KR940014288A - 아이오드화 방향족 화합물 - Google Patents
아이오드화 방향족 화합물 Download PDFInfo
- Publication number
- KR940014288A KR940014288A KR1019930023588A KR930023588A KR940014288A KR 940014288 A KR940014288 A KR 940014288A KR 1019930023588 A KR1019930023588 A KR 1019930023588A KR 930023588 A KR930023588 A KR 930023588A KR 940014288 A KR940014288 A KR 940014288A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- triiodobenzoate
- acetylamino
- bis
- alkyl
- Prior art date
Links
- -1 Iodide Aromatic Compounds Chemical class 0.000 title claims abstract 7
- 125000003118 aryl group Chemical group 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 5
- 125000004442 acylamino group Chemical group 0.000 claims abstract 4
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims abstract 2
- 125000005518 carboxamido group Chemical group 0.000 claims abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 125000004122 cyclic group Chemical group 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 229940124530 sulfonamide Drugs 0.000 claims abstract 2
- 150000003456 sulfonamides Chemical class 0.000 claims abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims 5
- QMKYBPDZANOJGF-UHFFFAOYSA-N benzene-1,3,5-tricarboxylic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC(C(O)=O)=C1 QMKYBPDZANOJGF-UHFFFAOYSA-N 0.000 claims 2
- FLOVEWSNNAUKLX-UHFFFAOYSA-N (3,4,5-trimethoxyphenyl) 3,5-diacetamido-2,4,6-triiodobenzoate Chemical compound COC1=C(OC)C(OC)=CC(OC(=O)C=2C(=C(NC(C)=O)C(I)=C(NC(C)=O)C=2I)I)=C1 FLOVEWSNNAUKLX-UHFFFAOYSA-N 0.000 claims 1
- MJLCPBUKDLGMKA-UHFFFAOYSA-N (4-cyanophenyl) 3,5-diacetamido-2,4,6-triiodobenzoate Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(=O)OC=2C=CC(=CC=2)C#N)=C1I MJLCPBUKDLGMKA-UHFFFAOYSA-N 0.000 claims 1
- OAPRMQDMRHZTIA-UHFFFAOYSA-N (4-methoxyphenyl) 3,5-diacetamido-2,4,6-triiodobenzoate Chemical compound C1=CC(OC)=CC=C1OC(=O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I OAPRMQDMRHZTIA-UHFFFAOYSA-N 0.000 claims 1
- FYFYCAVDUPOEOO-HNQUOIGGSA-N (ne)-n-(2-nitroethylidene)hydroxylamine Chemical compound O\N=C\C[N+]([O-])=O FYFYCAVDUPOEOO-HNQUOIGGSA-N 0.000 claims 1
- INPWHIBRMNBPDX-UHFFFAOYSA-N 2,3,5,6-tetraiodoterephthalic acid Chemical compound OC(=O)C1=C(I)C(I)=C(C(O)=O)C(I)=C1I INPWHIBRMNBPDX-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- GNOGSFBXBWBTIG-UHFFFAOYSA-N Acetrizoic acid Chemical compound CC(=O)NC1=C(I)C=C(I)C(C(O)=O)=C1I GNOGSFBXBWBTIG-UHFFFAOYSA-N 0.000 claims 1
- QLMIDRBAAYKBKW-UHFFFAOYSA-N CC(NC(C(I)=C(C(I)=C1C(OC2=CC=CC=C2)=O)NC(C)=O)=C1I)=O Chemical compound CC(NC(C(I)=C(C(I)=C1C(OC2=CC=CC=C2)=O)NC(C)=O)=C1I)=O QLMIDRBAAYKBKW-UHFFFAOYSA-N 0.000 claims 1
- UXIGWFXRQKWHHA-UHFFFAOYSA-N Iotalamic acid Chemical compound CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I UXIGWFXRQKWHHA-UHFFFAOYSA-N 0.000 claims 1
- NDLMWGWUFPOLOC-UHFFFAOYSA-N benzyl 3,5-diacetamido-2,4,6-triiodobenzoate Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(=O)OCC=2C=CC=CC=2)=C1I NDLMWGWUFPOLOC-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960000929 iotalamic acid Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/55—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and esterified hydroxy groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
본원은 X-선 이미징 조성물들 및 방법들에서 조영제로 유용한 하기식의 화합물들에 관한다.
