LT2888259T - Diazepino dariniai, tinkami trapios x chromosomos sindromo, parkinsono arba refliukso ligų gydymui - Google Patents

Diazepino dariniai, tinkami trapios x chromosomos sindromo, parkinsono arba refliukso ligų gydymui

Info

Publication number
LT2888259T
LT2888259T LTEP13783671.4T LT13783671T LT2888259T LT 2888259 T LT2888259 T LT 2888259T LT 13783671 T LT13783671 T LT 13783671T LT 2888259 T LT2888259 T LT 2888259T
Authority
LT
Lithuania
Prior art keywords
parkinsons
fragile
syndrome
treatment
reflux disease
Prior art date
Application number
LTEP13783671.4T
Other languages
English (en)
Inventor
Dirk Behnke
David Carcache
Peter Ertl
Manuel Koller
David Orain
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47045285&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2888259(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LT2888259T publication Critical patent/LT2888259T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEP13783671.4T 2012-08-23 2013-08-21 Diazepino dariniai, tinkami trapios x chromosomos sindromo, parkinsono arba refliukso ligų gydymui LT2888259T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1215033.0A GB201215033D0 (en) 2012-08-23 2012-08-23 Diazepinone derivatives
PCT/IB2013/056782 WO2014030128A1 (en) 2012-08-23 2013-08-21 Diazepinone derivatives useful for the treatment of fragile x syndrome, parkinsons or reflux disease

Publications (1)

Publication Number Publication Date
LT2888259T true LT2888259T (lt) 2018-06-11

Family

ID=47045285

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13783671.4T LT2888259T (lt) 2012-08-23 2013-08-21 Diazepino dariniai, tinkami trapios x chromosomos sindromo, parkinsono arba refliukso ligų gydymui

Country Status (44)

Country Link
US (4) US8853203B2 (lt)
EP (1) EP2888259B1 (lt)
JP (2) JP6169699B2 (lt)
KR (1) KR102104149B1 (lt)
CN (1) CN104520298B (lt)
AP (1) AP2014008140A0 (lt)
AR (1) AR092212A1 (lt)
AU (1) AU2013307239B2 (lt)
BR (1) BR112015003281A8 (lt)
CA (1) CA2878564C (lt)
CL (1) CL2015000416A1 (lt)
CR (1) CR20150092A (lt)
CU (1) CU20150016A7 (lt)
CY (1) CY1120728T1 (lt)
DK (1) DK2888259T3 (lt)
EA (1) EA029493B1 (lt)
ES (1) ES2672737T3 (lt)
GB (1) GB201215033D0 (lt)
GT (1) GT201500039A (lt)
HK (1) HK1206008A1 (lt)
HR (1) HRP20180850T1 (lt)
HU (1) HUE037971T2 (lt)
IL (1) IL237062A (lt)
JO (1) JOP20130250B1 (lt)
LT (1) LT2888259T (lt)
MA (1) MA37849A1 (lt)
MX (1) MX365253B (lt)
MY (1) MY170103A (lt)
NO (1) NO2888259T3 (lt)
NZ (1) NZ703628A (lt)
PE (1) PE20150401A1 (lt)
PH (1) PH12015500373A1 (lt)
PL (1) PL2888259T3 (lt)
PT (1) PT2888259T (lt)
RS (1) RS57231B1 (lt)
SG (2) SG10201701333WA (lt)
SI (1) SI2888259T1 (lt)
TN (1) TN2014000528A1 (lt)
TR (1) TR201807174T4 (lt)
TW (1) TWI616444B (lt)
UA (1) UA114326C2 (lt)
UY (1) UY34986A (lt)
WO (1) WO2014030128A1 (lt)
ZA (1) ZA201409345B (lt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201215033D0 (en) * 2012-08-23 2012-10-10 Novartis Ag Diazepinone derivatives
CA3066711A1 (en) 2017-07-31 2019-02-07 Novartis Ag Use of mavoglurant in the reduction of ***e use or in preventing relapse into ***e use
CA3124931A1 (en) 2019-01-29 2020-08-06 Novartis Ag The use of an mglur5 antagonist for treating opioid analgesic tolerance

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853851A (en) * 1972-01-26 1974-12-10 Ciba Geigy Corp Diazepinoisoquinolines
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
JP2006521358A (ja) * 2003-03-26 2006-09-21 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体のベンズアミドモジュレータ
GB0413605D0 (en) * 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
WO2011075699A2 (en) * 2009-12-18 2011-06-23 Sunovion Pharmaceuticals Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
JP6110787B2 (ja) 2011-05-10 2017-04-05 協和発酵キリン株式会社 ピリミドジアゼピノン化合物
GB201215033D0 (en) 2012-08-23 2012-10-10 Novartis Ag Diazepinone derivatives

