KR930000527A - 칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체 - Google Patents

칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체 Download PDF

Info

Publication number
KR930000527A
KR930000527A KR1019920011075A KR920011075A KR930000527A KR 930000527 A KR930000527 A KR 930000527A KR 1019920011075 A KR1019920011075 A KR 1019920011075A KR 920011075 A KR920011075 A KR 920011075A KR 930000527 A KR930000527 A KR 930000527A
Authority
KR
South Korea
Prior art keywords
alkyl
aryl
phosphate
formula
compound
Prior art date
Application number
KR1019920011075A
Other languages
English (en)
Inventor
쉬블러 베르너
덱케르트 엘케
드리프 에릭
파우.데.마렐. 기스
폰붐 야쿠에스
Original Assignee
자우너, 라피체
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 자우너, 라피체, 훽스트 아크티엔게젤샤프트 filed Critical 자우너, 라피체
Publication of KR930000527A publication Critical patent/KR930000527A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4081—Esters with cycloaliphatic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(I)의 화합물 및 생리학적으로 허용되는 이의 염.
    상기식에서, R1은 1)포스페이트 2)OH, 3)1,2디아실-sn-글리세르-3-일 포스페이트(여기서, 아실은 탄소수 2내지 20이고 C-C-이중 결합이 0 내지 4개인 지방산이다)이거나, 4)1,2디알킬sn-글리세르-3-일 포스페이트(여기서, 알킬은 탄소수 2내지 20이고 C-C-이중결합이 0내지 4개인 탄화수소이다)이며, R2는 1)OH, 또는 2) 포스페이트이고, R3은 1)포스페이트, 또는 2)OH, 3)일반식(II)의 라디칼
    (여기서 a) Y=Z=O 및 X=(C1-C8)-알킬, b) Y=Z=O 및 X=(C6-C18)-아릴, c) Y=S 및 Z=O 및 X=(C1-C8)-알킬, d) Y=S 및 Z=O 및 X=(C6-C18)-아릴, e) Y=O 및 Z=X-(C1-C8)-알킬, f) Y=O 및 Z=X=(C6-C18)-아릴, g) Y=S 및 Z=X=(C1-C8)-알킬, h) Y=S 및 Z=X=(C6-C18)=아릴, i) Y=Z=O 및 X=CF2H, j) Y=O 및 Z=X=F, k) Y=Z=O 및 X=O-(C1-C8)-알킬, l) Y=Z=O 및 X=O-(C6-C18)-아릴, m) Y=S 및 Z=O 및 X=O-(C6-C18)-알킬, n) Y=S 및 Z=O 및 X=O-(C6-C18)-아릴, o) Y=O 및 Z=X=O-(C6-C8)-알킬, p) Y=O 및 Z=X=O-(C6-C18)-아릴, q) Y=S 및 Z=X=O-(C1-C8)-알킬 및 r) Y=S 및 Z=X=O-(C6-C18)-아릴이다), 4) 일반식(III)의 라디칼
    [여기서, a) X=OR (여기서, R은 H, (C1-C8)-알킬, 또는 (C6-C18)-아릴이다), b) X=(C1-C8)-알킬, c) X=(C6-C18)-아릴, d) X=NH-(C1-C8)-알킬 및 e) X=NH-(C6-C18)-아릴이다], 및 5) 일반식(IV)의 라디칼
    [여기서, a) X=OR (여기서, R은 H, (C1-C8)-알킬, 또는 (C6-C18)-아릴이다), b) X=(C1-C8)-알킬, c) X=(C6-C18)-아릴, d) X=NH-(C1-C8)-알킬 및 e) X=NH-(C6-C18)-아릴이다]이며, R4는 1) 일반식(V)의 라디칼
    (여기서 a) Y=Z=O 및 X=(C1-C8)-알킬, b) Y=Z=O 및 X=(C6-C18)-아릴, c) Y=S 및 Z=O 및 X=(C1-C8)-알킬, d) Y=S 및 Z=O 및 X=(C6-C18)-아릴, e) Y=O 및 Z=X-(C1-C8)-알킬, f) Y=O 및 Z=X=(C6-C18)-아릴, g) Y=S 및 Z=X=(C1-C8)-알킬, h) Y=S 및 Z=X=(C6-C18)=아릴, i) Y=Z=O 및 X=CF2H, j) Y=O 및 Z=X=F, k) Y=Z=O 및 X=O-(C1-C8)-알킬, l) Y=Z=O 및 X=O-(C6-C18)-아릴, m) Y=S 및 Z=O 및 X=O-(C6-C18)-알킬, n) Y=S 및 Z=O 및 X=O-(C6-C18)-아릴, o) Y=O 및 Z=X=O-(C6-C8)-알킬, p) Y=O 및 Z=X=O-(C6-C18)-아릴, q) Y=S 및 Z=X=O-(C1-C8)-알킬 및 r) Y=S 및 Z=X=O-(C6-C18)-아릴이다), 2) 일반식(VI)의 라디칼
    [여기서, a) X=OR (여기서, R은 H, (C1-C8)-알킬, 또는 (C6-C18)-아릴이다), b) X=(C1-C8)-알킬, c) X=(C6-C18)-아릴, d) X=NH-(C1-C8)-알킬 및 e) X=NH-(C6-C18)-아릴이다] 및 3)일반식(VII)의 라디칼
    [여기서, a) X=OR (여기서, R은 H, (C1-C8)-알킬, 또는 (C6-C18)-아릴이다), b) X=(C1-C8)-알킬, c) X=(C6-C18)-아릴, d) X=NH-(C1-C8)-알킬 및 e) X=NH-(C6-C18)-아릴이다]이다.
  2. 제1항에 있어서, R1은 포스페이트 또는 1,2-디아실-sn-글리세르-3-일 포스페이트(여기서, 아실은 탄소수 2내지 20이고 C-C-이중 결합이 0 내지 4개인 지방산 라디칼이다)이고, R2는 OH, 또는 포스페이트이며, R3은 OH 또는 포스페이트이고, R4는 일반식의 라디칼 (여기서, Y=Z=O이고, X=(C1-C8)-알킬이다)인 일반식(I)의 화합물 및 생리학적으로 허용되는 이의 염.
  3. 제2항에 있어서, R4가 X가 메틸, 에틸 또는 프로필인 일반식(V)의 라디칼인 일반식(I)의 화합물.
  4. 미오-이노시톨 유도체로부터 출발하여 제1항에 내지 제3항중 어느 한 항에 따른 일반식(I)의 화합물을 제조하는 방법.
  5. 약물로서 사용하기 위한 제1항 내지 제3항중 어느 한 항에 따른 일반식(I)의 화합물.
  6. 심맥관계 질환 치료용 약물로서 사용하기 위한, 제1항 내지 제3항중 어느 한 항에 따른 일반식(I)의 화합물.
  7. 제1항에 따른 화합물 또는 생리학적으로 허용되는 이의 염의 유효량 및 생리학적으로 허용되는 비히클을 포함하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920011075A 1991-06-26 1992-06-25 칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체 KR930000527A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91110546.8 1991-06-26
EP91110546 1991-06-26

