MA38175B1 - Lactames fusionnés à un aryle et hétéroaryle - Google Patents

Lactames fusionnés à un aryle et hétéroaryle

Info

Publication number
MA38175B1
MA38175B1 MA38175A MA38175A MA38175B1 MA 38175 B1 MA38175 B1 MA 38175B1 MA 38175 A MA38175 A MA 38175A MA 38175 A MA38175 A MA 38175A MA 38175 B1 MA38175 B1 MA 38175B1
Authority
MA
Morocco
Prior art keywords
heteroaryl
aryl
compounds
salts
lactams
Prior art date
Application number
MA38175A
Other languages
English (en)
Other versions
MA38175A1 (fr
Inventor
Martin Paul Edwards
Robert Arnold Kumpf
Pei-Pei Kung
Indrawan James Mcalpine
Sacha Ninkovic
Eugene Yuanjin Rui
Scott Channing Sutton
John Howard Tatlock
Martin James Wythes
Luke Raymond Zehnder
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA38175A1 publication Critical patent/MA38175A1/fr
Publication of MA38175B1 publication Critical patent/MA38175B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Cette invention concerne des composés de formule générale (i), des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques contenant lesdits composés et sels, et des méthodes d'utilisation desdits composés, sels et compositions pour traiter une croissance cellulaire anormale, y compris le cancer. Dans la formule générale (i), r
MA38175A 2012-12-21 2013-12-05 Lactames fusionnés à un aryle et hétéroaryle MA38175B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261740596P 2012-12-21 2012-12-21
PCT/IB2013/060682 WO2014097041A1 (fr) 2012-12-21 2013-12-05 Lactames fusionnés à un aryle et hétéroaryle

Publications (2)

Publication Number Publication Date
MA38175A1 MA38175A1 (fr) 2018-08-31
MA38175B1 true MA38175B1 (fr) 2018-11-30

Family

ID=49917684

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38175A MA38175B1 (fr) 2012-12-21 2013-12-05 Lactames fusionnés à un aryle et hétéroaryle

Country Status (47)

