KR940018349A - 비페닐 유도체의 제조방법 - Google Patents

비페닐 유도체의 제조방법 Download PDF

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KR940018349A
KR940018349A KR1019940000065A KR19940000065A KR940018349A KR 940018349 A KR940018349 A KR 940018349A KR 1019940000065 A KR1019940000065 A KR 1019940000065A KR 19940000065 A KR19940000065 A KR 19940000065A KR 940018349 A KR940018349 A KR 940018349A
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South Korea
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compound
alkyl
formula
group
coor
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KR1019940000065A
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바그너 아달베르트
바트나가르 네르야
뷔엔디아 쟝
그리풀르 크리스틴
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엥엘하르트, 루츠
훽스트 아크데엔게젤샤프트
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Publication of KR940018349A publication Critical patent/KR940018349A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/04—Substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Abstract

본 발명은 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 치환된 페닐할로겐 화합물과 반응시킴을 특징으로 하는 일반식(Ⅰ)의 화합물을 제조하는 방법에 관한 것이다.
상기식에서, X는 임으로 보호된 포르밀 그룹이고, R은 합성 반응조건에 대해 그 자체가 불활성인 그룹이며, Hal은 할로겐 그룹이다.

Description

비페닐 유도체의 제보방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 치환된 페닐 할로겐 화합물과 반응시킴을 특징으로 하여 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, X는 임의로 보호된 포르밀 그룹이고, R은 합성 반응조건에 대해 그 자체가 불활성인 그룹이며, Hal은 할로겐 그룹이다.
  2. 제 1 항에 있어서, Xrk -CHO 또는 -CH(OR1)OR2[여기서, R1과 R2는 서로 독립적으로 (C1-C6)알킬이거나, R1과 R2는 함께 알킬렌 그룹 -(CH2)n- (이때, n은 2,3,4 또는 5이다)이다]이고, R이 -F, -Cl, -NO2, -(CH2)m-COOR3, -(CH2)m-CONHR3, -(CH2)m-CN, -SO2NH-COOR3, -SO2NH-CO-NHR3, -PO3R3, -NHSO2R3,트리틸, -SO2NH-SO2-R3, -NH-SO2-CF3또는 -SO2NR4[여기서, R3은 수소, (C1-C6)-알킬, (C3-C6)-사이클로알킬 또는 (C1-C6)-알킬-(C3-C6)-사이클로알킬이고, R4는 =C-N(CH3)2그룹이며, m은 0,1,2,3 또는 4이다]인 일반식(Ⅰ)인 화합물을 제조하는 방법.
  3. 제 1 항에 있어서, 일반식(Ⅱ)의 화합물과 일반식(Ⅲ)의 화합물의 커플링이 전이금속 촉매 팔라듐을 사용하여 수행되는 방법.
  4. 일반식(Ⅰ)의 화합물.
    상기식에서, X는 -CHO 또는 -CH(OR1)OR2[여기서, R1과 R2는 서로 독립적으로 (C1-C6)-알킬이거나, R1과 R2는 함께 알킬렌 그룹 -(CH2)n- (이때, n은 2,3,4 또는 5이다)이다]이고, R이 -F, -Cl, -NO2, -(CH2)m-COOR3, -(CH2)m-CONHR3, -(CH2)m-CN, -SO2NH-COOR3, -SO2NH-CO-NHR3, -SO2NH-SO2-R3, -NHSO2R3,트리틸, -PO3R3, -NH-SO2-CF3또는 -SO2NR4[여기서, R3은 수소, (C1-C6)-알킬, -C3-C6)-사이클로알킬 또는 (C1-C6)-알킬-(C3-C6)사이클로알킬이고, R4는 =C-N(CH3)2그룹이며, m은 0,1,2,3 또는 4이다]이다.
  5. 제 4 항에 있어서, R이 SO2-NR4[여기서, R4는 =C-N(CH3)2그룹이다]또는 SO2NHCONHR3(여기서, R3수소 또는 C1-C6-알킬이다)인 일반식(Ⅰ)인 화합물.
  6. 활성물질 합성용 중간체로서의, 제 1 항 내지 제 4 항 중의 어느 한 항에 따라 제조된 화합물의 용도.
  7. 안지오텐신 Ⅱ수용체 길항제 합성용 중간체로서의, 제 4 항 또는 제 5항에 따른 화합물의 용도.
  8. 일반식(Ⅲ)의 화합물.
    상기식에서, Hal은 브롬 또는 요오드이고, R은 -SO2NH-COOR3, -SO2NH-CO-NHR3또는 -SO2NH-SO2-R3[여기서, R3은 수소, (C1-C6)-알킬, (C3-C6)-사이클로알킬 또는 (C1-C6)-알킬-(C3-C6)-사이클로알킬이다]이다.
  9. 제 8 항에 있어서, R이 -SO2NH-CO-NHR3[여기서, R3은 (C1-C6)-알킬이다]인 일반식(Ⅲ)인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940000065A 1993-01-06 1994-01-04 비페닐 유도체의 제조방법 KR940018349A (ko)

