MA40794A1 - Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers - Google Patents
Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancersInfo
- Publication number
- MA40794A1 MA40794A1 MA40794A MA40794A MA40794A1 MA 40794 A1 MA40794 A1 MA 40794A1 MA 40794 A MA40794 A MA 40794A MA 40794 A MA40794 A MA 40794A MA 40794 A1 MA40794 A1 MA 40794A1
- Authority
- MA
- Morocco
- Prior art keywords
- peptides
- hcc
- scaffolds
- cancers
- combinations
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 title 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/50—Molecular design, e.g. of drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
La présente invention concerne des peptides, des protéines, des acides nucléiques et des cellules destinées à être utilisés dans des méthodes immunothérapeutiques. La présente invention concerne en particulier l'immunothérapie du cancer. La présente invention concerne en outre des épitopes peptidiques tumoraux de cellules t, seuls ou combinés à d'autres peptides tumoraux, qui peuvent par exemple servir d'ingrédients pharmaceutiques actifs de compositions vaccinales qui stimulent les réponses immunitaires
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1505585.8A GB201505585D0 (en) | 2015-03-31 | 2015-03-31 | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
PCT/EP2016/056601 WO2016156230A1 (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40794A1 true MA40794A1 (fr) | 2019-05-31 |
Family
ID=53178474
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041844A MA41844A (fr) | 2015-03-31 | 2016-03-23 | Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers |
MA046303A MA46303A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
MA40794A MA40794A1 (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers |
MA046305A MA46305A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
MA046304A MA46304A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041844A MA41844A (fr) | 2015-03-31 | 2016-03-23 | Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers |
MA046303A MA46303A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA046305A MA46305A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
MA046304A MA46304A (fr) | 2015-03-31 | 2016-03-24 | Nouveaux peptides et combinaison de peptides et d'échafaudages pour utilisation dans l'immunothérapie contre le carcinome cellulaire rénal (rcc) et autres cancers |
Country Status (25)
Country | Link |
---|---|
US (16) | US9993536B2 (fr) |
EP (4) | EP3517127A1 (fr) |
JP (3) | JP7146399B2 (fr) |
KR (2) | KR20220070328A (fr) |
CN (2) | CN113912702A (fr) |
AR (3) | AR104114A1 (fr) |
AU (5) | AU2016240341B2 (fr) |
BR (1) | BR112017019804A2 (fr) |
CA (1) | CA2980814A1 (fr) |
CL (5) | CL2017002448A1 (fr) |
CO (1) | CO2017009616A2 (fr) |
CR (3) | CR20170440A (fr) |
EA (1) | EA037050B1 (fr) |
GB (1) | GB201505585D0 (fr) |
HK (1) | HK1247085A1 (fr) |
IL (3) | IL289444B (fr) |
MA (5) | MA41844A (fr) |
MX (2) | MX2017012504A (fr) |
MY (1) | MY181449A (fr) |
PE (2) | PE20231650A1 (fr) |
PH (1) | PH12017501651A1 (fr) |
SG (2) | SG11201707043WA (fr) |
TW (5) | TWI758243B (fr) |
UA (1) | UA124519C2 (fr) |
WO (1) | WO2016156230A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2016109368A (ru) | 2013-10-03 | 2017-11-10 | Нитто Денко Корпорейшн | Мукозальная вакцинная композиция |
CN105555308A (zh) | 2013-10-03 | 2016-05-04 | 日东电工株式会社 | 粘膜疫苗组合物 |
BR112017020826A2 (pt) | 2015-03-31 | 2018-07-03 | Mutabilis | compostos, composição farmacêutica e kit |
