MD503C2 - Производные пентапептидов - Google Patents
Производные пентапептидовInfo
- Publication number
- MD503C2 MD503C2 MD95-0391A MD950391A MD503C2 MD 503 C2 MD503 C2 MD 503C2 MD 950391 A MD950391 A MD 950391A MD 503 C2 MD503 C2 MD 503C2
- Authority
- MD
- Moldova
- Prior art keywords
- derivatives
- pentapeptyd
- dna synthesis
- independently
- under
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/067—Hemoregulatory peptides based on sequence Glp-Glu-Asp-Cys-Lys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Настоящее изобретение относится к производным пентапептида и особенно к пентапептидным соединениям которые проявляют ингибирующее воздействие на синтез ДНК и на митотическую скорость при регенерации печени, а также на ДНК-синтез и рост линии злокачественных клеток гепатомы in vitro и in vivo.Производные пентапептидов общей формулы I:где X1, X2 и X3 каждый независимо представляет ОН или NH2 при условии, что X2 и X3 оба не обозначают NH2; или X1 обозначает ОН, X2 обозначает NH2 и X3 обозначает OH; или X1, X2 и X3 каждый независимо представляют ОН.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO884054A NO884054D0 (no) | 1988-09-13 | 1988-09-13 | Nytt pentapeptid og fremgangsmaate for fremstilling derav. |
| PCT/NO1989/000093 WO1990002754A1 (en) | 1988-09-13 | 1989-09-12 | New pentapeptide and a process for the preparation thereof |
| SU914895028A RU2010799C1 (ru) | 1988-09-13 | 1991-03-12 | Производные пентапептидов |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD503B1 MD503B1 (en) | 1996-03-29 |
| MD503C2 true MD503C2 (ru) | 1996-07-31 |
Family
ID=19891239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0391A MD503C2 (ru) | 1988-09-13 | 1994-12-29 | Производные пентапептидов |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0434722A1 (ru) |
| JP (1) | JPH04501710A (ru) |
| KR (1) | KR900701830A (ru) |
| CN (1) | CN1041158A (ru) |
| AT (1) | ATE102215T1 (ru) |
| AU (1) | AU623687B2 (ru) |
| DE (1) | DE68913411T2 (ru) |
| DK (1) | DK43891D0 (ru) |
| ES (1) | ES2062024T3 (ru) |
| FI (1) | FI911219A0 (ru) |
| HU (2) | HU206373B (ru) |
| LV (1) | LV10289B (ru) |
| MD (1) | MD503C2 (ru) |
| MY (1) | MY104912A (ru) |
| NO (2) | NO884054D0 (ru) |
| NZ (1) | NZ230625A (ru) |
| RU (1) | RU2010799C1 (ru) |
| WO (1) | WO1990002754A1 (ru) |
| ZA (1) | ZA896944B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620957A (en) * | 1989-07-14 | 1997-04-15 | Smithkline Beecham Corporation | Hemoregulatory peptides |
| TW222280B (ru) * | 1991-11-26 | 1994-04-11 | Smithkline Beecham Corp | |
| IL104323A0 (en) * | 1992-01-10 | 1993-05-13 | Smithkline Beecham Corp | Hemoregulatory peptides |
| RU2297239C1 (ru) * | 2006-05-30 | 2007-04-20 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Пептид, стимулирующий регенерацию ткани печени, фармацевтическая композиция на его основе и способ ее применения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2591748A (en) | 1949-12-23 | 1952-04-08 | Hercules Powder Co Ltd | Amphoteric cellulose derivatives |
| FR2110268B1 (ru) | 1970-10-07 | 1976-06-04 | Minnesota Mining & Mfg | |
| US4237253A (en) | 1977-04-21 | 1980-12-02 | L'oreal | Copolymers, their process of preparation, and cosmetic compounds containing them |
