MA34517B1 - Promédicaments comprenant un conjugué exendine-lieur - Google Patents
Promédicaments comprenant un conjugué exendine-lieurInfo
- Publication number
- MA34517B1 MA34517B1 MA35722A MA35722A MA34517B1 MA 34517 B1 MA34517 B1 MA 34517B1 MA 35722 A MA35722 A MA 35722A MA 35722 A MA35722 A MA 35722A MA 34517 B1 MA34517 B1 MA 34517B1
- Authority
- MA
- Morocco
- Prior art keywords
- fragment
- conjugate
- prodrugs
- relief
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
CETTE INVENTION CONCERNE UN PROMÉDICAMENT OU UN SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI COMPRENANT UN CONJUGUÉ EXENDINE-LIEUR D-L, D REPRÉSENTANT UN FRAGMENT D'EXENDINE ; ET -L, UN FRAGMENT LIEUR BIOLOGIQUEMENT NON ACTIF -L1 REPRÉSENTÉ PAR LA FORMULE (I). DANS LA FORMULE (I), LA LIGNE EN POINTILLÉS INDIQUE LA LIAISON À L'UN DES GROUPES AMINÉS DU FRAGMENT EXENDINE PAR FORMATION D'UNE LIAISON AMIDE. CETTE INVENTION CONCERNE, EN OUTRE, DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT LESDITS PROMÉDICAMENTS AINSI QUE LEUR UTILISATION EN TANT QUE MÉDICAMENT POUR TRAITER OU PRÉVENIR LES MALADIES OU LES TROUBLES QUI PEUVENT ÊTRE TRAITÉS PAR L'EXENDINE
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10177327A EP2438930A1 (fr) | 2010-09-17 | 2010-09-17 | Promédicaments comprenant un conjugué de liaison d'exendine |
PCT/EP2011/066097 WO2012035139A1 (fr) | 2010-09-17 | 2011-09-16 | Promédicaments comprenant un conjugué exendine-lieur |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34517B1 true MA34517B1 (fr) | 2013-09-02 |
Family
ID=43446651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35722A MA34517B1 (fr) | 2010-09-17 | 2011-09-16 | Promédicaments comprenant un conjugué exendine-lieur |
Country Status (29)
Country | Link |
---|---|
US (1) | US9133276B2 (fr) |
EP (2) | EP2438930A1 (fr) |
JP (1) | JP5932796B2 (fr) |
KR (1) | KR20130106820A (fr) |
CN (1) | CN103237561B (fr) |
AR (1) | AR082995A1 (fr) |
AU (1) | AU2011303823B2 (fr) |
BR (1) | BR112013006340A2 (fr) |
CA (1) | CA2811352C (fr) |
CL (1) | CL2013000716A1 (fr) |
CO (1) | CO6690765A2 (fr) |
CY (1) | CY1122226T1 (fr) |
DK (1) | DK2616102T3 (fr) |
ES (1) | ES2733734T3 (fr) |
HR (1) | HRP20191128T1 (fr) |
HU (1) | HUE044079T2 (fr) |
IL (1) | IL225127A (fr) |
LT (1) | LT2616102T (fr) |
MA (1) | MA34517B1 (fr) |
MX (1) | MX348983B (fr) |
MY (1) | MY158974A (fr) |
NZ (1) | NZ608387A (fr) |
PL (1) | PL2616102T3 (fr) |
PT (1) | PT2616102T (fr) |
RU (1) | RU2593774C2 (fr) |
SG (1) | SG188197A1 (fr) |
SI (1) | SI2616102T1 (fr) |
UY (1) | UY33605A (fr) |
WO (1) | WO2012035139A1 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2087910B1 (fr) * | 2004-03-23 | 2022-05-04 | Ascendis Pharma GmbH | Promédicaments polymères |
CA2712224C (fr) * | 2008-02-01 | 2016-03-08 | Ascendis Pharma As | Promedicament comprenant un conjugue medicament-lieur |
ES2833035T3 (es) * | 2009-07-31 | 2021-06-14 | Ascendis Pharma As | Hidrogeles biodegradables insolubles en agua a base de polietilenglicol |
CA2769340C (fr) | 2009-07-31 | 2018-09-11 | Harald Rau | Promedicaments contenant un conjugue associant une sequence de liaison et de l'insuline |
AU2010277560B2 (en) | 2009-07-31 | 2014-12-11 | Sanofi-Aventis Deutschland Gmbh | Long acting insulin composition |
EP2438930A1 (fr) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
CN104010626A (zh) * | 2011-10-12 | 2014-08-27 | 阿森迪斯药物眼科部股份有限公司 | 眼病症的预防和治疗 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
WO2014096150A1 (fr) | 2012-12-21 | 2014-06-26 | Sanofi | Agonistes du glp1/gip double ou du glp1/gip/glucagon trigonal |
