KR970701191A - 복소환 화합물 - Google Patents

복소환 화합물

Info

Publication number
KR970701191A
KR970701191A KR1019960704406A KR19960704406A KR970701191A KR 970701191 A KR970701191 A KR 970701191A KR 1019960704406 A KR1019960704406 A KR 1019960704406A KR 19960704406 A KR19960704406 A KR 19960704406A KR 970701191 A KR970701191 A KR 970701191A
Authority
KR
South Korea
Prior art keywords
pharmaceutically acceptable
serotonin
acceptable salt
pharmaceutical composition
compound according
Prior art date
Application number
KR1019960704406A
Other languages
English (en)
Inventor
유타카 오우치
마사지 스즈키
하지메 아사누마
사다카주 요코모리
가츠오 하타야마
요시히코 이소베
하루코 가지마
마코토 무라마츠
Original Assignee
우에하라 아키라
다이쇼 세야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우에하라 아키라, 다이쇼 세야쿠 가부시키가이샤 filed Critical 우에하라 아키라
Publication of KR970701191A publication Critical patent/KR970701191A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

식
로 표시되는 엔도-(8-메틸-8-아자비시클로[3,2,1]옥트-3-일) -이소프로필-2(1H)-퀴놀린-3-카르복실레이트퀴놀린 카르복실레이트 또는 그의 산부가염은 세로토닌 4수용체에 대해서 작용하여 세로토닌 같은 수용체 자극작용을 갖는다. 따라서, 소화관 운동 부활 작용을 발휘하고, 만성위염, 위절제후 증후군 등에 수반하는 명치언저리가 쓰리고 아픔, 식용부진, 상복부통 및 복부팽만감 등의 소화기 증상의 개선, 역류성 식도염, 가성 장폐색 및 변비등의 치료에 유효하다.

Description

복소환 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 식(1)
    로 표시되는 엔도-(8-메틸-8-아자비시클로[3,2,1]옥트-3-일) 1-이소프로필-2(1H)-퀴놀론-3-카르복실레이트퀴놀린 카르복실레이트 또는 그의 의약적으로 허용되는 염.
  2. 의약 조성물의 활성성분으로서 사용하기 위한 청구범위 제1항 기재의 화합물 또는 그의 의약적으로 허용되는 염.
  3. 청구범위 제1항 기재의 화합물 또는 그의 의약적으로 허용되는 염의 유효성분으로 함유하는 세로토닌 4수용체 자극을 위한 의약 조성물.
  4. 청구범위 제1항 기재의 화합물 또는 그의 의약적으로 허용되는 염의 약리학적 유효량을 사람을 포함한 포유동물에 투여함을 포함한 세로토닌 4 수용체를 자극하는 방법.
  5. 세로토닌 4 수용체 자극을 위한 의약 조성물을 제조하기 위한 청구의 범위 제1항 기재의 화합물 또는 그의 의약적으로 허용되는 염의 사용.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960704406A 1994-02-28 1995-02-17 복소환 화합물 KR970701191A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3011994 1994-02-28
JP30119/1994 1994-02-28
PCT/JP1995/000228 WO1995023147A1 (fr) 1994-02-28 1995-02-17 Compose heterocyclique

Publications (1)

Publication Number Publication Date
KR970701191A true KR970701191A (ko) 1997-03-17

Family

ID=12294900

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960704406A KR970701191A (ko) 1994-02-28 1995-02-17 복소환 화합물

Country Status (6)

Country Link
US (1) US5733917A (ko)
EP (1) EP0748808A4 (ko)
KR (1) KR970701191A (ko)
AU (1) AU679336B2 (ko)
CA (1) CA2184366A1 (ko)
WO (1) WO1995023147A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
WO2006069125A1 (en) * 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
US7446114B2 (en) * 2005-03-02 2008-11-04 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
US8334236B2 (en) 2009-02-03 2012-12-18 Kumiai Chemical Industry Co., Ltd. Ring-fused 2-pyridone derivatives and herbicides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
US5571820A (en) * 1992-11-20 1996-11-05 Taisho Pharmaceutical Co., Ltd. Heterocyclic compound
JP3829879B2 (ja) * 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体

Also Published As

Publication number Publication date
EP0748808A1 (en) 1996-12-18
CA2184366A1 (en) 1995-08-31
US5733917A (en) 1998-03-31
WO1995023147A1 (fr) 1995-08-31
AU679336B2 (en) 1997-06-26
AU1718095A (en) 1995-09-11
EP0748808A4 (en) 1998-10-07

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