KR970704444A - 트리아진 유도체 및 의약(triazine derivative and medicine) - Google Patents

트리아진 유도체 및 의약(triazine derivative and medicine) Download PDF

Info

Publication number
KR970704444A
KR970704444A KR1019970700786A KR19970700786A KR970704444A KR 970704444 A KR970704444 A KR 970704444A KR 1019970700786 A KR1019970700786 A KR 1019970700786A KR 19970700786 A KR19970700786 A KR 19970700786A KR 970704444 A KR970704444 A KR 970704444A
Authority
KR
South Korea
Prior art keywords
substituted
cyclic amino
unsubstituted
hydrogen
group
Prior art date
Application number
KR1019970700786A
Other languages
English (en)
Inventor
후사오 우에다
다카유키 오자키
겐이치 나카무라
Original Assignee
아만 히데아키
니뽄 신야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아만 히데아키, 니뽄 신야쿠 가부시키가이샤 filed Critical 아만 히데아키
Publication of KR970704444A publication Critical patent/KR970704444A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

본 발명은 하기 화학식(1)로 표시된 트리아진 유도체, 이의 용매화물, 또는 이의 염을 활성 성분으로 함유한 간염 치료용으로 유용한 의약에 관한 것이다.
식 중, R1및 R2는 동일하거나 또는 다르며, 수소, 치환 또는 비치환된 알킬, 아르알킬, 아르알케닐, 또는 알릴을 나타내거나, 또는 R1과R2가 인접하는 N과 함께 NR1R2로서 4~8원의 환형 아미노를 나타낸다. 이러한 환형 아미노는 상기 질소외에 환구성 원자로서 질소, 산소 또는 황을 가지고 있어도 좋으며, 또한 치환되어도 좋다. 단, R1및 R2가 모두 수소인 경우는 제외한다.

Description

트리아진 유도체 및 의약 (TRIAZINE DERIVATIVE AND MEDICINE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 화학식(1)로 표시된 화합물 및 그 용매화물과 그 염을 유효 성분으로 포함하는 약학 조성물:
    식 중, R1및 R2는 동일하거나 또는 다르며, 수소, 치환 또는 비치환된 알킬, 아르알킬, 아르알케닐, 또는 알릴을 나타내거나, 또는 R1과 R2가 인접하는 N과 함께 NR1R2로서 4~8원의 환형 아미노를 나타낸다. 이러한 환형 아미노는 상기 질소외에 환구성 원자로서 질소, 산소 또는 황을 가지고 있어도 좋으며, 또한 치환되어도 좋다. 단, R1및 R2가 모두 수소인 경우는 제외한다.
  2. 제1항에 있어서, R1및 R2가 동일하거나 또는 다르며, ①수소, ②무치환 또는 히드록시, 알콕시, 아미노, 모노알킬아미노, 디알킬아미노, 아릴아미노, 4~8원의 환형 아미노, 카르복시, 가르바모일, 아릴옥시,아로일옥시로 구성되는 군에서 선택되는 치환기에 의해 치환된 알킬, ③아르알킬, ④아르알케닐, 또는 ⑤아릴을 나타내는 약학 조성물.
  3. 제1항에 있어서, NR1R2가 무치환 또는 히드록시, 옥소, 카르복시, 알킬, 히드록시알킬,아리옥시알킬, 아노알킬, 알킬설포닐아미노알킬, 알킬설포닐아미노, 알킬설포닐아르알킬, 알킬설포닐, 아릴, 아르알킬, 2-피리미딜, 환형 아미노로 구성되는 군에서 선택되는 치환기에 의해 치환된 4~8원의 환형 아미노인 약학 조성물.
  4. 제1항에 있어서, R1및 R2가 동일하거나 또는 다르며, 히드록시알킬을 나타내거나, 또는 NR1R2가 치환되어 있어도 좋은 피롤리디노, 피레리디노 또는 모르폴리노인 약학 조성물.
  5. 제7항에 있어서, R1및 R2가 동일하거나 또는 다르며, 히드록시알킬을 나타내거나, 또는 NR1R2가 무치환또는 히드록시, 히드록시알킬, 옥소, 알킬, 아미노 또는 아미노알킬로 치환된 피롤리디노, 피페리디노 또는 모르폴리노인 약학 조성물.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 간염 치료제인 약학 조성물.
  7. 제1항 내지 제5항 중 어느 한 항의 화합물 및 그 용매화물과 그 염(단,R1및 R2가 모두 수소인 경우, 및 NR1R2가 무치환 피페리디노 또는 모르폴리노인 경우는 제외됨).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970700786A 1994-08-08 1995-08-08 트리아진 유도체 및 의약(triazine derivative and medicine) KR970704444A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18581094 1994-08-08
JP94-185810 1994-08-08
PCT/JP1995/001577 WO1996004914A1 (fr) 1994-08-08 1995-08-08 Derive de triazine et medicament

