MA40057A - Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants - Google Patents

Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants

Info

Publication number
MA40057A
MA40057A MA040057A MA40057A MA40057A MA 40057 A MA40057 A MA 40057A MA 040057 A MA040057 A MA 040057A MA 40057 A MA40057 A MA 40057A MA 40057 A MA40057 A MA 40057A
Authority
MA
Morocco
Prior art keywords
skin
therapeutic
tratment
abnormal skin
microorganisms
Prior art date
Application number
MA040057A
Other languages
English (en)
Inventor
Azim Momin Munivar
Travis Michael Whitfill
Original Assignee
Azitra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azitra filed Critical Azitra
Publication of MA40057A publication Critical patent/MA40057A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

La présente invention concerne des méthodes de traitement ou de prévention d'états cutanés anormaux chez un homme en ayant besoin, comprenant l'administration d'une composition de culture cellulaire qui comporte une culture vivante de bactéries incluant au moins une souche génétiquement modifiée qui produit un polypeptide recombinant pour le traitement thérapeutique dudit état cutané anormal. L'invention concerne également des compositions pharmaceutiques contenant, en tant que principes actifs, des microorganismes génétiquement modifiés exprimant des polypeptides thérapeutiques recombinants pharmacologiquement actifs non vaccinogènes, en vue de traiter ou de prévenir des états cutanés anormaux.
MA040057A 2014-05-30 2015-05-28 Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants MA40057A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462005558P 2014-05-30 2014-05-30
US201462005652P 2014-05-30 2014-05-30

Publications (1)

Publication Number Publication Date
MA40057A true MA40057A (fr) 2015-12-03

Family

ID=54699800

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040057A MA40057A (fr) 2014-05-30 2015-05-28 Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants

Country Status (7)

Country Link
US (2) US10702558B2 (fr)
EP (2) EP3148569B1 (fr)
JP (2) JP6810028B2 (fr)
CA (1) CA2979079A1 (fr)
ES (1) ES2929579T3 (fr)
MA (1) MA40057A (fr)
WO (1) WO2015184134A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3021793A1 (fr) 2016-04-21 2017-10-26 Naked Biome, Inc. Compositions et methodes pour le traitement de troubles cutanes
CN111050850A (zh) * 2017-06-16 2020-04-21 阿兹特拉公司 用于用表达lekti的重组微生物治疗内瑟顿综合征的组合物和方法
KR20200083435A (ko) * 2017-08-31 2020-07-08 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 피부 효소 활성을 제어하기 위한 분자 박테리아요법
KR20200051001A (ko) * 2017-09-05 2020-05-12 아지트라 인코포레이티드 재조합 미생물을 사용하여 염증성 피부 질환을 치료하기 위한 방법 및 조성물
JP7121969B2 (ja) * 2018-02-23 2022-08-19 株式会社北里コーポレーション 培養液保護用液状物
KR20200139760A (ko) 2018-04-05 2020-12-14 아지트라 인코포레이티드 재조합 미생물을 사용하여 피부 질환을 치료하기 위한 방법 및 조성물
AU2019203692A1 (en) * 2018-08-30 2020-03-19 Johnson & Johnson Consumer Inc. Topical composition containing glycerin and yeast extract
US20210355192A1 (en) * 2018-10-08 2021-11-18 Yale University Selective Binding and Aggregation of Human Keratin in the Skin Barrier Using Human Filaggrin Subdomains SD67 and SD150
KR20210092767A (ko) * 2018-11-16 2021-07-26 아지트라 인코포레이티드 스타필로코쿠스 박테리아의 영양요구성 균주
CZ308231B6 (cs) * 2019-02-11 2020-03-11 BiomCare s.r.o. Kombinované několikastupňové mikrobiální přípravky a způsob jejich aplikace
EP3946412A4 (fr) * 2019-04-05 2023-01-04 Azitra, Inc. Procédés et compositions pour traiter une dermatite atopique avec des microorganismes recombinants
EP4096699A4 (fr) * 2020-01-29 2024-03-13 Jackson Lab Mélanges bactériens
JP2023546925A (ja) * 2020-10-21 2023-11-08 ザ ジャクソン ラボラトリー 抗菌バイオセンサー

