LT2015064A - Karboanhidrazės selektyvūs inhibitoriai - Google Patents
Karboanhidrazės selektyvūs inhibitoriaiInfo
- Publication number
- LT2015064A LT2015064A LT2015064A LT2015064A LT2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A LT 2015064 A LT2015064 A LT 2015064A
- Authority
- LT
- Lithuania
- Prior art keywords
- carbonic anhydrase
- selective inhibitors
- compounds
- benzenesulfonamides
- biomedicine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Išradimas yra susijęs su naujais junginiais - benzensulfonamidais, kurių bendros formulės (I) ir (II). Junginiai gali būti naudojami biomedicinoje, kaip aktyvūs farmakologiniai ingredientai, nes jie slopina fermentus, dalyvaujančius ligos progresavime.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2015064A LT6401B (lt) | 2015-07-28 | 2015-07-28 | Karboanhidrazės selektyvūs inhibitoriai |
PCT/IB2015/056626 WO2017017505A1 (en) | 2015-07-28 | 2015-09-01 | Selective inhibitors of carbonic anhydrase |
EP15766651.2A EP3328833A1 (en) | 2015-07-28 | 2015-09-01 | Selective inhibitors of carbonic anhydrase |
US15/748,559 US11312682B2 (en) | 2015-07-28 | 2015-09-01 | Selective inhibitors of carbonic anhydrase |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2015064A LT6401B (lt) | 2015-07-28 | 2015-07-28 | Karboanhidrazės selektyvūs inhibitoriai |
Publications (2)
Publication Number | Publication Date |
---|---|
LT2015064A true LT2015064A (lt) | 2017-02-27 |
LT6401B LT6401B (lt) | 2017-06-12 |
Family
ID=54148589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT2015064A LT6401B (lt) | 2015-07-28 | 2015-07-28 | Karboanhidrazės selektyvūs inhibitoriai |
Country Status (4)
Country | Link |
---|---|
US (1) | US11312682B2 (lt) |
EP (1) | EP3328833A1 (lt) |
LT (1) | LT6401B (lt) |
WO (1) | WO2017017505A1 (lt) |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2910488A (en) | 1958-01-22 | 1959-10-27 | Merck & Co Inc | Aniline derivatives |
US3291824A (en) | 1962-04-06 | 1966-12-13 | Hoffmann La Roche | Nu-(2-halo-lower alkanoyl) anthranilic acid derivatives |
NL139742B (nl) | 1965-06-05 | 1973-09-17 | Hoechst Ag | Werkwijze voor het bereiden van n-benzyl- en n-furfuryl-5sulfamylantranilzuren. |
US3567746A (en) | 1968-07-10 | 1971-03-02 | Pennwalt Corp | N-aryl benzamides |
DE2031067A1 (de) | 1970-02-18 | 1971-09-02 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt, Budapest | Verfahren zur Herstellung von 2 Fur furylamino 4 chlor 5 sulfamoyl benzoe saure |
JPS58124767A (ja) * | 1982-01-21 | 1983-07-25 | Mitsui Toatsu Chem Inc | スルファモイル安息香酸誘導体 |
FR2540870A1 (fr) | 1983-02-15 | 1984-08-17 | Provesan Sa | Nouveaux derives de betaines n-iminopyridinium, leur preparation et leur application en tant que medicaments |
DE4430212A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Ortho-substituierte Benzoesäure-Derivate |
EP2070930A1 (en) | 1999-11-12 | 2009-06-17 | Biogen Idec MA, Inc. | Polycycloalkylpurines as adenosine receptor antagonists |
SI2594265T1 (sl) | 2002-11-26 | 2016-03-31 | Institute Of Virology Slovak Academy Of Sciences | CA-IX specifični inhibitorji |
CN1744899A (zh) | 2002-12-13 | 2006-03-08 | 史密丝克莱恩比彻姆公司 | 作为ccr5拮抗剂的哌啶衍生物 |
EP1667643A4 (en) | 2003-08-28 | 2008-03-05 | Nitromed Inc | NITROSIS AND NITROSYL CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF |
