KR920002791A - 항종양 항생제 bu-3285t - Google Patents
항종양 항생제 bu-3285t Download PDFInfo
- Publication number
- KR920002791A KR920002791A KR1019900010584A KR900010584A KR920002791A KR 920002791 A KR920002791 A KR 920002791A KR 1019900010584 A KR1019900010584 A KR 1019900010584A KR 900010584 A KR900010584 A KR 900010584A KR 920002791 A KR920002791 A KR 920002791A
- Authority
- KR
- South Korea
- Prior art keywords
- desulphate
- following structural
- structural formula
- producing
- pharmacological
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BU-3285T의 IR스펙트럼을 나타낸 도면.
제2도는 BU-3285T의 'H-NMR스펙트럼을 나타낸 도면.(400MHz, DMSO-d6)
Claims (9)
- 다음 구조식을 갖는 화합물 BU-3285T
- 자화가능한 탄소원과 질소원을 함유하는 수성 영양배지중, 함침된 호기적 조건하에서 차이니아 로제아의 BU-3285T-생산균주를 상기 배지에서 상기 균주가 실질적인 양의 BU-3285T를 생산할 때까지 배양한 다음 실제로 공동-생산된 물질이 없는 배양지로부터 BU-3285T를 회수하는 것으로 이루어짐을 특징으로 하는 다음 구조식을 갖는 BU-3285T의 제조방법.
- 제2항에 있어서, BU-3285T-생산균주가 차이니아 로제아 ATCC-53903호 또는 그의 돌연변이주 또는 변종인 것이 특징인 BU-3285T의 제조방법.
- 자화가능한 탄소원을 함유하는 수성 영양배지중 함침된 호기적 조건하에서 배양시키면 항생제 BU-3285T를 생산할 수 있는 미생물 차이니아 로제아 ATCC-53903호, 또는 BU-3285T 생산 특성을 유지하는 차이니아 로제아 ATCC-53903호의 변종이나 돌연변이주의 생물학적으로 순수한 배양제.
- 제1항에서 정의된 BU-3285T 의 치료적 유효량과 약리적인 담체로 이루어짐을 특징으로 하는, 진균류에 감염된 동물숙주를 치료하는데 사용하기 위한 약리적 조성물.
- BU-3285T의 종양억제량과 약리적인 담체로 이루어짐을 특징으로 하는, 제1항에서 정의된 BU-3285T에 민감한 종양에 걸린 포유류 숙주를 치료하는데 사용하기 위한 약리적 조성물.
- 다음 구조식을 갖는 BU-3285T 데슐페이트 화합물.
- 다음 구조식의 항생제 BU-3285T를BU-3285T를 목적하는 BU-3285T 데술페이트 유도체로 전환시킬 수 있는 술파타제 효소와 반응시키는 것으로 됨을 특징으로 하는, 다음 구조식을 갖는 BU-3285T 데술페이트의 제조방법.