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DE4300137 1993-01-06
DEP4300137.8 1993-01-06

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US (2) US5633400A (ko)
EP (1) EP0606065B1 (ko)
JP (1) JP3586288B2 (ko)
KR (1) KR940018349A (ko)
CN (1) CN1096511A (ko)
AT (1) ATE183732T1 (ko)
AU (1) AU677247B2 (ko)
BR (1) BR9400018A (ko)
CA (1) CA2112795A1 (ko)
CZ (1) CZ1494A3 (ko)
DE (1) DE59408646D1 (ko)
DK (1) DK0606065T3 (ko)
ES (1) ES2136669T3 (ko)
FI (1) FI940032A (ko)
GR (1) GR3031852T3 (ko)
HR (1) HRP940001A2 (ko)
HU (1) HUT67406A (ko)
IL (1) IL108262A0 (ko)
NO (1) NO301878B1 (ko)
NZ (2) NZ272704A (ko)
PL (1) PL301778A1 (ko)
SI (1) SI9400003A (ko)
SK (1) SK694A3 (ko)
TW (1) TW348175B (ko)
ZA (1) ZA9418B (ko)

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US8821710B2 (en) 2011-01-25 2014-09-02 Ceramatec, Inc. Production of fuel from chemicals derived from biomass
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EP0606065A1 (de) 1994-07-13
ZA9418B (en) 1994-08-18
DE59408646D1 (de) 1999-09-30
NO940023D0 (no) 1994-01-04
PL301778A1 (en) 1994-07-11
TW348175B (en) 1998-12-21
GR3031852T3 (en) 2000-02-29
BR9400018A (pt) 1994-07-26
CZ1494A3 (en) 1994-08-17
NZ250577A (en) 1997-02-24
US5633400A (en) 1997-05-27
CA2112795A1 (en) 1994-07-07
AU677247B2 (en) 1997-04-17
EP0606065B1 (de) 1999-08-25
NO940023L (ko) 1994-07-07
US5618975A (en) 1997-04-08
FI940032A0 (fi) 1994-01-04
FI940032A (fi) 1994-07-07
JP3586288B2 (ja) 2004-11-10
AU5302994A (en) 1994-07-14
ATE183732T1 (de) 1999-09-15
HU9400018D0 (en) 1994-05-30
ES2136669T3 (es) 1999-12-01
DK0606065T3 (da) 2000-03-13
JPH06234690A (ja) 1994-08-23
SI9400003A (en) 1994-09-30
SK694A3 (en) 1994-08-10
NO301878B1 (no) 1997-12-22
IL108262A0 (en) 1994-04-12
HRP940001A2 (en) 1996-06-30
NZ272704A (en) 1997-02-24
HUT67406A (en) 1995-04-28
CN1096511A (zh) 1994-12-21

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