KR960701880A - 아미노메탄포스폰산의 제조방법(process for the manufacture of aminomethanephosphonic acid) - Google Patents

아미노메탄포스폰산의 제조방법(process for the manufacture of aminomethanephosphonic acid)

Info

Publication number
KR960701880A
KR960701880A KR1019950704358A KR19950704358A KR960701880A KR 960701880 A KR960701880 A KR 960701880A KR 1019950704358 A KR1019950704358 A KR 1019950704358A KR 19950704358 A KR19950704358 A KR 19950704358A KR 960701880 A KR960701880 A KR 960701880A
Authority
KR
South Korea
Prior art keywords
formula
compound
phosphorus trichloride
phosphonating agent
alcohol
Prior art date
Application number
KR1019950704358A
Other languages
English (en)
Other versions
KR100253674B1 (ko
Inventor
리차드 랜들레스 케네쓰
폴 조지 레그라스
Original Assignee
비자야 쿠마리 말리페디
제네카 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10733471&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR960701880(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 비자야 쿠마리 말리페디, 제네카 리미티드 filed Critical 비자야 쿠마리 말리페디
Publication of KR960701880A publication Critical patent/KR960701880A/ko
Application granted granted Critical
Publication of KR100253674B1 publication Critical patent/KR100253674B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/42—Halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 a) 식 R-CH2-NH-CO-NH-CH2-R1(식중, R 및 R1은 동일하거나 상이할 수 있으며 포스폰화이탈그룹을 나타냄)의 화합물과 포스폰화제를 반응시키는 단계 및 계속하여 b) 단계 (a)의 생성물을 가수분해시켜 아미노메탄포스폰산을 얻는 단계로 구성되는 아미노메탄포스폰산의 제조방법에 관한다.

Description

아미노메탄포스폰산의 제조방법(PROCESS FOR THE MANUFACTURE OF AMINOMETHANEPHOSPHONIC ACID)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. a) 식 R-CH2-NH-CO-NH-CH2-R1(식중, R 및 R1은 동일하거나 상이할 수도 있으며 포스폰화 이탈 그룹임.)의 화합물을 포스폰화제와 반응시키는 단계 및 계속하여 b) 단계 (a)의 생성물을 가수분해시켜 아미노에탄포스폰산을 얻는 단계로 구성되는 아미노메탄포스폰산의 제조방법.
  2. 제1항에 있어서, R 및 R1이 동일하고 하이드록시 또는 C1-4알콕시인 방법.
  3. 제1항 또는 제2항에 있어서, 포스폰화제가 (i) 포스포러스 트리클로라이드, (ii) 아인산, (iii) 디알킬 포스파이트, (iv) 하기 식(Ⅵ)의 화합물 또는 이러한 화합물들의 혼합물 또는 (V) 식 R1OH(식중, R1은 앞에서 정의한 바와 같음)의 알콜과 혼합된 포스포러스 트리클로라이드인 방법.
    (Cl)nP (OR1)3-n(Ⅵ)
    식중, n은 1 또는 2이고, R1은 임의 치환된 알킬 또는 임의 치환된 아릴임.
  4. 제3항에 있어서, 포스폰화제가 상기 식(Ⅵ)(식중, n은 1이고 R1은 C1-7알킬임)의 화합물인 방법.
  5. 제3항에 있어서, 포스폰화제가 포스포러스 트리클로라이드 및 식 R1OH(식중, R1은 C1-7알킬임)의 알콜의 혼합물이고 포스포러스 트리클로라이드 몰당 1.8-2.2 몰의 알콜(R1OH)을 사용하는 방법.
  6. 전기한 항들 중 어느 한 항에 있어서, 반응 (a)가 0-50℃의 온도에서 일어나는 방법.
  7. 전기한 항들 중 어느 항에 있어서, 가수분해 반응 (b)가 100-200℃의 온도 및 이에 따라 조절된 압력에서 일어나는 방법.
  8. 전기한 항들 중 어느 항에 있어서, 반응 (a)가 케톤, 염소화된 탄화수소, 방향족 용매, 니트릴 또는 무수카복실산 또는 에스테르인 용매의 존재하에서 일어나는 방법.
  9. 제1항 내지 제7항 중 어느 한 항에 있어서, 반응 (a)가 가수분해 단계 (b)의 종료전에 분리되어 수불혼화성 용매로 대체되는 수혼화성 용매의 존재하에서 일어나는 방법.
  10. 1) 포스포러스 트리클로라이드 또는 식 ClP(OR1)2(식중, R1은 C1-7알킬임)의 디알킬 클로로포스피네이트인 포스폰화제 또는 식 R1OH의 알콜 및 포스포러스 트리클로라이드의 혼합물인 포스폰화제와, 식 R-CH2-NH-CO-NH-CH2-R1(식중, R 및 R1은 동일하거나 상이할 수 있으며, 포스폰화 이탈그룹임)의 화합물을수혼화성 용매의 존재하에 반응시켜 포스폰화제가 포스포러스 트리클로라이드일 경우 하기 식(Ⅱ)의 화합물을, 포스폰화제가 디알킬 클로로포스피네이트이거나 포스포러스 트리클로라이드 및 알콜(R1OH)의 혼합물일 경우 하기 식(Ⅱ')의 화합물을 얻는 단계
    2) 온건한 조건하에서 상기 식(Ⅱ) 또는 (Ⅱ')의 화합물을 물로 가수분해시켜 하기 식(Ⅳ)의 화합물을 얻는 단계
    3) 중류시켜 수혼화성 용매를 분리시킨 다음 이렇계 분리된 수혼화성 용매를 수불혼화성 용매를 대체시키는단계 4) 물을 가하고, 이렇계 형성된 수성상으로 상기 식(Ⅳ)의 화합물을 추출시키는 단계 5) 100-200℃의 온도 및 이에 따라 조절된 압력에서 단제 (4)로부터 얻은 수성 상을 가수분해시켜 아미노메탄포스폰산을 얻는단계로 구성되는 아미노메탄포스폰산의 제조방법.
  11. 전기한 항들 중 어느 항에 있어서, 아미노메탄포스폰산 생성물을 분리시키지 않고 계속 반응시켜 N-포스포노메틸글리신을 얻는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950704358A 1993-04-07 1994-03-15 아미노메탄포스폰산의 제조방법 KR100253674B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939307235A GB9307235D0 (en) 1993-04-07 1993-04-07 Process
GB9307235.3 1993-04-07
PCT/GB1994/000500 WO1994022880A1 (en) 1993-04-07 1994-03-15 Process for the manufacture of aminomethanephosphonic acid