- 제9항에서 정의된 BU-3285T 데술페이트의 종양억제량과 약리적인 담체로 이루어짐을 특징으로 하는, BU-3285T 데술페이트에 민감한 종양에 걸린 포유류 숙주를 치료하는데 사용하기 위한 약리적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37867789A | 1989-07-12 | 1989-07-12 | |
US378677 | 1989-07-12 | ||
US378,677 | 1989-07-12 | ||
US431,423 | 1989-11-03 | ||
US431423 | 1989-11-03 | ||
US07/431,423 US4952709A (en) | 1989-07-12 | 1989-11-03 | Antitumor antibiotic BU-3285T compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920002791A true KR920002791A (ko) | 1992-02-28 |
KR930005868B1 KR930005868B1 (ko) | 1993-06-25 |
Family
ID=27008309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900010584A KR930005868B1 (ko) | 1989-07-12 | 1990-07-12 | 항종양 항생제 bu-3285t |
Country Status (13)
Country | Link |
---|---|
US (1) | US4952709A (ko) |
EP (1) | EP0408336B1 (ko) |
JP (1) | JPH0684366B2 (ko) |
KR (1) | KR930005868B1 (ko) |
AT (1) | ATE111091T1 (ko) |
AU (1) | AU617950B2 (ko) |
CA (1) | CA2020878C (ko) |
DE (1) | DE69012245T2 (ko) |
DK (1) | DK0408336T3 (ko) |
ES (1) | ES2060957T3 (ko) |
FI (1) | FI95286C (ko) |
IE (1) | IE64853B1 (ko) |
PT (1) | PT94670B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100786785B1 (ko) * | 2006-11-27 | 2007-12-18 | 한국생산기술연구원 | 저공해 예혼합 연소기 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578383A (en) * | 1982-12-07 | 1986-03-25 | Warner-Lambert Company | CL 1565 antibiotic compounds |
EP0128651A3 (en) * | 1983-05-12 | 1987-01-07 | Warner-Lambert Company | Pyranones and related compounds and methods for their production and use |
US4680416A (en) * | 1983-05-12 | 1987-07-14 | Warner-Lambert Company | Antibiotic CL-1565 complex derivatives |
US4495286A (en) * | 1983-05-25 | 1985-01-22 | Warner-Lambert Company | Antibiotic complex producing bacterial culture |
CA1232852A (en) * | 1983-09-12 | 1988-02-16 | Gerard C. Hokanson | Cl-1957b antibiotic compound and its production |
US4792522A (en) * | 1983-12-12 | 1988-12-20 | Bristol-Myers Company | Rigolettone antitumor complex |
-
1989
- 1989-11-03 US US07/431,423 patent/US4952709A/en not_active Expired - Lifetime
-
1990
- 1990-07-09 FI FI903459A patent/FI95286C/fi active IP Right Grant
- 1990-07-11 JP JP2183875A patent/JPH0684366B2/ja not_active Expired - Lifetime
- 1990-07-11 IE IE253590A patent/IE64853B1/en not_active IP Right Cessation
- 1990-07-11 AT AT90307579T patent/ATE111091T1/de not_active IP Right Cessation
- 1990-07-11 EP EP90307579A patent/EP0408336B1/en not_active Expired - Lifetime
- 1990-07-11 ES ES90307579T patent/ES2060957T3/es not_active Expired - Lifetime
- 1990-07-11 CA CA002020878A patent/CA2020878C/en not_active Expired - Lifetime
- 1990-07-11 DK DK90307579.4T patent/DK0408336T3/da active
- 1990-07-11 DE DE69012245T patent/DE69012245T2/de not_active Expired - Lifetime
- 1990-07-11 PT PT94670A patent/PT94670B/pt not_active IP Right Cessation
- 1990-07-11 AU AU58928/90A patent/AU617950B2/en not_active Expired
- 1990-07-12 KR KR1019900010584A patent/KR930005868B1/ko not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100786785B1 (ko) * | 2006-11-27 | 2007-12-18 | 한국생산기술연구원 | 저공해 예혼합 연소기 |
Also Published As
Publication number | Publication date |
---|---|
DE69012245T2 (de) | 1995-01-05 |
ES2060957T3 (es) | 1994-12-01 |
EP0408336B1 (en) | 1994-09-07 |
FI95286C (fi) | 1996-01-10 |
DK0408336T3 (da) | 1994-10-10 |
FI903459A0 (fi) | 1990-07-09 |
PT94670A (pt) | 1991-03-20 |
CA2020878A1 (en) | 1991-01-13 |
IE64853B1 (en) | 1995-09-06 |
AU5892890A (en) | 1991-01-17 |
AU617950B2 (en) | 1991-12-05 |
ATE111091T1 (de) | 1994-09-15 |
EP0408336A3 (en) | 1991-04-03 |
JPH03115276A (ja) | 1991-05-16 |
KR930005868B1 (ko) | 1993-06-25 |
PT94670B (pt) | 1997-07-31 |
FI95286B (fi) | 1995-09-29 |
IE902535A1 (en) | 1991-02-13 |
DE69012245D1 (de) | 1994-10-13 |
US4952709A (en) | 1990-08-28 |
CA2020878C (en) | 1996-06-18 |
JPH0684366B2 (ja) | 1994-10-26 |
EP0408336A2 (en) | 1991-01-16 |
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