IL259931B2 (en) | 2015-12-16 | 2024-02-01 | Gritstone Bio Inc | Identification of neo-antigens, preparation, and use |
GB201604490D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides combination of peptides for use in immunotherapy against cancers |
GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
EP4317432A3 (fr) | 2016-12-08 | 2024-04-17 | Immatics Biotechnologies GmbH | Récepteurs de lymphocytes t à appariement amélioré |
IL299051A (en) * | 2017-01-27 | 2023-02-01 | Immatics Biotechnologies Gmbh | New peptides and their combinations for immunotherapy against ovarian cancer and other cancers |
AU2018298884A1 (en) | 2017-07-14 | 2020-02-27 | Immatics Biotechnologies Gmbh | Improved dual specificity polypeptide molecule |
DE102017115966A1 (de) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
CN111630183B (zh) * | 2017-09-05 | 2024-06-18 | 新加坡科技研究局 | 透明细胞肾细胞癌生物标志物 |
CN111465989B (zh) | 2017-10-10 | 2024-06-25 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
DE102017127984B4 (de) | 2017-11-27 | 2019-12-05 | Immatics US, Inc. | Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen |
CA3090416A1 (fr) | 2018-02-09 | 2019-08-15 | Immatics US, Inc. | Procedes de fabrication de lymphocytes t |
WO2020191172A1 (fr) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cultures de cellules t cd28, leurs compositions et leurs méthodes d'utilisation |
EP3976805A1 (fr) | 2019-05-27 | 2022-04-06 | Immatics US, Inc. | Vecteurs viraux et leur utilisation dans une thérapie cellulaire adoptive |
CA3142386A1 (fr) | 2019-06-06 | 2020-12-10 | Immatics Biotechnologies Gmbh | Tri avec selection de compteur a l'aide de peptides similaires a une sequence |
US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
JP2023515131A (ja) | 2020-02-24 | 2023-04-12 | イマティクス ユーエス,アイエヌシー. | がんおよび関連する悪性腫瘍の治療のためにt細胞を増殖させる方法 |
DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
DE102020106710A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
CN111413498B (zh) * | 2020-04-08 | 2023-08-04 | 复旦大学附属中山医院 | 一种肝细胞肝癌的自身抗体7-AAb检测panel及其应用 |
TW202227616A (zh) | 2020-08-21 | 2022-07-16 | 美商英麥提克斯股份有限公司 | 分離cd8+選擇t細胞的方法 |
TW202241938A (zh) | 2020-12-31 | 2022-11-01 | 美商英麥提克斯股份有限公司 | Cd8多肽、組合物及其使用方法 |
MX2023012899A (es) | 2021-05-05 | 2023-11-08 | Immatics Biotechnologies Gmbh | Polipeptidos de union a antigeno bma031 mejorados. |
WO2023025851A1 (fr) | 2021-08-24 | 2023-03-02 | Immatics US, Inc. | Sélection de cellules immunitaires à l'aide de complexes peptide-cmh générés par échange de ligands conditionnel |
TW202332765A (zh) | 2021-09-20 | 2023-08-16 | 美商英麥提克斯股份有限公司 | 用於t細胞療法之t細胞群體的單核球耗盡 |
WO2023081925A1 (fr) | 2021-11-08 | 2023-05-11 | Immatics Biotechnologies Gmbh | Traitement combiné de thérapie cellulaire adoptive et compositions associées |
WO2023153763A1 (fr) * | 2022-02-08 | 2023-08-17 | 고려대학교 산학협력단 | Vaccin contre le cancer comprenant un épitope de c-met et un épitope de hif1alpha, et son utilisation |
WO2023212697A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Il-15 liée à une membrane, polypeptides de cd8, cellules, compositions et leurs procédés d'utilisation |
WO2023212691A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Polypeptides récepteurs de tgfβ négatifs dominants, polypeptides cd8, cellules, compositions et leurs méthodes d'utilisation |
WO2023212655A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Polypeptides d'il-12, polypeptides d'il-15, polypeptides d'il-18, polypeptides de cd8, compositions et leurs procédés d'utilisation |
