LV5483A3 - Izohinolinija atvasinajumu iegusanas panemiens - Google Patents

Izohinolinija atvasinajumu iegusanas panemiens

Info

Publication number
LV5483A3
LV5483A3 LV930178A LV930178A LV5483A3 LV 5483 A3 LV5483 A3 LV 5483A3 LV 930178 A LV930178 A LV 930178A LV 930178 A LV930178 A LV 930178A LV 5483 A3 LV5483 A3 LV 5483A3
Authority
LV
Latvia
Prior art keywords
isohinolinium
derivatives
acquisition
yield
image
Prior art date
Application number
LV930178A
Other languages
English (en)
Inventor
Roy Archibald Swaringen Jr
Hassan A El-Sayad
David Arthur Yeowell
John Joseph Savarese
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LV5483A3 publication Critical patent/LV5483A3/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Cosmetics (AREA)
LV930178A 1984-07-18 1993-03-10 Izohinolinija atvasinajumu iegusanas panemiens LV5483A3 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds
SU853926201A SU1468414A3 (ru) 1984-07-18 1985-07-17 Способ получени производных изохинолини

Publications (1)

Publication Number Publication Date
LV5483A3 true LV5483A3 (lv) 1994-03-10

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
LV930178A LV5483A3 (lv) 1984-07-18 1993-03-10 Izohinolinija atvasinajumu iegusanas panemiens

Country Status (30)

Country Link
US (1) US4761418A (lv)
EP (1) EP0181055B1 (lv)
JP (1) JPH0662568B2 (lv)
AT (1) ATE60759T1 (lv)
AU (1) AU574481B2 (lv)
BG (1) BG60411B2 (lv)
CA (1) CA1273341A (lv)
CY (1) CY1687A (lv)
DD (1) DD235638A5 (lv)
DE (2) DE3581699D1 (lv)
DK (1) DK168093B1 (lv)
ES (1) ES8609260A1 (lv)
FI (1) FI85019C (lv)
GB (1) GB8418303D0 (lv)
GE (1) GEP19960468B (lv)
HK (1) HK47593A (lv)
HU (1) HU193996B (lv)
IE (1) IE58138B1 (lv)
IL (1) IL75833A (lv)
LT (1) LT2078B (lv)
LU (1) LU88801I2 (lv)
LV (1) LV5483A3 (lv)
MC (1) MC1690A1 (lv)
MX (1) MX9203667A (lv)
NL (1) NL940023I2 (lv)
NZ (1) NZ212766A (lv)
PL (1) PL146066B1 (lv)
SG (1) SG3493G (lv)
SU (1) SU1468414A3 (lv)
ZA (1) ZA855407B (lv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
ATE254107T1 (de) * 1997-03-25 2003-11-15 Avera Pharmaceuticals Inc Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
US8148398B2 (en) * 2006-12-06 2012-04-03 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
EP2867219B1 (en) 2012-06-29 2017-02-15 Cornell University Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
SE7808267L (sv) 1977-08-01 1979-02-02 Massachusetts Gen Hospital Neuromuskulert blockeringsmedel
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
JPH0662568B2 (ja) 1994-08-17
SU1468414A3 (ru) 1989-03-23
US4761418A (en) 1988-08-02
AU574481B2 (en) 1988-07-07
SG3493G (en) 1993-03-12
PL146066B1 (en) 1988-12-31
ZA855407B (en) 1986-04-30
BG60411B2 (bg) 1995-02-28
EP0181055B1 (en) 1991-02-06
DK168093B1 (da) 1994-02-07
IE851791L (en) 1986-01-18
ATE60759T1 (de) 1991-02-15
FI852807L (fi) 1986-01-19
CA1273341A (en) 1990-08-28
GEP19960468B (en) 1996-08-29
HU193996B (en) 1987-12-28
NZ212766A (en) 1988-03-30
DD235638A5 (de) 1986-05-14
DK324985D0 (da) 1985-07-17
ES8609260A1 (es) 1986-09-01
HUT40626A (en) 1987-01-28
DE3581699D1 (de) 1991-03-14
JPS6187666A (ja) 1986-05-06
GB8418303D0 (en) 1984-08-22
FI85019B (fi) 1991-11-15
IE58138B1 (en) 1993-07-14
LU88801I2 (fr) 1996-11-05
FI852807A0 (fi) 1985-07-17
HK47593A (en) 1993-05-21
NL940023I2 (nl) 1998-06-02
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
LT2078B (lt) 1993-06-15
IL75833A0 (en) 1985-11-29
MC1690A1 (fr) 1986-07-18
PL254571A1 (en) 1986-07-15
NL940023I1 (nl) 1995-01-02
EP0181055A1 (en) 1986-05-14
FI85019C (fi) 1992-02-25
DK324985A (da) 1986-01-19
MX9203667A (es) 1992-07-31
AU4510885A (en) 1986-01-23
CY1687A (en) 1993-10-10
DE19675039I2 (de) 2003-01-09

Similar Documents

Publication Publication Date Title
LV5483A3 (lv) Izohinolinija atvasinajumu iegusanas panemiens
MY102986A (en) Benzo (5,6) cycloheptapyridines, compositions and methods of use
GR3023825T3 (en) Benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
EP0176032A3 (en) Tetralin derivatives, their preparation and use
NZ208831A (en) Imidazolium derivatives and pharmaceutical compositions
DE3173954D1 (en) Use of adenosin derivatives for the manufacture of psychopharmacons
ES493269A0 (es) Procedimiento para la preparacion de nuevos derivados halo- genados de n-(3-trifluorometil-4-haloenalcoxi-fenil)n'-ben- zoilureas
GR861169B (en) Method for preparing n-(quinolyl) glycinamide derivatives and their application as psychotropes
ZA879280B (en) Basically substituted phenylacetonitriles,their preparation and drugs containing these compounds
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
ES477785A1 (es) Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas.
FI902901A0 (fi) Dibenzol/1,5/dioxocin-5-one-derivat, deras anvaendning i laekemedel och foerfarande foer deras framstaellning.
DE2966809D1 (en) 3,4-diaza-bicyclo(4.1.0)hepten-2-ones-5, process for their preparation and therapeutical compositions containing them
NO880405D0 (no) Fremgangsmaate til fremstilling av 3-fenyl-7h-tiazolo-/3,2-b//1,2,4/-tiazine-7-oner.
ES2096559T3 (es) Interferon gamma humano, procedimiento para la preparacion de dicho interferon gamma humano, y su uso.
NO903585L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
DK159184A (da) Pterinforbindelser