식중 : (Z)-COO는 아이오드화한 방향족산의 잔기 ; n은 0 내지 6인 정수이고 ; R1및 R2는 각기 독립하여 H, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시 또는 아릴옥시 ; R3및 R4는 각기 독립하여 H, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시 할로겐, 하이드록시 또는 아실아미노 ; Q는 탄소고리 또는 복소환식 불푸화 단일-또는 복환 방향족 고리를 완성하는데 필수적인 원소들을 나타내며 ; R5는 H, 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시, 할로겐, 하이드록시, 아미노, 아실아미노, 알콕시알킬, 플루오로알킬, 아세트아미노알킬, COO-알킬, 시아노, 카복스아미도, 설포네이트, 설폰아미드, 우레이도, 또는 카바밀임.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기식을 갖는 화합물식중 : (Z)-COO는 아이오드화한 방향족산의 잔기 ; n은 0 내지 6인 정수이고 ; R1및 R2는 각기 독립하여 H, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시 또는 아릴옥시 ; R3및 R4는 각기 독립하여 H, 알킬, 플루오로알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시 할로겐, 하이드록시 또는 아실아미노 ; Q는 탄소고리 또는 복소환식 불푸화 단일-또는 복환 방향족 고리를 완성하는데 필수적인 원소들을 나타내며 ; R5는 H, 알킬, 싸이클로알킬, 아릴, 아랄킬, 알콕시, 아릴옥시, 할로겐, 하이드록시, 아미노, 아실아미노, 알콕시알킬, 플루오로알킬, 아세트아미노알킬, COO-알킬, 시아노, 카복스아미도, 설포네이트, 설폰아미드, 우레이도, 또는 카바밀임.
- 제 1 항에 있어서, (Z)-COO가 디아트리조산, 메트리조산, 우로콘산, 아이오탈람산, 트리메스산, 아이옥산갈산, 아이옥시탈람산, 테트라아이오도테레프탈산, 아이오디프아미드에서 선택된 아이오드화한 방향족산의 잔기인 화합물.
- 제 1 항에 있어서, (Z)-COO가 디아트리조산의 잔기인 화합물.
- 제 1 항에 있어서, Q가 페닐고리를 완성하는데 필수적인 원소들로 나타내어지는 화합물.
- 제 1 항에 있어서, R1=R2=H인 화합물.
- 제 1 항에 있어서, 상기 혼합물이 4-(에톡시카보닐)페닐 3.5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 4-(2-프로폭시카보닐)페닐 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 4-메톡시페닐 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 4-시아노페닐 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 3,4,5-트리메톡시페닐 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, (3,5-디아이오도-4-메톡시)페닐 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 4-메톡시페닐 3-아세틸아미노-5-아세틸(메틸)-아미노-2,4,6-트리아이오도벤조에이트, 벤질 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트, 및 벤질 N,N′-디-n-헥실 3,5-비스(아세틸아미노)-2,4,6-트리아이오도벤조에이트로 구성되는 그룹에서 선택된 화합물.
- 제 1 항의 화합물들로 구성되는 X-선 조영조성물.
- 제 7 항에 있어서, 제약적으로 용인할만한 담체를 추가로 포함한 X-선 조영조성물.
- 조영생산 유효량이 제 7 항의 X-선 조영조성물을 시험대상물의 신체에 투여하는 것으로 구성되는 의료용 X-선 진단 이미징 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99030692A | 1992-12-14 | 1992-12-14 | |
US92-07/990,306 | 1992-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR940014288A true KR940014288A (ko) | 1994-07-18 |
Family
ID=25536008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930023588A KR940014288A (ko) | 1992-12-14 | 1993-11-08 | 아이오드화 방향족 화합물 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5384107A (ko) |
EP (1) | EP0603923B1 (ko) |
JP (1) | JPH06228068A (ko) |
KR (1) | KR940014288A (ko) |
AT (1) | ATE156805T1 (ko) |
AU (1) | AU670458B2 (ko) |
CA (1) | CA2102269A1 (ko) |
CZ (1) | CZ271193A3 (ko) |
DE (1) | DE69313088T2 (ko) |
ES (1) | ES2105088T3 (ko) |
FI (1) | FI935307A (ko) |
HU (1) | HUT66332A (ko) |
IL (1) | IL107795A (ko) |
MX (1) | MX9306937A (ko) |
MY (1) | MY141505A (ko) |
NO (1) | NO934316L (ko) |
NZ (1) | NZ250063A (ko) |
SK (1) | SK141793A3 (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527926A (en) * | 1990-11-26 | 1996-06-18 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
IT1256248B (it) * | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
US5316755A (en) * | 1993-02-02 | 1994-05-31 | Sterling Winthrop Inc. | Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract |
NO940115D0 (no) * | 1994-01-13 | 1994-01-13 | Nycomed Imaging As | Kontrastmidler for roentgen- og magnettomografisk avbildning |
EP0746339A1 (en) * | 1994-02-25 | 1996-12-11 | Nycomed Imaging As | X-ray contrast compositions containing cellulose derivatives |
US5488133A (en) * | 1994-03-10 | 1996-01-30 | Eastman Kodak Company | Iodinated aroyloxy ketones |