Country Link
US (3) US9040515B2 (fr)
EP (2) EP2935238B1 (fr)
JP (1) JP5909308B2 (fr)
KR (1) KR101712441B1 (fr)
CN (1) CN104870435B (fr)
AP (1) AP2015008574A0 (fr)
AR (1) AR094174A1 (fr)
AU (1) AU2013365908C1 (fr)
BR (1) BR112015014678B1 (fr)
CA (1) CA2893339C (fr)
CL (1) CL2015001733A1 (fr)
CR (2) CR20200273A (fr)
CU (1) CU24414B1 (fr)
CY (2) CY1119883T1 (fr)
DK (2) DK2935238T3 (fr)
DO (1) DOP2015000157A (fr)
EA (1) EA028317B1 (fr)
EC (1) ECSP15031579A (fr)
ES (2) ES2808987T3 (fr)
GE (1) GEP201706718B (fr)
GT (1) GT201500190A (fr)
HK (1) HK1208866A1 (fr)
HR (2) HRP20180060T1 (fr)
HU (2) HUE050009T2 (fr)
IL (1) IL239520B (fr)
LT (2) LT3339303T (fr)
MA (1) MA38175B1 (fr)
MD (1) MD4664C9 (fr)
ME (2) ME03793B (fr)
MX (2) MX2015008058A (fr)
MY (2) MY192259A (fr)
NO (1) NO2961649T3 (fr)
NZ (1) NZ708801A (fr)
PE (1) PE20151090A1 (fr)
PH (1) PH12015501367A1 (fr)
PL (2) PL3339303T3 (fr)
PT (2) PT2935238T (fr)
RS (2) RS60582B9 (fr)
SG (1) SG11201504076XA (fr)
SI (2) SI2935238T1 (fr)
TN (1) TN2015000281A1 (fr)
TR (1) TR201802791T4 (fr)
TW (1) TWI546293B (fr)
UA (1) UA111305C2 (fr)
UY (2) UY38712A (fr)
WO (1) WO2014097041A1 (fr)
ZA (1) ZA201504437B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013075084A1 (fr) 2011-11-18 2013-05-23 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
JP5989805B2 (ja) 2012-02-10 2016-09-07 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． メチル基変更酵素の調節物質、組成物及びその使用
AR092742A1 (es) * 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
UA111305C2 (uk) 2012-12-21 2016-04-11 Пфайзер Інк. Конденсовані лактами арилу та гетероарилу
KR102327888B1 (ko) 2012-12-21 2021-11-17 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
WO2014151142A1 (fr) 2013-03-15 2014-09-25 Constellation Pharmaceuticals, Inc. Modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées
EP3033334A1 (fr) 2013-08-15 2016-06-22 Constellation Pharmaceuticals, Inc. Dérivés d'indole utilisés en tant que modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées
WO2015193768A1 (fr) * 2014-06-17 2015-12-23 Pfizer Inc. Lactames à fusion aryle à utiliser en tant que modulateurs ezh2
SG11201609386YA (en) 2014-06-17 2017-01-27 Pfizer Substituted dihydroisoquinolinone compounds
US20170334891A1 (en) * 2014-10-28 2017-11-23 Glaxosmithkline Intellectual Property (No.2) Limited Enhancer of zeste homolog 2 inhibitors
TW201636344A (zh) 2014-12-05 2016-10-16 美國禮來大藥廠 Ｅｚｈ２抑制劑
EP3236962A2 (fr) 2014-12-23 2017-11-01 University of Copenhagen Traitement du cancer par inhibition de l'activité de l'ezh2
EA033690B1 (ru) * 2015-03-27 2019-11-18 Syngenta Participations Ag Микробиоцидные гетеробициклические производные
TW201708210A (zh) * 2015-06-30 2017-03-01 葛蘭素史克智慧財產（第二）有限公司 Ｚｅｓｔｅ同源物２增強子之抑制劑
TW201718598A (zh) * 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
US10577350B2 (en) 2015-08-28 2020-03-03 Constellation Pharmaceuticals, Inc. Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
RU2727198C2 (ru) 2015-11-19 2020-07-21 Цзянсу Хэнжуй Медицин Ко., Лтд. Производное бензофурана, способ его получения и его применение в медицине
BR112018072740A2 (pt) * 2016-05-05 2019-02-19 Glaxosmithkline Intellectual Property (No. realçador de inibidores de homólogo 2 de zeste
WO2018075598A1 (fr) 2016-10-19 2018-04-26 Constellation Pharmaceuticals, Inc. Synthèse d'inhibiteurs d'ezh2
US20200262813A1 (en) * 2016-11-11 2020-08-20 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. 1,5,7-trisubstituted isoquinoline derivatives, preparation thereof, and use thereof in medicines
US10266542B2 (en) 2017-03-15 2019-04-23 Mirati Therapeutics, Inc. EZH2 inhibitors
JP7125952B2 (ja) 2017-05-18 2022-08-25 江蘇恒瑞医薬股▲ふん▼有限公司 腫瘍を治療するための薬剤の製造におけるｂｔｋ阻害剤との組み合わせでのｅｚｈ２阻害剤の使用
AU2018269268B2 (en) 2017-05-18 2022-01-06 Jiangsu Hengrui Medicine Co., Ltd. Crystal of benzofuran derivative free base and preparation method
CN106977483A (zh) * 2017-06-02 2017-07-25 遵义医学院 一种二氟烷基取代的黄酮醇、异黄酮醇和香豆素类化合物的合成方法
AU2018369841A1 (en) 2017-11-14 2020-05-07 Pfizer Inc. EZH2 inhibitor combination therapies
PL3746446T3 (pl) 2018-01-31 2022-08-29 Mirati Therapeutics, Inc. Inhibitory PRC2
CA3104209A1 (fr) 2018-07-09 2020-01-16 Fondation Asile Des Aveugles Inhibition de sous-unites de prc2 permettant de traiter des troubles oculaires
WO2020086857A1 (fr) * 2018-10-24 2020-04-30 Vanderbilt University Modulateurs et inhibiteurs de wdr5
CN111320582A (zh) * 2018-12-17 2020-06-23 江苏恩华药业股份有限公司 一种类酰胺类衍生物及其中间体的制备方法
KR20200101219A (ko) * 2019-02-19 2020-08-27 한미약품 주식회사 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도
BR112023002077A2 (pt) 2020-08-13 2023-02-28 Hanmi Pharmaceutical Co Ltd Composto e seu uso, composição e formulação farmacêutica
KR102386403B1 (ko) * 2020-08-13 2022-04-15 한미약품 주식회사 신규한 디옥솔로이소퀴놀린온 유도체 화합물 및 이의 용도
WO2022179584A1 (fr) * 2021-02-26 2022-09-01 南京药石科技股份有限公司 Nouvel inhibiteur d'ezh2 et son utilisation