US10626156B2 (en) | 2013-12-06 | 2020-04-21 | Jie Han | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
EP3080154B1 (fr) | 2013-12-13 | 2018-02-07 | Sanofi | Agonistes doubles du récepteur glp-1/gip |
EP3080152A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Analogues peptidiques de l'exendine 4 non acylés |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
CN104945499B (zh) * | 2014-03-31 | 2019-12-10 | 博瑞生物医药(苏州)股份有限公司 | 结构修饰的glp-1类似物及其制备方法 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
AR105319A1 (es) * | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
CN106554403B (zh) * | 2015-09-25 | 2021-08-31 | 博瑞生物医药(苏州)股份有限公司 | 艾塞那肽修饰物及其用途 |
KR20230015517A (ko) | 2016-03-01 | 2023-01-31 | 아센디스 파마 본 디지즈 에이/에스 | Pth 프로드럭 |
SI3518960T1 (sl) | 2016-09-29 | 2023-11-30 | Ascendis Pharma Bone Diseases A/S, | Odmerni režim za PTH spojino z nadzorovanim sproščanjem |
CA3037447A1 (fr) | 2016-09-29 | 2018-04-05 | Ascendis Pharma Bone Diseases A/S | Composes de pth ayant un faible rapport entre le pic et le niveau minimum |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
EP3335695B1 (fr) * | 2016-12-15 | 2020-02-05 | UPM-Kymmene Corporation | Procédé de lyophilisation d'hydrogel comprenant de la cellulose nanofibrillaire, hydrogel therapeutique lyophilisé comprenant de la cellulose nanofibrillaire, et hydrogel comprenant de la cellulose nanofibrillaire |
TWI762706B (zh) | 2017-08-24 | 2022-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
UY38249A (es) | 2018-05-30 | 2019-12-31 | Sanofi Sa | Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico |
WO2020061244A2 (fr) * | 2018-09-19 | 2020-03-26 | Georgia Tech Research Corporation | Promédicament activé par protéase bactérienne à auto-dosage |
IL294520A (en) | 2020-02-18 | 2022-09-01 | Novo Nordisk As | Pharmaceutical formulations |
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-
2010
- 2010-09-17 EP EP10177327A patent/EP2438930A1/fr not_active Ceased
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2011
- 2011-09-15 AR ARP110103361A patent/AR082995A1/es unknown
- 2011-09-15 UY UY0001033605A patent/UY33605A/es not_active Application Discontinuation
- 2011-09-16 KR KR1020137006762A patent/KR20130106820A/ko not_active Application Discontinuation
- 2011-09-16 BR BR112013006340-8A patent/BR112013006340A2/pt not_active Application Discontinuation
- 2011-09-16 NZ NZ60838711A patent/NZ608387A/en not_active IP Right Cessation
- 2011-09-16 CN CN201180055486.3A patent/CN103237561B/zh not_active Expired - Fee Related
- 2011-09-16 AU AU2011303823A patent/AU2011303823B2/en not_active Ceased
- 2011-09-16 HU HUE11757861A patent/HUE044079T2/hu unknown
- 2011-09-16 US US13/822,170 patent/US9133276B2/en not_active Expired - Fee Related
- 2011-09-16 SG SG2013009881A patent/SG188197A1/en unknown
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- 2011-09-16 DK DK11757861.7T patent/DK2616102T3/da active
- 2011-09-16 EP EP11757861.7A patent/EP2616102B1/fr active Active
- 2011-09-16 PL PL11757861T patent/PL2616102T3/pl unknown
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- 2011-09-16 SI SI201131744T patent/SI2616102T1/sl unknown
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- 2011-09-16 JP JP2013528685A patent/JP5932796B2/ja not_active Expired - Fee Related
- 2011-09-16 CA CA2811352A patent/CA2811352C/fr not_active Expired - Fee Related
- 2011-09-16 WO PCT/EP2011/066097 patent/WO2012035139A1/fr active Application Filing
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