MXPA06008612A (es) | 2004-02-20 | 2007-01-25 | Aventis Pharma Inc | Derivados de furosemida como modulares de hm74 y su uso para el tratamiento de la inflamacion. |
WO2005107470A2 (en) | 2004-04-29 | 2005-11-17 | University Of Florida Research Foundation, Inc. | Use of carbonic anhydrase inhibitors for insect control and malaria treatment |
AU2005306629A1 (en) | 2004-11-15 | 2006-05-26 | Nicox S.A. | Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use |
WO2006137092A1 (en) | 2005-06-23 | 2006-12-28 | Supuran Claudiu T | Fluorescent sulfonamide derivatives having carbonic anhydrase inhibiting activity and their use as theapeutic and diagnostic agents |
EP1968603A4 (en) | 2006-01-03 | 2013-01-16 | Algebra Inc | THERAPEUTIC AMINARYLSULFONAMIDE CONJUGATE COMPOUNDS |
WO2008052190A2 (en) | 2006-10-26 | 2008-05-02 | Flynn Gary A | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance |
WO2008071421A1 (en) | 2006-12-15 | 2008-06-19 | Nicox S.A. | Nitrate esters of carbonic anhydrase inhibitors |
EP2129666A2 (en) | 2007-04-05 | 2009-12-09 | Siemens Medical Solutions USA, Inc. | Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry |
EP2240171B1 (en) | 2008-01-09 | 2014-08-13 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase IX |
EP2389371A4 (en) | 2009-01-22 | 2012-09-12 | Neurotherapeutics Pharma Inc | ANALOGUES OF BUMETANIDE, FUROSEMIDE, PIRETANIDE, AZOSEMIDE AND TORSEMID, AND RELATED COMPOSITIONS AND METHODS OF USE |
EP2533775A1 (en) | 2010-02-12 | 2012-12-19 | Universita' Degli Studi di Firenze | Carbonic anhydrase inhibitors |
EP2598478A2 (en) | 2010-07-26 | 2013-06-05 | Neurotherapeutics Pharma, Inc. | Arylsulfonamide derivatives, compositions, and methods of use |
WO2012070024A1 (en) | 2010-11-28 | 2012-05-31 | Metasignal Therapeutics Inc. | Carbonic anhydrase inhibitors with antimetastatic activity |
NL1038473C2 (en) | 2010-12-24 | 2012-06-27 | Centre Nat Rech Scient | Cancer targeting using carbonic anhydrase isoform ix inhibitors. |
WO2012175654A1 (en) | 2011-06-23 | 2012-12-27 | Facultes Universitaires Notre-Dame De La Paix | Tetraline sulfonamide derivatives for use in the treatment of proliferative disorders |
CZ2011676A3 (cs) | 2011-10-24 | 2013-05-02 | Ústav organické chemie a biochemie Akademie ved CR, v.v.i. | Inhibitory karbonické anhydrasy, zpusob jejich prípravy |
US9120837B2 (en) | 2012-01-06 | 2015-09-01 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX |
LT6064B (lt) | 2012-10-15 | 2014-08-25 | Vilniaus Universitetas | Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai |
WO2015025283A2 (en) | 2013-08-20 | 2015-02-26 | Stichting Maastricht Radiation Oncology "Maastro-Clinic" | Dual action carbonic anhydrase inhibitors |
-
2015
- 2015-07-28 LT LT2015064A patent/LT6401B/lt not_active IP Right Cessation
- 2015-09-01 WO PCT/IB2015/056626 patent/WO2017017505A1/en active Application Filing
- 2015-09-01 EP EP15766651.2A patent/EP3328833A1/en active Pending
- 2015-09-01 US US15/748,559 patent/US11312682B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3328833A1 (en) | 2018-06-06 |
LT6401B (lt) | 2017-06-12 |
WO2017017505A1 (en) | 2017-02-02 |
US20180222856A1 (en) | 2018-08-09 |
US11312682B2 (en) | 2022-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Patent application published |
Effective date: 20170227 |
|
FG9A | Patent granted |
Effective date: 20170612 |
|
MM9A | Lapsed patents |
Effective date: 20200728 |