MA31801B1 - Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase - Google Patents
Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturaseInfo
- Publication number
- MA31801B1 MA31801B1 MA32807A MA32807A MA31801B1 MA 31801 B1 MA31801 B1 MA 31801B1 MA 32807 A MA32807 A MA 32807A MA 32807 A MA32807 A MA 32807A MA 31801 B1 MA31801 B1 MA 31801B1
- Authority
- MA
- Morocco
- Prior art keywords
- stearoyl
- inhibitors
- triazole derivatives
- coa desaturase
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
La présente invention porte sur des composés substitués du triazole représentés par la formule (i) et sur des sels pharmaceutiquement acceptables de ceux-ci, sur des compositions pharmaceutiques les contenant et sur leur utilisation en médecine. En particulier, l'invention porte sur des composés pour moduler l'activité de la scd.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0722077.5A GB0722077D0 (en) | 2007-11-09 | 2007-11-09 | Compounds |
PCT/EP2008/065104 WO2009060053A1 (fr) | 2007-11-09 | 2008-11-07 | Dérivés de 1,2,3-triazole destinés à être utilisés comme inhibiteurs de la stéaroyl-coa désaturase |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31801B1 true MA31801B1 (fr) | 2010-10-01 |
Family
ID=38858481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32807A MA31801B1 (fr) | 2007-11-09 | 2010-04-30 | Derives de 1,2,3-triazole destines a etre utilises comme inhibiteurs de la stearoyl-coa desaturase |
Country Status (32)
Country | Link |
---|---|
US (2) | US8486977B2 (fr) |
EP (2) | EP2368887B8 (fr) |
JP (1) | JP5491407B2 (fr) |
KR (1) | KR101577080B1 (fr) |
CN (1) | CN101918376B (fr) |
AT (1) | ATE512140T1 (fr) |
AU (1) | AU2008324172B2 (fr) |
BR (1) | BRPI0820471A2 (fr) |
CA (1) | CA2705113C (fr) |
CO (1) | CO6270331A2 (fr) |
CR (1) | CR11482A (fr) |
CY (2) | CY1112233T1 (fr) |
DK (2) | DK2207770T3 (fr) |
DO (1) | DOP2010000137A (fr) |
EA (1) | EA016621B1 (fr) |
ES (2) | ES2457521T3 (fr) |
GB (1) | GB0722077D0 (fr) |
HK (2) | HK1141528A1 (fr) |
HR (2) | HRP20110552T1 (fr) |
IL (1) | IL205152A (fr) |
MA (1) | MA31801B1 (fr) |
ME (1) | ME01962B (fr) |
MX (1) | MX2010005187A (fr) |
MY (1) | MY163126A (fr) |
NZ (1) | NZ584725A (fr) |
PL (2) | PL2207770T3 (fr) |
PT (2) | PT2207770E (fr) |
RS (2) | RS51918B (fr) |
SI (2) | SI2207770T1 (fr) |
UA (1) | UA107324C2 (fr) |
WO (1) | WO2009060053A1 (fr) |
ZA (1) | ZA201002596B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0722077D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
GB0722075D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
CN102159605B (zh) * | 2008-09-15 | 2014-01-08 | 大金工业株式会社 | 水性聚合物分散组合物和表面处理剂 |
KR20110082145A (ko) * | 2008-10-21 | 2011-07-18 | 메타볼렉스, 인코포레이티드 | 아릴 gpr120 수용체 작동약 및 이의 용도 |
FR2974089B1 (fr) | 2011-04-18 | 2014-04-25 | Univ Nice Sophia Antipolis | Derives de l'acadesine, produits et compositions les comprenant, leurs utilisations therapeutiques et leurs procedes de synthese. |
WO2013134546A1 (fr) | 2012-03-07 | 2013-09-12 | Mayo Foundation For Medical Education And Research | Procédés et matériaux pour traiter le cancer |
ES2605632T3 (es) * | 2012-09-17 | 2017-03-15 | F. Hoffmann-La Roche Ag | Derivados triazol carboxamida |
IL227890A0 (en) * | 2013-08-08 | 2014-01-30 | Galderm Therapeutics Ltd | Antiaging compounds containing bile acid and fatty acid conjugates |
