LT2001078A - Imidazo[1,5-a]-pirido[3,2-e]-pirazinonų panaudojimas kaip medikamentų - Google Patents

Imidazo[1,5-a]-pirido[3,2-e]-pirazinonų panaudojimas kaip medikamentų

Info

Publication number
LT2001078A
LT2001078A LT2001078A LT2001078A LT2001078A LT 2001078 A LT2001078 A LT 2001078A LT 2001078 A LT2001078 A LT 2001078A LT 2001078 A LT2001078 A LT 2001078A LT 2001078 A LT2001078 A LT 2001078A
Authority
LT
Lithuania
Prior art keywords
pyrazinones
pyrido
imidazo
phosphodiesterase
medicaments
Prior art date
Application number
LT2001078A
Other languages
English (en)
Inventor
Norbert Hofgen
Stefan Szelenyi
Marx Degenhard
Ute Egerland
Original Assignee
Arzneimittelwerk Dresden Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999102082 external-priority patent/DE19902082A1/de
Priority claimed from DE1999161302 external-priority patent/DE19961302A1/de
Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh
Publication of LT2001078A publication Critical patent/LT2001078A/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Išradimas susijęs su (1) formulės imidazo[1,5-a]-pirido[3,2-e]-pirazinonų, kaip fosfodiesterazės 5 inhibitorių, panaudojimu medikamentų erekcijos disfunkcijos (impotencijos) terapijai gamyboje. Išradimas taip [at susijęs su (1) formulės imidazo[1,5-a]-pirido[3,2-e]-pirazinonų, kaip dvigubų fosfodieterazės 3 ir fosfodieterazės 5 inhibitorių panaudojimu širdies nepakankamumo, plaučių hipertenzijos ir kraujagyslių susirgimų, susijusiųsu nepakankama kraujotaka, terapijai skirtų medikamentų gamyboje. Išradimas dar susijęs su tų junginių gavimo būdu.ą
LT2001078A 1999-01-20 2001-07-19 Imidazo[1,5-a]-pirido[3,2-e]-pirazinonų panaudojimas kaip medikamentų LT2001078A (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999102082 DE19902082A1 (de) 1999-01-20 1999-01-20 Verwendung von Imidazo[1,5-a]-pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erectiler Dysfunktion und Verfahren zu deren Herstellung
DE1999161302 DE19961302A1 (de) 1999-12-18 1999-12-18 Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen

Publications (1)

Publication Number Publication Date
LT2001078A true LT2001078A (lt) 2002-08-26

Family

ID=26051406

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2001078A LT2001078A (lt) 1999-01-20 2001-07-19 Imidazo[1,5-a]-pirido[3,2-e]-pirazinonų panaudojimas kaip medikamentų

Country Status (23)

Country Link
EP (1) EP1144410A2 (lt)
JP (1) JP2002535330A (lt)
KR (1) KR20010101603A (lt)
CN (1) CN1344268A (lt)
AR (1) AR022318A1 (lt)
AU (1) AU2291200A (lt)
BG (1) BG105714A (lt)
BR (1) BR0007613A (lt)
CA (1) CA2296224A1 (lt)
CO (1) CO5190700A1 (lt)
CZ (1) CZ20012627A3 (lt)
EA (1) EA200100792A1 (lt)
EE (1) EE200100377A (lt)
HU (1) HUP0105132A3 (lt)
ID (1) ID29790A (lt)
IL (1) IL144156A0 (lt)
IS (1) IS5987A (lt)
LT (1) LT2001078A (lt)
LV (1) LV12793B (lt)
NO (1) NO20013334L (lt)
SK (1) SK10322001A3 (lt)
TR (1) TR200102121T2 (lt)
WO (1) WO2000043392A2 (lt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) * 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
EP1461022A2 (en) * 2001-12-17 2004-09-29 ALTANA Pharma AG Use of selective pde5 inhibitors for treating partial and global respiratory failure
FR2835741B1 (fr) * 2002-02-12 2006-05-05 Oreal Nouveaux coupleurs 6-alcoxy-2,3-diaminopyridine utiles pour la teinture des fibres keratiniques
US6916345B2 (en) 2002-02-12 2005-07-12 L'oreal S.A. 6-alkoxy-2,3-diaminopyridine couplers for dyeing keratin fibres
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
US8299083B2 (en) 2004-08-17 2012-10-30 The Johns Hopkins University PDE5 inhibitor compositions and methods for treating cardiac indications
KR101563103B1 (ko) * 2006-12-13 2015-10-23 아스카 세이야쿠 가부시키가이샤 퀴녹살린 유도체
US20090143361A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
CN101918408A (zh) 2007-11-30 2010-12-15 惠氏有限责任公司 作为磷酸二酯酶10的抑制剂的芳基和杂芳基稠合的咪唑并[1,5-a]吡嗪
IN2015DN02829A (lt) 2011-10-10 2015-09-11 Lundbeck & Co As H
AU2013213603B2 (en) 2012-01-26 2017-02-02 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone
JP5842640B2 (ja) * 2012-01-31 2016-01-13 株式会社東洋新薬 ホスホジエステラーゼ３阻害剤
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
WO2016022836A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
MX2018000283A (es) 2015-07-07 2018-11-22 H Lundbeck As Inhibidores de fde9 con estructura basica de imidazotriazinona y estructura basica de imidazopirazinona en el tratamiento de enfermedades perifericas.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
BG105714A (en) 2002-02-28
CN1344268A (zh) 2002-04-10
SK10322001A3 (sk) 2002-07-02
IS5987A (is) 2001-06-29
KR20010101603A (ko) 2001-11-14
JP2002535330A (ja) 2002-10-22
NO20013334D0 (no) 2001-07-05
TR200102121T2 (tr) 2002-01-21
EE200100377A (et) 2002-10-15
EP1144410A2 (de) 2001-10-17
IL144156A0 (en) 2002-05-23
HUP0105132A3 (en) 2002-12-28
LV12793A (lv) 2002-02-20
LV12793B (lv) 2002-05-20
ID29790A (id) 2001-10-11
CO5190700A1 (es) 2002-08-29
CZ20012627A3 (cs) 2002-01-16
NO20013334L (no) 2001-07-05
AR022318A1 (es) 2002-09-04
AU2291200A (en) 2000-08-07
BR0007613A (pt) 2001-10-30
HUP0105132A2 (hu) 2002-05-29
EA200100792A1 (ru) 2002-10-31
WO2000043392A2 (de) 2000-07-27
WO2000043392A3 (de) 2000-09-28
CA2296224A1 (en) 2000-07-20

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