Publications (1)

Publication Number Publication Date
KR970704444A true KR970704444A (ko) 1997-09-06

Family

ID=16177293

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970700786A KR970704444A (ko) 1994-08-08 1995-08-08 트리아진 유도체 및 의약(triazine derivative and medicine)

Country Status (10)

Country Link
EP (1) EP0775487A4 (ko)
KR (1) KR970704444A (ko)
AU (1) AU703263B2 (ko)
BR (1) BR9508539A (ko)
CA (1) CA2197091A1 (ko)
HU (1) HUT77735A (ko)
MX (1) MX9700928A (ko)
RU (1) RU2147233C1 (ko)
TW (1) TW340115B (ko)
WO (1) WO1996004914A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0813874A4 (en) * 1995-03-09 1998-05-06 Nippon Shinyaku Co Ltd MEDICINE FOR PANCREATITIS
US5962454A (en) * 1995-04-20 1999-10-05 Nippon Shinyaku Co., Ltd. Neovascularization inhibitor
DE19704922A1 (de) * 1997-02-10 1998-08-13 Hoechst Schering Agrevo Gmbh 2,4-Diamino-1,3,5-triazine, ihre Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
DE19735800A1 (de) * 1997-08-18 1999-02-25 Boehringer Ingelheim Pharma Triazine mit adenosinantagonistischer Wirkung
WO1999036410A1 (en) * 1998-01-13 1999-07-22 Scriptgen Pharmaceuticals, Inc. Triazine antiviral compounds
US6335339B1 (en) 1998-01-13 2002-01-01 Scriptgen Pharmaceuticals, Inc. Triazine antiviral compounds
PT1183245E (pt) * 1999-04-22 2007-07-12 Lundbeck & Co As H Antagonistas selectivos de npy (y5)
US6218408B1 (en) 1999-06-30 2001-04-17 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6340683B1 (en) * 1999-04-22 2002-01-22 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
US6222040B1 (en) 1999-06-30 2001-04-24 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
US6225330B1 (en) 1999-06-30 2001-05-01 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
AU2003249369A1 (en) 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
AU2004257289A1 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
WO2005028467A1 (en) 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
MY145822A (en) 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
CN102344416B (zh) * 2010-08-02 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 哒嗪衍生物及其作为抗小rna病毒感染药物的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5845429B2 (ja) * 1976-03-29 1983-10-08 日本新薬株式会社 ベンゾグアナミン誘導体
JPS5735587A (en) * 1980-06-04 1982-02-26 Nippon Shinyaku Co Ltd Benzoguanamine derivative
JPS57203083A (en) * 1981-06-05 1982-12-13 Nippon Shinyaku Co Ltd Nicotinic acid derivative
JPS5855423A (ja) * 1981-09-25 1983-04-01 Nippon Shinyaku Co Ltd ベンゾグアナミン類を主成分としする医薬
JPS59106473A (ja) * 1982-12-10 1984-06-20 Nippon Shinyaku Co Ltd トリアジン誘導体
WO1991001733A1 (en) * 1989-08-09 1991-02-21 Nippon Shinyaku Co., Ltd. Remedy