WO2023215825A1 (fr) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Procédés d'amélioration de l'efficacité d'un lymphocyte t |
CN115074445B (zh) * | 2022-08-09 | 2023-08-08 | 河北医科大学第二医院 | Eno3在肾癌诊断及治疗中的应用 |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
IN151589B (fr) | 1978-12-22 | 1983-05-28 | Biogen Nv | |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
US6193969B1 (en) | 1993-06-03 | 2001-02-27 | Protherics Inc. | Antibody fragments in therapy |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
ATE244300T1 (de) | 1996-01-17 | 2003-07-15 | Imp College Innovations Ltd | Immunotherapie mit verwendung von zytotoxischen t lymphozyten (ctl) |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
DE69738157T2 (de) * | 1996-10-01 | 2008-05-08 | Bio-Rad Laboratories, Inc., Hercules | Polymorphismus und neue gene in der region des menschlichen hemochromatosisgens |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
EP1294748B1 (fr) | 2000-03-27 | 2010-06-30 | Technion Research and Development of Foundation, Ltd. | Complexes majeurs d'histocompatibilite monocatenaires de classe 1, constructions les codant et leurs methodes de production |
US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
CN101712721A (zh) | 2000-06-05 | 2010-05-26 | 阿尔托生物科学有限公司 | T细胞受体融合物及共轭物以及其使用方法 |
US20070037165A1 (en) * | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
US20030191073A1 (en) * | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
US7803915B2 (en) * | 2001-06-20 | 2010-09-28 | Genentech, Inc. | Antibody compositions for the diagnosis and treatment of tumor |
US20030068636A1 (en) | 2001-06-21 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions, kits and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
US7705120B2 (en) | 2001-06-21 | 2010-04-27 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
JP4200100B2 (ja) * | 2001-11-07 | 2008-12-24 | アジェンシス,インコーポレイテッド | 癌の処置および検出において有用な161p2f10bと称される、核酸および対応タンパク質 |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
WO2003070752A2 (fr) | 2002-02-20 | 2003-08-28 | Dyax Corporation | Ligands de liaison au complexe mhc-peptide |
AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
AU2003263607A1 (en) * | 2002-10-25 | 2004-05-13 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosing diffuse-type gastric cancer |
CA2505558C (fr) | 2002-11-09 | 2013-07-02 | Avidex Limited | Presentation de recepteurs pour l'antigene des lymphocytes t |
WO2004048599A2 (fr) * | 2002-11-22 | 2004-06-10 | Incyte Corporation | Transporteurs et canaux ioniques |
GB0304068D0 (en) | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
DE10313819A1 (de) | 2003-03-24 | 2004-10-07 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
KR101520209B1 (ko) * | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
US7667001B1 (en) | 2004-01-27 | 2010-02-23 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
US7368548B2 (en) | 2004-01-27 | 2008-05-06 | Compugen Ltd. | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer |
US7569662B2 (en) | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
ATE440107T1 (de) | 2005-09-05 | 2009-09-15 | Immatics Biotechnologies Gmbh | Tumorassoziierte peptide, die hla klasse i oder ii-moleküle binden, und anti-tumor impfstoffe |
EP1806359B1 (fr) | 2005-09-05 | 2010-03-17 | Immatics Biotechnologies GmbH | Peptides associeés a des tumeurs et se liantes a des différentes antigènes d'histocompatibilité (HLA) de classe II |
JPWO2007119515A1 (ja) * | 2006-03-28 | 2009-08-27 | 昇志 佐藤 | 新規腫瘍抗原ペプチド |