Publications (2)

Publication Number Publication Date
KR960701880A true KR960701880A (ko) 1996-03-28
KR100253674B1 KR100253674B1 (ko) 2000-05-01

Family

ID=10733471

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950704358A KR100253674B1 (ko) 1993-04-07 1994-03-15 아미노메탄포스폰산의 제조방법

Country Status (28)

Country Link
US (1) US5471000A (ko)
EP (1) EP0693074B1 (ko)
JP (1) JP3547441B2 (ko)
KR (1) KR100253674B1 (ko)
CN (1) CN1044250C (ko)
AT (1) ATE155789T1 (ko)
AU (1) AU680480B2 (ko)
BG (1) BG62140B1 (ko)
BR (1) BR9406352A (ko)
CA (1) CA2158471C (ko)
CZ (1) CZ258595A3 (ko)
DE (1) DE69404454T2 (ko)
DK (1) DK0693074T3 (ko)
ES (1) ES2104363T3 (ko)
FI (1) FI954786A (ko)
GB (1) GB9307235D0 (ko)
GR (1) GR3024238T3 (ko)
HU (1) HU218867B (ko)
IL (1) IL108991A (ko)
MA (1) MA23155A1 (ko)
MY (1) MY110796A (ko)
NO (1) NO953992L (ko)
NZ (1) NZ262449A (ko)
PL (1) PL174910B1 (ko)
SK (1) SK124795A3 (ko)
WO (1) WO1994022880A1 (ko)
YU (1) YU14094A (ko)
ZA (1) ZA942047B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19717130A1 (de) * 1997-04-23 1998-10-29 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von Aminomethanphosphonsäure
CN102372594B (zh) * 2010-08-21 2016-02-24 武汉工程大学 一种反应在制备乙氧氟草醚以及其它有机合成中的应用
CN102442957B (zh) * 2010-10-06 2016-01-06 武汉工程大学 Lj反应在光延反应中的应用
WO2014012986A1 (en) 2012-07-17 2014-01-23 Straitmark Holding Ag Method for the synthesis of n-phosphonomethyliminodiacetic acid
US9676799B2 (en) 2012-07-17 2017-06-13 Straitmark Holding Ag Method for the synthesis of N-(phosphonomethyl)glycine
RU2674022C9 (ru) 2012-07-17 2019-01-24 МОНСАНТО ТЕКНОЛОДЖИ ЭлЭлСи Способ синтеза альфа-аминоалкиленфосфоновой кислоты
RU2694047C2 (ru) 2012-07-17 2019-07-09 МОНСАНТО ТЕКНОЛОДЖИ ЭлЭлСи Способ синтеза аминоалкиленфосфоновой кислоты