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0637384B2 (ja) 1985-09-21 1994-05-18 株式会社資生堂 皮膚化粧料
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
DE4221255C2 (de) 1992-06-26 1994-09-15 Lancaster Group Ag Phospholipide enthaltendes Kosmetikum
DE4221268C2 (de) 1992-06-26 1997-06-12 Lancaster Group Ag Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut
ES2664591T3 (es) 2009-09-25 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
US10336797B2 (en) 2009-11-23 2019-07-02 Research Development Foundation Recombinant filaggrin polypeptides for cell importation
WO2011150127A2 (fr) * 2010-05-25 2011-12-01 The Board Of Trustees Of The University Of Illinois Nouveaux systèmes, vecteurs, et procédés pour l'administration de biomolécules à des cellules eucaryotes
AU2013299605A1 (en) * 2012-08-07 2015-03-26 TopGeniX, Inc. Topical composition comprising transformed bacteria expressing a compound of interest
KR101491240B1 (ko) 2013-03-15 2015-02-11 현대자동차주식회사 인비저블 슬라이딩 도어 링크 구조

Also Published As

Publication number Publication date
EP3148569A1 (fr) 2017-04-05
EP3148569A4 (fr) 2017-11-22
EP3148569B1 (fr) 2022-07-06
CA2979079A1 (fr) 2015-12-03
JP6810028B2 (ja) 2021-01-06
EP4144756A1 (fr) 2023-03-08
WO2015184134A1 (fr) 2015-12-03
US10702558B2 (en) 2020-07-07
US20210379120A1 (en) 2021-12-09
ES2929579T3 (es) 2022-11-30
US20180161380A1 (en) 2018-06-14
JP2017518370A (ja) 2017-07-06
JP2021038271A (ja) 2021-03-11

Similar Documents

Publication Publication Date Title
MA40057A (fr) Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants
MX2019011215A (es) Ácidos nucleicos que codifican proteínas asociadas a crispr y usos de los mismos.
MX2021000071A (es) Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer.
MY189333A (en) Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii
UA117096C2 (uk) Поліпептид, що зв'язується з c5 комплементу людини
MX2020000083A (es) Factor de von willebrand recombinante ( rvwf ) y factor viii recombinante ( rfviii ) para usarse en un metodo para tratar la enfermedad de von willebrand.
MX2023000796A (es) Composicion farmaceutica, metodos para tratamiento y sus usos.
MX2017006938A (es) Terapia de combinacion para el tratamiento de cancer.
WO2011090297A3 (fr) Cellule souche adulte humaine pouvant exprimer anti-mdm2 et son utilisation
MX2014001393A (es) 3-(bifenil-3-il)-4-hidroxi-8-metoxi-1-azaespiro[4.5]dec-3-en-2-on as sustituidas.
EP4252742A3 (fr) Furoate de fluticasone utilisé dans le traitement de la bpco
PH12017500392A1 (en) Medical treatments based on anamorelin
PH12016502233A1 (en) (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine
PH12019501439A1 (en) Use of lactic acid bacteria to treat or prevent gestational diabetes mellitus
MY194448A (en) Short synthetic peptide for treating diseases and/or conditions related to angiogenesis
MX2017005522A (es) Tratamiento novedoso de la cornea usando laminina.
MX2015005733A (es) Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.
GB2537783A (en) Methods and compositions used in treating inflammatory and autoimmune diseases
MD4763B1 (ro) Compoziţie farmaceutică
MX2017013666A (es) Terapia de combinacion de agente anti-fuctactico y agente de inmunoterapia y composiciones para el tratamiento de cancer.
IN2013MN01547A (fr)
MX2023005014A (es) Metodos de tratamiento de enfermedades inflamatorias cronicas.
MX2016011002A (es) Tratamiento de angioedema hereditario con inhibidor c1.
BR112018069468A2 (pt) agente indutor da imunidade, métodos para preparar uma célula apresentadora de antígeno, para preparar uma célula t citotóxica e para induzir a imunidade
MX2018003308A (es) Suministro localizado de agente anti-fuctactico para tratamiento del cancer.