MA45665B1 - Dérivés d'éthynyle - Google Patents

Dérivés d'éthynyle

Info

Publication number
MA45665B1
MA45665B1 MA45665A MA45665A MA45665B1 MA 45665 B1 MA45665 B1 MA 45665B1 MA 45665 A MA45665 A MA 45665A MA 45665 A MA45665 A MA 45665A MA 45665 B1 MA45665 B1 MA 45665B1
Authority
MA
Morocco
Prior art keywords
compounds
ethynyl derivatives
neuroprotection
autism
obsessive
Prior art date
Application number
MA45665A
Other languages
English (en)
Inventor
Daniel Rueher
Georg Jaeschke
Antonio Ricci
Barbara Biemans
Fionn O`Hara
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA45665B1 publication Critical patent/MA45665B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés de formules ia et ib ia ib ou à un sel pharmaceutiquement accepté ou un sel d'addition acide, à un mélange racémique, ou à son énantiomère correspondant et/ou isomère optique et/ou stéréoisomère de celui-ci. Les composés peuvent être utilisés pour le traitement de la maladie de parkinson, de l'anxiété, des vomissements, d'un trouble obsessionnel compulsif, de l'autisme, la neuroprotection, du cancer, de la dépression et du diabète de type 2.
MA45665A 2016-07-18 2017-07-12 Dérivés d'éthynyle MA45665B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16179837 2016-07-18
PCT/EP2017/067495 WO2018015235A1 (fr) 2016-07-18 2017-07-12 Dérivés d'éthynyle

Publications (1)

Publication Number Publication Date
MA45665B1 true MA45665B1 (fr) 2020-11-30

Family

ID=56418435

Family Applications (1)

Application Number Title Priority Date Filing Date
MA45665A MA45665B1 (fr) 2016-07-18 2017-07-12 Dérivés d'éthynyle

Country Status (31)

Country Link
US (3) US20190144458A1 (fr)
EP (1) EP3484889B1 (fr)
JP (1) JP6936305B2 (fr)
KR (1) KR20190026805A (fr)
CN (1) CN109476671B (fr)
AR (1) AR109075A1 (fr)
AU (1) AU2017299083B2 (fr)
BR (1) BR112019000314A2 (fr)
CA (1) CA3030788A1 (fr)
CL (1) CL2019000045A1 (fr)
CO (1) CO2018013824A2 (fr)
CR (1) CR20190014A (fr)
DK (1) DK3484889T3 (fr)
ES (1) ES2826389T3 (fr)
HR (1) HRP20201615T1 (fr)
HU (1) HUE051006T2 (fr)
IL (1) IL263884A (fr)
LT (1) LT3484889T (fr)
MA (1) MA45665B1 (fr)
MX (1) MX2019000442A (fr)
PE (1) PE20190382A1 (fr)
PH (1) PH12019500119A1 (fr)
PL (1) PL3484889T3 (fr)
PT (1) PT3484889T (fr)
RS (1) RS60908B1 (fr)
RU (1) RU2745068C2 (fr)
SG (1) SG11201811829QA (fr)
SI (1) SI3484889T1 (fr)
TW (1) TWI729169B (fr)
WO (1) WO2018015235A1 (fr)
ZA (1) ZA201900113B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2733468T3 (es) 2015-07-15 2019-11-29 Hoffmann La Roche Derivados de etinilo como moduladores de los receptores metabotrópicos de glutamato
CN110183456A (zh) * 2019-07-11 2019-08-30 河南师范大学 一种2-芳基吲唑琥珀酰亚胺螺环化合物的合成方法
US11515154B2 (en) * 2020-10-27 2022-11-29 Applied Materials, Inc. Selective deposition of a passivation film

