US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
EP0143949B1
(fr)
|
1983-11-01 |
1988-10-12 |
TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION |
Composition pharmaceutique contenant de l'urokinase
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
US4740461A
(en)
|
1983-12-27 |
1988-04-26 |
Genetics Institute, Inc. |
Vectors and methods for transformation of eucaryotic cells
|
EP0154316B1
(fr)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Lymphokine chimiquement modifiée et son procédé de préparation
|
US4959455A
(en)
|
1986-07-14 |
1990-09-25 |
Genetics Institute, Inc. |
Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
EP0281604B1
(fr)
|
1986-09-02 |
1993-03-31 |
Enzon Labs Inc. |
Molecules de liaison de chaines de polypeptide simples
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
US4970154A
(en)
|
1987-10-09 |
1990-11-13 |
Baylor College Of Medicine |
Method for inserting foreign genes into cells using pulsed radiofrequency
|
US4892538A
(en)
|
1987-11-17 |
1990-01-09 |
Brown University Research Foundation |
In vivo delivery of neurotransmitters by implanted, encapsulated cells
|
US5106627A
(en)
|
1987-11-17 |
1992-04-21 |
Brown University Research Foundation |
Neurological therapy devices
|
US5158881A
(en)
|
1987-11-17 |
1992-10-27 |
Brown University Research Foundation |
Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
|
US6018026A
(en)
|
1988-01-22 |
2000-01-25 |
Zymogenetics, Inc. |
Biologically active dimerized and multimerized polypeptide fusions
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
US5011472A
(en)
|
1988-09-06 |
1991-04-30 |
Brown University Research Foundation |
Implantable delivery system for biological factors
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
JP2877509B2
(ja)
|
1989-05-19 |
1999-03-31 |
アムジエン・インコーポレーテツド |
メタロプロテイナーゼ阻害剤
|
US5676954A
(en)
|
1989-11-03 |
1997-10-14 |
Vanderbilt University |
Method of in vivo delivery of functioning foreign genes
|
US6641809B1
(en)
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
US5723286A
(en)
|
1990-06-20 |
1998-03-03 |
Affymax Technologies N.V. |
Peptide library and screening systems
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
WO1993012227A1
(fr)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Animaux transgeniques non humains capables de produire des anticorps heterologues
|
US6565841B1
(en)
|
1991-03-15 |
2003-05-20 |
Amgen, Inc. |
Pulmonary administration of granulocyte colony stimulating factor
|
WO1992022646A1
(fr)
|
1991-06-14 |
1992-12-23 |
Dnx Corp. |
Procede d'utilisation de porcs transgeniques dans la production d'hemoglobine humaine
|
US5733731A
(en)
|
1991-10-16 |
1998-03-31 |
Affymax Technologies N.V. |
Peptide library and screening method
|
US5270170A
(en)
|
1991-10-16 |
1993-12-14 |
Affymax Technologies N.V. |
Peptide library and screening method
|
WO1993015722A1
(fr)
|
1992-02-07 |
1993-08-19 |
Syntex (Usa) Inc. |
Liberation controlee de produits pharmaceutiques a partir de microparticules poreuses preformees
|
US5417972A
(en)
|
1993-08-02 |
1995-05-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
|
AU7568094A
(en)
|
1993-08-12 |
1995-03-14 |
Cytotherapeutics, Inc. |
Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
|
US6268212B1
(en)
|
1993-10-18 |
2001-07-31 |