CN107406420B (zh) | 2015-01-30 | 2020-11-06 | 纽罗克里生物科学有限公司 | 取代的***及与其相关的方法 |
KR20180036318A (ko) * | 2016-09-30 | 2018-04-09 | 경북대학교 산학협력단 | 2-아미노-2-(1-도데실-1h-1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체를 유효성분으로 포함하는 퇴행성 신경질환 및 우울증 예방 또는 치료용 약학적 조성물 |
WO2018081167A1 (fr) | 2016-10-24 | 2018-05-03 | Yumanity Therapeutics | Composés et utilisations de ces derniers |
EA201991650A1 (ru) * | 2017-01-06 | 2020-01-20 | Юманити Терапьютикс, Инк. | Способы лечения неврологических расстройств |
KR102292989B1 (ko) * | 2017-03-29 | 2021-08-26 | 재단법인 아산사회복지재단 | S1pr4를 타겟으로 하는 비알코올성 지방간염 예방 또는 치료용 조성물 |
EP3700934A4 (fr) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | Composés et utilisations de ces composés |
JP2021522253A (ja) | 2018-04-25 | 2021-08-30 | ユマニティ セラピューティクス,インコーポレーテッド | 化合物及びその使用 |
KR102017324B1 (ko) * | 2018-04-30 | 2019-09-02 | 경북대학교 산학협력단 | 신규한 asm 활성 직접 억제 화합물 2-아미노-2-(1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체 및 이의 용도 |
CN114656414B (zh) * | 2022-05-24 | 2022-08-23 | 常熟华虞环境科技有限公司 | 三氮唑改性二氧化钛光催化剂及其制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4722941A (en) | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
US20070087363A1 (en) | 1998-12-22 | 2007-04-19 | Myriad Genetics, Incorporated | Therapeutic methods, compounds and compositions |
AU2001247228B2 (en) | 2000-02-24 | 2007-01-18 | Wisconsin Alumni Research Foundation | Stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents |
EP1322767B1 (fr) | 2000-09-26 | 2008-07-23 | Xenon Pharmaceuticals Inc. | Techniques et compositions utilisant une nouvelle stearyle-coa desaturase hscd5 |
PE20040600A1 (es) * | 2002-04-26 | 2004-09-15 | Lilly Co Eli | Derivados de triazol como antagonistas del receptor de taquicinina |
US20060160794A1 (en) * | 2003-06-12 | 2006-07-20 | Amegadzie Albert K | Tachykinin receptor antagonists |
BRPI0412343A (pt) | 2003-07-30 | 2006-09-05 | Xenon Pharmaceuticals Inc | derivados de piridazina e seu uso como agentes terapêuticos |
CN101693697A (zh) * | 2003-07-30 | 2010-04-14 | 泽农医药公司 | 哌嗪衍生物和它们作为治疗剂的用途 |
WO2007046868A2 (fr) | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Derives de thiazolidine et leurs utilisations en tant qu’agents therapeutiques |
WO2007046867A2 (fr) | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Derives de piperidine et leurs utilisations comme agents therapeutiques |
WO2008073461A2 (fr) | 2006-12-11 | 2008-06-19 | Wyeth | Modulateurs de canaux ioniques |
GB0625654D0 (en) | 2006-12-21 | 2007-01-31 | Smithkline Beecham Corp | Compounds |
GB0625605D0 (en) | 2006-12-21 | 2007-01-31 | Smithkline Beecham Corp | Compounds |
GB0625604D0 (en) | 2006-12-21 | 2007-01-31 | Smithkline Beecham Corp | Compounds |
EP2125799A1 (fr) | 2007-02-28 | 2009-12-02 | Smithkline Beecham Corporation | Dérivés de thiadiazole, inhibiteurs de stéoryl-coa désaturase |
JP2010526850A (ja) * | 2007-05-15 | 2010-08-05 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤として有用な、新規な芳香族複素環式カルボン酸アミド誘導体 |
GB0714129D0 (en) | 2007-07-19 | 2007-08-29 | Smithkline Beecham Corp | compounds |
GB0715055D0 (en) | 2007-08-02 | 2007-09-12 | Smithkline Beecham Corp | Compounds |
GB0721419D0 (en) | 2007-10-31 | 2007-12-12 | Smithkline Beecham Corp | Compounds |
GB0722075D0 (en) | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