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US404406A (en) * 1889-06-04 Buckle
US2304156A (en) * 1940-03-07 1942-12-08 Du Pont Organic compound and process of preparing the same
US4044006A (en) * 1970-06-26 1977-08-23 Stauffer Chemical Company Oxazine containing ureidoalkylphosphonates
US3992294A (en) * 1974-01-07 1976-11-16 Hooker Chemicals & Plastics Corporation Process for sequestering metal ions
ES443323A1 (es) * 1974-12-11 1977-04-16 Monsanto Co Un procedimiento para obtener compuestos de carbonilaldimi- nometanfosfonato.
US4221583A (en) * 1978-12-22 1980-09-09 Monsanto Company N-Phosphonomethylglycinonitrile and certain derivatives thereof
US4830788A (en) * 1987-11-20 1989-05-16 Crompton & Knowles Corporation Process for preparation of substituted-aminomethylphosphonic acids
DE4026028A1 (de) * 1990-08-17 1992-02-20 Hoechst Ag Verfahren zur herstellung von aminomethanphosphonsaeure und aminomethyl-phosphinsaeuren aus n-hydroxymethyl-amiden

Also Published As

Publication number Publication date
SK124795A3 (en) 1996-02-07
FI954786A0 (fi) 1995-10-06
NO953992D0 (no) 1995-10-06
JPH08508284A (ja) 1996-09-03
BG100092A (bg) 1996-05-31
MY110796A (en) 1999-04-30
CN1044250C (zh) 1999-07-21
HU218867B (hu) 2000-12-28
EP0693074B1 (en) 1997-07-23
FI954786A (fi) 1995-10-06
YU14094A (sh) 1996-10-09
DE69404454D1 (de) 1997-08-28
JP3547441B2 (ja) 2004-07-28
AU680480B2 (en) 1997-07-31
US5471000A (en) 1995-11-28
CA2158471A1 (en) 1994-10-13
HU9502821D0 (en) 1995-11-28
CN1120841A (zh) 1996-04-17
ATE155789T1 (de) 1997-08-15
ZA942047B (en) 1995-01-16
HUT72040A (en) 1996-03-28
NO953992L (no) 1995-10-06
PL174910B1 (pl) 1998-10-30
PL311002A1 (en) 1996-01-22
GB9307235D0 (en) 1993-06-02
ES2104363T3 (es) 1997-10-01
WO1994022880A1 (en) 1994-10-13
DK0693074T3 (da) 1998-02-16
BR9406352A (pt) 1996-02-06
KR100253674B1 (ko) 2000-05-01
IL108991A0 (en) 1994-06-24
IL108991A (en) 1998-01-04
EP0693074A1 (en) 1996-01-24
GR3024238T3 (en) 1997-10-31
NZ262449A (en) 1997-11-24
BG62140B1 (bg) 1999-03-31
CZ258595A3 (en) 1996-01-17
AU6213694A (en) 1994-10-24
DE69404454T2 (de) 1997-12-04
CA2158471C (en) 2005-01-04
MA23155A1 (fr) 1994-12-31

Similar Documents

Publication Publication Date Title
US4327039A (en) Process for the production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid
US3168547A (en) Method of sulfating alcohols
JPS63201194A (ja) モノアルキルリン酸エステルの製造および分離方法
IE44245B1 (en) A process for the production of n-phosphonomethyl glycine
CA1052807A (en) Process of synthesizing di-polyoxyalkylene hydroxymethylphosphonate
KR960701880A (ko) 아미노메탄포스폰산의 제조방법(process for the manufacture of aminomethanephosphonic acid)
US2488449A (en) Organo-silicon-phosphorus condensation products
US3792132A (en) Process for preparing alkyl phenyl phosphate and phosphorothionate compounds
KR840005158A (ko) N-포스포노 메틸글리신의 제조방법
KR890017264A (ko) N-포스포노메틸 글리신의 제조방법
GB1131916A (en) Process for preparing ethane-1-hydroxy-1,1-diphosphonic acid
CN116284123A (zh) 一种2-乙基己基磷酸单（2-乙基己基）酯的合成方法
US4007229A (en) Preparation of hydroxyalkyl phosphine oxides and sulfides
SU1002300A1 (ru) Способ получени @ -аминозамещенных- @ -оксипропилидендифосфоновых кислот
US4034023A (en) Process for preparing mixed phosphate ester compositions
US2510033A (en) Manufacture of phosphoric acid esters
US3272892A (en) Method of preparing organic phosphonates by transesterification
US2228653A (en) Method of preparing metalloorganic compounds
ATE21107T1 (de) Verfahren zur herstellung von 3-amino-1hydroxypropan-1,1-diphosphonsaeure.
US3259671A (en) Process for preparing organic phosphinic acids and esters from olefins and products produced thereby
US3502749A (en) Process for production of organo-phosphorus compounds from white phosphorus and mono epoxy containing compounds
EP0078766A1 (de) Verfahren zur Herstellung von Aminomethylphosphonsäure
US4528140A (en) Synthesis of alpha-dithiophosphato amides
SU374322A1 (ru) ВСГСЭ;ОсНАЯП <-.,.„..,. ,j,-j.,,,,,,J,j. ц,,.ll.-;ii->&i:riw-Si-.^55inu rlAf
US2880226A (en) Manufacture of esters of thiophosphoric acid

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20090123

Year of fee payment: 10

LAPS Lapse due to unpaid annual fee