| NO860752L (no) * | 1985-06-26 | 1986-12-29 | Bio Tech As | Pentapeptider med cellevekstregulerende virkning og fremgangsmaate for fremstilling derav. |
| GB8626539D0 (en) * | 1986-11-06 | 1986-12-10 | Nycomed As | Peptide compounds |
-
1988
- 1988-09-13 NO NO884054A patent/NO884054D0/no unknown
-
1989
- 1989-09-11 CN CN89107061A patent/CN1041158A/zh active Pending
- 1989-09-12 AT AT89309237T patent/ATE102215T1/de not_active IP Right Cessation
- 1989-09-12 MY MYPI89001244A patent/MY104912A/en unknown
- 1989-09-12 ES ES89309237T patent/ES2062024T3/es not_active Expired - Lifetime
- 1989-09-12 DE DE68913411T patent/DE68913411T2/de not_active Expired - Fee Related
- 1989-09-12 EP EP89910214A patent/EP0434722A1/en active Pending
- 1989-09-12 AU AU42240/89A patent/AU623687B2/en not_active Ceased
- 1989-09-12 HU HU9057Q patent/HU206373B/hu not_active IP Right Cessation
- 1989-09-12 ZA ZA896944A patent/ZA896944B/xx unknown
- 1989-09-12 WO PCT/NO1989/000093 patent/WO1990002754A1/en active Application Filing
- 1989-09-12 EP EP89309237A patent/EP0360481B1/en not_active Expired - Lifetime
- 1989-09-12 NZ NZ230625A patent/NZ230625A/xx unknown
- 1989-09-12 HU HU895790A patent/HU895790D0/hu unknown
- 1989-09-12 JP JP1509645A patent/JPH04501710A/ja active Pending
- 1989-09-12 KR KR1019900700995A patent/KR900701830A/ko not_active Application Discontinuation
-
1991
- 1991-03-08 NO NO91910933A patent/NO910933L/no unknown
- 1991-03-12 DK DK91438A patent/DK43891D0/da not_active Application Discontinuation
- 1991-03-12 RU SU914895028A patent/RU2010799C1/ru active
- 1991-03-12 FI FI911219A patent/FI911219A0/fi not_active Application Discontinuation
-
1993
- 1993-06-15 LV LVP-93-590A patent/LV10289B/xx unknown
-
1994
- 1994-12-29 MD MD95-0391A patent/MD503C2/ru active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet nr.WO 87/00180, Int. Cl. C 07 K 7/06, 1987. * |
| Ян Эрик Паульсен, Карл-Л. Рейхельт, Анна К. Петерсен, Purification and characterization of a growth inhibitory hepatic peptide, apreliminary note, Virehows Arch B. 54, 152-154, 1987. * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990002754A1 (en) | 1990-03-22 |
| ATE102215T1 (de) | 1994-03-15 |
| KR900701830A (ko) | 1990-12-04 |
| RU2010799C1 (ru) | 1994-04-15 |
| NO910933D0 (no) | 1991-03-08 |
| MD503B1 (en) | 1996-03-29 |
| HU206373B (en) | 1992-10-28 |
| DE68913411D1 (de) | 1994-04-07 |
| LV10289B (en) | 1995-04-20 |
| FI911219A0 (fi) | 1991-03-12 |
| CN1041158A (zh) | 1990-04-11 |
| EP0434722A1 (en) | 1991-07-03 |
| HU895790D0 (en) | 1991-11-28 |
| EP0360481B1 (en) | 1994-03-02 |
| AU623687B2 (en) | 1992-05-21 |
| EP0360481A1 (en) | 1990-03-28 |
| DK43891A (da) | 1991-03-12 |
| JPH04501710A (ja) | 1992-03-26 |
| LV10289A (lv) | 1994-10-20 |
| MY104912A (en) | 1994-06-30 |
| ES2062024T3 (es) | 1994-12-16 |
| AU4224089A (en) | 1990-04-02 |
| DE68913411T2 (de) | 1994-06-23 |
| NO910933L (no) | 1991-03-08 |
| DK43891D0 (da) | 1991-03-12 |
| NZ230625A (en) | 1991-06-25 |
| HUT58766A (en) | 1992-03-30 |
| ZA896944B (en) | 1990-06-27 |
| NO884054D0 (no) | 1988-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110312 |