WO2007114954A2 (fr) * | 2006-04-05 | 2007-10-11 | Corixa Corporation | Méthodes, compositions et trousses pour détection et observation de cancer du rein |
CA2660286A1 (fr) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Proteines specifiques d'organes et procedes d'utilisation |
WO2008053573A1 (fr) | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
EP2562182B1 (fr) | 2007-07-27 | 2015-10-07 | Immatics Biotechnologies GmbH | Nouveaux épitopes immunogènes pour l'immunothérapie |
US20090263574A1 (en) | 2008-04-21 | 2009-10-22 | Quinn Daniel E | Method of restoring an article |
FR2933304A1 (fr) * | 2008-07-07 | 2010-01-08 | Adocia | Composition synergique osteogenique |
CA2754461A1 (fr) | 2009-03-06 | 2010-09-10 | Halozyme, Inc. | Mutants thermosensibles de metalloprotease matricielle 1 et leurs utilisations |
WO2011097221A2 (fr) * | 2010-02-02 | 2011-08-11 | Children's Medical Center Corporation | Procédés permettant de favoriser la croissance des tissus et la régénération des tissus |
WO2011119484A1 (fr) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Procédés bioinformatiques pour déterminer la liaison de peptides |
GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
CA2816225A1 (fr) | 2010-10-26 | 2012-05-03 | Technion Research & Development Foundation Ltd. | Anticorps qui se lient a des ligands de recepteurs de lymphocytes t solubles |
GB201021289D0 (en) * | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
US20120207743A1 (en) * | 2011-02-14 | 2012-08-16 | Allergan, Inc. | Inhibiting Aberrant Blood Vessel Formation Using Retargeted Endopeptidases |
WO2012162468A1 (fr) | 2011-05-25 | 2012-11-29 | Janssen Pharmaceutica Nv | Dérivés de thiazole en tant qu'inhibiteurs de pro-métalloprotéinases de matrice |
TW201302800A (zh) * | 2011-06-10 | 2013-01-16 | Oncotherapy Science Inc | Sema5b胜肽及含其之疫苗 |
WO2013057586A1 (fr) | 2011-10-19 | 2013-04-25 | Oslo Universitetssykehus Hf | Compositions et procédés de production de récepteurs solubles des lymphocytes t |
EP3501550A1 (fr) | 2012-04-02 | 2019-06-26 | Moderna Therapeutics, Inc. | Polynucléotides modifiés pour la production de protéines associées à une maladie humaine |
US9540657B2 (en) * | 2012-05-25 | 2017-01-10 | California Institute Of Technology | Expression of secreted and cell-surface polypeptides |
US20190292535A1 (en) | 2012-11-08 | 2019-09-26 | Roche Diagnostics Operations, Inc. | Nucleic acids encoding chimeric polypeptides for library screening |
AU2013356143A1 (en) * | 2012-12-04 | 2015-06-04 | Oncotherapy Science, Inc. | SEMA5B peptides and vaccines containing the same |
EP2808392A1 (fr) | 2013-05-28 | 2014-12-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamères et utilisation de ces aptamères dans le diagnostic et le traitement du cancer |
TWI777195B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(三) |
CN107074910B (zh) * | 2014-08-17 | 2022-02-18 | 塞里维瑞疗法公司 | 高级大分子转导域序列、编码其的多核苷酸及其用途 |
-
2015
- 2015-03-31 GB GBGB1505585.8A patent/GB201505585D0/en not_active Ceased
-
2016
- 2016-03-23 MA MA041844A patent/MA41844A/fr unknown
- 2016-03-24 EA EA201791950A patent/EA037050B1/ru unknown
- 2016-03-24 KR KR1020227015914A patent/KR20220070328A/ko not_active Application Discontinuation
- 2016-03-24 AU AU2016240341A patent/AU2016240341B2/en active Active
- 2016-03-24 PE PE2022002819A patent/PE20231650A1/es unknown
- 2016-03-24 MY MYPI2017703153A patent/MY181449A/en unknown
- 2016-03-24 CN CN202111198057.3A patent/CN113912702A/zh active Pending
- 2016-03-24 EP EP19160322.4A patent/EP3517127A1/fr active Pending
- 2016-03-24 CR CR20170440A patent/CR20170440A/es unknown
