LU85528A1 - Aminocyclopentanes et leur procede de preparation - Google Patents
Aminocyclopentanes et leur procede de preparation Download PDFInfo
- Publication number
- LU85528A1 LU85528A1 LU85528A LU85528A LU85528A1 LU 85528 A1 LU85528 A1 LU 85528A1 LU 85528 A LU85528 A LU 85528A LU 85528 A LU85528 A LU 85528A LU 85528 A1 LU85528 A1 LU 85528A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- radical
- compound
- formula
- phenyl
- alkyl
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 183
- -1 alkylene radical Chemical class 0.000 claims description 124
- 239000002253 acid Substances 0.000 claims description 58
- 239000004305 biphenyl Substances 0.000 claims description 57
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 49
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 38
- 150000003254 radicals Chemical class 0.000 claims description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
- 235000010290 biphenyl Nutrition 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 20
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- 125000001544 thienyl group Chemical group 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 230000006870 function Effects 0.000 claims description 7
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 5
- 239000012453 solvate Substances 0.000 claims description 5
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- 125000003944 tolyl group Chemical group 0.000 claims description 4
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- 150000001408 amides Chemical class 0.000 claims description 3
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 150000003840 hydrochlorides Chemical class 0.000 claims description 3
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- 125000003545 alkoxy group Chemical group 0.000 claims description 2
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- CMSYDJVRTHCWFP-UHFFFAOYSA-N triphenylphosphane;hydrobromide Chemical compound Br.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 CMSYDJVRTHCWFP-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8323830 | 1983-09-06 | ||
| GB838323830A GB8323830D0 (en) | 1983-09-06 | 1983-09-06 | Carbocyclic compounds |
| GB848414676A GB8414676D0 (en) | 1984-06-08 | 1984-06-08 | Carbocyclic compounds |
| GB8414676 | 1984-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU85528A1 true LU85528A1 (fr) | 1985-04-29 |
Family
ID=26286823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU85528A LU85528A1 (fr) | 1983-09-06 | 1984-09-05 | Aminocyclopentanes et leur procede de preparation |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4613597A (xx) |
| KR (1) | KR850002476A (xx) |
| AU (1) | AU574711B2 (xx) |
| BE (1) | BE900502A (xx) |
| CA (1) | CA1234811A (xx) |
| CH (1) | CH662350A5 (xx) |
| DE (1) | DE3432658A1 (xx) |
| DK (1) | DK422984A (xx) |
| ES (1) | ES535674A0 (xx) |
| FI (1) | FI843469A (xx) |
| FR (1) | FR2551440B1 (xx) |
| GB (1) | GB2146023B (xx) |
| GR (1) | GR80294B (xx) |
| IL (1) | IL72862A (xx) |
| IT (1) | IT1177981B (xx) |
| LU (1) | LU85528A1 (xx) |
| NL (1) | NL8402713A (xx) |
| NO (1) | NO843529L (xx) |
| NZ (1) | NZ209447A (xx) |
| PT (1) | PT79175B (xx) |
| SE (1) | SE8404456L (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ212108A (en) * | 1984-05-18 | 1988-10-28 | Glaxo Group Ltd | Aminocyclopentyl ethers and pharmaceutical compositions |
| GB2165535A (en) * | 1984-09-05 | 1986-04-16 | Glaxo Group Ltd | Carbocyclic compounds |
| GB2165235A (en) * | 1984-09-05 | 1986-04-09 | Glaxo Group Ltd | Carbocyclic compounds |
| GB8625326D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Medicaments |
