LT3341380T - Chromono oksimo darinys, prasiskverbiantis į smegenis, skirtas levadopa sukeltos diskinezijos gydymui - Google Patents

Chromono oksimo darinys, prasiskverbiantis į smegenis, skirtas levadopa sukeltos diskinezijos gydymui

Info

Publication number
LT3341380T
LT3341380T LTEP16769872.9T LT16769872T LT3341380T LT 3341380 T LT3341380 T LT 3341380T LT 16769872 T LT16769872 T LT 16769872T LT 3341380 T LT3341380 T LT 3341380T
Authority
LT
Lithuania
Prior art keywords
levodopa
penetrant
brain
therapy
oxime derivative
Prior art date
Application number
LTEP16769872.9T
Other languages
English (en)
Inventor
Delphine CHARVIN
Francois Conquet
Original Assignee
Prexton Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2015/069601 external-priority patent/WO2016030444A1/en
Application filed by Prexton Therapeutics Sa filed Critical Prexton Therapeutics Sa
Publication of LT3341380T publication Critical patent/LT3341380T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
LTEP16769872.9T 2015-08-27 2016-08-26 Chromono oksimo darinys, prasiskverbiantis į smegenis, skirtas levadopa sukeltos diskinezijos gydymui LT3341380T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2015/069601 WO2016030444A1 (en) 2014-08-27 2015-08-27 Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors
EP15188368 2015-10-05
PCT/EP2016/070175 WO2017032874A1 (en) 2015-08-27 2016-08-26 Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia

Publications (1)

Publication Number Publication Date
LT3341380T true LT3341380T (lt) 2020-01-10

Family

ID=54260666

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP16769872.9T LT3341380T (lt) 2015-08-27 2016-08-26 Chromono oksimo darinys, prasiskverbiantis į smegenis, skirtas levadopa sukeltos diskinezijos gydymui

Country Status (30)

Country Link
US (2) US10532057B2 (lt)
EP (2) EP3341380B1 (lt)
JP (1) JP2018528205A (lt)
KR (1) KR20180041234A (lt)
CN (1) CN108349993A (lt)
AU (1) AU2016313138A1 (lt)
CA (1) CA2995313A1 (lt)
CL (1) CL2018000497A1 (lt)
CY (1) CY1122401T1 (lt)
DK (1) DK3341380T3 (lt)
DO (1) DOP2018000060A (lt)
EA (1) EA035016B1 (lt)
ES (1) ES2764490T3 (lt)
HR (1) HRP20192250T1 (lt)
HU (1) HUE047531T2 (lt)
IL (1) IL257655A (lt)
LT (1) LT3341380T (lt)
MA (1) MA42700B1 (lt)
ME (1) ME03591B (lt)
MX (1) MX2018002255A (lt)
NI (1) NI201800031A (lt)
PH (1) PH12018500430A1 (lt)
PL (1) PL3341380T3 (lt)
PT (1) PT3341380T (lt)
RS (1) RS59651B1 (lt)
RU (1) RU2018110580A (lt)
SI (1) SI3341380T1 (lt)
TN (1) TN2018000061A1 (lt)
WO (1) WO2017032874A1 (lt)
ZA (1) ZA201801642B (lt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA40530A (fr) 2014-08-27 2017-07-05 Prexton Therapeutics Sa Nouveau dérivé d'oxime de chromone et son utilisation comme modulateur allostérique de récepteurs métabotropiques du glutamate
DK3341380T3 (da) 2015-08-27 2019-12-16 Prexton Therapeutics Sa Hjernegennemtrængelig chromonoximderivat til terapien af levodopa-induceret dyskinesi
JP2022511236A (ja) 2018-07-26 2022-01-31 ドメイン・セラピューティクス 置換キナゾリノン誘導体、及びｍＧｌｕＲ４のポジティブアロステリック調節剤としてのその使用
EP3807077A4 (en) 2018-12-14 2021-12-29 Hewlett-Packard Development Company, L.P. Evaluating candidate virtual build volumes
CN115594655B (zh) * 2022-09-16 2023-08-15 桂林医学院 色酮肟类衍生物及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065467A (en) 1973-12-27 1977-12-27 Carlo Erba, S. P. A. 5:6-Benzo δ-pyrone derivatives and process for their preparation
US4777252A (en) 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US5354885A (en) * 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
JP3993651B2 (ja) 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
EP1298129A3 (en) 2001-09-28 2003-06-04 Central Glass Company, Limited Process for producing 4-sustituted benzopyran derivatives
PE20040801A1 (es) 2002-12-12 2004-11-25 Hoffmann La Roche Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa
CA2522595A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
WO2007011701A1 (en) 2005-07-15 2007-01-25 Transform Pharmaceuticals, Inc. Novel hydrochloride salts of levodopa
GB0713686D0 (en) 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2
EA201070143A1 (ru) 2007-07-13 2010-08-30 Аддекс Фарма С.А. Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
WO2011051478A1 (en) 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
RU2707067C2 (ru) 2009-12-04 2019-11-22 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения
WO2011107653A2 (en) * 2010-03-04 2011-09-09 Orion Corporation Method for treating parkinson's disease
MA40530A (fr) 2014-08-27 2017-07-05 Prexton Therapeutics Sa Nouveau dérivé d'oxime de chromone et son utilisation comme modulateur allostérique de récepteurs métabotropiques du glutamate
DK3341380T3 (da) 2015-08-27 2019-12-16 Prexton Therapeutics Sa Hjernegennemtrængelig chromonoximderivat til terapien af levodopa-induceret dyskinesi

Also Published As

Publication number Publication date
EA201890590A1 (ru) 2018-07-31
RS59651B1 (sr) 2020-01-31
ES2764490T3 (es) 2020-06-03
DOP2018000060A (es) 2018-06-30
IL257655A (en) 2018-04-30
AU2016313138A1 (en) 2018-03-15
EP3341380A1 (en) 2018-07-04
PT3341380T (pt) 2019-12-19
EP3696182A1 (en) 2020-08-19
SI3341380T1 (sl) 2020-02-28
CA2995313A1 (en) 2017-03-02
RU2018110580A (ru) 2019-09-30
ME03591B (me) 2020-07-20
HUE047531T2 (hu) 2020-04-28
TN2018000061A1 (en) 2019-07-08
PH12018500430A1 (en) 2018-08-29
PL3341380T3 (pl) 2020-04-30
EP3341380B1 (en) 2019-11-13
US20180271874A1 (en) 2018-09-27
EA035016B1 (ru) 2020-04-17
ZA201801642B (en) 2019-01-30
US20200171042A1 (en) 2020-06-04
NI201800031A (es) 2018-08-30
CY1122401T1 (el) 2021-01-27
KR20180041234A (ko) 2018-04-23
CL2018000497A1 (es) 2018-06-01
HRP20192250T1 (hr) 2020-05-15
MX2018002255A (es) 2018-06-06
MA42700B1 (fr) 2019-12-31
WO2017032874A1 (en) 2017-03-02
DK3341380T3 (da) 2019-12-16
RU2018110580A3 (lt) 2019-10-21
US10532057B2 (en) 2020-01-14
CN108349993A (zh) 2018-07-31
JP2018528205A (ja) 2018-09-27

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