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050039A2 (fr) * 2002-12-04 2004-06-17 Merck & Co., Inc. Urees spirocycliques, compositions les contenant et procedes d'utilisation
EP1891075B1 (fr) 2005-05-24 2011-10-19 Merck Serono SA Derives spiro tricycliques servant de modulateurs de crth2
JP2010502617A (ja) 2006-08-31 2010-01-28 シェーリング コーポレイション 抗菌物質として有用なヒダントイン誘導体
BRPI0812363A2 (pt) 2007-06-03 2015-02-03 Univ Vanderbilt Moduladores alostéricos positivos de mglurs de benzamida e métodos de preparação e utilização dos mesmos
CN102740699A (zh) 2009-09-04 2012-10-17 范德比尔特大学 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法
US8389536B2 (en) 2009-10-27 2013-03-05 Hoffmann-La Roche Inc. Positive allosteric modulators (PAM)
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8420661B2 (en) 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US8772300B2 (en) 2011-04-19 2014-07-08 Hoffmann-La Roche Inc. Phenyl or pyridinyl-ethynyl derivatives
HUE025031T2 (en) 2011-04-26 2016-02-29 Hoffmann La Roche Ethinyl derivatives as positive allosteric modulators of MGLUR5
CA2837312A1 (fr) 2011-05-26 2012-11-29 Sunovion Pharmaceuticals Inc. Modulateurs allosteriques du recepteur 5 du glutamate methabotropique et methodes d'utilisation associees
ES2553449T3 (es) * 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
UA114934C2 (uk) 2012-10-18 2017-08-28 Ф. Хоффманн-Ля Рош Аг Похідне етинілу як модулятор активності метаботропного глутаматного рецептора підтипу 5
CN104603110B (zh) 2012-10-18 2016-08-31 霍夫曼-拉罗奇有限公司 作为mGluR5受体活性的调节剂的乙炔基衍生物
WO2014124560A1 (fr) 2013-02-18 2014-08-21 Hua Medicine (Shanghai) Ltd. Régulateurs de mglur
UY35400A (es) 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
DK3049409T3 (en) * 2013-09-25 2017-07-10 Hoffmann La Roche ethynyl derivatives
TWI649310B (zh) 2014-01-10 2019-02-01 赫孚孟拉羅股份公司 乙炔基衍生物
PE20161415A1 (es) 2014-02-25 2017-01-06 Hoffmann La Roche Derivados de etinilo
CN104860941B (zh) 2014-02-25 2017-03-22 上海海雁医药科技有限公司 2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
JP6539749B2 (ja) 2015-03-19 2019-07-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ｍＧｌｕＲ４のモジュレーターとしての３−（４−エチニルフェニル）ヘキサヒドロピリミジン−２，４−ジオン誘導体
ES2733468T3 (es) 2015-07-15 2019-11-29 Hoffmann La Roche Derivados de etinilo como moduladores de los receptores metabotrópicos de glutamato
US10391998B2 (en) 2016-11-16 2019-08-27 Ford Global Technologies, Llc Vehicle systems and methods for reducing electrified vehicle noise, vibration, and harshness

Also Published As

Publication number Publication date
HUE051006T2 (hu) 2021-01-28
BR112019000314A2 (pt) 2019-04-16
CA3030788A1 (fr) 2018-01-25
TW201805287A (zh) 2018-02-16
PT3484889T (pt) 2020-10-15
EP3484889B1 (fr) 2020-08-19
US20190144458A1 (en) 2019-05-16
TWI729169B (zh) 2021-06-01
CN109476671A (zh) 2019-03-15
AU2017299083A1 (en) 2019-01-24
AU2017299083B2 (en) 2021-06-24
CL2019000045A1 (es) 2019-06-07
RU2745068C2 (ru) 2021-03-18
SG11201811829QA (en) 2019-02-27
WO2018015235A1 (fr) 2018-01-25
EP3484889A1 (fr) 2019-05-22
KR20190026805A (ko) 2019-03-13
CO2018013824A2 (es) 2018-12-28
JP2019521158A (ja) 2019-07-25
LT3484889T (lt) 2020-11-10
ZA201900113B (en) 2019-09-25
IL263884A (en) 2019-01-31
RU2019102757A (ru) 2020-08-18
US20220127275A1 (en) 2022-04-28
CR20190014A (es) 2019-03-04
PL3484889T3 (pl) 2020-12-28
PH12019500119A1 (en) 2019-12-11
RU2019102757A3 (fr) 2020-08-18
MX2019000442A (es) 2019-06-20
DK3484889T3 (da) 2020-10-26
PE20190382A1 (es) 2019-03-08
SI3484889T1 (sl) 2020-11-30
ES2826389T3 (es) 2021-05-18
HRP20201615T1 (hr) 2020-12-11
JP6936305B2 (ja) 2021-09-15
US11242349B2 (en) 2022-02-08
CN109476671B (zh) 2021-09-24
AR109075A1 (es) 2018-10-24
RS60908B1 (sr) 2020-11-30
US20200255440A1 (en) 2020-08-13

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