Publications (1)

Publication Number Publication Date
KR930000527A true KR930000527A (ko) 1993-01-15

Family

ID=8206868

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920011075A KR930000527A (ko) 1991-06-26 1992-06-25 칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체

Country Status (11)

Country Link
US (1) US5395828A (ko)
EP (1) EP0520372B1 (ko)
JP (1) JP3161813B2 (ko)
KR (1) KR930000527A (ko)
AT (1) ATE145911T1 (ko)
CA (1) CA2072303A1 (ko)
DE (1) DE69215588T2 (ko)
DK (1) DK0520372T3 (ko)
ES (1) ES2095985T3 (ko)
GR (1) GR3022546T3 (ko)
HU (2) HUT64081A (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000586A2 (en) * 1994-06-30 1996-01-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Methods for treating cell proliferative disorders by modulating signal transduction
US6953781B2 (en) 2000-05-12 2005-10-11 Rodaris Pharmaceuticals Limited Compounds and their uses
US6759390B2 (en) 2000-05-12 2004-07-06 Manuel Martin-Lomas Compounds and their uses
US6939857B2 (en) 2000-05-12 2005-09-06 Rodaris Pharmaceuticals Limited Compounds and their uses
US6716826B2 (en) 2000-05-12 2004-04-06 Rodaris Pharmaceuticals Limited Compounds and their uses
WO2002038140A2 (en) * 2000-11-09 2002-05-16 Contrimmune Biotechnology Inc Therapeutic uses for ip3 receptor-mediated calcium channel modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515722A (en) * 1982-03-30 1985-05-07 Merck & Co., Inc. Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
EP0262227B1 (en) * 1986-03-11 1993-01-20 MITSUI TOATSU CHEMICALS, Inc. Process for the preparation of myoinositol derivatives
SE8605063D0 (sv) * 1986-11-26 1986-11-26 Matti Siren Derivatives of cyclohexane

