MA33765B1 - Nouvelles formes polymorphes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle - Google Patents

Nouvelles formes polymorphes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle

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Publication number
MA33765B1
MA33765B1 MA34894A MA34894A MA33765B1 MA 33765 B1 MA33765 B1 MA 33765B1 MA 34894 A MA34894 A MA 34894A MA 34894 A MA34894 A MA 34894A MA 33765 B1 MA33765 B1 MA 33765B1
Authority
MA
Morocco
Prior art keywords
fluorobenzyl
pyrazolo
pyrimidin
diamino
pyridin
Prior art date
Application number
MA34894A
Other languages
Arabic (ar)
English (en)
Inventor
Alfons Grunenberg
Franz-Josef Mais
Winfried Joentgen
Birgit Keil
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA33765B1 publication Critical patent/MA33765B1/fr

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne de nouvelles formes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle de formule (i), en particulier la modification i, un procédé permettant de les fabriquer, des médicaments les contenant ainsi que leur utilisation pour la lutte contre les maladies.
MA34894A 2009-11-27 2012-05-25 Nouvelles formes polymorphes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle MA33765B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09177373 2009-11-27
EP09177908 2009-12-03
PCT/EP2010/067985 WO2011064189A1 (fr) 2009-11-27 2010-11-23 Nouvelles formes polymorphes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle

Publications (1)

Publication Number Publication Date
MA33765B1 true MA33765B1 (fr) 2012-11-01

Family

ID=43530231

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34894A MA33765B1 (fr) 2009-11-27 2012-05-25 Nouvelles formes polymorphes de {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate de méthyle

Country Status (21)

Country Link
US (1) US20110183999A1 (fr)
EP (1) EP2504337A1 (fr)
JP (1) JP2013512213A (fr)
KR (1) KR20120098816A (fr)
CN (1) CN102741246A (fr)
AR (1) AR079136A1 (fr)
AU (1) AU2010323245A1 (fr)
BR (1) BR112012012458A2 (fr)
CA (1) CA2781808A1 (fr)
CO (1) CO6541577A2 (fr)
CU (1) CU20120081A7 (fr)
DO (1) DOP2012000142A (fr)
EA (1) EA201270629A1 (fr)
EC (1) ECSP12011923A (fr)
IL (1) IL219826A0 (fr)
MA (1) MA33765B1 (fr)
MX (1) MX2012005944A (fr)
TN (1) TN2012000258A1 (fr)
TW (1) TW201139433A (fr)
UY (1) UY33040A (fr)
WO (1) WO2011064189A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2504334E (pt) 2009-11-27 2014-12-03 Bayer Ip Gmbh Processo para a purificação de metil-{4,6-diamino-2-[1-(2- fluorobenzil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5- il}metilcarbamato
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
RS55387B1 (sr) * 2011-11-25 2017-03-31 Adverio Pharma Gmbh Postupak za dobijanje supstituisanih (z)-alfa-fluoro-beta-amino-akrilaldehida
MX2015010725A (es) 2013-02-21 2016-05-31 Adverio Pharma Gmbh Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.
CN104327107A (zh) 2013-10-17 2015-02-04 广东东阳光药业有限公司 一种氟喹诺酮类抗菌药物的制备方法
WO2019078233A1 (fr) * 2017-10-19 2019-04-25 株式会社佐藤園 Composition pour améliorer les capacités d'apprentissage et de mémoire

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834047A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
US6452805B1 (en) * 1999-09-29 2002-09-17 Silicon Graphics, Inc. Computer module mounting system and method
DE10220570A1 (de) * 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
US7137037B2 (en) * 2003-03-27 2006-11-14 Silicon Motion, Inc. Data storage system and method for testing the same
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung

Also Published As

Publication number Publication date
US20110183999A1 (en) 2011-07-28
IL219826A0 (en) 2012-07-31
EA201270629A1 (ru) 2013-01-30
EP2504337A1 (fr) 2012-10-03
CO6541577A2 (es) 2012-10-16
UY33040A (es) 2011-06-30
DOP2012000142A (es) 2013-01-15
AU2010323245A1 (en) 2012-06-14
TW201139433A (en) 2011-11-16
ECSP12011923A (es) 2012-07-31
WO2011064189A1 (fr) 2011-06-03
MX2012005944A (es) 2012-10-03
CU20120081A7 (es) 2012-10-15
TN2012000258A1 (en) 2013-12-12
JP2013512213A (ja) 2013-04-11
KR20120098816A (ko) 2012-09-05
AR079136A1 (es) 2011-12-28
CA2781808A1 (fr) 2011-06-03
BR112012012458A2 (pt) 2017-10-10
CN102741246A (zh) 2012-10-17

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