- 2016-03-24 BR BR112017019804-5A patent/BR112017019804A2/pt active Search and Examination
- 2016-03-24 EP EP19160307.5A patent/EP3517126A1/fr active Pending
- 2016-03-24 MA MA046303A patent/MA46303A/fr unknown
- 2016-03-24 UA UAA201708037A patent/UA124519C2/uk unknown
- 2016-03-24 MA MA40794A patent/MA40794A1/fr unknown
- 2016-03-24 JP JP2017550874A patent/JP7146399B2/ja active Active
- 2016-03-24 MA MA046305A patent/MA46305A/fr unknown
- 2016-03-24 KR KR1020177027590A patent/KR102451645B1/ko active IP Right Grant
- 2016-03-24 EP EP19160336.4A patent/EP3517128A1/fr active Pending
- 2016-03-24 MA MA046304A patent/MA46304A/fr unknown
- 2016-03-24 SG SG11201707043WA patent/SG11201707043WA/en unknown
- 2016-03-24 IL IL289444A patent/IL289444B/en unknown
- 2016-03-24 PE PE2017001627A patent/PE20180505A1/es unknown
- 2016-03-24 EP EP16715808.8A patent/EP3277310A1/fr not_active Withdrawn
- 2016-03-24 MX MX2017012504A patent/MX2017012504A/es unknown
- 2016-03-24 CA CA2980814A patent/CA2980814A1/fr active Pending
- 2016-03-24 CR CR20220164A patent/CR20220164A/es unknown
- 2016-03-24 CR CR20220163A patent/CR20220163A/es unknown
- 2016-03-24 WO PCT/EP2016/056601 patent/WO2016156230A1/fr active Application Filing
- 2016-03-24 CN CN201680020165.2A patent/CN107438619B/zh active Active
- 2016-03-24 SG SG10202001834UA patent/SG10202001834UA/en unknown
- 2016-03-28 AR ARP160100819A patent/AR104114A1/es unknown
- 2016-03-28 TW TW105109709A patent/TWI758243B/zh active
- 2016-03-28 US US15/082,876 patent/US9993536B2/en active Active
- 2016-03-28 TW TW109136260A patent/TWI758912B/zh active
- 2016-03-28 US US15/082,920 patent/US9931388B2/en active Active
- 2016-03-28 TW TW111113655A patent/TW202231656A/zh unknown
- 2016-03-28 TW TW109136263A patent/TWI756874B/zh active
- 2016-03-28 TW TW109136262A patent/TWI745127B/zh active
-
2017
- 2017-08-29 IL IL254204A patent/IL254204B/en unknown
- 2017-09-11 PH PH12017501651A patent/PH12017501651A1/en unknown
- 2017-09-22 CO CONC2017/0009616A patent/CO2017009616A2/es unknown
- 2017-09-28 MX MX2022000219A patent/MX2022000219A/es unknown
- 2017-09-28 CL CL2017002448A patent/CL2017002448A1/es unknown
- 2017-10-31 US US15/799,495 patent/US10105428B2/en active Active
-
2018
- 2018-05-14 US US15/978,700 patent/US10213498B2/en active Active
- 2018-05-17 HK HK18106394.9A patent/HK1247085A1/zh unknown
- 2018-08-03 US US16/054,561 patent/US10357552B2/en active Active
- 2018-11-23 CL CL2018003348A patent/CL2018003348A1/es unknown
- 2018-12-07 US US16/212,787 patent/US10314899B2/en active Active
- 2018-12-07 US US16/212,783 patent/US10363296B2/en active Active
-
2019
- 2019-03-13 AU AU2019201713A patent/AU2019201713B2/en active Active
- 2019-03-13 AU AU2019201708A patent/AU2019201708B2/en active Active
- 2019-03-13 AU AU2019201714A patent/AU2019201714B2/en active Active
- 2019-03-28 US US16/367,790 patent/US10548958B2/en active Active
- 2019-05-17 US US16/415,686 patent/US10449240B2/en active Active
- 2019-05-17 US US16/415,753 patent/US10478481B2/en active Active
- 2019-09-17 CL CL2019002663A patent/CL2019002663A1/es unknown
- 2019-12-16 US US16/715,846 patent/US10835586B2/en active Active
-
2020
- 2020-06-11 AU AU2020203850A patent/AU2020203850B2/en active Active
- 2020-10-16 US US17/072,528 patent/US20210030854A1/en not_active Abandoned
-
2021
- 2021-02-19 AR ARP210100436A patent/AR121380A2/es unknown
- 2021-02-19 AR ARP210100439A patent/AR121383A2/es unknown
- 2021-05-07 US US17/314,492 patent/US11938176B2/en active Active
