MD1744F2 - Săruri ale acidului clavulanic şi procedeu de obţinere a lor - Google Patents
Săruri ale acidului clavulanic şi procedeu de obţinere a lorInfo
- Publication number
- MD1744F2 MD1744F2 MD97-0269A MD970269A MD1744F2 MD 1744 F2 MD1744 F2 MD 1744F2 MD 970269 A MD970269 A MD 970269A MD 1744 F2 MD1744 F2 MD 1744F2
- Authority
- MD
- Moldova
- Prior art keywords
- clavulanates
- salt
- pharmaceutically acceptable
- preparation
- benzhydrylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D503/10—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Sunt revendicate săruri ale acidului clavulanic, obţinute prin interacţiunea acidului clavulanic (sau a unei sări a acestuia) şi benzhidrilaminei (sau a unei sări a acesteia) cu formula Iîn care fiecare din radicalii R1 şi R2, independent, reprezintă atom de hidrogen sau un aşa substituent, pentru care sarea acidului clavulanic este acceptabilă farmaceutic.Aceste săruri se pot utiliza în formulări farmaceutice împreună cu un purtător acceptabil farmaceutic şi, opţional, cu un antibiotic beta-lactamic.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9503839.4A GB9503839D0 (en) | 1995-02-25 | 1995-02-25 | Claulanic acid salt |
GBGB9520915.1A GB9520915D0 (en) | 1995-02-25 | 1995-10-12 | Clavulanic acid salt |
PCT/GB1996/000382 WO1996026944A1 (en) | 1995-02-25 | 1996-02-21 | Clavulanic acid salts |
Publications (2)
Publication Number | Publication Date |
---|---|
MD970269A MD970269A (ro) | 1999-05-31 |
MD1744F2 true MD1744F2 (ro) | 2001-09-30 |
Family
ID=26306586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD97-0269A MD1744F2 (ro) | 1995-02-25 | 1996-02-21 | Săruri ale acidului clavulanic şi procedeu de obţinere a lor |
Country Status (27)
Country | Link |
---|---|
US (1) | US5726170A (ro) |
EP (1) | EP0729961B1 (ro) |
JP (1) | JPH11501023A (ro) |
CN (1) | CN1175952A (ro) |
AP (2) | AP9701116A0 (ro) |
AT (1) | ATE211143T1 (ro) |
AU (1) | AU691727B2 (ro) |
BG (1) | BG62490B1 (ro) |
BR (1) | BR9607258A (ro) |
CA (1) | CA2213563A1 (ro) |
CZ (1) | CZ266697A3 (ro) |
DE (1) | DE69618045D1 (ro) |
EE (1) | EE9700186A (ro) |
FI (1) | FI973287A (ro) |
HK (1) | HK1006571A1 (ro) |
IL (1) | IL117217A0 (ro) |
IS (1) | IS4541A (ro) |
MD (1) | MD1744F2 (ro) |
NO (1) | NO973744D0 (ro) |
NZ (1) | NZ301765A (ro) |
OA (1) | OA10444A (ro) |
PL (1) | PL321871A1 (ro) |
SE (1) | SE9703056D0 (ro) |
SK (1) | SK111197A3 (ro) |
TR (1) | TR199700828T1 (ro) |
WO (1) | WO1996026944A1 (ro) |
ZA (1) | ZA961457B (ro) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
US6414142B1 (en) * | 1996-06-13 | 2002-07-02 | Smithkline Beecham Corporation | Process for preparing potassium clavulanate |
DZ2456A1 (fr) * | 1997-04-04 | 2003-01-18 | Smithkline Beecham Plc | Procédé de préparation de sels de l'acide clavulanique. |
US8034120B2 (en) * | 2002-12-20 | 2011-10-11 | Ossur Hf | Suspension liner system with seal |
CN103304583B (zh) * | 2013-07-09 | 2016-01-20 | 山东新时代药业有限公司 | 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法 |
CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
CN113979856B (zh) * | 2021-11-09 | 2024-04-19 | 国药集团威奇达药业有限公司 | 从克拉维酸钾釜残液中回收叔丁胺和异辛酸盐的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
