
Prior art keywords
muscarinic
positive allosteric
receptor positive
allosteric modulators
modulators
Prior art date
Application number
MEP-2019-99A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ramakrishna Nirogi
Abdul Rasheed Mohammed
Anil Karbhari Shinde
Shankar Reddy Gagginapally
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of ME03379B publication Critical patent/ME03379B/me

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/161,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
MEP-2019-99A 2015-06-08 2016-06-08 Pozitivni alosterni modulatori muskarinskog m1 receptora ME03379B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2851CH2015 2015-06-08
PCT/IB2016/000771 WO2016198937A1 (en) 2015-06-08 2016-06-08 Muscarinic m1 receptor positive allosteric modulators
EP16738860.2A EP3303331B1 (en) 2015-06-08 2016-06-08 Muscarinic m1 receptor positive allosteric modulators

Publications (1)

Publication Number Publication Date
ME03379B true ME03379B (me) 2020-01-20

Family

ID=56411822

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-99A ME03379B (me) 2015-06-08 2016-06-08 Pozitivni alosterni modulatori muskarinskog m1 receptora

Country Status (29)

Country Link
US (1) US10308620B2 (me)
EP (1) EP3303331B1 (me)
JP (1) JP6466602B2 (me)
KR (1) KR102052058B1 (me)
CN (1) CN107922400B (me)
AU (1) AU2016276139B2 (me)
BR (1) BR112017026272B1 (me)
CA (1) CA2987843C (me)
CY (1) CY1121693T1 (me)
DK (1) DK3303331T3 (me)
EA (1) EA032602B1 (me)
ES (1) ES2719626T3 (me)
HK (1) HK1247919A1 (me)
HR (1) HRP20190624T1 (me)
HU (1) HUE044902T2 (me)
IL (1) IL255994B (me)
LT (1) LT3303331T (me)
MA (1) MA43913B1 (me)
MD (1) MD3303331T2 (me)
ME (1) ME03379B (me)
MX (1) MX2017015961A (me)
NZ (1) NZ737892A (me)
PL (1) PL3303331T3 (me)
PT (1) PT3303331T (me)
RS (1) RS58665B1 (me)
SI (1) SI3303331T1 (me)
TR (1) TR201904639T4 (me)
WO (1) WO2016198937A1 (me)
ZA (1) ZA201708108B (me)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11234979B2 (en) * 2017-10-18 2022-02-01 Suven Life Sciences Limited Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators
CA3078164C (en) * 2017-10-27 2022-11-15 Suven Life Sciences Limited Polycyclic amides as muscarinic m1 receptor positive allosteric modulators
US20220152005A1 (en) * 2019-04-04 2022-05-19 Andrew Coop Methods of using muscarinic antagonists in the treatment of depression
KR102285472B1 (ko) 2019-06-14 2021-08-03 엘지전자 주식회사 음향의 이퀄라이징 방법과, 이를 구현하는 로봇 및 ai 서버
CN110606827B (zh) * 2019-09-26 2023-03-14 西安凯立新材料股份有限公司 一步法合成甲氨基吡啶类化合物的方法
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
JP5192389B2 (ja) 2005-12-05 2013-05-08 メルク・シャープ・エンド・ドーム・コーポレイション キノロンm1レセプター陽性アロステリックモジュレータ
EP2575454B1 (en) 2010-05-28 2018-08-29 Merck Sharp & Dohme Corp. Naphthalene carboxamide m1 receptor positive allosteric modulators
JP2014076948A (ja) 2011-02-09 2014-05-01 Astellas Pharma Inc イソキノリンアミド誘導体
US9403802B2 (en) * 2012-03-02 2016-08-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use therefor
TW201512197A (zh) * 2013-08-30 2015-04-01 Hoffmann La Roche 吡咯并吡啶或吡唑并吡啶衍生物
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
US9708278B2 (en) * 2013-11-27 2017-07-18 Vanderbilt University Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
GB201409044D0 (en) * 2014-05-21 2014-07-02 Ucl Business Plc New compounds

Also Published As

Publication number Publication date
JP2018521024A (ja) 2018-08-02
EP3303331A1 (en) 2018-04-11
CY1121693T1 (el) 2020-07-31
CN107922400A (zh) 2018-04-17
RS58665B1 (sr) 2019-06-28
MD3303331T2 (ro) 2019-05-31
TR201904639T4 (tr) 2019-05-21
US10308620B2 (en) 2019-06-04
EP3303331B1 (en) 2019-02-27
DK3303331T3 (en) 2019-04-23
CA2987843A1 (en) 2016-12-15
JP6466602B2 (ja) 2019-02-06
HUE044902T2 (hu) 2019-11-28
ZA201708108B (en) 2018-11-28
PT3303331T (pt) 2019-04-30
CN107922400B (zh) 2021-05-11
US20180155302A1 (en) 2018-06-07
PL3303331T3 (pl) 2019-06-28
CA2987843C (en) 2020-07-14
WO2016198937A1 (en) 2016-12-15
MA43913B1 (fr) 2019-05-31
NZ737892A (en) 2018-09-28
EA201792594A1 (ru) 2018-06-29
BR112017026272A2 (pt) 2018-09-11
EA032602B1 (ru) 2019-06-28
HRP20190624T1 (hr) 2019-05-31
KR102052058B1 (ko) 2019-12-04
IL255994A (en) 2018-01-31
AU2016276139B2 (en) 2018-07-19
KR20180016528A (ko) 2018-02-14
HK1247919A1 (zh) 2018-10-05
BR112017026272B1 (pt) 2023-04-11
IL255994B (en) 2018-04-30
ES2719626T3 (es) 2019-07-11
AU2016276139A1 (en) 2018-01-04
MX2017015961A (es) 2018-07-06
SI3303331T1 (sl) 2019-05-31
LT3303331T (lt) 2019-04-25
MA43913A (fr) 2018-04-11

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