CA2187019A1 (en) * | 1994-04-21 | 1995-11-02 | Stephen B. Ruddy | X-ray contrast compositions containing pharmaceutically acceptable clays |
NL9400762A (nl) * | 1994-05-09 | 1995-12-01 | T G Wiersma | Vaginaal contrastmiddel voor röntgendiagnostisch onderzoek en werkwijze voor de bereiding ervan. |
GB9419203D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
GB9419206D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
WO2003039601A1 (en) * | 2001-11-07 | 2003-05-15 | Imcor Pharmaceutical Company | Methods for vascular imaging using nanoparticulate contrast agents |
AU2003224808A1 (en) * | 2002-03-28 | 2003-10-13 | Imcor Pharmaceutical Company | Compositions and methods for delivering pharmaceutically active agents using nanoparticulates |
WO2016205334A1 (en) * | 2015-06-16 | 2016-12-22 | Vascular Strategies Llc | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL239757A (ko) * | 1958-06-03 | |||
US3144479A (en) * | 1958-08-07 | 1964-08-11 | Chemie Linz Ag | New iodine-containing benzoic acid esters |
NL7102816A (ko) * | 1970-03-12 | 1971-09-14 | ||
US4018783A (en) * | 1970-09-09 | 1977-04-19 | Beecham Group Limited | Esters of metrizoic acid |
GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
US5330739A (en) * | 1992-12-04 | 1994-07-19 | Sterling Winthrop Inc. | Iodinated benzoyl acetals and ketals for x-ray imaging |
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1993
- 1993-10-26 NZ NZ250063A patent/NZ250063A/en unknown
- 1993-11-02 CA CA002102269A patent/CA2102269A1/en not_active Abandoned
- 1993-11-05 AU AU50467/93A patent/AU670458B2/en not_active Ceased
- 1993-11-05 MX MX9306937A patent/MX9306937A/es unknown
- 1993-11-08 KR KR1019930023588A patent/KR940014288A/ko not_active Application Discontinuation
- 1993-11-19 JP JP5290977A patent/JPH06228068A/ja active Pending
- 1993-11-26 DE DE69313088T patent/DE69313088T2/de not_active Expired - Fee Related
- 1993-11-26 ES ES93203302T patent/ES2105088T3/es not_active Expired - Lifetime
- 1993-11-26 EP EP93203302A patent/EP0603923B1/en not_active Expired - Lifetime
- 1993-11-26 AT AT93203302T patent/ATE156805T1/de not_active IP Right Cessation
- 1993-11-29 FI FI935307A patent/FI935307A/fi not_active Application Discontinuation
- 1993-11-29 NO NO934316A patent/NO934316L/no unknown
- 1993-11-29 IL IL107795A patent/IL107795A/xx not_active IP Right Cessation
- 1993-12-03 MY MYPI93002577A patent/MY141505A/en unknown
- 1993-12-10 CZ CZ932711A patent/CZ271193A3/cs unknown
- 1993-12-13 HU HU9303559A patent/HUT66332A/hu unknown
- 1993-12-14 SK SK1417-93A patent/SK141793A3/sk unknown
-
1994
- 1994-08-03 US US08/285,595 patent/US5384107A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5384107A (en) | 1995-01-24 |
FI935307A0 (fi) | 1993-11-29 |
AU5046793A (en) | 1994-06-23 |
NO934316L (no) | 1994-06-15 |
IL107795A (en) | 1997-09-30 |
SK141793A3 (en) | 1994-07-06 |
NZ250063A (en) | 1996-03-26 |
HUT66332A (en) | 1994-11-28 |
NO934316D0 (no) | 1993-11-29 |
EP0603923B1 (en) | 1997-08-13 |
JPH06228068A (ja) | 1994-08-16 |
ES2105088T3 (es) | 1997-10-16 |
DE69313088D1 (de) | 1997-09-18 |
CA2102269A1 (en) | 1994-06-15 |
HU9303559D0 (en) | 1994-04-28 |
AU670458B2 (en) | 1996-07-18 |
EP0603923A1 (en) | 1994-06-29 |
IL107795A0 (en) | 1994-02-27 |
FI935307A (fi) | 1994-06-15 |
MY141505A (en) | 2010-05-14 |
DE69313088T2 (de) | 1998-01-29 |
CZ271193A3 (en) | 1995-09-13 |
ATE156805T1 (de) | 1997-08-15 |
MX9306937A (es) | 1994-06-30 |
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