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846412A (en) 1971-03-18 1974-11-05 Lepetit Spa Dihydro-2-amino-isoquinolines and their derivatives
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (fr) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing-gum contenant des agents medicamenteux actifs
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
US20070093515A1 (en) 2005-08-16 2007-04-26 Arrington Mark P Phosphodiesterase 10 inhibitors
US20100113415A1 (en) 2008-05-29 2010-05-06 Rajapakse Hemaka A Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
WO2011103016A2 (fr) 2010-02-19 2011-08-25 The Regents Of The University Of Michigan Compositions et méthodes d'inhibition d'ezh2
EP2566328B1 (fr) 2010-05-07 2015-03-04 GlaxoSmithKline LLC Indazoles
US8637509B2 (en) 2010-05-07 2014-01-28 Glaxosmithkline Llc Azaindazoles
HUE034787T2 (en) 2010-05-07 2018-02-28 Glaxosmithkline Llc Indole derivatives and pharmaceutical compositions containing them
HUE028977T2 (en) 2010-09-10 2017-02-28 Epizyme Inc A method for determining the suitability of human EZH2 inhibitors during treatment
WO2012035078A1 (fr) 2010-09-16 2012-03-22 Novartis Ag Inhibiteurs de la 17α-hydroxylase/c17,20-lyase
US20130310379A1 (en) 2010-11-19 2013-11-21 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
WO2012118812A2 (fr) * 2011-02-28 2012-09-07 Epizyme, Inc. Composés hétéroaryles bicycliques substitués condensés en 6,5
TW201733984A (zh) * 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
WO2013049770A2 (fr) 2011-09-30 2013-04-04 Glaxosmithkline Llc Méthodes de traitement du cancer
WO2013173441A2 (fr) 2012-05-16 2013-11-21 Glaxosmithkline Llc Inhibiteurs d'homologue d'activateur de zeste 2
WO2014049488A1 (fr) 2012-09-28 2014-04-03 Pfizer Inc. Composés de benzamide et hétérobenzamide
EA026687B1 (ru) 2012-12-21 2017-05-31 Ф. Хоффманн-Ля Рош Аг Пептиды в качестве агонистов окситоцина
EP2935248B1 (fr) 2012-12-21 2018-02-28 Plexxikon Inc. Composés et procédés pour la modulation de kinase, et indications associées
KR102327888B1 (ko) 2012-12-21 2021-11-17 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
FR3000059A1 (fr) 2012-12-21 2014-06-27 Saint Gobain Placo Composition pour plaques de platre et produits obtenus
RS54873B1 (sr) 2012-12-21 2016-10-31 Gilead Sciences Policiklična-karbamoilpiridonska jedinjenja i njihova farmaceutska upotreba
JP6678455B2 (ja) 2012-12-21 2020-04-08 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
AR094181A1 (es) 2012-12-21 2015-07-15 Sanofi Sa Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon
FR3000065A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
UA111305C2 (uk) 2012-12-21 2016-04-11 Пфайзер Інк. Конденсовані лактами арилу та гетероарилу
US9233974B2 (en) 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds
SG11201609386YA (en) 2014-06-17 2017-01-27 Pfizer Substituted dihydroisoquinolinone compounds