Also Published As

Publication number Publication date
WO1996004914A1 (fr) 1996-02-22
TW340115B (en) 1998-09-11
HUT77735A (hu) 1998-07-28
RU2147233C1 (ru) 2000-04-10
MX9700928A (es) 1997-04-30
AU703263B2 (en) 1999-03-25
EP0775487A4 (en) 1999-03-10
EP0775487A1 (en) 1997-05-28
BR9508539A (pt) 1997-10-28
AU3192095A (en) 1996-03-07
CA2197091A1 (en) 1996-02-22

Similar Documents

Publication Publication Date Title
KR970704444A (ko) 트리아진 유도체 및 의약(triazine derivative and medicine)
DK490288A (da) Substituerede thiazolidindionderivater
AR012315A1 (es) Derivados de ditiolan y el uso de los mismos en la fabricacion de un medicamento.
ATE206412T1 (de) Heterocyclische verbindungen als bradykinin antagonisten
ATE230729T1 (de) Benzamid-derivate und ihre verwendung als vasopressin-antagonisten
FI934274A (fi) N-sulfonyl-2-oxi-indolderivat, deras framstaellning och dessa innehaollande farmaceutiska kompositioner
DE69331843D1 (de) Xanthine-Derivate als Antidepressiva
HUP0004531A2 (hu) VLA-4 által mediált leukocita adhéziót gátló 4-aminofenilalanin-vegyületek, ezeket tartalmazó gyógyászati készítmények, valamint alkalmazásuk
DE69230163D1 (de) Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
MX9306831A (es) Nuevos compuestos heterociclicos.
RU97103983A (ru) Лекарственные композиции и производные триазина
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
HUP9801356A2 (hu) Triciklusos (2-hidroxi-2-metil-3,3,3-trifluor-propanoil)-amino-benzoxepin-, -benzotiepin-, -benzocikloheptén-, -indén-származékok és az ezeket tartalmazó gyógyszerkészítmények
DE69507293T2 (de) Benzamid-derivate als vasopressin-antagonisten
ATE145906T1 (de) Benzamid-derivate
HUP9802995A2 (hu) Szubsztituált szulfonil-amino-(tio)karbonil-származékok, intermedierjeik, a vegyületeket hatóanyagként tartalmazó herbicid készítmények, valamint eljárás a vegyületek, és készítmények előállítására és alkalmazására
DE69201451D1 (de) Thiazolidinone und Oxazolidenonederivate, ihre Herstellung und ihre Anwendung als Vasodilatatoren.
HUP0102522A2 (hu) 3',3'-N-bisz-helyettesített makrolid LHRH antagonista vegyületek és alkalmazásuk, eljárás előállításukra, valamint e vegyületeket tartalmazó gyógyászati készítmények
SE8303913D0 (sv) Heterocykliska foreningar
ATE195517T1 (de) Chinolinonderivate und diese enthaltende antiallergische zusammensetzungen
DE69226931D1 (de) Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten
DE59915244D1 (de) Kosmetische oder pharmazeutische Zubereitungen enthaltend 1,3,5-Triazinderivate und Zinkoxid
DE69006897D1 (de) Benzothiazolinon-Derivate, ihre Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten.
HUP0203455A2 (hu) 2-Arilkinolin-származékok, a vegyületek előállítása és gyógyászati készítményekben való alkalmazása
ATE9798T1 (de) Dibenz-oxazonine, dibenz-oxazecine und dibenzoxaazacycloundekan-derivate und uebereinstimmende thia- und aza-verbindungen, ihre herstellung und pharmazeutische zusammensetzungen.

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid