KR940703654A - 약물 전달의 지연 활성화 삼투 장치(Osmotic Device with Delayed Activa-tion of Drug Delivery) - Google Patents

약물 전달의 지연 활성화 삼투 장치(Osmotic Device with Delayed Activa-tion of Drug Delivery)

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Publication number
KR940703654A
KR940703654A KR1019940702383A KR19940702383A KR940703654A KR 940703654 A KR940703654 A KR 940703654A KR 1019940702383 A KR1019940702383 A KR 1019940702383A KR 19940702383 A KR19940702383 A KR 19940702383A KR 940703654 A KR940703654 A KR 940703654A
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KR
South Korea
Prior art keywords
housing
fluid
active drug
delivery device
drug formulation
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KR1019940702383A
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English (en)
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KR100246157B1 (ko
Inventor
패드릭 에스.-엘. 왕
Original Assignee
에드워드 엘. 만델
앨자 코포레이션
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Application filed by 에드워드 엘. 만델, 앨자 코포레이션 filed Critical 에드워드 엘. 만델
Publication of KR940703654A publication Critical patent/KR940703654A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

본 발명은 활성 약물 제제(16)을 예정된 기간동안 초기에 지연시켜 사용되는 유체 환경에 전달하는데 유용한 유체-흡수 약물 전달 장치(1)에 관한 것이다. 투약 장치(1)로부터의 약물 제제(16)의 전달은 일단 개시된 다음 예정된 기간동안 계속된다.

Description

약물 전달의 지연 활성화 삼투 장치(Osmotic Device with Delayed Activation of Drug Delivery)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 사용되는 환경에 배치되기 이전의 밀폐형 또는 제조형으로 도시한 본 발명의 전달 장치의 한 실시태양의 단면도, 제2도는 제1도의 장치가 사용되는 환경에 배치된 후 작동하여, 제2팽창 수단이 팽창하여 장치의 제1 및 제2하우징이 분리됨으로써 제1팽창 수단이 활성화되어 활성 약물 제제가 환경에 전달되기 시작하는 것을 나타낸 도면, 제3도는 제1도의 장치의 제1하우징이 그의 유효 수명의 만료까지 작동하여 제1팽창 수단이 팽창하고 활성 약물 제제의 대부분이 환경에 전달된 것을 나타낸 도면, 제4도는 밀폐형 또는 제조형으로서 도시한 본 발명의 전달 장치의 다른 실시태양의 단면도, 제5도는 밀폐형 또는 제조형으로 도시한 본 발명의 전달 장치의 또 다른 실시태양의 단면도.

Claims (8)

  1. (a) 서로 가역적으로 미끄러져 겹쳐질 수 있는 배열로 된, 적어도 일부분이 불투과성이고 그 단부가 제2하우징 내에 맞추어지도록 조정된 제1하우징, 및 적어도 일부가 반투과성인 제2하우징; (b) (ⅰ) 1종 이상의 활성 약물 제제, (ⅱ) 활성 약물 제제를 전달 장치로부터 방출시키기 위한 제1유체-활성화 팽창 수단, (ⅲ) 출구 수단, 및(ⅳ) 유체-통과 수단으로 이루어진 제1하우징 내의 활성 약물 전달 챔버; 및 (c) (ⅰ) 제1 및 제2하우징을 분리시키기 위한 제2유체-활성화 팽창 수단, 및 (ⅱ) 제1하우징의 겹쳐지는 단부에 인접한 밀판으로 이루어진 제2하우징 내의 팽창 챔버로 이루어지고, 유체환경 내에서 그의 원형을 유지하는, 초기의 예정된 지연 전달개시 후에 예정된 연장 기간에 걸쳐 활성 약물을 사용되는 유체 환경에 투여하기 위한 유체-흡수 전달 장치.
  2. 제1항에 있어서, 활성 약물 제제와 제1팽창 수단 사이에 분할 층을 더 포함하는 전달 장치.
  3. 제1항에 있어서, 제1하우징이 불투과성 재료로 이루어지고, 제2하우징이 반투과성 재료로 이루어진 전달 장치.
  4. 제1항에 있어서, 활성 약물 제제가 액체, 고체, 반고체, 열반응성 조성물 또는 복수개의 투여 형태인 전달 장치.
  5. (1) (a) 서로 가역적으로 미끄러져 겹쳐질 수 있는 배열로 된, 적어도 일부분이 불투과성이고 그 단부가 제2하우징 내에 맞추어지도록 조정된 제1하우징, 및 적어도 일부가 반투과성인 제2하우징; (b) (ⅰ) 1종 이상의 활성 약물 제제, (ⅱ) 활성 약물 제제를 전달 장치로부터 방출시키기 위한 제1유체-활성화 팽창 수단, (ⅲ) 출구 수단, 및 (ⅳ) 유체-통과 수단으로 이루어진 제1하우징 내의 활성 약물 전달 챔버; 및 (c) (ⅰ) 제1 및 제2하우징을 분리시키기 위한 제2유체-활성화 팽창 수단, 및 (ⅱ) 제1하우징의 겹쳐지는 단부에 인접한 밀판으로 이루어진 제2하우징 내의 팽창 챔버로 이루어지고, 유체환경 내에서 그의 원형을 유지하는 유체-흡수 전달 장치를 유체 환경에 배치하는 단계; (2) 유체를 전달 장치의 제2하우징의 적어도 일부를 통하여 흡수하도록 함으로써 제2팽창 수단이 팽창하여 미끄러지도록 연결된 제1 및 제2하우징에 압력을 주어 2개의 하우징이 서로 밀어내어 분리되도록 하여 유체-통과 수단을 환경에 노출시키는 단계; 및 (3) 유체를 유체-통과 수단을 통하여 흡수되도록 함으로써 제1팽창 수단이 팽창하여 전달 장치로부터 활성 약물 제제를 밀어내도록 하는 단계로 이루어진, 초기의 예정된 지연 전달 개시 후에 예정된 연장 기간에 걸쳐 활성 약물을 사용되는 유체 환경에 전달하는 방법.
  6. 제5항에 있어서, 장치가 활성 약물 제제와 제1팽창 수단 사이에 분할 층을 더 포함하는 방법.
  7. 제5항에 있어서, 제1하우징이 불투과성 재료로 이루어지고, 제2하우징이 반투과성 재료로 이루어진 방법.
  8. 제5항에 있어서, 활성 약물 제제가 액체, 고체, 반고체, 열반응성 조성물 또는 복수개의 투여 형태인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702383A 1992-01-10 1993-01-08 약물 전달의 지연 활성화 삼투 장치 KR100246157B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US819.417 1992-01-10
US07/819,417 US5223265A (en) 1992-01-10 1992-01-10 Osmotic device with delayed activation of drug delivery
US819,417 1992-01-10
PCT/US1993/000110 WO1993013759A1 (en) 1992-01-10 1993-01-08 Osmotic device with delayed activation of drug delivery

Publications (2)

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KR940703654A true KR940703654A (ko) 1994-12-12
KR100246157B1 KR100246157B1 (ko) 2000-04-01

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Country Status (16)

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US (2) US5223265A (ko)
EP (1) EP0620729B1 (ko)
JP (1) JP3514756B2 (ko)
KR (1) KR100246157B1 (ko)
AT (1) ATE127338T1 (ko)
AU (1) AU659285B2 (ko)
CA (1) CA2124829C (ko)
DE (1) DE69300451T2 (ko)
DK (1) DK0620729T3 (ko)
ES (1) ES2076837T3 (ko)
FI (1) FI943280A0 (ko)
MX (1) MX9300101A (ko)
NO (1) NO942525D0 (ko)
NZ (1) NZ246796A (ko)
WO (1) WO1993013759A1 (ko)
ZA (1) ZA93133B (ko)

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AU3436893A (en) 1993-08-03
ES2076837T3 (es) 1995-11-01
FI943280A (fi) 1994-07-08
FI943280A0 (fi) 1994-07-08
NZ246796A (en) 1995-10-26
CA2124829C (en) 2004-03-16
WO1993013759A1 (en) 1993-07-22
CA2124829A1 (en) 1993-07-22
JPH07504401A (ja) 1995-05-18
DE69300451T2 (de) 1996-05-02
DE69300451D1 (de) 1995-10-12
AU659285B2 (en) 1995-05-11
ZA93133B (en) 1993-08-16
DK0620729T3 (da) 1995-12-04
JP3514756B2 (ja) 2004-03-31
EP0620729B1 (en) 1995-09-06
EP0620729A1 (en) 1994-10-26
US5312390A (en) 1994-05-17
MX9300101A (es) 1994-01-31
ATE127338T1 (de) 1995-09-15
NO942525L (no) 1994-07-05
US5223265A (en) 1993-06-29
KR100246157B1 (ko) 2000-04-01
NO942525D0 (no) 1994-07-05

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