MD3645518T2 - Sinteză de mercabil omecamtiv - Google Patents

Sinteză de mercabil omecamtiv

Info

Publication number
MD3645518T2
MD3645518T2 MDE20200486T MDE20200486T MD3645518T2 MD 3645518 T2 MD3645518 T2 MD 3645518T2 MD E20200486 T MDE20200486 T MD E20200486T MD E20200486 T MDE20200486 T MD E20200486T MD 3645518 T2 MD3645518 T2 MD 3645518T2
Authority
MD
Moldova
Prior art keywords
synthesis
omecamtiv mecarbil
mecarbil
hydrochloride
omecamtiv
Prior art date
Application number
MDE20200486T
Other languages
English (en)
Inventor
Sebastien Caille
Kyle Quasdorf
Philipp Roosen
Xianqing Shi
Andrew Cosbie
Fang Wang
Zufan Wu
Archana Neergunda
Bin Peter Quan
Lianxiu Guan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MD3645518T2 publication Critical patent/MD3645518T2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Este furnizată aici o sinteză pentru mecarbil omecamtiv diclorhidrat hidrat şi diferiţi intermediari.
MDE20200486T 2017-06-30 2018-06-29 Sinteză de mercabil omecamtiv MD3645518T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527174P 2017-06-30 2017-06-30
US201862664363P 2018-04-30 2018-04-30
PCT/US2018/040176 WO2019006231A1 (en) 2017-06-30 2018-06-29 SYNTHESIS OF OMECAMTIV MECARBIL

Publications (1)

Publication Number Publication Date
MD3645518T2 true MD3645518T2 (ro) 2021-11-30

Family

ID=62976317

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20200486T MD3645518T2 (ro) 2017-06-30 2018-06-29 Sinteză de mercabil omecamtiv

Country Status (27)

Country Link
US (3) US11040956B2 (ro)
EP (3) EP4265597A3 (ro)
JP (2) JP7181896B2 (ro)
KR (1) KR102625774B1 (ro)
CN (1) CN110799503B (ro)
AU (1) AU2018294254C1 (ro)
BR (1) BR112019028205A2 (ro)
CA (1) CA3063102A1 (ro)
CL (2) CL2019003898A1 (ro)
CY (1) CY1124427T1 (ro)
DK (1) DK3645518T3 (ro)
ES (1) ES2882905T3 (ro)
GE (1) GEP20227340B (ro)
HR (1) HRP20211290T1 (ro)
HU (1) HUE055242T2 (ro)
IL (2) IL270663B (ro)
LT (1) LT3645518T (ro)
MD (1) MD3645518T2 (ro)
MX (2) MX2021009594A (ro)
PL (1) PL3645518T3 (ro)
PT (1) PT3645518T (ro)
RS (1) RS62328B1 (ro)
SG (1) SG10202111790YA (ro)
SI (1) SI3645518T1 (ro)
TW (2) TW202235415A (ro)
UA (1) UA127517C2 (ro)
WO (1) WO2019006231A1 (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ711225A (en) 2013-03-14 2020-06-26 Amgen Inc A pharmaceutical formulation comprising omecamtiv mecarbil, processess and uses
IL270663B (en) 2017-06-30 2022-08-01 Amgen Inc Synthesis of omecamtib from carbyl
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS
IL272573B2 (en) 2017-09-13 2023-10-01 Amgen Inc Sarcomere activating bisamide compounds and their uses
EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
WO2021070124A1 (en) * 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
EP4041198A4 (en) * 2019-10-09 2023-08-16 Dr. Reddy's Laboratories Limited SOLID FORMS OF OMECAMTIV MECARBIL DIHYDROCHLORIDE AND PROCESS THEREOF
JP2024509797A (ja) 2021-03-10 2024-03-05 アムジェン インコーポレイテッド オメカムチブメカルビルの合成
WO2023205291A2 (en) * 2022-04-21 2023-10-26 The Board Of Regents Of The University Of Oklahoma Targeting myocardial tissue for delivery of therapeutic and imaging agents
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492529B1 (en) * 2000-01-18 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Bis pyrazole-1H-pyrazole intermediates and their synthesis
ES2522579T3 (es) 2004-06-17 2014-11-17 Cytokinetics, Inc. Compuestos, composiciones y métodos
US20070161617A1 (en) 2005-12-15 2007-07-12 Morgan Bradley P Certain chemical entities, compositions and methods
US20070208000A1 (en) 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
US7989455B2 (en) * 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
MX2009004233A (es) * 2006-10-18 2009-08-12 Pfizer Prod Inc Compuestos de biaril eter urea.
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
WO2010141817A1 (en) * 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
JP6634368B2 (ja) 2013-03-14 2020-01-22 アムジエン・インコーポレーテツド 複素環式化合物及びそれらの使用
NZ711225A (en) 2013-03-14 2020-06-26 Amgen Inc A pharmaceutical formulation comprising omecamtiv mecarbil, processess and uses
CN106163585B (zh) 2014-03-31 2019-07-16 株式会社美迪克 血液净化装置及血液净化装置的启动加注方法
TW201625568A (zh) * 2014-11-24 2016-07-16 歌林達有限公司 作爲類香草素受體之配位體ｉｉ之經取代以噁唑及噻唑爲主之甲醯胺及脲衍生物
US20180022710A1 (en) 2015-01-29 2018-01-25 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
MX2017016347A (es) 2015-06-26 2018-08-15 Amgen Inc Terapia de combinacion de activador de miosina cardiaca e inhibidor de corriente if del nodo sinusal.
WO2019006235A1 (en) 2017-06-30 2019-01-03 Amgen Inc. METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS
IL270663B (en) 2017-06-30 2022-08-01 Amgen Inc Synthesis of omecamtib from carbyl
DK3594199T3 (da) 2018-07-09 2020-09-14 Fis Fabbrica Italiana Sintetici Spa Krystallinsk 2-flour-3-nitrotoluen og proces til forberedelse deraf
EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
WO2020131574A1 (en) 2018-12-18 2020-06-25 Amgen Inc. Method of reducing aromatic nitro compounds
WO2021070124A1 (en) 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Alternate processes for the preparation of omecamtiv mecarbil
US20230090391A1 (en) 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
EP4243825A1 (en) 2020-11-12 2023-09-20 Amgen Inc. Methods of treating heart failure by administering omecamtiv mecarbil
JP2024509797A (ja) 2021-03-10 2024-03-05 アムジェン インコーポレイテッド オメカムチブメカルビルの合成