Amgen Inc. |
Tissue specific transgene expression
|
US5625825A
(en)
|
1993-10-21 |
1997-04-29 |
Lsi Logic Corporation |
Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
|
US5922545A
(en)
|
1993-10-29 |
1999-07-13 |
Affymax Technologies N.V. |
In vitro peptide and antibody display libraries
|
US5484720A
(en)
|
1994-09-08 |
1996-01-16 |
Genentech, Inc. |
Methods for calcium phosphate transfection
|
DE4435919C1
(de)
|
1994-10-07 |
1995-12-07 |
Deutsches Krebsforsch |
Zinkfinger-DNA, -Protein und ihre Verwendung
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
AU705035B2
(en)
|
1995-06-07 |
1999-05-13 |
Baylor College Of Medicine |
Nucleic acid transporters for delivery of nucleic acids into a cell
|
US6127977A
(en)
|
1996-11-08 |
2000-10-03 |
Cohen; Nathan |
Microstrip patch antenna with fractal structure
|
US5679559A
(en)
|
1996-07-03 |
1997-10-21 |
University Of Utah Research Foundation |
Cationic polymer and lipoprotein-containing system for gene delivery
|
DE69718341T2
(de)
|
1996-10-08 |
2003-10-30 |
Bisys B V U |
Verfahren und mittel zur auswahl von peptiden und proteinen mit spezifischer affinität zu einem zielmolekül
|
ATE302272T1
(de)
|
1996-10-25 |
2005-09-15 |
Human Genome Sciences Inc |
Neutrokin alpha
|
US6812327B1
(en)
|
1996-10-25 |
2004-11-02 |
Human Genome Sciences, Inc. |
Neutrokine-alpha polypeptides
|
JP4215172B2
(ja)
|
1996-12-03 |
2009-01-28 |
アムジェン フレモント インク. |
複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
|
AU5705898A
(en)
|
1996-12-17 |
1998-07-15 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
JP3521382B2
(ja)
|
1997-02-27 |
2004-04-19 |
日本たばこ産業株式会社 |
細胞間接着及びシグナル伝達を媒介する細胞表面分子
|
US7112655B1
(en)
|
1997-02-27 |
2006-09-26 |
Japan Tobacco, Inc. |
JTT-1 protein and methods of inhibiting lymphocyte activation
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
CA2232743A1
(fr)
|
1997-04-02 |
1998-10-02 |
Smithkline Beecham Corporation |
Tl5, homologue tnf
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
JP2002504818A
(ja)
|
1997-06-06 |
2002-02-12 |
リジェネロン ファーマシューティカルズ,インコーポレイテッド |
リガンドファミリーのntn−2メンバー
|
AU7608898A
(en)
|
1997-06-06 |
1998-12-21 |
Regeneron Pharmaceuticals, Inc. |
Ntn-2 member of tnf ligand family
|
AU9376498A
(en)
|
1997-09-05 |
1999-03-22 |
University Of Washington |
Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
|
EA200000311A1
(ru)
|
1997-09-12 |
2000-10-30 |
Апотек Р Энд Д Са |
Новый белок иммунной системы - кау
|
DE19821060A1
(de)
|
1997-09-23 |
1999-04-15 |
Bundesrepublik Deutschland Let |
Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
|
ES2279585T3
(es)
|
1997-09-23 |
2007-08-16 |
Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts |
Polipeptido coestimulante de celulas t, anticuerpos monoclonales, su preparacion y su uso.
|
AU2212299A
(en)
|
1998-01-05 |
1999-07-26 |
Genentech Inc. |
Compositions and methods for the treatment of tumor
|
WO1999062951A1
(fr)
|
1998-06-04 |
1999-12-09 |
Shanghai Second Medical University |
Gene humain de proteine a doigts de zinc (bmzf3)
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
DE60042617D1
(de)
|
1999-01-07 |
2009-09-03 |
Zymogenetics Inc |
Verfahren zur therapeutischen Verwendung von löslichen rezeptoren BR43X2
|
EP2298332B1
(fr)
|
1999-01-25 |
2015-07-08 |
Biogen MA Inc. |