Also Published As

Publication number Publication date
GR3022546T3 (en) 1997-05-31
HU9202103D0 (en) 1992-10-28
DE69215588D1 (de) 1997-01-16
ES2095985T3 (es) 1997-03-01
ATE145911T1 (de) 1996-12-15
US5395828A (en) 1995-03-07
EP0520372A1 (en) 1992-12-30
HU211491A9 (en) 1995-11-28
DE69215588T2 (de) 1997-05-15
JPH05213975A (ja) 1993-08-24
CA2072303A1 (en) 1992-12-27
HUT64081A (en) 1993-11-29
DK0520372T3 (da) 1997-05-12
EP0520372B1 (en) 1996-12-04
JP3161813B2 (ja) 2001-04-25

Similar Documents

Publication Publication Date Title
PT75649A (de) Neue carbonsaeurederivate verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
ATE89263T1 (de) Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
KR890011601A (ko) (사이클로알킬아미노)메틸렌비스(포스폰산)및 활성성분으로서 이를 함유한 의약
ATE25974T1 (de) Acyl-substituierte derivate von 1,2,3,4tetrahydroisochinolin-3-carboxysaeuren, ihre salze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung.
DE3778951D1 (de) 1,2,5,6-tetrahydropyridin-3-carboxaldehydoximderivate, verfahren zur herstellung, sie enthaltende zusammensetzungen und deren anwendung als heilmittel.
ATE46696T1 (de) 1- und 1,1-disubstituierte, 6-substituierte, 2carbamimidoyl-1-carbadethiapen-2-em-3carbons|uren, verfahren zur herstellung und diese enthaltende antibiotische zusammensetzung.
EP0193148A3 (en) 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
KR840007596A (ko) 유기인 유도체의염의 제조방법
KR940021059A (ko) 지질 대사 개선제
HUT55032A (en) Process for producing 19-norsteroids comprising carbon chain substituted in 11beta position by amide or carbamagte group, as well as pharmaceutical compositions comprising such compounds as active ingredient
ATE25847T1 (de) Derivate von pyridinium-thiomethylcephalosporinen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
DE69409337D1 (de) Verzweigte Aminothiazole-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Zusammenstellungen die sie enthalten
ATE64368T1 (de) Ester von mit pyrethrumsaeure verwandten cyclopropancarbonsaeuren, verfahren zur ihrer herstellung und ihre verwendung als parasitizide.
AU6476394A (en) 19-nor steroids having a phenoxyalkylsulphonamide or phenoxyalkylsulphonylurea chain in position 11beta, preparation process and intermediates, use as medicaments and pharmaceutical compositions containing them
KR900016098A (ko) 카페인산의 유도체 및 이를 함유하는 약제학적 조성물
DE59105219D1 (de) Neue 4-Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln.
KR930000527A (ko) 칼슘-길항성 물질로서의 이노시톨 포스페이트 동족체
FR2663328B1 (fr) Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.
ATE135681T1 (de) Diclofenac-cholinsalz, verfahren zur herstellung und pharmazeutische zusammensetzungen, die es enthalten
ATE166060T1 (de) Neue (estradiol-derivat)-chlorambucil-konjugate, verfahren zu ihrer herstellung und pharmazeutische präparate
DE69711920D1 (de) Neue histidinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel gegen freie radikale
ATE69611T1 (de) Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE162195T1 (de) 4-hydroxy-phenyl-beta-d-glukose-monoester, verfahren zur ihrer herstellung und ihre verwendung in der kosmetik, der pharmazie, als zahnpflegemitteln und lebensmitteln
DE3866603D1 (de) 1-benzoyl-2-oxo-5-alkoxy-pyrrolidin-derivate, ihre herstellung und verwendung als heilmittel und zubereitungen, die sie enthalten.
ATE34740T1 (de) (bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee