MD20160121A2 - Pirazolopiridine şi pirazolopirimidine - Google Patents
Pirazolopiridine şi pirazolopirimidineInfo
- Publication number
- MD20160121A2 MD20160121A2 MDA20160121A MD20160121A MD20160121A2 MD 20160121 A2 MD20160121 A2 MD 20160121A2 MD A20160121 A MDA20160121 A MD A20160121A MD 20160121 A MD20160121 A MD 20160121A MD 20160121 A2 MD20160121 A2 MD 20160121A2
- Authority
- MD
- Moldova
- Prior art keywords
- alkyl
- cycloalkyl
- phenyl
- heteroaryl
- halo
- Prior art date
Links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Invenţia se referă la un compus având structura (I):(I)sau la o sare farmaceutic acceptabilă a acestuia, sau un solvat farmaceutic acceptabil al compusului menţionat sau sare farmaceutic acceptabilă, unde A şi A′ sunt independent C sau N, unde C poate fi nesubstituit sau substituit prin halo sau C1-C6 alchil; R şi R0 sunt independent selectaţi din grupa care constă din H, C1-C6 alchil, hidroxi(C1-C6 alchil), fenil(C1-C6 alchil) şi -(CH2)n-W, unde W este C3-C8 cicloalchil, fenil, naftil, heteroaril sau heterociclu cu 5 sau 6 membri care conţine 1…3 atomi de N, S şi/sau O, -SO2-R′, -NHSO2-R′, -NR″SO2-R′ şi SR′, unde R′ şi R″ sunt independent C1-C6 alchil sau C3-C8 cicloalchil etc.; unde fiecare dintre alchilul, cicloalchilul, heterociclul, fenilul, naftilul sau heteroarilul menţionat poate fi nesubstituit sau substituit prin fenil, heteroaril etc.; sau R, R0 şi atomul N, de care ei sunt legaţi, formează împreună un inel heterociclic monociclic sau biciclic care poate fi nesubstituit sau substituit cu (a) halo, hidroxi, heteroaril, C1-C6 alchil, C1-C6 alcoxi etc., sau (b) -(CH2)n-W, unde W este C3-C8 cicloalchil, fenil etc.; R1 este H, halo sau ciano; R2 şi R2′ sunt independent H, C1-C6 alchil, ciano, C1-C6 alcoxi, C1-C6 alchiltio sau C3-C8 cicloalchil, unde alchil, alcoxi sau cicloalchil este opţional substituit cu unu sau mai mulţi atomi de fluor; X este o legătură, -CO-, -CONH-, -SO2-, -SONH- sau -(CH2)m-; R3 este H, C1-C4 alchil, fenil, naftil, heteroaril sau heterociclu cu 5 sau 6 membri care conţine 1…3 atomi de N, un heteroaril sau heterociclu cu 5 membri etc., sau (c) 2 atomi de O sau S şi 0…2 atomi de N; unde fiecare dintre fenilul, naftilul, heteroarilul sau heterociclul menţionat este opţional substituit cu alchil, un substituent -Y-R4 şi/sau 1…4 substituenţi, fiecare fiind selectat independent din R5; cu condiţia că atunci când X este -CO- sau -SO2-, R3 nu este H; Y este o legătură, -(CH2)m- sau -O-; R4 este (a) H, C1-C6 alchil, C3-C8 cicloalchil, halo, oxo, -OR6, -NR7R8, -SR6, -SOR9, -SO2R9, -COR6, -OCOR6, -COOR6, -NR6COR6, -CONR7R8 etc.; (b) fenil sau naftil, fenilul şi naftilul menţionaţi fiind substituiţi opţional cu 1…5 substituenţi selectaţi dintre C1-C6 alchil, C3-C8 cicloalchil, halo, ciano, -OR6, -NR7R8 etc.; sau (c) un heteroaril monociclic saturat sau parţial nesaturat cu 3…8 membri etc.; R6 este H, C1-C6 alchil sau C3-C8 cicloalchil etc.; R7 şi R8 sunt fiecare independent H, C1-C6 alchil sau C3-C8 cicloalchil sau sunt luaţi împreună cu atomul de azot la care ei sunt ataşaţi pentru a forma un inel heterociclic saturat cu 4, 5 sau 6 membri, ce conţine 1...2 atomi de azot sau un atom de azot şi unul de oxigen, unde alchilul C1-C6 menţionat este substituit opţional cu C3-C8 cicloalchil, halo etc.; inelul heterociclic menţionat fiind substituit opţional prin una sau mai multe grupe C1-C6 alchil sau C3-C8 cicloalchil; R9 este C1-C6 alchil sau C3-C8 cicloalchil; m şi n sunt independent 0, 1, 2 sau 3. Invenţia de asemenea se referă la sărurile şi solvaţii farmaceutic acceptabili ai acestor compuşi; la compoziţiile care conţin asemenea compuşi şi la utilizarea acestor compuşi în tratamentul diferitor boli, în special astmul şi COPD.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461993138P | 2014-05-14 | 2014-05-14 | |
PCT/IB2015/053174 WO2015173683A1 (en) | 2014-05-14 | 2015-04-30 | Pyrazolopyridines and pyrazolopyrimidines |
Publications (1)
Publication Number | Publication Date |
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MD20160121A2 true MD20160121A2 (ro) | 2017-05-31 |
Family
ID=53264695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MDA20160121A MD20160121A2 (ro) | 2014-05-14 | 2015-04-30 | Pirazolopiridine şi pirazolopirimidine |
Country Status (29)
Country | Link |
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US (2) | US9518052B2 (ro) |
EP (1) | EP3143021B1 (ro) |
JP (1) | JP6663857B2 (ro) |
KR (1) | KR20170002623A (ro) |
CN (1) | CN106459048A (ro) |
AP (1) | AP2016009562A0 (ro) |
AR (1) | AR100438A1 (ro) |
AU (1) | AU2015260905A1 (ro) |
CA (1) | CA2948587C (ro) |
CL (1) | CL2016002888A1 (ro) |
CR (1) | CR20160525A (ro) |
CU (1) | CU20160167A7 (ro) |
DO (1) | DOP2016000298A (ro) |
EA (1) | EA201650029A1 (ro) |
EC (1) | ECSP16087271A (ro) |
ES (1) | ES2737696T3 (ro) |
GE (1) | GEP20186921B (ro) |
IL (1) | IL248970A0 (ro) |
MD (1) | MD20160121A2 (ro) |
MX (1) | MX2016014878A (ro) |
NI (1) | NI201600170A (ro) |
PE (1) | PE20161475A1 (ro) |
PH (1) | PH12016502228A1 (ro) |
SG (1) | SG11201609139WA (ro) |
SV (1) | SV2016005318A (ro) |
TN (1) | TN2016000503A1 (ro) |
TW (1) | TWI591067B (ro) |
UY (1) | UY36121A (ro) |
WO (1) | WO2015173683A1 (ro) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TN2016000503A1 (en) | 2014-05-14 | 2018-04-04 | Pfizer | Pyrazolopyridines and pyrazolopyrimidines |
TW201946921A (zh) | 2014-05-14 | 2019-12-16 | 瑞士商諾華公司 | 甲醯胺衍生物 |
CA3037243A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1 h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
KR20180073687A (ko) | 2015-11-03 | 2018-07-02 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물 |
WO2017077288A1 (en) | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
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