BAFF, ses inhibiteurs et leur utilisation pour moduler la réponse immunitaire des cellules B et des immunoglobulines
|
US20030095967A1
(en)
|
1999-01-25 |
2003-05-22 |
Mackay Fabienne |
BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
|
US7708993B2
(en)
|
1999-02-03 |
2010-05-04 |
Amgen Inc. |
Polypeptides involved in immune response
|
CN1309734C
(zh)
|
1999-02-03 |
2007-04-11 |
安姆根有限公司 |
与免疫应答有关的新颖多肽
|
US7435796B1
(en)
|
1999-02-03 |
2008-10-14 |
Amgen Inc. |
Antibodies which bind B7RP1
|
US8624010B1
(en)
|
1999-02-03 |
2014-01-07 |
Steven K. Yoshinaga |
Nucleic acids encoding B7RP1
|
AU2880400A
(en)
|
1999-02-12 |
2000-08-29 |
Amgen, Inc. |
Tnf-related proteins
|
BR0009323A
(pt)
|
1999-03-25 |
2002-01-08 |
Knoll Gmbh |
Anticorpos humanos que ligam a il-12 humana e métodos para a produção
|
US20030022233A1
(en)
|
1999-04-30 |
2003-01-30 |
Raymond G. Goodwin |
Methods of use of the taci/taci-l interaction
|
AU4986700A
(en)
|
1999-05-06 |
2000-11-21 |
National Jewish Medical And Research Center |
Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof
|
WO2001002440A1
(fr)
|
1999-07-02 |
2001-01-11 |
Genentech, Inc. |
Peptides de fusion comprenant un domaine ligand peptide et un domaine de multimerisation
|
JP2003516718A
(ja)
|
1999-07-29 |
2003-05-20 |
メダレックス インク |
HER2/neuに対するヒトモノクローナル抗体
|
WO2001012658A2
(fr)
|
1999-08-11 |
2001-02-22 |
Isis Innovations Limited |
Acides nucleiques, polypeptides, analyses, moyens et techniques therapeutiques
|
EP1792991A1
(fr)
|
1999-08-24 |
2007-06-06 |
Medarex, Inc. |
Anticorps humains contre CTLA-4 et leur utilisation
|
JP3871503B2
(ja)
|
1999-08-30 |
2007-01-24 |
日本たばこ産業株式会社 |
免疫性疾患治療剤
|
JP4210454B2
(ja)
|
2001-03-27 |
2009-01-21 |
日本たばこ産業株式会社 |
炎症性腸疾患治療剤
|
EP1900816A3
(fr)
|
1999-09-21 |
2008-03-26 |
Genetics Institute, LLC |
Molécules de gl50 et leurs utilisations
|
ES2290052T3
(es)
|
1999-09-21 |
2008-02-16 |
Genetics Institute, Llc |
Moleculas gl50 y usos para las mismas.
|
WO2001085782A2
(fr)
|
2000-02-11 |
2001-11-15 |
Amgen Inc. |
Recepteur de la famille tnf
|
WO2001064704A1
(fr)
|
2000-03-02 |
2001-09-07 |
Mayo Foundation For Medical Education And Research |
LA hB7-H2, NOUVELLE MOLECULE CO-STIMULANTE
|
KR101155294B1
(ko)
|
2000-06-16 |
2013-03-07 |
캠브리지 안티바디 테크놀로지 리미티드 |
면역특이적으로 BLyS에 결합하는 항체
|
US7879328B2
(en)
|
2000-06-16 |
2011-02-01 |
Human Genome Sciences, Inc. |
Antibodies that immunospecifically bind to B lymphocyte stimulator
|
GB0016633D0
(en)
|
2000-07-07 |
2000-08-23 |
Bp Exploration Operating |
Process
|
US6635750B1
(en)
|
2000-07-20 |
2003-10-21 |
Millennium Pharmaceuticals, Inc. |
B7-H2 nucleic acids, members of the B7 family
|
US20030091565A1
(en)
|
2000-08-18 |
2003-05-15 |
Beltzer James P. |
Binding polypeptides and methods based thereon
|
EP2267020A3
(fr)
|
2000-08-18 |
2011-04-20 |
Human Genome Sciences, Inc. |
Polypeptides de liaison pour la protéine stimulatrice des lymphocytes B (BLyS)
|
EP1337634A2
(fr)
|
2000-11-28 |
2003-08-27 |
Amgen Inc. |
Nouveaux polypeptides impliques dans la reponse immunitaire
|
HUP0401300A3
(en)
|
2001-01-18 |
2005-06-28 |
Merck Patent Gmbh |
Bifunctional fusion proteins with glucocerebrosidase activity
|
EP2292655B1
(fr)
|
2001-05-11 |
2012-03-14 |
Amgen SF, LLC |
Peptides et molécules associées qui sont liées à tall-1
|
AR035119A1
(es)
|
2001-08-16 |