- 2021-07-05 CL CL2021001776A patent/CL2021001776A1/es unknown
- 2021-08-08 IL IL285434A patent/IL285434B/en unknown
- 2021-08-13 US US17/402,068 patent/US20210393756A1/en active Pending
- 2021-10-29 US US17/514,599 patent/US20220040278A1/en active Pending
- 2021-11-04 US US17/519,192 patent/US12005105B2/en active Active
-
2023
- 2023-01-27 JP JP2023010823A patent/JP2023061974A/ja active Pending
- 2023-03-21 CL CL2023000812A patent/CL2023000812A1/es unknown
- 2023-11-22 JP JP2023197848A patent/JP2024028730A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA40794A1 (fr) | Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers | |
MA40813A1 (fr) | Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre diverses tumeurs | |
MA40713A1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie du cancer du pancréas et d'autres cancers | |
MA41879A1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de la prostate et d'autres cancers | |
MA41717A1 (fr) | Nouveaux peptides et combinaison de peptides destinés à être utilisés en immunothérapie contre le cancer ovarien épithélial et d'autres cancers | |
MA39907B1 (fr) | Nouvelle immunothérapie contre plusieurs tumeurs, du sang, notamment la leucémie aiguë myéloïde (lam) | |
MA43075A1 (fr) | Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre le lymphome non hodgkinien et d'autres cancers | |
MA42073A1 (fr) | Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre divers cancers | |
MA42021A1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer du poumon à petites cellules et d'autres cancers | |
MA43466A1 (fr) | Traitements du cancer de l'utérus | |
MA42020A1 (fr) | Peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer du sein et d'autres cancers | |
MA41393A1 (fr) | Nouveaux peptides et combinaisons de peptides et échafaudages formés de ceux-ci destinés à être utilisés en immunothérapie contre le carcinome colorectal (crc) et d'autres cancers | |
MA42072A1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre la cll et d'autres cancers | |
MA41237B1 (fr) | Nouveaux peptides et combinaisons de peptides pour une utilisation en immunothérapie contre le carcinome hépatocellulaire (chc) et autres cancers | |
MA41520B2 (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers | |
MA43461B1 (fr) | Nouveaux peptides, combinaisons de peptides et supports pour utilisation dans le traitementimmunothérapeutique de divers cancers | |
MA43618A1 (fr) | Nouveaux peptides, association de peptides en tant que cibles et destinés à être utilisés en immunothérapie contre le cancer de la vésicule biliaire et le cholangiocarcinome et autres cancers | |
MA42294A (fr) | Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers | |
MA43477A1 (fr) | Immunothérapie contre le mélanome et d'autres cancers | |
EA201690016A1 (ru) | Новый метод иммунотерапии нескольких видов опухолей, таких как рак легкого, включая нмрл | |
EA201100586A1 (ru) | Новая иммунотерапия против нескольких видов опухолей, включая нейрональные опухоли и опухоли головного мозга | |
MA43482A1 (fr) | Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre la leucémie myéloïde aiguë (lma) et d'autres cancers | |
MA49155B1 (fr) | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers | |
MA42022A1 (fr) | Nouveaux peptides, combinaisons de peptides et supports pour utilisation dans le traitement immunothérapeutique de divers cancers | |
MA38794B1 (fr) | Nouvelle immunothérapie contre plusieurs tumeurs, tels que le cancer du poumon, comprenant le cancer du poumon à grandes cellules |