Also Published As

Publication number Publication date
NO2888259T3 (lt) 2018-08-04
CA2878564A1 (en) 2014-02-27
KR20150044897A (ko) 2015-04-27
CN104520298B (zh) 2016-10-19
CL2015000416A1 (es) 2015-04-24
EA201590415A1 (ru) 2015-06-30
PE20150401A1 (es) 2015-04-16
CN104520298A (zh) 2015-04-15
TN2014000528A1 (en) 2016-03-30
MX2015002367A (es) 2015-06-03
PH12015500373B1 (en) 2015-04-20
US8853203B2 (en) 2014-10-07
PL2888259T3 (pl) 2018-08-31
ES2672737T3 (es) 2018-06-15
US9650377B2 (en) 2017-05-16
US9284331B2 (en) 2016-03-15
KR102104149B1 (ko) 2020-04-24
MY170103A (en) 2019-07-05
UA114326C2 (uk) 2017-05-25
SI2888259T1 (en) 2018-07-31
CA2878564C (en) 2021-08-03
EP2888259B1 (en) 2018-03-07
MA37849A1 (fr) 2017-09-29
BR112015003281A2 (pt) 2017-07-04
EA029493B1 (ru) 2018-04-30
CY1120728T1 (el) 2019-12-11
TWI616444B (zh) 2018-03-01
TW201412736A (zh) 2014-04-01
HUE037971T2 (hu) 2018-10-29
JP2015526461A (ja) 2015-09-10
NZ703628A (en) 2018-05-25
MX365253B (es) 2019-05-28
PH12015500373A1 (en) 2015-04-20
CR20150092A (es) 2015-05-04
HK1206008A1 (en) 2015-12-31
AU2013307239A1 (en) 2015-01-29
ZA201409345B (en) 2015-12-23
EP2888259A1 (en) 2015-07-01
HRP20180850T1 (hr) 2018-06-29
JP6169699B2 (ja) 2017-07-26
US20140357625A1 (en) 2014-12-04
IL237062A (en) 2016-11-30
SG10201701333WA (en) 2017-04-27
AU2013307239B2 (en) 2015-12-24
RS57231B1 (sr) 2018-07-31
JOP20130250B1 (ar) 2021-08-17
US20140057902A1 (en) 2014-02-27
US20170305903A1 (en) 2017-10-26
US20160159795A1 (en) 2016-06-09
JP2017226661A (ja) 2017-12-28
CU20150016A7 (es) 2015-07-30
SG11201500068QA (en) 2015-05-28
UY34986A (es) 2014-03-31
WO2014030128A1 (en) 2014-02-27
GB201215033D0 (en) 2012-10-10
AP2014008140A0 (en) 2014-12-31
DK2888259T3 (en) 2018-06-14
BR112015003281A8 (pt) 2018-01-16
PT2888259T (pt) 2018-06-06
TR201807174T4 (tr) 2018-06-21
GT201500039A (es) 2018-11-27
AR092212A1 (es) 2015-04-08

Similar Documents

Publication Publication Date Title
HK1256490A1 (zh) 用於治療病毒感染的嘧啶衍生物
HK1208223A1 (en) 1,2,4-triazine derivatives for the treatment of viral infections 124-
HK1211589A1 (en) Compounds for the treatment of paramoxyvirus viral infections
HK1201254A1 (en) Piperidino pyrimidine derivatives for the treatment of viral infections
SG11201503042QA (en) Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
HK1195309A1 (zh) 作為激酶 調節劑用於治療帕金森病的 -苯基氨基嘧啶衍生物
IL230635A (en) An outgrowth of 4,3,2,1-tetrahydroquinoline used to treat diabetes
HK1206721A1 (en) 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders cns 2--23--
HRP20180850T1 (hr) Derivati diazepinona korisni za liječenje fragilnog x-sindroma, parkinsonove bolesti ili bolesti refluksa
IT1400278B1 (it) Procedimento per la fabbricazione di manufatti sinterizzati
TH1501000894A (th) อนุพันธ์ไดอะซีพิโนนที่เป็นประโยชน์สำหรับการรักษาของกลุ่มอาการ โครโมโซมเอกซ์เปราะบาง, พาร์กินสันส์หรือโรคกรดไหลย้อน