| US5039673A (en) * | 1987-06-22 | 1991-08-13 | Glaxo Group Limited | Aminocyclopentyl ethers and their preparation and pharmaceutical formulation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265891A (en) * | 1978-07-11 | 1981-05-05 | Glaxo Group Limited | Prostanoid compounds and compositions |
| GB2028805B (en) * | 1978-07-11 | 1982-11-03 | Glaxo Group Ltd | Prostanoid compounds |
| IL62734A (en) * | 1980-04-30 | 1985-10-31 | Glaxo Group Ltd | Aminocyclopentane alkenoic acids and esters,their preparation and pharmaceutical formulations |
| GB2079281B (en) * | 1980-07-04 | 1984-04-18 | Glaxo Group Ltd | Aminocyclopentanone amides and their preparation and pharmaceutical formulation |
| JPS57183772A (en) * | 1981-04-29 | 1982-11-12 | Glaxo Group Ltd | Aminocyclopentanol acids and esters, manufacture and medicinal composition |
| IL67041A (en) * | 1981-10-29 | 1988-03-31 | Glaxo Group Ltd | 2-aminocyclopentane alkanoic and alkenoic acid esters,process for their preparation and pharmaceutical compositions containing them |
-
1984
- 1984-09-05 IT IT48800/84A patent/IT1177981B/it active
- 1984-09-05 NZ NZ209447A patent/NZ209447A/xx unknown
- 1984-09-05 KR KR1019840005434A patent/KR850002476A/ko not_active Application Discontinuation
- 1984-09-05 LU LU85528A patent/LU85528A1/fr unknown
- 1984-09-05 NO NO843529A patent/NO843529L/no unknown
- 1984-09-05 DE DE19843432658 patent/DE3432658A1/de not_active Withdrawn
- 1984-09-05 FI FI843469A patent/FI843469A/fi not_active Application Discontinuation
- 1984-09-05 ES ES535674A patent/ES535674A0/es active Granted
- 1984-09-05 IL IL72862A patent/IL72862A/xx unknown
- 1984-09-05 AU AU32753/84A patent/AU574711B2/en not_active Ceased
- 1984-09-05 DK DK422984A patent/DK422984A/da not_active Application Discontinuation
- 1984-09-05 SE SE8404456A patent/SE8404456L/xx not_active Application Discontinuation
- 1984-09-05 US US06/647,537 patent/US4613597A/en not_active Expired - Fee Related
- 1984-09-05 CH CH4237/84A patent/CH662350A5/fr not_active IP Right Cessation
- 1984-09-05 CA CA000462455A patent/CA1234811A/en not_active Expired
- 1984-09-05 GB GB08422453A patent/GB2146023B/en not_active Expired
- 1984-09-05 BE BE0/213592A patent/BE900502A/fr not_active IP Right Cessation
- 1984-09-05 NL NL8402713A patent/NL8402713A/nl not_active Application Discontinuation
- 1984-09-05 GR GR80294A patent/GR80294B/el unknown
- 1984-09-05 PT PT79175A patent/PT79175B/pt unknown
- 1984-09-06 FR FR8413706A patent/FR2551440B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL72862A (en) | 1988-07-31 |
| FI843469A (fi) | 1985-03-07 |
| CH662350A5 (fr) | 1987-09-30 |
| GB2146023A (en) | 1985-04-11 |
| ES8600241A1 (es) | 1985-10-01 |
| SE8404456D0 (sv) | 1984-09-05 |
| KR850002476A (ko) | 1985-05-13 |
| US4613597A (en) | 1986-09-23 |
| IL72862A0 (en) | 1984-12-31 |
| AU574711B2 (en) | 1988-07-14 |
| IT8448800A1 (it) | 1986-03-05 |
| NO843529L (no) | 1985-03-07 |
| DK422984D0 (da) | 1984-09-05 |
| FR2551440B1 (fr) | 1986-12-26 |
| DE3432658A1 (de) | 1985-03-21 |
| NZ209447A (en) | 1988-07-28 |
| PT79175B (en) | 1986-11-10 |
| PT79175A (en) | 1984-10-01 |
| GR80294B (en) | 1985-01-07 |
| FR2551440A1 (fr) | 1985-03-08 |
| NL8402713A (nl) | 1985-04-01 |
| IT8448800A0 (it) | 1984-09-05 |
| BE900502A (fr) | 1985-03-05 |
| DK422984A (da) | 1985-03-07 |
| CA1234811A (en) | 1988-04-05 |
| AU3275384A (en) | 1985-03-14 |
| ES535674A0 (es) | 1985-10-01 |
| GB2146023B (en) | 1987-03-25 |
| IT1177981B (it) | 1987-09-03 |
| SE8404456L (sv) | 1985-03-07 |
| GB8422453D0 (en) | 1984-10-10 |
| FI843469A0 (fi) | 1984-09-05 |
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