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UY38712A (es) 2020-06-30
ME03793B (fr) 2021-04-20
TN2015000281A1 (fr) 2016-10-03
PH12015501367B1 (en) 2015-09-02
AU2013365908A1 (en) 2015-06-11
TWI546293B (zh) 2016-08-21
CL2015001733A1 (es) 2015-10-23
UA111305C2 (uk) 2016-04-11
CA2893339C (fr) 2017-06-13
ES2658974T3 (es) 2018-03-13
MD20150052A2 (ro) 2015-12-31
MD4664B1 (ro) 2019-12-31
IL239520A0 (en) 2015-08-31
LT3339303T (lt) 2020-09-10
CA2893339A1 (fr) 2014-06-26
PE20151090A1 (es) 2015-08-07
HRP20180060T1 (hr) 2018-02-23
MD4664C9 (ro) 2020-07-31
ES2808987T3 (es) 2021-03-02
CY1119883T1 (el) 2018-06-27
KR101712441B1 (ko) 2017-03-07
KR20150100823A (ko) 2015-09-02
CN104870435B (zh) 2016-12-07
CU20150062A7 (es) 2015-11-27
DK2935238T3 (en) 2018-01-22
MA38175A1 (fr) 2018-08-31
CR20150279A (es) 2015-09-03
NO2961649T3 (fr) 2018-02-17
ME02980B (fr) 2018-10-20
DK3339303T3 (da) 2020-08-10
EA201590879A1 (ru) 2015-12-30
RS60582B9 (sr) 2021-09-30
EP3339303A1 (fr) 2018-06-27
RS56815B1 (sr) 2018-04-30
NZ708801A (en) 2018-08-31
PL2935238T3 (pl) 2018-05-30
ZA201504437B (en) 2016-07-27
US20150175572A1 (en) 2015-06-25
PH12015501367A1 (en) 2015-09-02
AU2013365908B2 (en) 2017-07-20
PT2935238T (pt) 2018-02-09
SG11201504076XA (en) 2015-06-29
CU24414B1 (es) 2019-05-03
TR201802791T4 (tr) 2018-03-21
AU2013365908C1 (en) 2018-01-25
US10246433B2 (en) 2019-04-02
CN104870435A (zh) 2015-08-26
AP2015008574A0 (en) 2015-07-31
AR094174A1 (es) 2015-07-15
JP5909308B2 (ja) 2016-04-26
EA028317B1 (ru) 2017-11-30
HUE038238T2 (hu) 2018-10-29
TW201446753A (zh) 2014-12-16
GT201500190A (es) 2016-01-21
EP3339303B9 (fr) 2021-07-21
MY192259A (en) 2022-08-12
MY176307A (en) 2020-07-28
EP3339303B1 (fr) 2020-06-24
US9040515B2 (en) 2015-05-26
RS60582B1 (sr) 2020-08-31
PT3339303T (pt) 2020-07-30
GEP201706718B (en) 2017-08-10
LT2935238T (lt) 2018-02-26
US20170233368A1 (en) 2017-08-17
HUE050009T2 (hu) 2020-11-30
ECSP15031579A (es) 2017-08-31
ES2808987T9 (es) 2021-11-29
SI3339303T1 (sl) 2020-09-30
WO2014097041A1 (fr) 2014-06-26
JP2016507497A (ja) 2016-03-10
HRP20201194T1 (hr) 2020-11-13
MX2020002924A (es) 2020-07-22
IL239520B (en) 2018-05-31
HRP20201194T2 (hr) 2021-09-17
SI2935238T1 (en) 2018-04-30
UY35225A (es) 2014-07-31
EP2935238A1 (fr) 2015-10-28
EP2935238B1 (fr) 2017-12-27
PL3339303T3 (pl) 2021-01-25
DOP2015000157A (es) 2015-11-30
CR20200273A (es) 2020-09-23
MX2015008058A (es) 2015-10-30
US20140179667A1 (en) 2014-06-26
CY1123237T1 (el) 2021-10-29
BR112015014678A2 (pt) 2017-07-11
BR112015014678B1 (pt) 2021-12-07
HK1208866A1 (en) 2016-03-18

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