GB0722077D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
GB0810913D0 (en) | 2008-06-13 | 2008-07-23 | Smithkline Beecham Corp | Comppounds |
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2007
- 2007-11-09 GB GBGB0722077.5A patent/GB0722077D0/en not_active Ceased
-
2008
- 2008-07-11 UA UAA201007152A patent/UA107324C2/ru unknown
- 2008-11-07 JP JP2010532598A patent/JP5491407B2/ja not_active Expired - Fee Related
- 2008-11-07 ME MEP-2011-369A patent/ME01962B/fr unknown
- 2008-11-07 PL PL08846247T patent/PL2207770T3/pl unknown
- 2008-11-07 MX MX2010005187A patent/MX2010005187A/es active IP Right Grant
- 2008-11-07 ES ES11168642.4T patent/ES2457521T3/es active Active
- 2008-11-07 ES ES08846247T patent/ES2366422T3/es active Active
- 2008-11-07 BR BRPI0820471-3A patent/BRPI0820471A2/pt not_active Application Discontinuation
- 2008-11-07 AT AT08846247T patent/ATE512140T1/de active
- 2008-11-07 KR KR1020107012597A patent/KR101577080B1/ko active IP Right Grant
- 2008-11-07 MY MYPI2010002145A patent/MY163126A/en unknown
- 2008-11-07 PT PT08846247T patent/PT2207770E/pt unknown
- 2008-11-07 AU AU2008324172A patent/AU2008324172B2/en not_active Ceased
- 2008-11-07 SI SI200830349T patent/SI2207770T1/sl unknown
- 2008-11-07 CA CA2705113A patent/CA2705113C/fr not_active Expired - Fee Related
- 2008-11-07 US US12/741,637 patent/US8486977B2/en not_active Expired - Fee Related
- 2008-11-07 EP EP11168642.4A patent/EP2368887B8/fr active Active
- 2008-11-07 DK DK08846247.8T patent/DK2207770T3/da active
- 2008-11-07 EA EA201070588A patent/EA016621B1/ru not_active IP Right Cessation
- 2008-11-07 RS RS20110369A patent/RS51918B/en unknown
- 2008-11-07 CN CN2008801245066A patent/CN101918376B/zh not_active Expired - Fee Related
- 2008-11-07 PL PL11168642T patent/PL2368887T3/pl unknown
- 2008-11-07 SI SI200831183T patent/SI2368887T1/sl unknown
- 2008-11-07 PT PT111686424T patent/PT2368887E/pt unknown
- 2008-11-07 DK DK11168642.4T patent/DK2368887T3/da active
- 2008-11-07 WO PCT/EP2008/065104 patent/WO2009060053A1/fr active Application Filing
- 2008-11-07 NZ NZ584725A patent/NZ584725A/en not_active IP Right Cessation
- 2008-11-07 EP EP08846247A patent/EP2207770B1/fr active Active
- 2008-11-07 RS RS20140219A patent/RS53294B/en unknown
-
2010
- 2010-04-14 ZA ZA2010/02596A patent/ZA201002596B/en unknown
- 2010-04-15 IL IL205152A patent/IL205152A/en active IP Right Grant
- 2010-04-30 MA MA32807A patent/MA31801B1/fr unknown
- 2010-05-06 CO CO10054279A patent/CO6270331A2/es active IP Right Grant
- 2010-05-07 DO DO2010000137A patent/DOP2010000137A/es unknown
- 2010-06-09 CR CR11482A patent/CR11482A/es unknown
- 2010-08-20 HK HK10108014.3A patent/HK1141528A1/xx not_active IP Right Cessation
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2011
- 2011-07-25 HR HR20110552T patent/HRP20110552T1/hr unknown
- 2011-08-26 CY CY20111100816T patent/CY1112233T1/el unknown
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2012
- 2012-02-02 HK HK12100960.2A patent/HK1160467A1/xx not_active IP Right Cessation
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2013
- 2013-06-21 US US13/923,420 patent/US9051281B2/en not_active Expired - Fee Related
-
2014
- 2014-04-11 HR HRP20140346AT patent/HRP20140346T1/hr unknown
- 2014-05-09 CY CY20141100328T patent/CY1115058T1/el unknown
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