Also Published As

Publication number Publication date
TW202235415A (zh) 2022-09-16
CN110799503A (zh) 2020-02-14
EP3925950C0 (en) 2023-09-06
CL2021002167A1 (es) 2022-03-18
IL270663A (ro) 2020-01-30
AU2018294254B2 (en) 2022-04-07
HUE055242T2 (hu) 2021-11-29
IL294834A (en) 2022-09-01
GEP20227340B (en) 2022-01-25
JP2020526476A (ja) 2020-08-31
TWI769272B (zh) 2022-07-01
EP3925950A1 (en) 2021-12-22
WO2019006231A1 (en) 2019-01-03
LT3645518T (lt) 2021-10-11
EP3645518A1 (en) 2020-05-06
UA127517C2 (uk) 2023-09-20
DK3645518T3 (en) 2021-08-02
CA3063102A1 (en) 2019-01-03
US20200308143A1 (en) 2020-10-01
PL3645518T3 (pl) 2021-12-06
PT3645518T (pt) 2021-08-23
JP7181896B2 (ja) 2022-12-01
JP2022166243A (ja) 2022-11-01
RS62328B1 (sr) 2021-10-29
US20230373955A1 (en) 2023-11-23
AU2018294254C1 (en) 2022-10-13
MX2021013326A (es) 2022-08-11
KR102625774B1 (ko) 2024-01-16
US11753394B2 (en) 2023-09-12
CY1124427T1 (el) 2022-07-22
CN110799503B (zh) 2023-06-27
SG10202111790YA (en) 2021-12-30
KR20200018664A (ko) 2020-02-19
EP4265597A3 (en) 2023-11-22
US20210371397A1 (en) 2021-12-02
EP3645518B1 (en) 2021-05-19
SI3645518T1 (sl) 2021-11-30
BR112019028205A2 (pt) 2020-10-06
IL270663B (en) 2022-08-01
ES2882905T3 (es) 2021-12-03
CL2019003898A1 (es) 2020-07-31
TW201906826A (zh) 2019-02-16
EP4265597A2 (en) 2023-10-25
US11040956B2 (en) 2021-06-22
EP3925950B1 (en) 2023-09-06
AU2022204648A1 (en) 2022-07-28
HRP20211290T1 (hr) 2021-11-12
AU2018294254A1 (en) 2019-11-21
MX2021009594A (es) 2022-10-24

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