GB2264944A (en) * | 1992-03-10 | 1993-09-15 | Biochemie Gmbh | 2-amino-2,4,4-trimethylpentane salt of clavulanic acid |
WO1993025557A1 (en) * | 1992-06-11 | 1993-12-23 | Smithkline Beecham Plc | Process for the preparation of clavulanic acid |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB157873A (en) * | 1920-01-16 | 1921-08-17 | Schneider & Cie | Improvements in gas turbines |
GB704438A (en) * | 1951-04-06 | 1954-02-24 | Chimiotherapie Lab Franc | Penicillin preparations for injection |
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB1543563A (en) * | 1975-02-07 | 1979-04-04 | Glaxo Lab Ltd | Beta-lactam antibiotic in purified form |
BE862211A (fr) * | 1977-12-22 | 1978-06-22 | Beecham Group Ltd | Agents antibacteriens |
DE3063683D1 (en) * | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
MX7417E (es) * | 1984-10-27 | 1988-10-14 | Antibioticos Sa | Metodo para la preparacion de acido clavulanico y sus derivados |
ES2010143A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
DK0647229T3 (da) * | 1993-03-26 | 1996-10-07 | Gist Brocades Nv | Diaminsalte af clavulansyre |
-
1996
- 1996-02-21 CA CA002213563A patent/CA2213563A1/en not_active Abandoned
- 1996-02-21 MD MD97-0269A patent/MD1744F2/ro unknown
- 1996-02-21 TR TR97/00828T patent/TR199700828T1/xx unknown
- 1996-02-21 SK SK1111-97A patent/SK111197A3/sk unknown
- 1996-02-21 AP APAP/P/1997/001116A patent/AP9701116A0/en unknown
- 1996-02-21 AU AU47261/96A patent/AU691727B2/en not_active Ceased
- 1996-02-21 EP EP96301136A patent/EP0729961B1/en not_active Expired - Lifetime
- 1996-02-21 BR BR9607258A patent/BR9607258A/pt not_active Application Discontinuation
- 1996-02-21 DE DE69618045T patent/DE69618045D1/de not_active Expired - Lifetime
- 1996-02-21 NZ NZ301765A patent/NZ301765A/en unknown
- 1996-02-21 AP APAP/P/1997/001067A patent/AP749A/en active
- 1996-02-21 IL IL11721796A patent/IL117217A0/xx unknown
- 1996-02-21 EE EE9700186A patent/EE9700186A/xx unknown
- 1996-02-21 CZ CZ972666A patent/CZ266697A3/cs unknown
- 1996-02-21 WO PCT/GB1996/000382 patent/WO1996026944A1/en not_active Application Discontinuation
- 1996-02-21 CN CN96192116A patent/CN1175952A/zh active Pending
- 1996-02-21 AT AT96301136T patent/ATE211143T1/de not_active IP Right Cessation
- 1996-02-21 PL PL96321871A patent/PL321871A1/xx unknown
- 1996-02-21 JP JP8526082A patent/JPH11501023A/ja active Pending
- 1996-02-22 ZA ZA961457A patent/ZA961457B/xx unknown
- 1996-02-22 US US08/605,367 patent/US5726170A/en not_active Expired - Fee Related
-
1997
- 1997-08-08 IS IS4541A patent/IS4541A/is unknown
- 1997-08-08 FI FI973287A patent/FI973287A/fi unknown
- 1997-08-14 NO NO973744A patent/NO973744D0/no unknown
- 1997-08-25 SE SE9703056A patent/SE9703056D0/xx not_active Application Discontinuation
- 1997-08-25 OA OA70067A patent/OA10444A/en unknown
- 1997-09-11 BG BG101884A patent/BG62490B1/bg unknown
-
1998
- 1998-06-18 HK HK98105631A patent/HK1006571A1/xx not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
GB2264944A (en) * | 1992-03-10 | 1993-09-15 | Biochemie Gmbh | 2-amino-2,4,4-trimethylpentane salt of clavulanic acid |
WO1993025557A1 (en) * | 1992-06-11 | 1993-12-23 | Smithkline Beecham Plc | Process for the preparation of clavulanic acid |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD99 | Pending application |