2004-04-14 |
Lilly Co Eli |
Anticuerpos humanos antagonistas anti-htnfsf13b
|
AU2003295411A1
(en)
|
2002-11-07 |
2004-06-03 |
Celltech R & D |
Human monoclonal antibodies to heparanase
|
WO2004055056A1
(fr)
|
2002-12-17 |
2004-07-01 |
Merck Patent Gmbh |
Forme humanisee de l'anticorps de souris 14.18 (h14.18) se liant au gd2 et fusion de celle-ci avec il-2
|
EP1578782A4
(fr)
|
2002-12-30 |
2007-09-12 |
Amgen Inc |
Polytherapie a facteurs costimulants
|
US8784821B1
(en)
|
2003-05-31 |
2014-07-22 |
Amgen Research (Munich) Gmbh |
Human-anti-human cd3 binding molecules
|
US7271245B2
(en)
|
2004-02-13 |
2007-09-18 |
The Scripps Research Institute |
Methods and compositions for inhibition of metastasis
|
WO2006003999A1
(fr)
|
2004-07-05 |
2006-01-12 |
Juridical Foundation The Chemo-Sero-Therapeutic Research Institute |
Anticorps de b7rp-1 antihumain humain et son fragment d’anticorps
|
WO2006010057A2
(fr)
|
2004-07-08 |
2006-01-26 |
Amgen Inc. |
Peptides therapeutiques
|
AU2005289685B2
(en)
|
2004-09-24 |
2009-07-16 |
Amgen Inc. |
Modified Fc molecules
|
EP2397497A3
(fr)
|
2005-07-18 |
2013-11-27 |
Amgen, Inc |
Anticorps humains à neutralisation anti-B7RP1
|
KR20140053410A
(ko)
|
2005-08-19 |
2014-05-07 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
AR056806A1
(es)
|
2005-11-14 |
2007-10-24 |
Amgen Inc |
Moleculas quimericas de anticuerpo rankl- pth/ pthrp
|
CA2681728C
(fr)
*
|
2007-03-27 |
2015-12-22 |
Zymogenetics, Inc. |
Combinaison d'inhibition de blys ou d'april et immunosuppresseurs destines au traitement de maladies auto-immunes
|
CL2008002092A1
(es)
|
2007-07-20 |
2009-05-29 |
Hoffmann La Roche |
Conjugado que contiene dos o mas peptidos antifusogenicos y un anticuerpo anti-cd-4; metodo de produccion; composicion farmaceutica que lo comprende; polipeptidos antifusogenicos y uso del conjugado para tratar infecciones viricas.
|
WO2009015345A1
(fr)
|
2007-07-25 |
2009-01-29 |
Amgen Inc. |
Compositions pharmaceutiques comprenant des protéines de fusion fc
|
HUE030134T2
(en)
*
|
2007-10-16 |
2017-04-28 |
Zymogenetics Inc |
Combination of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and anti-CD20 agents for the treatment of autoimmune diseases
|
EA201500156A3
(ru)
|
2008-01-03 |
2017-09-29 |
Дзе Скриппс Рисерч Инститьют |
Доставка антител посредством модульного домена распознавания
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
EP3663318A1
(fr)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Procédé de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
|
FR2944448B1
(fr)
|
2008-12-23 |
2012-01-13 |
Adocia |
Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes.
|
AU2012258637B2
(en)
|
2011-05-24 |
2017-07-20 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
AR090626A1
(es)
|
2012-04-20 |
2014-11-26 |
Lilly Co Eli |
Anticuerpos anti-baff-anti-il-17 biespecificos
|
JOP20140087B1
(ar)
*
|
2013-03-13 |
2021-08-17 |
Amgen Inc |
بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
|
US9458246B2
(en)
|
2013-03-13 |
2016-10-04 |
Amgen Inc. |
Proteins specific for BAFF and B7RP1
|
EP2968541A4
(fr)
|
2013-03-15 |
2017-02-08 |
Zyngenia, Inc. |
Complexes multispécifiques multivalents et monovalents et leurs utilisations
|
KR20160113715A
(ko)
|
2014-01-31 |
2016-09-30 |
베링거 인겔하임 인터내셔날 게엠베하 |
신규한 항-baff 항체
|